Gene Symbol: Mir128-2
Description: microRNA 128-2
Alias: Mirn128-2, Mirn128b, mir-128b
Species: mouse

Top Publications

  1. Rybak A, Fuchs H, Smirnova L, Brandt C, Pohl E, Nitsch R, et al. A feedback loop comprising lin-28 and let-7 controls pre-let-7 maturation during neural stem-cell commitment. Nat Cell Biol. 2008;10:987-93 pubmed publisher
  2. Lin Q, Wei W, Coelho C, Li X, Baker Andresen D, Dudley K, et al. The brain-specific microRNA miR-128b regulates the formation of fear-extinction memory. Nat Neurosci. 2011;14:1115-7 pubmed publisher
    ..Increased miR-128b activity may therefore facilitate the transition from retrieval of the original fear memory toward the formation of a new fear-extinction memory. ..
  3. Franzoni E, Booker S, Parthasarathy S, Rehfeld F, Grosser S, Srivatsa S, et al. miR-128 regulates neuronal migration, outgrowth and intrinsic excitability via the intellectual disability gene Phf6. elife. 2015;4: pubmed publisher
    ..Our results place miR-128 upstream of PHF6 in a pathway vital for cortical lamination as well as for the development of neuronal morphology and intrinsic excitability. ..
  4. Liu J, Zhao C, Li Z, Wang Y, Miao W, Wu X, et al. miR-218 Involvement in Cardiomyocyte Hypertrophy Is Likely through Targeting REST. Int J Mol Sci. 2016;17: pubmed publisher
    ..These results showed that miR-218 plays a crucial role in cardiomyocyte hypertrophy, likely via targeting REST, suggesting a potential candidate target for interfering hypertrophy. ..
  5. Hackler L, Wan J, Swaroop A, Qian J, Zack D. MicroRNA profile of the developing mouse retina. Invest Ophthalmol Vis Sci. 2010;51:1823-31 pubmed publisher
    ..Conclusions. Global expression profiling revealed dozens of miRNAs with significant expression changes in the developing retina. Precise patterns of expression of miRNAs suggest their specific roles in development. ..
  6. Adlakha Y, Khanna S, Singh R, Singh V, Agrawal A, Saini N. Pro-apoptotic miRNA-128-2 modulates ABCA1, ABCG1 and RXR? expression and cholesterol homeostasis. Cell Death Dis. 2013;4:e780 pubmed publisher
    ..In this study, we provide the first evidence of miR-128-2 to be a new regulator of cholesterol homeostasis. Our study shows dual role of miR-128-2, as a pro-apoptotic molecule as well as a regulator of cholesterol homeostasis...
  7. Krol J, Krol I, Alvarez C, Fiscella M, Hierlemann A, Roska B, et al. A network comprising short and long noncoding RNAs and RNA helicase controls mouse retina architecture. Nat Commun. 2015;6:7305 pubmed publisher
    ..Our results suggest that the precise timing of glia-neuron interaction controlled by noncoding RNAs and Ddx3x is important for the even distribution of cells across layers. ..
  8. Yang Y, Xu J, Chen H, Fei X, Tang Y, Yan Y, et al. MiR-128-2 inhibits common lymphoid progenitors from developing into progenitor B cells. Oncotarget. 2016;7:17520-31 pubmed publisher
    ..Such findings have prompted future investigations on the function of miR-128-2 in lymph genesis. ..
  9. Huang W, Feng Y, Liang J, Yu H, Wang C, Wang B, et al. Loss of microRNA-128 promotes cardiomyocyte proliferation and heart regeneration. Nat Commun. 2018;9:700 pubmed publisher
    ..These results suggest that miR-128 serves as a critical regulator of endogenous CM proliferation, and might be a novel therapeutic target for heart repair. ..

More Information


  1. Smirnova L, Gräfe A, Seiler A, Schumacher S, Nitsch R, Wulczyn F. Regulation of miRNA expression during neural cell specification. Eur J Neurosci. 2005;21:1469-77 pubmed
    ..miRNA were strongly induced during neural differentiation of embryonic stem cells, suggesting the validity of the stem cell model for studying miRNA regulation in neural development. ..
  2. Tan C, Plotkin J, Venø M, von Schimmelmann M, Feinberg P, Mann S, et al. MicroRNA-128 governs neuronal excitability and motor behavior in mice. Science. 2013;342:1254-8 pubmed publisher
    ..These data suggest a therapeutic potential for miR-128 in the treatment of epilepsy and movement disorders. ..