Miat

Summary

Gene Symbol: Miat
Description: myocardial infarction associated transcript (non-protein coding)
Alias: 3632434I06, A230057G18Rik, Rncr2, gomafu
Species: mouse

Top Publications

  1. Sone M, Hayashi T, Tarui H, Agata K, Takeichi M, Nakagawa S. The mRNA-like noncoding RNA Gomafu constitutes a novel nuclear domain in a subset of neurons. J Cell Sci. 2007;120:2498-506 pubmed
    ..We have identified a novel mRNA-like noncoding gene, named Gomafu, which is expressed in a distinct set of neurons in the mouse nervous system...
  2. Sheik Mohamed J, Gaughwin P, Lim B, Robson P, Lipovich L. Conserved long noncoding RNAs transcriptionally regulated by Oct4 and Nanog modulate pluripotency in mouse embryonic stem cells. RNA. 2010;16:324-37 pubmed publisher
    ..These results for the first time implicate lncRNAs in the modulation of mESC pluripotency and expand the established mESC regulatory network model to include functional lncRNAs directly controlled by key mESC transcription factors. ..
  3. Rapicavoli N, Poth E, Blackshaw S. The long noncoding RNA RNCR2 directs mouse retinal cell specification. BMC Dev Biol. 2010;10:49 pubmed publisher
    ..We have investigated the highly abundant lncRNA RNCR2 in regulation of mouse retinal cell differentiation...
  4. Nakagawa S, Ip J, Shioi G, Tripathi V, Zong X, Hirose T, et al. Malat1 is not an essential component of nuclear speckles in mice. RNA. 2012;18:1487-99 pubmed publisher
    ..We propose that Malat1 is not essential in living mice maintained under normal laboratory conditions and that its function becomes apparent only in specific cell types and under particular conditions. ..
  5. Mercer T, Dinger M, Sunkin S, Mehler M, Mattick J. Specific expression of long noncoding RNAs in the mouse brain. Proc Natl Acad Sci U S A. 2008;105:716-21 pubmed publisher
    ..Our results show that the majority of ncRNAs are expressed in the brain and provide strong evidence that the majority of processed transcripts with no protein-coding capacity function intrinsically as RNAs. ..
  6. Ishizuka A, Hasegawa Y, Ishida K, Yanaka K, Nakagawa S. Formation of nuclear bodies by the lncRNA Gomafu-associating proteins Celf3 and SF1. Genes Cells. 2014;19:704-21 pubmed publisher
    b>Gomafu/MIAT/Rncr2 is a long noncoding RNA that has been proposed to control retinal cell specification, stem cell differentiation and alternative splicing of schizophrenia-related genes...
  7. Ip J, Sone M, Nashiki C, Pan Q, Kitaichi K, Yanaka K, et al. Gomafu lncRNA knockout mice exhibit mild hyperactivity with enhanced responsiveness to the psychostimulant methamphetamine. Sci Rep. 2016;6:27204 pubmed publisher
    The long noncoding RNA Gomafu/MIAT/Rncr2 is thought to function in retinal cell specification, stem cell differentiation and the control of alternative splicing...
  8. Jiang Q, Shan K, Qun Wang X, Zhou R, Yang H, Liu C, et al. Long non-coding RNA-MIAT promotes neurovascular remodeling in the eye and brain. Oncotarget. 2016;7:49688-49698 pubmed publisher
    ..Here we show that long non-coding RNA-MIAT is aberrantly expressed under neurovascular dysfunction condition...
  9. Wycisk K, Budde B, Feil S, Skosyrski S, Buzzi F, Neidhardt J, et al. Structural and functional abnormalities of retinal ribbon synapses due to Cacna2d4 mutation. Invest Ophthalmol Vis Sci. 2006;47:3523-30 pubmed

More Information

Publications12

  1. Aprea J, Prenninger S, Dori M, Ghosh T, Monasor L, Wessendorf E, et al. Transcriptome sequencing during mouse brain development identifies long non-coding RNAs functionally involved in neurogenic commitment. EMBO J. 2013;32:3145-60 pubmed publisher
    ..Finally, we focussed on one lncRNA, Miat, whose manipulation was found to trigger pleiotropic effects on brain development and aberrant splicing of Wnt7b...
  2. Yan B, Yao J, Liu J, Li X, Wang X, Li Y, et al. lncRNA-MIAT regulates microvascular dysfunction by functioning as a competing endogenous RNA. Circ Res. 2015;116:1143-56 pubmed publisher
    ..To elucidate whether lncRNA-myocardial infarction-associated transcript (MIAT) is involved in diabetes mellitus-induced microvascular dysfunction...
  3. Zhang J, Chen M, Chen J, Lin S, Cai D, Chen C, et al. Long non-coding RNA MIAT acts as a biomarker in diabetic retinopathy by absorbing miR-29b and regulating cell apoptosis. Biosci Rep. 2017;37: pubmed publisher
    ..The biologic significance of myocardial infarction associated transcript (MIAT) in DR remains unknown. Here, we aim to explore the mechanism between MIAT and DR, which is essential for RD...