Gene Symbol: Mir106a
Description: microRNA 106a
Alias: Mirn106a
Species: mouse
Products:     Mir106a

Top Publications

  1. Lum A, Wang B, Li L, Channa N, Bartha G, Wabl M. Retroviral activation of the mir-106a microRNA cistron in T lymphoma. Retrovirology. 2007;4:5 pubmed
    ..These findings suggest the mir-106a cistron plays an important role in T cell tumorigenesis...
  2. Ventura A, Young A, Winslow M, Lintault L, Meissner A, Erkeland S, et al. Targeted deletion reveals essential and overlapping functions of the miR-17 through 92 family of miRNA clusters. Cell. 2008;132:875-86 pubmed publisher
    ..These results provide key insights into the physiologic functions of this family of microRNAs and suggest a link between the oncogenic properties of miR-17 approximately 92 and its functions during B lymphopoiesis and lung development. ..
  3. Liao B, Bao X, Liu L, Feng S, Zovoilis A, Liu W, et al. MicroRNA cluster 302-367 enhances somatic cell reprogramming by accelerating a mesenchymal-to-epithelial transition. J Biol Chem. 2011;286:17359-64 pubmed publisher
    ..Our work thus provides an interesting alternative for improving reprogramming using miRNAs and adds new evidence for the emerging relationship between pluripotency and the epithelial phenotype. ..
  4. Lu Y, Thomson J, Wong H, Hammond S, Hogan B. Transgenic over-expression of the microRNA miR-17-92 cluster promotes proliferation and inhibits differentiation of lung epithelial progenitor cells. Dev Biol. 2007;310:442-53 pubmed
    ..Together, these studies suggest that mir-17-92 normally promotes the high proliferation and undifferentiated phenotype of lung epithelial progenitor cells. ..
  5. Foshay K, Gallicano G. miR-17 family miRNAs are expressed during early mammalian development and regulate stem cell differentiation. Dev Biol. 2009;326:431-43 pubmed publisher
    ..Additionally, we demonstrate that these miRNAs regulate STAT3 mRNA in vitro. We suggest that STAT3, a known ES cell regulator, is one target mRNA responsible for the effects of these miRNAs on cellular differentiation. ..
  6. Jiang Z, Yu N, Kuang P, Chen M, Shao F, Martin G, et al. Trinucleotide repeat containing 6a (Tnrc6a)-mediated microRNA function is required for development of yolk sac endoderm. J Biol Chem. 2012;287:5979-87 pubmed publisher
  7. Pernaute B, Spruce T, Smith K, Sánchez Nieto J, Manzanares M, Cobb B, et al. MicroRNAs control the apoptotic threshold in primed pluripotent stem cells through regulation of BIM. Genes Dev. 2014;28:1873-8 pubmed publisher
    ..These families therefore represent an essential buffer needed to maintain cell survival in stem cells that are primed for not only differentiation but also cell death. ..
  8. Larabee S, Coia H, Jones S, Cheung E, Gallicano G. miRNA-17 members that target Bmpr2 influence signaling mechanisms important for embryonic stem cell differentiation in vitro and gastrulation in embryos. Stem Cells Dev. 2015;24:354-71 pubmed publisher
    ..This suppression influences fate decisions of cells by affecting genes downstream of BMPR2 as well as mesoderm invasion through regulation of actin dynamics. ..
  9. Kuppers D, Hwang H, Jackson A, Linsley P, Clurman B, Fero M. Effect of Xpcl1 activation and p27(Kip1) loss on gene expression in murine lymphoma. PLoS ONE. 2011;6:e14758 pubmed publisher
    ..Confirmation of miR-106a~363 gene targeting relevant to the tumor phenotype requires in vivo validation, because only a subset of predicted targets are consistently reduced in tumors that overexpress miR-106a~363. ..

More Information


  1. Mao S, Li H, Sun Q, Zen K, Zhang C, Li L. miR-17 regulates the proliferation and differentiation of the neural precursor cells during mouse corticogenesis. FEBS J. 2014;281:1144-58 pubmed publisher
    ..Taken together, these findings suggest that miR-17 family members play a pivotal role in regulating cell activity during early development of the mouse cortex. ..
  2. Cong J, Wang C, Pu D, Liu J, Hu G, Gao C, et al. Expression of early growth response 1 affects miR-106a/signal transducer and activator of transcription 3 regulating cognitive impairment in ovariectomized mice. Menopause. 2014;21:1143-50 pubmed publisher
    ..This study suggests that Egr1 decreases STAT3 expression via miR-106a in ovariectomized mice with cognitive impairment, indicating that Egr1 represents a potential target for therapeutic intervention in postmenopausal cognitive decline. ..
  3. Kästle M, Bartel S, Geillinger Kästle K, Irmler M, Beckers J, Ryffel B, et al. microRNA cluster 106a~363 is involved in T helper 17 cell differentiation. Immunology. 2017;152:402-413 pubmed publisher
    ..Here, we provide evidence that miRNAs are involved in controlling the differentiation and function of T helper cells, offering useful tools to study and modify Th17-mediated inflammation. ..
  4. Ries R, Yu W, Holton N, Cao H, Amendt B. Inhibition of the miR-17-92 Cluster Separates Stages of Palatogenesis. J Dent Res. 2017;96:1257-1264 pubmed publisher
    ..The differential regulation of palatogenesis by members of the miR-17-92 cluster indicates that several gene combinations regulate palate elevation and extension during development. ..
  5. Mukhopadhyay P, Brock G, Pihur V, Webb C, Pisano M, Greene R. Developmental microRNA expression profiling of murine embryonic orofacial tissue. Birth Defects Res A Clin Mol Teratol. 2010;88:511-34 pubmed publisher
    ..MicroRNA gene expression profiling is an effective means of acquiring novel and valuable information regarding the expression and regulation of genes, under the control of miRNA, involved in mammalian orofacial development...
  6. He Z, Jiang J, Kokkinaki M, Tang L, Zeng W, Gallicano I, et al. MiRNA-20 and mirna-106a regulate spermatogonial stem cell renewal at the post-transcriptional level via targeting STAT3 and Ccnd1. Stem Cells. 2013;31:2205-17 pubmed publisher
    ..This study thus provides novel insights into molecular mechanisms regulating renewal and differentiation of SSCs and may have important implications for regulating male reproduction. ..
  7. Wu Y, Xu D, Zhu X, Yang G, Ren M. MiR-106a Associated with Diabetic Peripheral Neuropathy Through the Regulation of 12/15-LOX-meidiated Oxidative/Nitrative Stress. Curr Neurovasc Res. 2017;14:117-124 pubmed publisher
    ..MiR-106 may be associated with 12/15-LOX mediated OS/NS in DPN and may be considered as a potential therapeutic target. ..