Gene Symbol: Mir101b
Description: microRNA 101b
Alias: Mirn101b, mir-101b
Zongaro S, Hukema R, D Antoni S, Davidovic L, Barbry P, Catania M, et al
. The 3' UTR of FMR1 mRNA is a target of miR-101, miR-129-5p and miR-221: implications for the molecular pathology of FXTAS at the synapse. Hum Mol Genet. 2013;22:1971-82 pubmed publisher
..These findings suggest the presence of a synaptopathy in these animals. Interestingly, many of those deregulated mRNAs are target of the same microRNAs that modulate the expression of FMR1 at the synapse. ..
Liu W, Liu C, Zhu J, Shu P, Yin B, Gong Y, et al
. MicroRNA-16 targets amyloid precursor protein to potentially modulate Alzheimer's-associated pathogenesis in SAMP8 mice. Neurobiol Aging. 2012;33:522-34 pubmed publisher
..Taken together, these findings demonstrate that APP is a target of miR-16 and the abnormally low expression of miR-16 could potentially lead to APP protein accumulation in AD mice. ..
Merkel O, Hamacher F, Laimer D, Sifft E, Trajanoski Z, Scheideler M, et al
. Identification of differential and functionally active miRNAs in both anaplastic lymphoma kinase (ALK)+ and ALK- anaplastic large-cell lymphoma. Proc Natl Acad Sci U S A. 2010;107:16228-33 pubmed publisher
..In addition to future therapeutical and diagnostic applications, it will be of interest to study the physiological implications and prognostic value of the identified miRNA profiles. ..
Liu J, Lin X, Yang X, Zhou L, He S, Zhuang S, et al
. A novel AP-1/miR-101 regulatory feedback loop and its implication in the migration and invasion of hepatoma cells. Nucleic Acids Res. 2014;42:12041-51 pubmed publisher
..Our results suggest that the AP-1/miR-101 feedback loop may prevent the excessive activation of metastatic signals imposed by ERK2/AP-1 and highlight the biological significance of miR-101 downregulation in cancer metastasis. ..
Li L, Zhang H, Min D, Zhang R, Wu J, Qu H, et al
. Sox9 activation is essential for the recovery of lung function after acute lung injury. Cell Physiol Biochem. 2015;37:1113-22 pubmed publisher
..Our data suggest that Sox9 activation is essential for the recovery of lung function after ALI, which highlights a previously unappreciated mechanism that controls the post-ALI lung recovery. ..
Barritt L, Miller J, Scheetz L, Gardner K, Pierce M, Soukup G, et al
. Conditional deletion of the human ortholog gene Dicer1 in Pax2-Cre expression domain impairs orofacial development. Indian J Hum Genet. 2012;18:310-9 pubmed publisher
Liu D, Tang H, Li X, Deng M, Wei N, Wang X, et al
. Targeting the HDAC2/HNF-4A/miR-101b/AMPK Pathway Rescues Tauopathy and Dendritic Abnormalities in Alzheimer's Disease. Mol Ther. 2017;25:752-764 pubmed publisher
..Taken together, the current findings implicate the HDAC2/miR-101/AMPK pathway as a critical mediator of AD pathogenesis. These studies also highlight the importance of epigenetics in AD and provide novel therapeutic targets. ..
Liu P, Baumgart M, Groth M, Wittmann J, Jack H, Platzer M, et al
. Dicer ablation in osteoblasts by Runx2 driven cre-loxP recombination affects bone integrity, but not glucocorticoid-induced suppression of bone formation. Sci Rep. 2016;6:32112 pubmed publisher
..Therefore, Dicer-dependent small RNA biogenesis in osteoblasts plays only a minor role in the pathogenesis of GC-induced inhibition of bone formation. ..
Tu X, Zhang H, Zhang J, Zhao S, Zheng X, Zhang Z, et al
. MicroRNA-101 suppresses liver fibrosis by targeting the TGF? signalling pathway. J Pathol. 2014;234:46-59 pubmed publisher
..The pleiotropic roles of miR-101 in hepatic fibrogenesis suggest that it could be a potential therapeutic target for liver fibrosis. ..