Mgll

Summary

Gene Symbol: Mgll
Description: monoglyceride lipase
Alias: AA589436, Magl, Mgl, monoglyceride lipase, monoacylglycerol lipase
Species: mouse
Products:     Mgll

Top Publications

  1. Chon S, Zhou Y, Dixon J, Storch J. Intestinal monoacylglycerol metabolism: developmental and nutritional regulation of monoacylglycerol lipase and monoacylglycerol acyltransferase. J Biol Chem. 2007;282:33346-57 pubmed
    ..We recently provided evidence for enterocyte MG hydrolysis and demonstrated expression of the monoacylglycerol lipase (MGL) gene in human intestinal Caco-2 cells and rodent small intestinal mucosa...
  2. Blankman J, Simon G, Cravatt B. A comprehensive profile of brain enzymes that hydrolyze the endocannabinoid 2-arachidonoylglycerol. Chem Biol. 2007;14:1347-56 pubmed
    ..about the inactivation of 2-AG, which can be hydrolyzed by multiple enzymes in vitro, including FAAH and monoacylglycerol lipase (MAGL)...
  3. Long J, Nomura D, Vann R, Walentiny D, Booker L, Jin X, et al. Dual blockade of FAAH and MAGL identifies behavioral processes regulated by endocannabinoid crosstalk in vivo. Proc Natl Acad Sci U S A. 2009;106:20270-5 pubmed publisher
    ..upon pharmacological inhibition or genetic deletion of either fatty acid amide hydrolase (FAAH) or monoacylglycerol lipase (MAGL), enzymes that regulate the two major endocannabinoids anandamide (AEA) and 2-arachidonoylglycerol (..
  4. Chen R, Zhang J, Wu Y, Wang D, Feng G, Tang Y, et al. Monoacylglycerol lipase is a therapeutic target for Alzheimer's disease. Cell Rep. 2012;2:1329-39 pubmed publisher
    ..b>Monoacylglycerol lipase (MAGL) is the primary enzyme metabolizing the endocannabinoid 2-arachidonoylglycerol in the brain...
  5. Keimpema E, Barabas K, Morozov Y, Tortoriello G, Torii M, Cameron G, et al. Differential subcellular recruitment of monoacylglycerol lipase generates spatial specificity of 2-arachidonoyl glycerol signaling during axonal pathfinding. J Neurosci. 2010;30:13992-4007 pubmed publisher
    ..Therefore, we hypothesized that local 2-AG degradation by monoacylglycerol lipase (MGL) must play a role...
  6. Uchigashima M, Yamazaki M, Yamasaki M, Tanimura A, Sakimura K, Kano M, et al. Molecular and morphological configuration for 2-arachidonoylglycerol-mediated retrograde signaling at mossy cell-granule cell synapses in the dentate gyrus. J Neurosci. 2011;31:7700-14 pubmed publisher
    ..On the other hand, the major 2-AG-degrading enzyme, monoacylglycerol lipase (MGL), was absent at MC-GC synapses but was expressed in astrocytes and some inhibitory terminals...
  7. Karlsson M, Reue K, Xia Y, Lusis A, Langin D, Tornqvist H, et al. Exon-intron organization and chromosomal localization of the mouse monoglyceride lipase gene. Gene. 2001;272:11-8 pubmed
    b>Monoglyceride lipase (MGL) functions together with hormone-sensitive lipase to hydrolyze intracellular triglyceride stores of adipocytes and other cells to fatty acids and glycerol...
  8. Marrs W, Blankman J, Horne E, Thomazeau A, Lin Y, Coy J, et al. The serine hydrolase ABHD6 controls the accumulation and efficacy of 2-AG at cannabinoid receptors. Nat Neurosci. 2010;13:951-7 pubmed publisher
    ..Enzymes that hydrolyze 2-AG, such as monoacylglycerol lipase, regulate the accumulation and efficacy of 2-AG at cannabinoid receptors...
  9. Schlosburg J, Blankman J, Long J, Nomura D, Pan B, Kinsey S, et al. Chronic monoacylglycerol lipase blockade causes functional antagonism of the endocannabinoid system. Nat Neurosci. 2010;13:1113-9 pubmed publisher
    ..We found that a similar form of functional antagonism was produced by sustained inactivation of monoacylglycerol lipase (MAGL), the principal degradative enzyme for the endocannabinoid 2-arachidonoylglycerol...

More Information

Publications39

  1. Pan B, Wang W, Zhong P, Blankman J, Cravatt B, Liu Q. Alterations of endocannabinoid signaling, synaptic plasticity, learning, and memory in monoacylglycerol lipase knock-out mice. J Neurosci. 2011;31:13420-30 pubmed publisher
    ..The eCB 2-arachidonoylglycerol (2-AG) is hydrolyzed primarily by monoacylglycerol lipase (MAGL)...
  2. Taschler U, Radner F, Heier C, Schreiber R, Schweiger M, Schoiswohl G, et al. Monoglyceride lipase deficiency in mice impairs lipolysis and attenuates diet-induced insulin resistance. J Biol Chem. 2011;286:17467-77 pubmed publisher
    b>Monoglyceride lipase (MGL) influences energy metabolism by at least two mechanisms. First, it hydrolyzes monoacylglycerols (MG) into fatty acids and glycerol. These products can be used for energy production or synthetic reactions...
  3. Karlsson M, Contreras J, Hellman U, Tornqvist H, Holm C. cDNA cloning, tissue distribution, and identification of the catalytic triad of monoglyceride lipase. Evolutionary relationship to esterases, lysophospholipases, and haloperoxidases. J Biol Chem. 1997;272:27218-23 pubmed
    b>Monoglyceride lipase catalyzes the last step in the hydrolysis of stored triglycerides in the adipocyte and presumably also complements the action of lipoprotein lipase in degrading triglycerides from chylomicrons and very low density ..
  4. Tanimura A, Uchigashima M, Yamazaki M, Uesaka N, Mikuni T, Abe M, et al. Synapse type-independent degradation of the endocannabinoid 2-arachidonoylglycerol after retrograde synaptic suppression. Proc Natl Acad Sci U S A. 2012;109:12195-200 pubmed publisher
    ..Here we found that expression of the 2-AG hydrolyzing enzyme monoacylglycerol lipase (MGL) was highly heterogeneous in the cerebellum, being rich within parallel fiber (PF) terminals, weak ..
  5. Wu C, Zhu J, Wager Miller J, Wang S, O LEARY D, Monory K, et al. Requirement of cannabinoid CB(1) receptors in cortical pyramidal neurons for appropriate development of corticothalamic and thalamocortical projections. Eur J Neurosci. 2010;32:693-706 pubmed publisher
    ..The presence of monoglyceride lipase, a 2-AG degrading enzyme, in both thalamocortical and corticothalamic tracts probably serves to restrict 2-..
  6. Vujić N, Korbelius M, Leopold C, Duta Mare M, Rainer S, Schlager S, et al. Monoglyceride lipase deficiency affects hepatic cholesterol metabolism and lipid-dependent gut transit in ApoE-/- mice. Oncotarget. 2017;8:33122-33136 pubmed publisher
    b>Monoglyceride lipase (MGL) hydrolyzes monoglycerides (MGs) to glycerol and fatty acids...
  7. Leishman E, Cornett B, Spork K, Straiker A, Mackie K, Bradshaw H. Broad impact of deleting endogenous cannabinoid hydrolyzing enzymes and the CB1 cannabinoid receptor on the endogenous cannabinoid-related lipidome in eight regions of the mouse brain. Pharmacol Res. 2016;110:159-172 pubmed publisher
    The enzymes fatty acid amide hydrolase (FAAH) and monoacylglycerol lipase (MAGL) hydrolyze endogenous cannabinoids (eCBs), N-arachidonoyl ethanolamine (AEA) and 2-arachidonoyl glycerol (2-AG), respectively...
  8. Sanchez Alavez M, Nguyen W, Mori S, Moroncini G, Viader A, Nomura D, et al. Monoacylglycerol Lipase Regulates Fever Response. PLoS ONE. 2015;10:e0134437 pubmed publisher
    ..However, recent studies have demonstrated that monoacyglycerol lipase (MAGL), through hydrolysis of the endocannabinoid 2-arachidonoylglycerol, provides a major source of AA for PGE2 ..
  9. Heier C, Taschler U, Rengachari S, Oberer M, Wolinski H, Natter K, et al. Identification of Yju3p as functional orthologue of mammalian monoglyceride lipase in the yeast Saccharomycescerevisiae. Biochim Biophys Acta. 2010;1801:1063-71 pubmed publisher
    ..Loss of this activity was restored by heterologous expression of murine monoglyceride lipase (MGL)...
  10. Suzuki H, Ito Y, Noro Y, Koketsu M, Kamijima M, Tomizawa M. Organophosphate agents induce plasma hypertriglyceridemia in mouse via single or dual inhibition of the endocannabinoid hydrolyzing enzyme(s). Toxicol Lett. 2014;225:153-7 pubmed publisher
    ..serine hydrolases including endocannabinoid metabolizing enzymes fatty acid amide hydrolase (FAAH) and monoacylglycerol lipase (MAGL) have been suggested as secondary targets for organophosphate (OP) agents to exert adverse toxic ..
  11. Petrenko A, Yamazaki M, Sakimura K, Kano M, Baba H. Augmented tonic pain-related behavior in knockout mice lacking monoacylglycerol lipase, a major degrading enzyme for the endocannabinoid 2-arachidonoylglycerol. Behav Brain Res. 2014;271:51-8 pubmed publisher
    b>Monoacylglycerol lipase (MGL) is the main enzyme responsible for degradation of the endocannabinoid 2-arachidonoylglycerol (2-AG)...
  12. Zhong P, Pan B, Gao X, Blankman J, Cravatt B, Liu Q. Genetic deletion of monoacylglycerol lipase alters endocannabinoid-mediated retrograde synaptic depression in the cerebellum. J Physiol. 2011;589:4847-55 pubmed publisher
    The endocannabinoid (eCB) 2-arachidonoylglycerol (2-AG) is hydrolysed primarily by monoacylglycerol lipase (MAGL)...
  13. Grabner G, Eichmann T, Wagner B, Gao Y, Farzi A, Taschler U, et al. Deletion of Monoglyceride Lipase in Astrocytes Attenuates Lipopolysaccharide-induced Neuroinflammation. J Biol Chem. 2016;291:913-23 pubmed publisher
    b>Monoglyceride lipase (MGL) is required for efficient hydrolysis of the endocannabinoid 2-arachidonoylglyerol (2-AG) in the brain generating arachidonic acid (AA) and glycerol...
  14. Keimpema E, Tortoriello G, Alpar A, Capsoni S, Arisi I, Calvigioni D, et al. Nerve growth factor scales endocannabinoid signaling by regulating monoacylglycerol lipase turnover in developing cholinergic neurons. Proc Natl Acad Sci U S A. 2013;110:1935-40 pubmed publisher
    ..In doing so, NGF limits the sorting of monoacylglycerol lipase (MGL), rate limiting 2-AG bioavailability, to proximal neurites, allowing cell-autonomous 2-AG signaling ..
  15. Ohno H, Shinoda K, Ohyama K, Sharp L, Kajimura S. EHMT1 controls brown adipose cell fate and thermogenesis through the PRDM16 complex. Nature. 2013;504:163-7 pubmed publisher
    ..These data indicate that EHMT1 is an essential enzymatic switch that controls brown adipose cell fate and energy homeostasis. ..
  16. Alpár A, Tortoriello G, Calvigioni D, Niphakis M, Milenkovic I, Bakker J, et al. Endocannabinoids modulate cortical development by configuring Slit2/Robo1 signalling. Nat Commun. 2014;5:4421 pubmed publisher
  17. Imperatore R, Morello G, Luongo L, Taschler U, Romano R, De Gregorio D, et al. Genetic deletion of monoacylglycerol lipase leads to impaired cannabinoid receptor CB₁R signaling and anxiety-like behavior. J Neurochem. 2015;135:799-813 pubmed publisher
    ..The most abundant eCB in the brain, that is 2-arachidonoylglycerol (2-AG), is hydrolyzed by the enzyme monoacylglycerol lipase (MAGL), whose chronic inhibition in the brain was reported to cause CB1 R desensitization...
  18. Viader A, Blankman J, Zhong P, Liu X, Schlosburg J, Joslyn C, et al. Metabolic Interplay between Astrocytes and Neurons Regulates Endocannabinoid Action. Cell Rep. 2015;12:798-808 pubmed publisher
    ..2-AG signaling is terminated by enzymatic hydrolysis-a reaction that is principally performed by monoacylglycerol lipase (MAGL)...
  19. Kishimoto Y, Cagniard B, Yamazaki M, Nakayama J, Sakimura K, Kirino Y, et al. Task-specific enhancement of hippocampus-dependent learning in mice deficient in monoacylglycerol lipase, the major hydrolyzing enzyme of the endocannabinoid 2-arachidonoylglycerol. Front Behav Neurosci. 2015;9:134 pubmed publisher
    ..functions, we conducted a comprehensive behavioral test battery in knockout (KO) mice deficient in monoacylglycerol lipase (MGL), the major hydrolyzing enzyme of 2-AG...
  20. Douglass J, Zhou Y, Wu A, Zadrogra J, Gajda A, Lackey A, et al. Global deletion of MGL in mice delays lipid absorption and alters energy homeostasis and diet-induced obesity. J Lipid Res. 2015;56:1153-71 pubmed publisher
    b>Monoacylglycerol lipase (MGL) is a ubiquitously expressed enzyme that catalyzes the hydrolysis of monoacylglycerols (MGs) to yield FFAs and glycerol...
  21. Tomas Roca L, Perez Aytes A, Puelles L, Marin F. In silico identification of new candidate genes for hereditary congenital facial paresis. Int J Dev Neurosci. 2011;29:451-60 pubmed publisher
    ..As a result of this screening, we found a new gene (Mgll) from the HCFP1 locus that has strong and specific expression in the developing FBM nucleus...
  22. Sun X, Xie H, Yang J, Wang H, Bradshaw H, Dey S. Endocannabinoid signaling directs differentiation of trophoblast cell lineages and placentation. Proc Natl Acad Sci U S A. 2010;107:16887-92 pubmed publisher
  23. Chon S, Douglass J, Zhou Y, Malik N, Dixon J, Brinker A, et al. Over-expression of monoacylglycerol lipase (MGL) in small intestine alters endocannabinoid levels and whole body energy balance, resulting in obesity. PLoS ONE. 2012;7:e43962 pubmed publisher
    The function of small intestinal monoacylglycerol lipase (MGL) is unknown...
  24. Nomura D, Morrison B, Blankman J, Long J, Kinsey S, Marcondes M, et al. Endocannabinoid hydrolysis generates brain prostaglandins that promote neuroinflammation. Science. 2011;334:809-13 pubmed publisher
    ..Here, we show that a distinct pathway exists in brain, where monoacylglycerol lipase (MAGL) hydrolyzes the endocannabinoid 2-arachidonoylglycerol to generate a major arachidonate precursor ..
  25. Maleńczyk K, Keimpema E, Piscitelli F, Calvigioni D, Björklund P, Mackie K, et al. Fetal endocannabinoids orchestrate the organization of pancreatic islet microarchitecture. Proc Natl Acad Sci U S A. 2015;112:E6185-94 pubmed publisher
    ..Overall, our data mechanistically link endocannabinoids to cell proliferation and sorting during pancreatic islet formation, as well as to life-long programming of hormonal determinants of glucose homeostasis. ..
  26. Chanda P, Gao Y, Mark L, Btesh J, Strassle B, Lu P, et al. Monoacylglycerol lipase activity is a critical modulator of the tone and integrity of the endocannabinoid system. Mol Pharmacol. 2010;78:996-1003 pubmed publisher
    ..abundant endocannabinoid in the brain and is believed to be hydrolyzed primarily by the serine hydrolase monoacylglycerol lipase (MAGL)...
  27. Comelli F, Giagnoni G, Bettoni I, Colleoni M, Costa B. The inhibition of monoacylglycerol lipase by URB602 showed an anti-inflammatory and anti-nociceptive effect in a murine model of acute inflammation. Br J Pharmacol. 2007;152:787-94 pubmed
    ..2-AG) is an endocannabinoid whose hydrolysis is predominantly catalysed by the enzyme monoacylglycerol lipase (MAGL)...
  28. Chen Y, Liu X, Vickstrom C, Liu M, Zhao L, Viader A, et al. Neuronal and Astrocytic Monoacylglycerol Lipase Limit the Spread of Endocannabinoid Signaling in the Cerebellum. Eneuro. 2016;3: pubmed publisher
    Endocannabinoids are diffusible lipophilic molecules that may spread to neighboring synapses. Monoacylglycerol lipase (MAGL) is the principal enzyme that degrades the endocannabinoid 2-arachidonoylglycerol (2-AG)...
  29. Woo J, Kang S. Diet change and exercise enhance protein expression of CREB, CRTC 2 and lipolitic enzymes in adipocytes of obese mice. Lipids Health Dis. 2016;15:147 pubmed publisher
    ..05). Activities of adipose triglyceride lipase (ATGL), hormone sensitive lipolitic enzyme (HSL) and monoacylglycerol lipase (MGL) were significantly higher (51 %, 38 %, 49 %) in the DE group than the HF group (p?<?0.05)...
  30. Walter L, Dinh T, Stella N. ATP induces a rapid and pronounced increase in 2-arachidonoylglycerol production by astrocytes, a response limited by monoacylglycerol lipase. J Neurosci. 2004;24:8068-74 pubmed
    ..Furthermore, we show that astrocytes express monoacylglycerol lipase (MGL), the main hydrolyzing enzyme of 2-AG, the pharmacological inhibition of which potentiates the ATP-..