Gene Symbol: Mir101a
Description: microRNA 101a
Alias: Mirn101, Mirn101a, miR-101
Species: mouse

Top Publications

  1. Zhu Q, Liu Q, Chen J, Lan K, Ge B. MicroRNA-101 targets MAPK phosphatase-1 to regulate the activation of MAPKs in macrophages. J Immunol. 2010;185:7435-42 pubmed publisher
    ..Together, these results indicate that miR-101 regulates the innate immune responses of macrophages to LPS through targeting MKP-1. ..
  2. Zongaro S, Hukema R, D Antoni S, Davidovic L, Barbry P, Catania M, et al. The 3' UTR of FMR1 mRNA is a target of miR-101, miR-129-5p and miR-221: implications for the molecular pathology of FXTAS at the synapse. Hum Mol Genet. 2013;22:1971-82 pubmed publisher
    ..These findings suggest the presence of a synaptopathy in these animals. Interestingly, many of those deregulated mRNAs are target of the same microRNAs that modulate the expression of FMR1 at the synapse. ..
  3. Huang C, Xiao X, Yang Y, Mishra A, Liang Y, Zeng X, et al. MicroRNA-101 attenuates pulmonary fibrosis by inhibiting fibroblast proliferation and activation. J Biol Chem. 2017;292:16420-16439 pubmed publisher
    ..Our data suggest that miR-101 is an anti-fibrotic microRNA and a potential therapeutic target for pulmonary fibrosis. ..
  4. Saika R, Sakuma H, Noto D, Yamaguchi S, Yamamura T, Miyake S. MicroRNA-101a regulates microglial morphology and inflammation. J Neuroinflammation. 2017;14:109 pubmed publisher
    ..Finally, miR-101a downregulated the expression of MAPK phosphatase-1. miR-101a, which is enriched in the brain, promotes the differentiation of bone marrow cells into microglia-like cells. ..
  5. Li L, Zhang H, Min D, Zhang R, Wu J, Qu H, et al. Sox9 activation is essential for the recovery of lung function after acute lung injury. Cell Physiol Biochem. 2015;37:1113-22 pubmed publisher
    ..Our data suggest that Sox9 activation is essential for the recovery of lung function after ALI, which highlights a previously unappreciated mechanism that controls the post-ALI lung recovery. ..
  6. Liu D, Wang D, Xu Z, Gao J, Liu M, Liu Y, et al. Dysregulated expression of miR-101b and miR-26b lead to age-associated increase in LPS-induced COX-2 expression in murine macrophage. Age (Dordr). 2015;37:97 pubmed publisher
    ..Epigenetic regulation of the microRNAs (miRNAs) provides an important evidence for the treatment of innate inflammatory disease with HDAC inhibitors in elderly. ..
  7. Kim J, Lee K, Lee D, Kim J, Kwak S, Ha K, et al. Hypoxia-responsive microRNA-101 promotes angiogenesis via heme oxygenase-1/vascular endothelial growth factor axis by targeting cullin 3. Antioxid Redox Signal. 2014;21:2469-82 pubmed publisher
    ..Thus, miR-101 is a novel angiomir. Our results provide new mechanistic insights into a functional role of miR-101 as a potential therapeutic target in angiogenesis and vascular remodeling...
  8. Tu X, Zhang H, Zhang J, Zhao S, Zheng X, Zhang Z, et al. MicroRNA-101 suppresses liver fibrosis by targeting the TGF? signalling pathway. J Pathol. 2014;234:46-59 pubmed publisher
    ..The pleiotropic roles of miR-101 in hepatic fibrogenesis suggest that it could be a potential therapeutic target for liver fibrosis. ..
  9. Zhang J, Han C, Zhu H, Song K, Wu T. miR-101 inhibits cholangiocarcinoma angiogenesis through targeting vascular endothelial growth factor (VEGF). Am J Pathol. 2013;182:1629-39 pubmed publisher
    ..This study established a novel tumor-suppressor role of miR-101 in cholangiocarcinoma and it suggests the possibility of targeting miR-101 and related signaling pathways for future therapy. ..

More Information


  1. Chakrabarty A, Tranguch S, Daikoku T, Jensen K, Furneaux H, Dey S. MicroRNA regulation of cyclooxygenase-2 during embryo implantation. Proc Natl Acad Sci U S A. 2007;104:15144-9 pubmed
    ..Thus, elucidating the physiological roles of uterine miRNAs will help us better understand the genetic control of implantation, the gateway to a successful pregnancy. ..
  2. Hassan F, Nuovo G, Crawford M, Boyaka P, Kirkby S, Nana Sinkam S, et al. MiR-101 and miR-144 regulate the expression of the CFTR chloride channel in the lung. PLoS ONE. 2012;7:e50837 pubmed publisher
    ..Taken together, these results suggest that chronic cigarette smoking up-regulates miR-101 and that this miRNA could contribute to suppression of CFTR in the lungs of COPD patients. ..
  3. Yoshioka W, Higashiyama W, Tohyama C. Involvement of microRNAs in dioxin-induced liver damage in the mouse. Toxicol Sci. 2011;122:457-65 pubmed publisher
    ..In conclusion, this study demonstrated that TCDD dysregulates the expression of miR101a and miR122 and that COX-2, a target gene of miR101a, plays a significant role in liver damage in mice exposed to ..
  4. Liu W, Liu C, Zhu J, Shu P, Yin B, Gong Y, et al. MicroRNA-16 targets amyloid precursor protein to potentially modulate Alzheimer's-associated pathogenesis in SAMP8 mice. Neurobiol Aging. 2012;33:522-34 pubmed publisher
    ..Taken together, these findings demonstrate that APP is a target of miR-16 and the abnormally low expression of miR-16 could potentially lead to APP protein accumulation in AD mice. ..
  5. Merkel O, Hamacher F, Laimer D, Sifft E, Trajanoski Z, Scheideler M, et al. Identification of differential and functionally active miRNAs in both anaplastic lymphoma kinase (ALK)+ and ALK- anaplastic large-cell lymphoma. Proc Natl Acad Sci U S A. 2010;107:16228-33 pubmed publisher
    ..In addition to future therapeutical and diagnostic applications, it will be of interest to study the physiological implications and prognostic value of the identified miRNA profiles. ..
  6. Lippi G, Fernandes C, Ewell L, John D, Romoli B, Curia G, et al. MicroRNA-101 Regulates Multiple Developmental Programs to Constrain Excitation in Adult Neural Networks. Neuron. 2016;92:1337-1351 pubmed publisher
    ..Our results provide new mechanistic insight into brain development and suggest novel candidates for therapeutic intervention. ..
  7. Tanaka T, Haneda S, Imakawa K, Sakai S, Nagaoka K. A microRNA, miR-101a, controls mammary gland development by regulating cyclooxygenase-2 expression. Differentiation. 2009;77:181-7 pubmed publisher
    ..Taken together, these results suggest that miR-101a regulates cell proliferation via altering Cox-2 expression, which is critical for controlling mammary gland development. ..
  8. Daikoku T, Hirota Y, Tranguch S, Joshi A, DeMayo F, Lydon J, et al. Conditional loss of uterine Pten unfailingly and rapidly induces endometrial cancer in mice. Cancer Res. 2008;68:5619-27 pubmed publisher
    ..These mouse models have the added advantage because they mimic several features of human EMC. ..