Gene Symbol: Mir15a
Description: microRNA 15a
Alias: Mirn15a, mmu-mir-15a
Species: mouse

Top Publications

  1. Yin K, Olsen K, Hamblin M, Zhang J, Schwendeman S, Chen Y. Vascular endothelial cell-specific microRNA-15a inhibits angiogenesis in hindlimb ischemia. J Biol Chem. 2012;287:27055-64 pubmed publisher
    ..Pharmacological modulation of miR-15a function may provide a new therapeutic strategy to intervene against angiogenesis in a variety of pathological conditions...
  2. Liu X, Wang R, Hu B, Luo M, Zeng Q, Zhou H, et al. MiR-15a contributes abnormal immune response in myasthenia gravis by targeting CXCL10. Clin Immunol. 2016;164:106-13 pubmed publisher
    ..Take together, our data suggest that decreased miR-15a expression facilitates proinflammatory cytokines production and contributes to immune response at least in part via regulating CXCL10 expression in MG. ..
  3. Du J, Zhang X, Cao H, Jiang D, Wang X, Zhou W, et al. MiR-194 is involved in morphogenesis of spiral ganglion neurons in inner ear by rearranging actin cytoskeleton via targeting RhoB. Int J Dev Neurosci. 2017;63:16-26 pubmed publisher
  4. Yang J, Wu S, Rau C, Chen Y, Lu T, Wu Y, et al. TLR4/NF-κB-responsive microRNAs and their potential target genes: a mouse model of skeletal muscle ischemia-reperfusion injury. Biomed Res Int. 2015;2015:410721 pubmed publisher
    ..This study profiled TLR4/NF-κB-responsive miRNAs and their potential target genes in mouse skeletal muscle subjected to ischemia-reperfusion injury. ..
  5. Pan Y, Balazs L, Tigyi G, Yue J. Conditional deletion of Dicer in vascular smooth muscle cells leads to the developmental delay and embryonic mortality. Biochem Biophys Res Commun. 2011;408:369-74 pubmed publisher
    ..5. Expression of most miRNAs examined was compromised in VSMCs of Dicer KO. Our results indicate that Dicer is required for vascular development and regulates vascular remodeling by modulating VSMC proliferation and differentiation. ..
  6. Friedman L, Dror A, Mor E, Tenne T, Toren G, Satoh T, et al. MicroRNAs are essential for development and function of inner ear hair cells in vertebrates. Proc Natl Acad Sci U S A. 2009;106:7915-20 pubmed publisher
    ..Our data support the hypothesis that inner ear tissue differentiation and maintenance are regulated and controlled by conserved sets of cell-specific miRNAs in both mouse and zebrafish. ..
  7. Klein U, Lia M, Crespo M, Siegel R, Shen Q, Mo T, et al. The DLEU2/miR-15a/16-1 cluster controls B cell proliferation and its deletion leads to chronic lymphocytic leukemia. Cancer Cell. 2010;17:28-40 pubmed publisher
    ..miR-15a/16-1-deletion accelerates the proliferation of both human and mouse B cells by modulating the expression of genes controlling cell-cycle progression. These results define the role of 13q14 deletions in the pathogenesis of CLL. ..
  8. Moon H, Yang J, Zheng Y, Jin Y. miR-15a/16 regulates macrophage phagocytosis after bacterial infection. J Immunol. 2014;193:4558-67 pubmed publisher
    ..Taken together, miR-15a/16 altered phagocytosis and bacterial clearance by targeting, at least partially, on the TLR4-associated pathways, subsequently affecting the survival of septic mice. ..
  9. Sun L, Jiang B, Li W, Zou J, Shi Y, Liu Z. MicroRNA-15a positively regulates insulin synthesis by inhibiting uncoupling protein-2 expression. Diabetes Res Clin Pract. 2011;91:94-100 pubmed publisher
    ..This study suggests miR-15a is a mediator of ? cell function and insulin biosynthesis, thus offering a new target for the development of preventive or therapeutic agents against diabetes. ..

More Information


  1. Volk N, Pape J, Engel M, Zannas A, Cattane N, Cattaneo A, et al. Amygdalar MicroRNA-15a Is Essential for Coping with Chronic Stress. Cell Rep. 2016;17:1882-1891 pubmed publisher
    ..Taken together, our results support an important role for microRNA-15a in stress adaptation and the pathogenesis of stress-related psychopathologies. ..
  2. Teng Y, Wang Y, Fu J, Cheng X, Miao S, Wang L. Cyclin T2: a novel miR-15a target gene involved in early spermatogenesis. FEBS Lett. 2011;585:2493-500 pubmed publisher
    ..Subsequently, miR-15a and Ccnt2 were profiled in developing mice testes to observe their inverse correlations in the postnatal 3-week period to understand their roles in spermatogenesis. ..
  3. Callegari E, Gramantieri L, Domenicali M, D Abundo L, Sabbioni S, Negrini M. MicroRNAs in liver cancer: a model for investigating pathogenesis and novel therapeutic approaches. Cell Death Differ. 2015;22:46-57 pubmed publisher
    ..In general, the safety of miRNAs has been proven and antitumor activity has been observed. Moreover, because of the absence or presence of mild side effects, the prophylactic use of miRNA-based approaches may be foreseen. ..
  4. Tijsen A, van der Made I, van den Hoogenhof M, Wijnen W, van Deel E, de Groot N, et al. The microRNA-15 family inhibits the TGF?-pathway in the heart. Cardiovasc Res. 2014;104:61-71 pubmed publisher
    ..We identified the miR-15 family as a novel regulator of cardiac hypertrophy and fibrosis acting by inhibition of the TGF?-pathway. ..
  5. Dorval V, Mandemakers W, Jolivette F, Coudert L, Mazroui R, De Strooper B, et al. Gene and MicroRNA transcriptome analysis of Parkinson's related LRRK2 mouse models. PLoS ONE. 2014;9:e85510 pubmed publisher
    ..Our data thus set the stage for future investigations regarding LRRK2 function in PD development. ..
  6. Wang Q, Navitskaya S, Chakravarthy H, Huang C, Kady N, Lydic T, et al. Dual Anti-Inflammatory and Anti-Angiogenic Action of miR-15a in Diabetic Retinopathy. EBioMedicine. 2016;11:138-150 pubmed publisher
    ..Importantly, miR-15a overexpression led to modulation toward nondiabetic levels, rather than complete inhibition of ASM and VEGF-A providing therapeutic effect without detrimental consequences of ASM and VEGF-A deficiencies. ..
  7. Yang J, Liu R, Deng Y, Qian J, Lu Z, Wang Y, et al. MiR-15a/16 deficiency enhances anti-tumor immunity of glioma-infiltrating CD8+ T cells through targeting mTOR. Int J Cancer. 2017;141:2082-2092 pubmed publisher
    ..Our findings provide evidence for the potential immunotherapy through targeting miR-15a/16 in tumor-infiltrating immune cells. ..
  8. Andersen D, Jensen C, Schneider M, Nossent A, Eskildsen T, Hansen J, et al. MicroRNA-15a fine-tunes the level of Delta-like 1 homolog (DLK1) in proliferating 3T3-L1 preadipocytes. Exp Cell Res. 2010;316:1681-91 pubmed publisher
    ..Our data thus imply that miR-15a regulates cell size and proliferation by fine-tuning Dlk1 among others, and further emphasize miR-15a and DLK1 levels to play important roles in growth signaling networks. ..
  9. Rawal S, Munasinghe P, Nagesh P, Lew J, Jones G, Williams M, et al. Down-regulation of miR-15a/b accelerates fibrotic remodelling in the Type 2 diabetic human and mouse heart. Clin Sci (Lond). 2017;131:847-863 pubmed publisher
  10. Liu R, Lu Z, Gu J, Liu J, Huang E, Liu X, et al. MicroRNAs 15A and 16-1 Activate Signaling Pathways That Mediate Chemotaxis of Immune Regulatory B cells to Colorectal Tumors. Gastroenterology. 2018;154:637-651.e7 pubmed publisher
    B cells infiltrate tumors, but little is known about how they affect tumor growth and progression. microRNA15A (MIR15A or miRNA15A) and microRNA16-1 (MIR16-1 or miRNA16-1) regulate cell proliferation, apoptosis, and drug resistance...
  11. Lindner S, Lohmüller M, Kotkamp B, Schüler F, Knust Z, Villunger A, et al. The miR-15 family reinforces the transition from proliferation to differentiation in pre-B cells. EMBO Rep. 2017;18:1604-1617 pubmed publisher
    ..These findings identify the miR-15 family as a novel element required to promote the switch from pre-B cell proliferation to differentiation. ..
  12. Andl T, Murchison E, Liu F, Zhang Y, Yunta Gonzalez M, Tobias J, et al. The miRNA-processing enzyme dicer is essential for the morphogenesis and maintenance of hair follicles. Curr Biol. 2006;16:1041-9 pubmed
    ..These results reveal critical roles for Dicer in the skin and implicate miRNAs in key aspects of epidermal and hair-follicle development and function. ..
  13. Hullinger T, Montgomery R, Seto A, Dickinson B, Semus H, Lynch J, et al. Inhibition of miR-15 protects against cardiac ischemic injury. Circ Res. 2012;110:71-81 pubmed publisher
  14. Pekarsky Y, Zanesi N, Croce C. Molecular basis of CLL. Semin Cancer Biol. 2010;20:370-6 pubmed publisher
    ..Here, we present what has been learned from these new pathways, discuss mouse CLL models and how these mouse models recapitulate the molecular mechanisms of this common leukemia. ..
  15. Hoesel B, Bhujabal Z, Przemeck G, Kurz Drexler A, Weisenhorn D, Angelis M, et al. Combination of in silico and in situ hybridisation approaches to identify potential Dll1 associated miRNAs during mouse embryogenesis. Gene Expr Patterns. 2010;10:265-73 pubmed publisher
    ..5 dpc. This suggests that these miRNAs could possibly target the Dll1 3'UTR in these regions. The other miRNAs are not expressed or below the detection limit and thus are unlikely to regulate Dll1 at the analyzed embryonic stages. ..
  16. Thomson J, Newman M, Parker J, Morin Kensicki E, Wright T, Hammond S. Extensive post-transcriptional regulation of microRNAs and its implications for cancer. Genes Dev. 2006;20:2202-7 pubmed
    ..These data uncover a novel regulatory step in miRNA function and provide a mechanism for miRNA down-regulation in cancer. ..
  17. Sullivan R, Leong J, Schneider S, Ireland A, Berrien Elliott M, Singh A, et al. MicroRNA-15/16 Antagonizes Myb To Control NK Cell Maturation. J Immunol. 2015;195:2806-17 pubmed publisher
    ..Thus, miR-15/16 regulation of Myb controls the NK cell maturation program. ..
  18. Zheng X, Li A, Zhao L, Zhou T, Shen Q, Cui Q, et al. Key role of microRNA-15a in the KLF4 suppressions of proliferation and angiogenesis in endothelial and vascular smooth muscle cells. Biochem Biophys Res Commun. 2013;437:625-31 pubmed publisher
  19. Underbayev C, Kasar S, Ruezinsky W, Degheidy H, Schneider J, Marti G, et al. Role of mir-15a/16-1 in early B cell development in a mouse model of chronic lymphocytic leukemia. Oncotarget. 2016;7:60986-60999 pubmed publisher
    ..This work will help understand the role of miR-15a in early events of CLL and points to B1P cells as potential cells of origin for this incurable disease. ..
  20. Yuan Y, Kasar S, Underbayev C, Vollenweider D, Salerno E, Kotenko S, et al. Role of microRNA-15a in autoantibody production in interferon-augmented murine model of lupus. Mol Immunol. 2012;52:61-70 pubmed publisher
    ..In conclusion, our data support the involvement of elevated miR-15a in autoimmune disease development in B/W mice and suggest that decreasing this microRNA might be beneficial in B/W mice. ..
  21. Ikeda S, He A, Kong S, Lu J, Bejar R, Bodyak N, et al. MicroRNA-1 negatively regulates expression of the hypertrophy-associated calmodulin and Mef2a genes. Mol Cell Biol. 2009;29:2193-204 pubmed publisher
    ..Our data indicate that miR-1 regulates cardiomyocyte growth responses by negatively regulating the calcium signaling components calmodulin, Mef2a, and Gata4. ..