Mir16-2

Summary

Gene Symbol: Mir16-2
Description: microRNA 16-2
Alias: Mirn16-2, mir-16-2
Species: mouse

Top Publications

  1. Smits G, Mungall A, Griffiths Jones S, Smith P, Beury D, Matthews L, et al. Conservation of the H19 noncoding RNA and H19-IGF2 imprinting mechanism in therians. Nat Genet. 2008;40:971-6 pubmed publisher
    ..The conservation in all therians of the mechanism controlling imprinting of the IGF2-H19 locus suggests a sequential model of imprinting evolution. ..
  2. Ikeda S, He A, Kong S, Lu J, Bejar R, Bodyak N, et al. MicroRNA-1 negatively regulates expression of the hypertrophy-associated calmodulin and Mef2a genes. Mol Cell Biol. 2009;29:2193-204 pubmed publisher
    ..Our data indicate that miR-1 regulates cardiomyocyte growth responses by negatively regulating the calcium signaling components calmodulin, Mef2a, and Gata4. ..
  3. Dorval V, Mandemakers W, Jolivette F, Coudert L, Mazroui R, De Strooper B, et al. Gene and MicroRNA transcriptome analysis of Parkinson's related LRRK2 mouse models. PLoS ONE. 2014;9:e85510 pubmed publisher
    ..Our data thus set the stage for future investigations regarding LRRK2 function in PD development. ..
  4. Chen C, Li L, Lodish H, Bartel D. MicroRNAs modulate hematopoietic lineage differentiation. Science. 2004;303:83-6 pubmed
    ..Our results indicate that microRNAs are components of the molecular circuitry that controls mouse hematopoiesis and suggest that other microRNAs have similar regulatory roles during other facets of vertebrate development. ..
  5. Pan Y, Balazs L, Tigyi G, Yue J. Conditional deletion of Dicer in vascular smooth muscle cells leads to the developmental delay and embryonic mortality. Biochem Biophys Res Commun. 2011;408:369-74 pubmed publisher
    ..5. Expression of most miRNAs examined was compromised in VSMCs of Dicer KO. Our results indicate that Dicer is required for vascular development and regulates vascular remodeling by modulating VSMC proliferation and differentiation. ..
  6. Yi R, O Carroll D, Pasolli H, Zhang Z, Dietrich F, Tarakhovsky A, et al. Morphogenesis in skin is governed by discrete sets of differentially expressed microRNAs. Nat Genet. 2006;38:356-62 pubmed
    ..Here we characterize miRNAs in skin, the existence of which was hitherto unappreciated, and demonstrate their differential expression and importance in the morphogenesis of epithelial tissues within this vital organ. ..
  7. Thomson J, Newman M, Parker J, Morin Kensicki E, Wright T, Hammond S. Extensive post-transcriptional regulation of microRNAs and its implications for cancer. Genes Dev. 2006;20:2202-7 pubmed
    ..These data uncover a novel regulatory step in miRNA function and provide a mechanism for miRNA down-regulation in cancer. ..
  8. Zhu R, Ji Y, Xiao L, Matin A. Testicular germ cell tumor susceptibility genes from the consomic 129.MOLF-Chr19 mouse strain. Mamm Genome. 2007;18:584-95 pubmed
    ..Our data advance the use of CSS to identify disease susceptibility genes and demonstrate that the 129.MOLF-Chr19 strain serves as a useful model to elucidate the genetics and biology of germ cell transformation and tumor development. ..
  9. Jevnaker A, Osmundsen H. MicroRNA expression profiling of the developing murine molar tooth germ and the developing murine submandibular salivary gland. Arch Oral Biol. 2008;53:629-45 pubmed publisher
    ..g., epithelical cell proliferation, mesodermal cell fate determination and salivary gland morphogenesis...

More Information

Publications21

  1. Gaughwin P, Ciesla M, Yang H, Lim B, Brundin P. Stage-specific modulation of cortical neuronal development by Mmu-miR-134. Cereb Cortex. 2011;21:1857-69 pubmed publisher
  2. Otsuka M, Jing Q, Georgel P, New L, Chen J, Mols J, et al. Hypersusceptibility to vesicular stomatitis virus infection in Dicer1-deficient mice is due to impaired miR24 and miR93 expression. Immunity. 2007;27:123-34 pubmed
    ..Our data suggest that host miRNA can play a role in host interactions with viruses. ..
  3. Krol J, Krol I, Alvarez C, Fiscella M, Hierlemann A, Roska B, et al. A network comprising short and long noncoding RNAs and RNA helicase controls mouse retina architecture. Nat Commun. 2015;6:7305 pubmed publisher
    ..Our results suggest that the precise timing of glia-neuron interaction controlled by noncoding RNAs and Ddx3x is important for the even distribution of cells across layers. ..
  4. Lovat F, Fassan M, Gasparini P, Rizzotto L, Cascione L, Pizzi M, et al. miR-15b/16-2 deletion promotes B-cell malignancies. Proc Natl Acad Sci U S A. 2015;112:11636-41 pubmed publisher
    ..These results are the first, to our knowledge, to suggest an important role of miR-15b/16-2 loss in the pathogenesis of B-cell chronic lymphocytic leukemia. ..
  5. Mukhopadhyay P, Brock G, Appana S, Webb C, Greene R, Pisano M. MicroRNA gene expression signatures in the developing neural tube. Birth Defects Res A Clin Mol Teratol. 2011;91:744-62 pubmed publisher
    ..This study is the first to identify miRNA expression profiles and their potential regulatory networks in the developing mammalian NT. ..
  6. Liu W, Liu C, Zhu J, Shu P, Yin B, Gong Y, et al. MicroRNA-16 targets amyloid precursor protein to potentially modulate Alzheimer's-associated pathogenesis in SAMP8 mice. Neurobiol Aging. 2012;33:522-34 pubmed publisher
    ..Taken together, these findings demonstrate that APP is a target of miR-16 and the abnormally low expression of miR-16 could potentially lead to APP protein accumulation in AD mice. ..
  7. Liu W, Pang R, Chiu P, Wong B, Lao K, Lee K, et al. Sperm-borne microRNA-34c is required for the first cleavage division in mouse. Proc Natl Acad Sci U S A. 2012;109:490-4 pubmed publisher
    ..Our findings provide evidence that sperm-borne miR-34c is important for the first cell division via modulation of Bcl-2 expression. ..
  8. Shoji M, Tanaka T, Hosokawa M, Reuter M, Stark A, Kato Y, et al. The TDRD9-MIWI2 complex is essential for piRNA-mediated retrotransposon silencing in the mouse male germline. Dev Cell. 2009;17:775-87 pubmed publisher
  9. Cordes K, Sheehy N, White M, Berry E, Morton S, Muth A, et al. miR-145 and miR-143 regulate smooth muscle cell fate and plasticity. Nature. 2009;460:705-10 pubmed publisher
    ..These findings demonstrate that miR-145 can direct the smooth muscle fate and that miR-145 and miR-143 function to regulate the quiescent versus proliferative phenotype of smooth muscle cells. ..
  10. Liu X, Jin D, McManus M, Mourelatos Z. Precursor microRNA-programmed silencing complex assembly pathways in mammals. Mol Cell. 2012;46:507-17 pubmed publisher
    ..Our studies provide a comprehensive view of miRNP/RISC assembly pathways in mammals, and our assay provides a versatile platform for further mechanistic dissection of such pathways in mammals. ..
  11. Moon H, Yang J, Zheng Y, Jin Y. miR-15a/16 regulates macrophage phagocytosis after bacterial infection. J Immunol. 2014;193:4558-67 pubmed publisher
    ..Taken together, miR-15a/16 altered phagocytosis and bacterial clearance by targeting, at least partially, on the TLR4-associated pathways, subsequently affecting the survival of septic mice. ..
  12. Porrello E, Johnson B, Aurora A, Simpson E, Nam Y, Matkovich S, et al. MiR-15 family regulates postnatal mitotic arrest of cardiomyocytes. Circ Res. 2011;109:670-9 pubmed publisher
    ..These findings suggest that upregulation of the miR-15 family during the neonatal period may be an important regulatory mechanism governing cardiomyocyte cell cycle withdrawal and binucleation. ..