Gene Symbol: Mir137
Description: microRNA 137
Alias: Mirn137, mmu-mir-137
Species: mouse
Products:     Mir137

Top Publications

  1. Li W, Zhang X, Zhuang H, Chen H, Chen Y, Tian W, et al. MicroRNA-137 is a novel hypoxia-responsive microRNA that inhibits mitophagy via regulation of two mitophagy receptors FUNDC1 and NIX. J Biol Chem. 2014;289:10691-701 pubmed publisher
    ..Our results demonstrated the regulatory role of miRNA to mitophagy receptors and revealed a novel link between miR-137 and mitophagy. ..
  2. Lee H, Palkovits M, Young W. miR-7b, a microRNA up-regulated in the hypothalamus after chronic hyperosmolar stimulation, inhibits Fos translation. Proc Natl Acad Sci U S A. 2006;103:15669-74 pubmed
    ..Various pathways have been identified through which Fos family proteins are degraded; our results indicate a significant additional mechanism by which Fos protein and activity may be regulated. ..
  3. THOMAS K, ANDERSON B, Shah N, Zimmer S, Hawkins D, Valdez A, et al. Inhibition of the Schizophrenia-Associated MicroRNA miR-137 Disrupts Nrg1α Neurodevelopmental Signal Transduction. Cell Rep. 2017;20:1-12 pubmed publisher
    ..We conclude that miR-137 regulates neuronal responses to Nrg1α and BDNF through convergent mechanisms, which might contribute to schizophrenia risk by altering neural development. ..
  4. Zhang Y, Xie R, Croce C, Stein J, Lian J, Van Wijnen A, et al. A program of microRNAs controls osteogenic lineage progression by targeting transcription factor Runx2. Proc Natl Acad Sci U S A. 2011;108:9863-8 pubmed publisher
    ..These findings demonstrate that osteoblastogenesis is limited by an elaborate network of functionally tested miRNAs that directly target the osteogenic master regulator Runx2. ..
  5. Sun G, Ye P, Murai K, Lang M, Li S, Zhang H, et al. miR-137 forms a regulatory loop with nuclear receptor TLX and LSD1 in neural stem cells. Nat Commun. 2011;2:529 pubmed publisher
    ..Thus, miR-137 forms a feedback regulatory loop with TLX and LSD1 to control the dynamics between neural stem cell proliferation and differentiation during neural development. ..
  6. Dong C, Wang H, Xue L, Dong Y, Yang L, Fan R, et al. Coat color determination by miR-137 mediated down-regulation of microphthalmia-associated transcription factor in a mouse model. RNA. 2012;18:1679-86 pubmed publisher
    ..Our study provides the first mouse model for the study of coat color controlled by miRNAs in animals and may have important applications in wool production. ..
  7. Vallès A, Martens G, De Weerd P, Poelmans G, Aschrafi A. MicroRNA-137 regulates a glucocorticoid receptor-dependent signalling network: implications for the etiology of schizophrenia. J Psychiatry Neurosci. 2014;39:312-20 pubmed
    ..We have identified a miR-137-regulated protein network that contributes to our understanding of the molecular basis of schizophrenia and provides clues for future research into psychopharmacological treatments for schizophrenia. ..
  8. Crowley J, Collins A, Lee R, Nonneman R, Farrell M, Ancalade N, et al. Disruption of the microRNA 137 primary transcript results in early embryonic lethality in mice. Biol Psychiatry. 2015;77:e5-7 pubmed publisher
  9. Schouten M, Fratantoni S, Hubens C, Piersma S, Pham T, Bielefeld P, et al. MicroRNA-124 and -137 cooperativity controls caspase-3 activity through BCL2L13 in hippocampal neural stem cells. Sci Rep. 2015;5:12448 pubmed publisher

More Information


  1. Chen F, Zhang L, Wang E, Zhang C, Li X. LncRNA GAS5 regulates ischemic stroke as a competing endogenous RNA for miR-137 to regulate the Notch1 signaling pathway. Biochem Biophys Res Commun. 2018;496:184-190 pubmed publisher
  2. He D, Tan J, Zhang J. miR-137 attenuates A?-induced neurotoxicity through inactivation of NF-?B pathway by targeting TNFAIP1 in Neuro2a cells. Biochem Biophys Res Commun. 2017;490:941-947 pubmed publisher
    ..miR-137 attenuated A?-induced neurotoxicity through inactivation of NF-?B pathway by targeting TNFAIP1 in N2a cells, shedding light on the molecular mechanism of miR-137 underlying A?-induced neurotoxicity. ..
  3. Wang J, Xu R, Wu J, Li Z. MicroRNA-137 Negatively Regulates Hâ‚‚Oâ‚‚-Induced Cardiomyocyte Apoptosis Through CDC42. Med Sci Monit. 2015;21:3498-504 pubmed
    ..Our work demonstrated miR-137 and CDC42 are critical regulators in cardiomyocyte apoptosis. It may help to identify the molecular targets to prevent myocardial injury in human patients. ..
  4. Santos M, Tegge A, Correa B, Mahesula S, Kohnke L, Qiao M, et al. miR-124, -128, and -137 Orchestrate Neural Differentiation by Acting on Overlapping Gene Sets Containing a Highly Connected Transcription Factor Network. Stem Cells. 2016;34:220-32 pubmed publisher
    ..In summary, our results show that miRNAs can act cooperatively and synergistically to regulate complex biological processes like neurogenesis and that transcription factors are heavily targeted to branch out their regulatory effect. ..
  5. Zhang L, Li Z, Gai F, Wang Y. MicroRNA-137 suppresses tumor growth in epithelial ovarian cancer in vitro and in vivo. Mol Med Rep. 2015;12:3107-14 pubmed publisher
    ..Notably, the enforced expression of miR-137 suppressed tumor growth in the nude mice models. These findings suggested that miR-137 may act as a tumor suppressor and be used as a potential therapeutic agent for the treatment of EOC. ..
  6. Jiang K, Ren C, Nair V. MicroRNA-137 represses Klf4 and Tbx3 during differentiation of mouse embryonic stem cells. Stem Cell Res. 2013;11:1299-313 pubmed publisher
    ..Taken together, our results suggest that miR-137 regulates ES cell proliferation and differentiation by repressing the expression of downstream targets, including Klf4 and Tbx3. ..
  7. Smrt R, Szulwach K, Pfeiffer R, Li X, Guo W, Pathania M, et al. MicroRNA miR-137 regulates neuronal maturation by targeting ubiquitin ligase mind bomb-1. Stem Cells. 2010;28:1060-70 pubmed publisher
    ..These results demonstrate a novel miRNA-mediated mechanism involving miR-137 and Mib1 that function to regulate neuronal maturation and dendritic morphogenesis during development. ..
  8. Tarantino C, Paolella G, Cozzuto L, Minopoli G, Pastore L, Parisi S, et al. miRNA 34a, 100, and 137 modulate differentiation of mouse embryonic stem cells. FASEB J. 2010;24:3255-63 pubmed publisher
    ..These results demonstrate that miR-34a, miR-100, and miR-137 are required for proper differentiation of mouse ESCs, and that they function in part by targeting Sirt1, Smarca5, and Jarid1b mRNAs. ..
  9. Liu B, Cunha G, Baskin L. Differential expression of microRNAs in mouse embryonic bladder. Biochem Biophys Res Commun. 2009;385:528-33 pubmed publisher
    ..The identification of unique miRNAs expression before and after smooth muscle differentiation in site-specific area of the bladder indicates their roles in embryogenesis and may aid in future clinical intervention. ..
  10. Xiao J, Peng F, Yu C, Wang M, Li X, Li Z, et al. microRNA-137 modulates pancreatic cancer cells tumor growth, invasion and sensitivity to chemotherapy. Int J Clin Exp Pathol. 2014;7:7442-50 pubmed
    ..Our study demonstrated that miR-137 played an important role in pancreatic cancer development. It may become a new therapeutic target for gene therapy in patients suffered from pancreatic cancer. ..