Gene Symbol: Mir128-1
Description: microRNA 128-1
Alias: Mirn128, Mirn128-1, Mirn128a
Species: mouse

Top Publications

  1. Tan C, Plotkin J, Venø M, von Schimmelmann M, Feinberg P, Mann S, et al. MicroRNA-128 governs neuronal excitability and motor behavior in mice. Science. 2013;342:1254-8 pubmed publisher
    ..These data suggest a therapeutic potential for miR-128 in the treatment of epilepsy and movement disorders. ..
  2. Huang W, Feng Y, Liang J, Yu H, Wang C, Wang B, et al. Loss of microRNA-128 promotes cardiomyocyte proliferation and heart regeneration. Nat Commun. 2018;9:700 pubmed publisher
    ..These results suggest that miR-128 serves as a critical regulator of endogenous CM proliferation, and might be a novel therapeutic target for heart repair. ..
  3. Hackler L, Wan J, Swaroop A, Qian J, Zack D. MicroRNA profile of the developing mouse retina. Invest Ophthalmol Vis Sci. 2010;51:1823-31 pubmed publisher
    ..Conclusions. Global expression profiling revealed dozens of miRNAs with significant expression changes in the developing retina. Precise patterns of expression of miRNAs suggest their specific roles in development. ..
  4. Yang Z, Xu J, Zhu R, Liu L. Down-Regulation of miRNA-128 Contributes to Neuropathic Pain Following Spinal Cord Injury via Activation of P38. Med Sci Monit. 2017;23:405-411 pubmed
    ..CONCLUSIONS Our findings indicate that down-regulation of miR-128 in murine microglial cells may contribute to the development of NPP following SCI via activation of P38. MiR-128 may be a potential intervention target for NPP. ..
  5. Liu J, Zhao C, Li Z, Wang Y, Miao W, Wu X, et al. miR-218 Involvement in Cardiomyocyte Hypertrophy Is Likely through Targeting REST. Int J Mol Sci. 2016;17: pubmed publisher
    ..These results showed that miR-218 plays a crucial role in cardiomyocyte hypertrophy, likely via targeting REST, suggesting a potential candidate target for interfering hypertrophy. ..
  6. Lawson S, Dobrikova E, Shveygert M, Gromeier M. p38? mitogen-activated protein kinase depletion and repression of signal transduction to translation machinery by miR-124 and -128 in neurons. Mol Cell Biol. 2013;33:127-35 pubmed publisher
    ..This regulatory axis is greatly diminished in neurons, which may insulate brain physiology and function from p38?-Mnk1-mediated signaling. ..
  7. Motohashi N, Alexander M, Shimizu Motohashi Y, Myers J, Kawahara G, Kunkel L. Regulation of IRS1/Akt insulin signaling by microRNA-128a during myogenesis. J Cell Sci. 2013;126:2678-91 pubmed publisher
    ..In summary, we demonstrate that miR-128a regulates myoblast proliferation and myotube hypertrophy, and provides a novel mechanism through which IRS1-dependent insulin signaling is regulated in skeletal muscle. ..
  8. Smirnova L, Gräfe A, Seiler A, Schumacher S, Nitsch R, Wulczyn F. Regulation of miRNA expression during neural cell specification. Eur J Neurosci. 2005;21:1469-77 pubmed
    ..miRNA were strongly induced during neural differentiation of embryonic stem cells, suggesting the validity of the stem cell model for studying miRNA regulation in neural development. ..
  9. Franzoni E, Booker S, Parthasarathy S, Rehfeld F, Grosser S, Srivatsa S, et al. miR-128 regulates neuronal migration, outgrowth and intrinsic excitability via the intellectual disability gene Phf6. elife. 2015;4: pubmed publisher
    ..Our results place miR-128 upstream of PHF6 in a pathway vital for cortical lamination as well as for the development of neuronal morphology and intrinsic excitability. ..

More Information


  1. Krol J, Krol I, Alvarez C, Fiscella M, Hierlemann A, Roska B, et al. A network comprising short and long noncoding RNAs and RNA helicase controls mouse retina architecture. Nat Commun. 2015;6:7305 pubmed publisher
    ..Our results suggest that the precise timing of glia-neuron interaction controlled by noncoding RNAs and Ddx3x is important for the even distribution of cells across layers. ..
  2. Chen J, Li W, Li Y, He S, Li L, Liang L, et al. MicroRNA-128-3p impaired water maze learning by suppressing Doublecortin expression in both wild type and Aβ-42 infused mice. Neurosci Lett. 2016;626:79-85 pubmed publisher
    ..Collectively, the regulation axis from miR-128 to Dcx is critical for hippocampus-related contextual learning not only in wild type, but also in mice infused with Aβ-42. ..
  3. Zhang W, Kim P, Chen Z, Lokman H, Qiu L, Zhang K, et al. MiRNA-128 regulates the proliferation and neurogenesis of neural precursors by targeting PCM1 in the developing cortex. elife. 2016;5: pubmed publisher
    ..Taken together, these results demonstrate a novel mechanism by which miR-128 regulates the proliferation and differentiation of NPCs in the developing neocortex. ..
  4. Zhang T, Yu J, Zhang Y, Li L, Chen Y, Li D, et al. Salmonella enterica serovar enteritidis modulates intestinal epithelial miR-128 levels to decrease macrophage recruitment via macrophage colony-stimulating factor. J Infect Dis. 2014;209:2000-11 pubmed publisher
    ..Salmonella can upregulate intestinal epithelial miR-128 expression, which, in turn, decreases levels of epithelial cell-secreted M-CSF and M-CSF-induced macrophage recruitment. ..
  5. Santos M, Tegge A, Correa B, Mahesula S, Kohnke L, Qiao M, et al. miR-124, -128, and -137 Orchestrate Neural Differentiation by Acting on Overlapping Gene Sets Containing a Highly Connected Transcription Factor Network. Stem Cells. 2016;34:220-32 pubmed publisher
    ..In summary, our results show that miRNAs can act cooperatively and synergistically to regulate complex biological processes like neurogenesis and that transcription factors are heavily targeted to branch out their regulatory effect. ..
  6. Motohashi N, Alexander M, Casar J, Kunkel L. Identification of a novel microRNA that regulates the proliferation and differentiation in muscle side population cells. Stem Cells Dev. 2012;21:3031-43 pubmed publisher
    ..These results demonstrate that miR-128a contributes to the maintenance of the quiescent state, and it regulates cellular differentiation by repressing individual genes in SP cells. ..
  7. Huang Y, Dai Y, Zhang J, Wang C, Li D, Cheng J, et al. Circulating microRNAs as potential biomarkers for smoking-related interstitial fibrosis. Biomarkers. 2012;17:435-40 pubmed publisher
    ..These findings suggested a potential use of specific circulating miRNAs as sensitive and informative biomarkers for smoking-induced lung disease. ..
  8. Rybak A, Fuchs H, Smirnova L, Brandt C, Pohl E, Nitsch R, et al. A feedback loop comprising lin-28 and let-7 controls pre-let-7 maturation during neural stem-cell commitment. Nat Cell Biol. 2008;10:987-93 pubmed publisher