Mir155

Summary

Gene Symbol: Mir155
Description: microRNA 155
Alias: Mirn155, mmu-mir-155
Species: mouse
Products:     Mir155

Top Publications

  1. Kumar R, Halder P, Sahu S, Kumar M, Kumari M, Jana K, et al. Identification of a novel role of ESAT-6-dependent miR-155 induction during infection of macrophages with Mycobacterium tuberculosis. Cell Microbiol. 2012;14:1620-31 pubmed publisher
    ..Inhibition of miR-155 hindered survival of M.tb. in RAW264.7 and in murine BMDMs. Thus, our results offer new insights into the role of miRNAs in modulation of the host innate immune response by M.tb. for its own benefit. ..
  2. Liu S, Yang Y, Wu J. TNF?-induced up-regulation of miR-155 inhibits adipogenesis by down-regulating early adipogenic transcription factors. Biochem Biophys Res Commun. 2011;414:618-24 pubmed publisher
    ..Taken together, these findings reveal a novel role for TNF? in the regulation of anti-adipogenic miRNAs. ..
  3. Worm J, Stenvang J, Petri A, Frederiksen K, Obad S, Elmen J, et al. Silencing of microRNA-155 in mice during acute inflammatory response leads to derepression of c/ebp Beta and down-regulation of G-CSF. Nucleic Acids Res. 2009;37:5784-92 pubmed publisher
  4. Costinean S, Sandhu S, Pedersen I, Tili E, Trotta R, Perrotti D, et al. Src homology 2 domain-containing inositol-5-phosphatase and CCAAT enhancer-binding protein beta are targeted by miR-155 in B cells of Emicro-MiR-155 transgenic mice. Blood. 2009;114:1374-82 pubmed publisher
    ..We hypothesize that miR-155, by down-modulating Ship and C/EBPbeta, initiates a chain of events that leads to the accumulation of large pre-B cells and acute lymphoblastic leukemia/high-grade lymphoma...
  5. Ruggiero T, Trabucchi M, De Santa F, Zupo S, Harfe B, McManus M, et al. LPS induces KH-type splicing regulatory protein-dependent processing of microRNA-155 precursors in macrophages. FASEB J. 2009;23:2898-908 pubmed publisher
    ..Our studies unveil the existence of an LPS-dependent post-transcriptional regulation of miR-155 biogenesis. Once induced, miR-155 finely tunes the expression of select inflammation mediators in response to LPS. ..
  6. O Connell R, Chaudhuri A, Rao D, Baltimore D. Inositol phosphatase SHIP1 is a primary target of miR-155. Proc Natl Acad Sci U S A. 2009;106:7113-8 pubmed publisher
    ..Our study unveils a molecular link between miR-155 and SHIP1 and provides evidence that repression of SHIP1 is an important component of miR-155 biology. ..
  7. Escobar T, Kanellopoulou C, Kugler D, Kilaru G, Nguyen C, Nagarajan V, et al. miR-155 activates cytokine gene expression in Th17 cells by regulating the DNA-binding protein Jarid2 to relieve polycomb-mediated repression. Immunity. 2014;40:865-79 pubmed publisher
    ..Here we found defective Th17 cell cytokine expression in miR-155-deficient CD4+ T cells in vitro and in vivo. Mir155 was bound by Th17 cell transcription factors and was highly expressed during Th17 cell differentiation...
  8. Thai T, Calado D, Casola S, Ansel K, Xiao C, Xue Y, et al. Regulation of the germinal center response by microRNA-155. Science. 2007;316:604-8 pubmed
    ..miR-155 exerts this control, at least in part, by regulating cytokine production. These results also suggest that individual microRNAs can exert critical control over mammalian differentiation processes in vivo. ..
  9. Nazari Jahantigh M, Wei Y, Noels H, Akhtar S, Zhou Z, Koenen R, et al. MicroRNA-155 promotes atherosclerosis by repressing Bcl6 in macrophages. J Clin Invest. 2012;122:4190-202 pubmed publisher
    ..Leukocyte-specific Mir155 deficiency reduced plaque size and number of lesional macrophages after partial carotid ligation in ..
  10. Corsten M, Papageorgiou A, Verhesen W, Carai P, Lindow M, Obad S, et al. MicroRNA profiling identifies microRNA-155 as an adverse mediator of cardiac injury and dysfunction during acute viral myocarditis. Circ Res. 2012;111:415-25 pubmed publisher
    ..The inflammatory microRNA-155 is upregulated during acute myocarditis, contributes to the adverse inflammatory response to viral infection of the heart, and is a potential therapeutic target for viral myocarditis. ..

Detail Information

Publications62

  1. Kumar R, Halder P, Sahu S, Kumar M, Kumari M, Jana K, et al. Identification of a novel role of ESAT-6-dependent miR-155 induction during infection of macrophages with Mycobacterium tuberculosis. Cell Microbiol. 2012;14:1620-31 pubmed publisher
    ..Inhibition of miR-155 hindered survival of M.tb. in RAW264.7 and in murine BMDMs. Thus, our results offer new insights into the role of miRNAs in modulation of the host innate immune response by M.tb. for its own benefit. ..
  2. Liu S, Yang Y, Wu J. TNF?-induced up-regulation of miR-155 inhibits adipogenesis by down-regulating early adipogenic transcription factors. Biochem Biophys Res Commun. 2011;414:618-24 pubmed publisher
    ..Taken together, these findings reveal a novel role for TNF? in the regulation of anti-adipogenic miRNAs. ..
  3. Worm J, Stenvang J, Petri A, Frederiksen K, Obad S, Elmen J, et al. Silencing of microRNA-155 in mice during acute inflammatory response leads to derepression of c/ebp Beta and down-regulation of G-CSF. Nucleic Acids Res. 2009;37:5784-92 pubmed publisher
  4. Costinean S, Sandhu S, Pedersen I, Tili E, Trotta R, Perrotti D, et al. Src homology 2 domain-containing inositol-5-phosphatase and CCAAT enhancer-binding protein beta are targeted by miR-155 in B cells of Emicro-MiR-155 transgenic mice. Blood. 2009;114:1374-82 pubmed publisher
    ..We hypothesize that miR-155, by down-modulating Ship and C/EBPbeta, initiates a chain of events that leads to the accumulation of large pre-B cells and acute lymphoblastic leukemia/high-grade lymphoma...
  5. Ruggiero T, Trabucchi M, De Santa F, Zupo S, Harfe B, McManus M, et al. LPS induces KH-type splicing regulatory protein-dependent processing of microRNA-155 precursors in macrophages. FASEB J. 2009;23:2898-908 pubmed publisher
    ..Our studies unveil the existence of an LPS-dependent post-transcriptional regulation of miR-155 biogenesis. Once induced, miR-155 finely tunes the expression of select inflammation mediators in response to LPS. ..
  6. O Connell R, Chaudhuri A, Rao D, Baltimore D. Inositol phosphatase SHIP1 is a primary target of miR-155. Proc Natl Acad Sci U S A. 2009;106:7113-8 pubmed publisher
    ..Our study unveils a molecular link between miR-155 and SHIP1 and provides evidence that repression of SHIP1 is an important component of miR-155 biology. ..
  7. Escobar T, Kanellopoulou C, Kugler D, Kilaru G, Nguyen C, Nagarajan V, et al. miR-155 activates cytokine gene expression in Th17 cells by regulating the DNA-binding protein Jarid2 to relieve polycomb-mediated repression. Immunity. 2014;40:865-79 pubmed publisher
    ..Here we found defective Th17 cell cytokine expression in miR-155-deficient CD4+ T cells in vitro and in vivo. Mir155 was bound by Th17 cell transcription factors and was highly expressed during Th17 cell differentiation...
  8. Thai T, Calado D, Casola S, Ansel K, Xiao C, Xue Y, et al. Regulation of the germinal center response by microRNA-155. Science. 2007;316:604-8 pubmed
    ..miR-155 exerts this control, at least in part, by regulating cytokine production. These results also suggest that individual microRNAs can exert critical control over mammalian differentiation processes in vivo. ..
  9. Nazari Jahantigh M, Wei Y, Noels H, Akhtar S, Zhou Z, Koenen R, et al. MicroRNA-155 promotes atherosclerosis by repressing Bcl6 in macrophages. J Clin Invest. 2012;122:4190-202 pubmed publisher
    ..Leukocyte-specific Mir155 deficiency reduced plaque size and number of lesional macrophages after partial carotid ligation in ..
  10. Corsten M, Papageorgiou A, Verhesen W, Carai P, Lindow M, Obad S, et al. MicroRNA profiling identifies microRNA-155 as an adverse mediator of cardiac injury and dysfunction during acute viral myocarditis. Circ Res. 2012;111:415-25 pubmed publisher
    ..The inflammatory microRNA-155 is upregulated during acute myocarditis, contributes to the adverse inflammatory response to viral infection of the heart, and is a potential therapeutic target for viral myocarditis. ..
  11. Kong W, Yang H, He L, Zhao J, Coppola D, Dalton W, et al. MicroRNA-155 is regulated by the transforming growth factor beta/Smad pathway and contributes to epithelial cell plasticity by targeting RhoA. Mol Cell Biol. 2008;28:6773-84 pubmed publisher
    ..These data suggest that miR-155 may play an important role in TGF-beta-induced EMT and cell migration and invasion by targeting RhoA and indicate that it is a potential therapeutic target for breast cancer intervention. ..
  12. Wang P, Hou J, Lin L, Wang C, Liu X, Li D, et al. Inducible microRNA-155 feedback promotes type I IFN signaling in antiviral innate immunity by targeting suppressor of cytokine signaling 1. J Immunol. 2010;185:6226-33 pubmed publisher
    ..Therefore, we demonstrate that inducible miR-155 feedback positively regulates host antiviral innate immune response by promoting type I IFN signaling via targeting SOCS1. ..
  13. Lind E, Elford A, Ohashi P. Micro-RNA 155 is required for optimal CD8+ T cell responses to acute viral and intracellular bacterial challenges. J Immunol. 2013;190:1210-6 pubmed publisher
    ..These data suggest that mir-155 may be a good target for therapies aimed at modulating immune responses. ..
  14. Banerjee A, Schambach F, Dejong C, Hammond S, Reiner S. Micro-RNA-155 inhibits IFN-gamma signaling in CD4+ T cells. Eur J Immunol. 2010;40:225-31 pubmed publisher
    ..These results identify IFN-gammaRalpha as a second miR-155 target in T cells and suggest that miR-155 contributes to Th1 differentiation in CD4+ T cells by inhibiting IFN-gamma signaling. ..
  15. O Connell R, Kahn D, Gibson W, Round J, Scholz R, Chaudhuri A, et al. MicroRNA-155 promotes autoimmune inflammation by enhancing inflammatory T cell development. Immunity. 2010;33:607-19 pubmed publisher
    ..Consistent with a positive role for miR-155 in mediating inflammatory responses, Mir155(-/-) mice were highly resistant to experimental autoimmune encephalomyelitis (EAE)...
  16. Seok H, Tatsuguchi M, Callis T, He A, Pu W, Wang D. miR-155 inhibits expression of the MEF2A protein to repress skeletal muscle differentiation. J Biol Chem. 2011;286:35339-46 pubmed publisher
    ..Our data therefore establish miR-155 as an important regulator of MEF2A expression and uncover its function in muscle gene expression and myogenic differentiation. ..
  17. Ghorpade D, Leyland R, Kurowska Stolarska M, Patil S, Balaji K. MicroRNA-155 is required for Mycobacterium bovis BCG-mediated apoptosis of macrophages. Mol Cell Biol. 2012;32:2239-53 pubmed publisher
    ..Overall, M. bovis BCG-driven miR-155 dictates cell fate decisions of infected macrophages, strongly implicating a novel role for miR-155 in orchestrating cellular reprogramming during immune responses to mycobacterial infection. ..
  18. Cardoso A, Guedes J, Pereira de Almeida L, Pedroso de Lima M. miR-155 modulates microglia-mediated immune response by down-regulating SOCS-1 and promoting cytokine and nitric oxide production. Immunology. 2012;135:73-88 pubmed publisher
  19. Donners M, Wolfs I, Stöger L, van der Vorst E, Pöttgens C, Heymans S, et al. Hematopoietic miR155 deficiency enhances atherosclerosis and decreases plaque stability in hyperlipidemic mice. PLoS ONE. 2012;7:e35877 pubmed publisher
    microRNA-155 (miR155) is a central regulator of immune responses that is induced by inflammatory mediators...
  20. Zonari E, Pucci F, Saini M, Mazzieri R, Politi L, Gentner B, et al. A role for miR-155 in enabling tumor-infiltrating innate immune cells to mount effective antitumor responses in mice. Blood. 2013;122:243-52 pubmed publisher
    ..This study highlights the importance of tumor-infiltrating hematopoietic cells in constraining carcinogenesis and establishes an antitumoral function of a prototypical oncomiR. ..
  21. Rai D, Kim S, McKeller M, Dahia P, Aguiar R. Targeting of SMAD5 links microRNA-155 to the TGF-beta pathway and lymphomagenesis. Proc Natl Acad Sci U S A. 2010;107:3111-6 pubmed publisher
    ..Together, our data helped explain miR-155 function, highlighted a hitherto unappreciated role of SMAD5 in lymphoma biology, and defined a unique mechanism used by cancer cells to escape TGF-beta's growth-inhibitory effects. ..
  22. Kurowska Stolarska M, Alivernini S, Ballantine L, Asquith D, Millar N, Gilchrist D, et al. MicroRNA-155 as a proinflammatory regulator in clinical and experimental arthritis. Proc Natl Acad Sci U S A. 2011;108:11193-8 pubmed publisher
    ..Our data therefore identify a role of miR-155 in clinical and experimental arthritis and suggest that miR-155 may be an intriguing therapeutic target. ..
  23. Tsai C, Allie S, Zhang W, Usherwood E. MicroRNA miR-155 affects antiviral effector and effector Memory CD8 T cell differentiation. J Virol. 2013;87:2348-51 pubmed publisher
    ..At the memory stage, miR-155-deficient CD8 T cells preferentially differentiated into central memory cells and were capable of mounting a potent secondary response. ..
  24. Sandhu S, Volinia S, Costinean S, Galasso M, Neinast R, Santhanam R, et al. miR-155 targets histone deacetylase 4 (HDAC4) and impairs transcriptional activity of B-cell lymphoma 6 (BCL6) in the E?-miR-155 transgenic mouse model. Proc Natl Acad Sci U S A. 2012;109:20047-52 pubmed publisher
    ..Hence this study provides a better understanding of how miR-155 causes disruption of the BCL6 transcriptional machinery that leads to up-regulation of the survival and proliferation genes in miR-155-induced leukemias. ..
  25. Oertli M, Engler D, Kohler E, Koch M, Meyer T, Muller A. MicroRNA-155 is essential for the T cell-mediated control of Helicobacter pylori infection and for the induction of chronic Gastritis and Colitis. J Immunol. 2011;187:3578-86 pubmed publisher
    ..In conclusion, miR-155 expression is required for the Th17/Th1 differentiation that underlies immunity to H. pylori infection on the one hand and infection-associated immunopathology on the other. ..
  26. Dagan L, Jiang X, Bhatt S, Cubedo E, Rajewsky K, Lossos I. miR-155 regulates HGAL expression and increases lymphoma cell motility. Blood. 2012;119:513-20 pubmed publisher
    ..Furthermore, this effect may contribute to lymphoma cell dissemination and aggressiveness, characteristic of activated B cell-like diffuse large B-cell lymphoma typically expressing high levels of miR-155 and lacking HGAL expression. ..
  27. Miller A, Gilchrist D, Nijjar J, Araldi E, Ramírez C, Lavery C, et al. MiR-155 has a protective role in the development of non-alcoholic hepatosteatosis in mice. PLoS ONE. 2013;8:e72324 pubmed publisher
    ..Together these data indicate that miR-155 plays a pivotal role regulating lipid metabolism in liver and that its deregulation may lead to hepatic steatosis in patients with diabetes. ..
  28. Clare S, John V, Walker A, Hill J, Abreu Goodger C, Hale C, et al. Enhanced susceptibility to Citrobacter rodentium infection in microRNA-155-deficient mice. Infect Immun. 2013;81:723-32 pubmed publisher
    ..A similarly susceptible phenotype was observed in ?MT mice reconstituted with miR-155-deficient B cells, indicating that miR-155 is required intrinsically for mediating protection against this predominantly luminal bacterial pathogen. ..
  29. Dorsett Y, McBride K, Jankovic M, Gazumyan A, Thai T, Robbiani D, et al. MicroRNA-155 suppresses activation-induced cytidine deaminase-mediated Myc-Igh translocation. Immunity. 2008;28:630-8 pubmed publisher
    ..A similar but more pronounced translocation phenotype was also found in miR-155-deficient mice. Our experiments indicate that miR-155 can act as a tumor suppressor by reducing potentially oncogenic translocations generated by AID. ..
  30. Kohlhaas S, Garden O, Scudamore C, Turner M, Okkenhaug K, Vigorito E. Cutting edge: the Foxp3 target miR-155 contributes to the development of regulatory T cells. J Immunol. 2009;182:2578-82 pubmed publisher
    ..However, we found no evidence for defective suppressor activity of miR-155-deficient Tregs, either in vitro or in vivo. Our results indicate that miR-155 contributes to Treg development, but that additional miRNAs control Treg function. ..
  31. Cremer T, Ravneberg D, Clay C, Piper Hunter M, Marsh C, Elton T, et al. MiR-155 induction by F. novicida but not the virulent F. tularensis results in SHIP down-regulation and enhanced pro-inflammatory cytokine response. PLoS ONE. 2009;4:e8508 pubmed publisher
    ..However, impaired miR-155 induction by SCHU S4 may help explain the lack of both SHIP down-regulation and pro-inflammatory response and may account for the virulence of Type A Francisella. ..
  32. Koch M, Mollenkopf H, Klemm U, Meyer T. Induction of microRNA-155 is TLR- and type IV secretion system-dependent in macrophages and inhibits DNA-damage induced apoptosis. Proc Natl Acad Sci U S A. 2012;109:E1153-62 pubmed publisher
    ..pylori pathogenicity factor, the T4SS, in the up-regulation of miR-155 in BMMs. We propose the antiapoptotic effects of miR-155 could enhance macrophage resistance to apoptosis induced by DNA damage during H. pylori infection. ..
  33. Tam W. Identification and characterization of human BIC, a gene on chromosome 21 that encodes a noncoding RNA. Gene. 2001;274:157-67 pubmed
    ..Based on the lack of a conserved ORF and the evolutionary conservation of RNA secondary structure, we presume that BIC functions as a noncoding RNA. ..
  34. Lu L, Thai T, Calado D, Chaudhry A, Kubo M, Tanaka K, et al. Foxp3-dependent microRNA155 confers competitive fitness to regulatory T cells by targeting SOCS1 protein. Immunity. 2009;30:80-91 pubmed publisher
    ..We found that Foxp3 controlled the elevated miR155 expression required for maintaining Treg cell proliferative activity and numbers under nonlymphopenic conditions...
  35. Rodriguez A, Vigorito E, Clare S, Warren M, Couttet P, Soond D, et al. Requirement of bic/microRNA-155 for normal immune function. Science. 2007;316:608-11 pubmed
    ..Our work suggests that bic/microRNA-155 plays a key role in the homeostasis and function of the immune system. ..
  36. Hu R, Huffaker T, Kagele D, Runtsch M, Bake E, Chaudhuri A, et al. MicroRNA-155 confers encephalogenic potential to Th17 cells by promoting effector gene expression. J Immunol. 2013;190:5972-80 pubmed publisher
  37. Bala S, Marcos M, Kodys K, Csak T, Catalano D, Mandrekar P, et al. Up-regulation of microRNA-155 in macrophages contributes to increased tumor necrosis factor {alpha} (TNF{alpha}) production via increased mRNA half-life in alcoholic liver disease. J Biol Chem. 2011;286:1436-44 pubmed publisher
    ..In conclusion, our novel data demonstrate that chronic alcohol consumption increases miR-155 in macrophages via NF-?B and the increased miR-155 contributes to alcohol-induced elevation in TNF? production via increased mRNA stability...
  38. Zhang J, Zhao H, Chen J, Xia B, Jin Y, Wei W, et al. Interferon-?-induced miR-155 inhibits osteoclast differentiation by targeting SOCS1 and MITF. FEBS Lett. 2012;586:3255-62 pubmed publisher
    ..These findings have not only demonstrated that miR-155 inhibits osteoclast differentiation, but also provided a new therapeutic target for treatment of osteoclast-mediated diseases. ..
  39. Teng G, Hakimpour P, Landgraf P, Rice A, Tuschl T, Casellas R, et al. MicroRNA-155 is a negative regulator of activation-induced cytidine deaminase. Immunity. 2008;28:621-9 pubmed publisher
    ..Thus, miR-155, which has recently been shown to play important roles in regulating the germinal-center reaction, does so in part by directly downmodulating AID expression. ..
  40. Trotta R, Chen L, Ciarlariello D, Josyula S, Mao C, Costinean S, et al. miR-155 regulates IFN-? production in natural killer cells. Blood. 2012;119:3478-85 pubmed publisher
    ..These findings may have clinical relevance for targeting miR-155 in neoplastic disease. ..
  41. Schulte L, Westermann A, Vogel J. Differential activation and functional specialization of miR-146 and miR-155 in innate immune sensing. Nucleic Acids Res. 2013;41:542-53 pubmed publisher
    ..We predict that dose-dependent responses to environmental stimuli may involve functional specialization of seemingly co-induced miRNAs in other cellular circuitries as well. ..
  42. Lu C, Huang X, Zhang X, Roensch K, Cao Q, Nakayama K, et al. miR-221 and miR-155 regulate human dendritic cell development, apoptosis, and IL-12 production through targeting of p27kip1, KPC1, and SOCS-1. Blood. 2011;117:4293-303 pubmed publisher
    ..Thus, our study uncovered miRNA signatures during monocyte differentiation into DCs and the new regulatory role of miR-221 and miR-155 in DC apoptosis and IL-12p70 production. ..
  43. Huffaker T, Hu R, Runtsch M, Bake E, Chen X, Zhao J, et al. Epistasis between microRNAs 155 and 146a during T cell-mediated antitumor immunity. Cell Rep. 2012;2:1697-709 pubmed publisher
    ..Our work reveals critical roles for miRNAs in the reciprocal regulation of CD4(+) and CD8(+) T cell-mediated antitumor immunity and demonstrates the dominant nature of miR-155 during its promotion of immune responses. ..
  44. Li L, Zhang J, Diao W, Wang D, Wei Y, Zhang C, et al. MicroRNA-155 and MicroRNA-21 promote the expansion of functional myeloid-derived suppressor cells. J Immunol. 2014;192:1034-43 pubmed publisher
    ..These results demonstrate a novel miR-155/miR-21-based regulatory mechanism that modulates functional MDSC induction. ..
  45. Lind E, Millar D, Dissanayake D, Savage J, Grimshaw N, Kerr W, et al. miR-155 Upregulation in Dendritic Cells Is Sufficient To Break Tolerance In Vivo by Negatively Regulating SHIP1. J Immunol. 2015;195:4632-40 pubmed publisher
    ..This process is independent of the induction of conventional DC maturation markers, indicating that miR-155 regulation of SHIP represents a unique axis that regulates DC function in vivo. ..
  46. Jiang D, Aguiar R. MicroRNA-155 controls RB phosphorylation in normal and malignant B lymphocytes via the noncanonical TGF-?1/SMAD5 signaling module. Blood. 2014;123:86-93 pubmed publisher
  47. Zhang D, Cui Y, Li B, Luo X, Li B, Tang Y. A comparative study of the characterization of miR-155 in knockout mice. PLoS ONE. 2017;12:e0173487 pubmed publisher
    ..miR-155 deficiency did not affect the development and growth of naturally ageing mice during the 42 days after birth. Thus, studying the complex biological functions of miR-155 requires the further use of KO mouse models. ..
  48. Seok H, Chen J, Kataoka M, Huang Z, Ding J, Yan J, et al. Loss of MicroRNA-155 protects the heart from pathological cardiac hypertrophy. Circ Res. 2014;114:1585-95 pubmed publisher
    ..Our studies uncover miR-155 as an inducer of pathological cardiomyocyte hypertrophy and suggest that inhibition of endogenous miR-155 might have clinical potential to suppress cardiac hypertrophy and heart failure. ..
  49. Forzati F, De Martino M, Esposito F, Sepe R, Pellecchia S, Malapelle U, et al. miR-155 is positively regulated by CBX7 in mouse embryonic fibroblasts and colon carcinomas, and targets the KRAS oncogene. BMC Cancer. 2017;17:170 pubmed publisher
    ..miR-155 is positively regulated by CBX7 in MEFs and colon carcinomas, and has KRAS as one of the target genes likely accounting for the anti-apoptotic activity ascribed to miR-155 in some tissue contexts. ..
  50. Fonken L, Gaudet A, Gaier K, Nelson R, Popovich P. MicroRNA-155 deletion reduces anxiety- and depressive-like behaviors in mice. Psychoneuroendocrinology. 2016;63:362-9 pubmed publisher
    ..Together, these data highlight the importance of studying microRNAs in the context of anxiety and depression and identify miR-155 as a novel potential therapeutic target for improving mood disorders. ..
  51. Ying W, Riopel M, Bandyopadhyay G, Dong Y, Birmingham A, Seo J, et al. Adipose Tissue Macrophage-Derived Exosomal miRNAs Can Modulate In Vivo and In Vitro Insulin Sensitivity. Cell. 2017;171:372-384.e12 pubmed publisher
    ..These miRNAs can be transferred to insulin target cell types through mechanisms of paracrine or endocrine regulation with robust effects on cellular insulin action, in vivo insulin sensitivity, and overall glucose homeostasis. ..
  52. Yao M, Wang X, Tang Y, Zhang W, Cui B, Liu Q, et al. Dicer mediating the expression of miR-143 and miR-155 regulates hexokinase II associated cellular response to hypoxia. Am J Physiol Lung Cell Mol Physiol. 2014;307:L829-37 pubmed publisher
    ..Our data demonstrate that Dicer regulation of miRNAs promotes HK2 activation and glycolysis, which might protect the cell from hypoxic damage and enter into an adaptive process. ..
  53. Biethahn K, Orinska Z, Vigorito E, Goyeneche Patino D, Mirghomizadeh F, Foger N, et al. miRNA-155 controls mast cell activation by regulating the PI3K? pathway and anaphylaxis in a mouse model. Allergy. 2014;69:752-62 pubmed publisher
    ..This newly identified mechanism of miRNA-controlled MC activation may affect the initiation and maintenance of allergic disorders. ..
  54. Lescher J, Paap F, Schultz V, Redenbach L, Scheidt U, Rosewich H, et al. MicroRNA regulation in experimental autoimmune encephalomyelitis in mice and marmosets resembles regulation in human multiple sclerosis lesions. J Neuroimmunol. 2012;246:27-33 pubmed publisher
  55. Callegari E, Gramantieri L, Domenicali M, D Abundo L, Sabbioni S, Negrini M. MicroRNAs in liver cancer: a model for investigating pathogenesis and novel therapeutic approaches. Cell Death Differ. 2015;22:46-57 pubmed publisher
    ..In general, the safety of miRNAs has been proven and antitumor activity has been observed. Moreover, because of the absence or presence of mild side effects, the prophylactic use of miRNA-based approaches may be foreseen. ..