Mest

Summary

Gene Symbol: Mest
Description: mesoderm specific transcript
Alias: AA408879, AI256745, Peg1, mesoderm-specific transcript protein, paternally-expressed gene 1 protein
Species: mouse
Products:     Mest

Top Publications

  1. Croteau S, Roquis D, Charron M, Frappier D, Yavin D, Loredo Osti J, et al. Increased plasticity of genomic imprinting of Dlk1 in brain is due to genetic and epigenetic factors. Mamm Genome. 2005;16:127-35 pubmed
    The expression of six imprinted genes (Dlk1, Gt12, Igf2r, Kcnq1, Nnat, and Peg1) was examined in brains of 21 mice derived from N2 x N2 intercrosses between C57BL/6 and MOLF/Ei strains...
  2. Katsanou V, Milatos S, Yiakouvaki A, Sgantzis N, Kotsoni A, Alexiou M, et al. The RNA-binding protein Elavl1/HuR is essential for placental branching morphogenesis and embryonic development. Mol Cell Biol. 2009;29:2762-76 pubmed publisher
    ..Collectively, our data demonstrate the dominant role of HuR in organizing gene expression programs guiding placental labyrinth morphogenesis, skeletal specification patterns, and splenic ontogeny. ..
  3. Kaneko ishino T, Kuroiwa Y, Miyoshi N, Kohda T, Suzuki R, Yokoyama M, et al. Peg1/Mest imprinted gene on chromosome 6 identified by cDNA subtraction hybridization. Nat Genet. 1995;11:52-9 pubmed
    ..Peg1 (paternally expressed gene 1) or Mest, the first imprinted gene found on the mouse chromosome 6, may contribute to the lethality of parthenogenones and ..
  4. Kaneda M, Okano M, Hata K, Sado T, Tsujimoto N, Li E, et al. Essential role for de novo DNA methyltransferase Dnmt3a in paternal and maternal imprinting. Nature. 2004;429:900-3 pubmed
    ..These results indicate that both Dnmt3a and Dnmt3L are required for methylation of most imprinted loci in germ cells, but also suggest the involvement of other factors...
  5. Parker Katiraee L, Carson A, Yamada T, Arnaud P, Feil R, Abu Amero S, et al. Identification of the imprinted KLF14 transcription factor undergoing human-specific accelerated evolution. PLoS Genet. 2007;3:e65 pubmed
    ..Thus, KLF14 may be the first example of an imprinted transcript undergoing accelerated evolution in the human lineage. ..
  6. Schuster Gossler K, Bilinski P, Sado T, Ferguson Smith A, Gossler A. The mouse Gtl2 gene is differentially expressed during embryonic development, encodes multiple alternatively spliced transcripts, and may act as an RNA. Dev Dyn. 1998;212:214-28 pubmed
    ..Gtl2 transcript levels are present in parthenogenic embryos but may be reduced, consistent with the pattern of inheritance of the Gtl2lacZ phenotype. ..
  7. Lee Y, Park C, Hahn Y, Park J, Lee J, Yun J, et al. Mit1/Lb9 and Copg2, new members of mouse imprinted genes closely linked to Peg1/Mest(1). FEBS Lett. 2000;472:230-4 pubmed
    Two mouse genes, Mit1/Lb9 and Copg2, linked to Peg1/Mest on mouse chromosome 6, were identified to be imprinted maternally and paternally, respectively. Mit1/Lb9 encoding untranslated transcripts resides within the intron 20 of Copg2...
  8. Kobayashi S, Kohda T, Miyoshi N, Kuroiwa Y, Aisaka K, Tsutsumi O, et al. Human PEG1/MEST, an imprinted gene on chromosome 7. Hum Mol Genet. 1997;6:781-6 pubmed
    The mouse Peg1/Mest gene is an imprinted gene that is expressed particularly in mesodermal tissues in early embryonic stages...
  9. Lefebvre L, Viville S, Barton S, Ishino F, Surani M. Genomic structure and parent-of-origin-specific methylation of Peg1. Hum Mol Genet. 1997;6:1907-15 pubmed
    We previously identified Peg1/Mest as a novel paternally expressed gene in the developing mouse embryo. The human PEG1 gene was recently assigned to 7q32 and shown to be imprinted and paternally expressed...

More Information

Publications69

  1. Lefebvre L, Viville S, Barton S, Ishino F, Keverne E, Surani M. Abnormal maternal behaviour and growth retardation associated with loss of the imprinted gene Mest. Nat Genet. 1998;20:163-9 pubmed
    Mest (also known as Peg1), an imprinted gene expressed only from the paternal allele during development, was disrupted by gene targeting in embryonic stem (ES) cells...
  2. Mayer W, Hemberger M, Frank H, Grummer R, Winterhager E, Kaufmann P, et al. Expression of the imprinted genes MEST/Mest in human and murine placenta suggests a role in angiogenesis. Dev Dyn. 2000;217:1-10 pubmed
    In the mouse fetus, Mest is widely expressed in mesoderm derived tissues. In separate studies in mice and in humans, it has been shown to be maternally imprinted, that is, only the paternally inherited allele is active...
  3. Beechey C. Peg1/Mest locates distal to the currently defined imprinting region on mouse proximal chromosome 6 and identifies a new imprinting region affecting growth. Cytogenet Cell Genet. 2000;90:309-14 pubmed
    ..2 and the centromere. The paternally expressed imprinted gene Mest had been mapped within the original imprinting region and was therefore a candidate for the early embryonic ..
  4. Nakabayashi K, Bentley L, Hitchins M, Mitsuya K, Meguro M, Minagawa S, et al. Identification and characterization of an imprinted antisense RNA (MESTIT1) in the human MEST locus on chromosome 7q32. Hum Mol Genet. 2002;11:1743-56 pubmed
    ..MESTIT1 (also known as PEG1-AS) is now the third independent transcript (with MEST and COPG2IT1) identified at human chromosome 7q32 ..
  5. Caldas H, Cunningham D, Wang X, Jiang F, Humphries L, Kelley R, et al. Placental defects are associated with male lethality in bare patches and striated embryos deficient in the NAD(P)H Steroid Dehydrogenase-like (NSDHL) Enzyme. Mol Genet Metab. 2005;84:48-60 pubmed
  6. Monnier P, Martinet C, Pontis J, Stancheva I, Ait Si Ali S, Dandolo L. H19 lncRNA controls gene expression of the Imprinted Gene Network by recruiting MBD1. Proc Natl Acad Sci U S A. 2013;110:20693-8 pubmed publisher
    ..For three of these genes--Igf2 (insulin-like growth factor 2), Slc38a4 (solute carrier family 38 member 4), and Peg1 (paternally expressed gene 1)--both MBD1 and H3K9me3 binding were detected on their differentially methylated ..
  7. Koza R, Rogers P, Kozak L. Inter-individual variation of dietary fat-induced mesoderm specific transcript in adipose tissue within inbred mice is not caused by altered promoter methylation. Epigenetics. 2009;4:512-8 pubmed
    Mesoderm specific transcript (Mest), an imprinted gene associated with fat mass expansion under conditions of positive energy balance, shows highly variable expression (approximately 80-fold) in white adipose tissue (WAT) of C57BL/6J (B6) ..
  8. Macisaac J, Bogutz A, Morrissy A, Lefebvre L. Tissue-specific alternative polyadenylation at the imprinted gene Mest regulates allelic usage at Copg2. Nucleic Acids Res. 2012;40:1523-35 pubmed publisher
    The gene Mest (also known as Peg1) is regulated by genomic imprinting in the mouse and only the paternal allele is active for transcription...
  9. Takahashi M, Kamei Y, Ezaki O. Mest/Peg1 imprinted gene enlarges adipocytes and is a marker of adipocyte size. Am J Physiol Endocrinol Metab. 2005;288:E117-24 pubmed
    ..We have found that mesoderm-specific transcript (Mest)/paternally expressed gene 1 (Peg1) gene expression was markedly enhanced in white adipose tissue of mice with diet-..
  10. Pennisi D, Kinna G, Chiu H, Simmons D, Wilkinson L, Little M. Crim1 has an essential role in glycogen trophoblast cell and sinusoidal-trophoblast giant cell development in the placenta. Placenta. 2012;33:175-82 pubmed publisher
    ..Our findings show that Crim1 is required for placental development, and is necessary for the proper differentiation of sinusoidal-trophoblast giant cells and glycogen trophoblast cells. ..
  11. Lui J, Finkielstain G, Barnes K, Baron J. An imprinted gene network that controls mammalian somatic growth is down-regulated during postnatal growth deceleration in multiple organs. Am J Physiol Regul Integr Comp Physiol. 2008;295:R189-96 pubmed publisher
    ..For these genes, Igf2, H19, Plagl1, Mest, Peg3, Dlk1, Gtl2, Grb10, Ndn, Cdkn1c, and SLC38a4, the declines show a temporal pattern similar to the decline in ..
  12. Tilghman S. The sins of the fathers and mothers: genomic imprinting in mammalian development. Cell. 1999;96:185-93 pubmed
  13. Ciccone D, Su H, Hevi S, Gay F, Lei H, Bajko J, et al. KDM1B is a histone H3K4 demethylase required to establish maternal genomic imprints. Nature. 2009;461:415-8 pubmed publisher
    ..Our results suggest that demethylation of H3K4 is critical for establishing the DNA methylation imprints during oogenesis. ..
  14. Shaw L, Johnson P, Kimber S. Gene expression profiling of the developing mouse kidney and embryo. In Vitro Cell Dev Biol Anim. 2010;46:155-65 pubmed publisher
    ..We then analysed their expression in other developing tissues. Results show Dcn, Hoxc9, Mest, Wt1 and Ywhaq were expressed at moderate to high levels during the window of metanephric specification and early ..
  15. King T, Bland Y, Webb S, Barton S, Brown N. Expression of Peg1 (Mest) in the developing mouse heart: involvement in trabeculation. Dev Dyn. 2002;225:212-5 pubmed
    Peg1 (Mest) is an imprinted gene of unknown function widely expressed in the mouse embryo, predominantly in cells of the mesodermal lineage. We have revealed a restricted expression pattern within the developing heart...
  16. Jahangiri M, Shahhoseini M, Movaghar B. H19 and MEST gene expression and histone modification in blastocysts cultured from vitrified and fresh two-cell mouse embryos. Reprod Biomed Online. 2014;29:559-66 pubmed publisher
    ..The effect of vitrification on gene expression and some modifications of H3 histone in H19 and MEST imprinted genes in blastocysts produced in vitro from non-vitrified and vitrified two-cell embryos was investigated...
  17. Jura M, Jarosławska J, Chu D, Kozak L. Mest and Sfrp5 are biomarkers for healthy adipose tissue. Biochimie. 2016;124:124-133 pubmed publisher
    ..We have utilized Mest and Sfrp5 genes, two genes highly correlated with adipose tissue expansion in diet-induced obesity, to characterize ..
  18. Imamura T, Kerjean A, Heams T, Kupiec J, Thenevin C, Paldi A. Dynamic CpG and non-CpG methylation of the Peg1/Mest gene in the mouse oocyte and preimplantation embryo. J Biol Chem. 2005;280:20171-5 pubmed
    In somatic tissues, the CpG island of the imprinted Peg1/Mest gene is methylated on the maternal allele...
  19. Gabory A, Ripoche M, Le Digarcher A, Watrin F, Ziyyat A, Forné T, et al. H19 acts as a trans regulator of the imprinted gene network controlling growth in mice. Development. 2009;136:3413-21 pubmed publisher
    ..Our results also bring further experimental evidence for the existence of the IGN and open new perspectives in the comprehension of the role of genomic imprinting in embryonic growth and in human imprinting pathologies. ..
  20. Penkov L, Kondrakhina M, Mironova O, Platonov E. [Expression of imprinted Igf2 and Peg1/Mest genes in postimplantation parthenogenetic mouse embryos treated with transforming growth factor alpha in vitro]. Genetika. 2008;44:1148-52 pubmed
    The effect of transforming growth factor alpha (TGFt) on the expression of imprinted Igf2 and Peg1/Mest genes was studied in diploid parthenogenetic embryos (PEs) of (CBA x C57BL/6)F1 mice during the postimplantation period of ..
  21. Kadota Y, Yanagawa M, Nakaya T, Kawakami T, Sato M, Suzuki S. Gene expression of mesoderm-specific transcript is upregulated as preadipocytes differentiate to adipocytes in vitro. J Physiol Sci. 2012;62:403-11 pubmed publisher
    Mesoderm-specific transcript (Mest) is a distinct gene associated with adipocyte differentiation and proliferation. The mechanisms regulating expression of the Mest gene are not established...
  22. Yang D, Lutter D, Burtscher I, Uetzmann L, Theis F, Lickert H. miR-335 promotes mesendodermal lineage segregation and shapes a transcription factor gradient in the endoderm. Development. 2014;141:514-25 pubmed publisher
    ..miR-335 is encoded in the mesoderm-specific transcript (Mest) and targets the 3'-UTRs of the endoderm-determining TFs Foxa2 and Sox17...
  23. Anunciado Koza R, Higgins D, Koza R. Adipose tissue Mest and Sfrp5 are concomitant with variations of adiposity among inbred mouse strains fed a non-obesogenic diet. Biochimie. 2016;124:134-140 pubmed publisher
    The expression of a subset of genes including mesoderm specific transcript (Mest), secreted frizzled-related protein 5 (Sfrp5) and bone morphogenetic protein 3 (Bmp3) in adipose tissue biopsies of C57BL/6J mice before exposure to an ..
  24. Buttitta L, Tanaka T, Chen A, Ko M, Fan C. Microarray analysis of somitogenesis reveals novel targets of different WNT signaling pathways in the somitic mesoderm. Dev Biol. 2003;258:91-104 pubmed
  25. Reule M, Krause R, Hemberger M, Fundele R. Analysis of Peg1/Mest imprinting in the mouse. Dev Genes Evol. 1998;208:161-3 pubmed
    In the mouse, Peg1/Mest is widely expressed in mesoderm-derived tissues. In separate studies, it has been shown to be maternally imprinted, that is, only the paternally inherited allele is active in mice and in humans...
  26. Luhmann U, Meunier D, Shi W, Lüttges A, Pfarrer C, Fundele R, et al. Fetal loss in homozygous mutant Norrie disease mice: a new role of Norrin in reproduction. Genesis. 2005;42:253-62 pubmed
    ..Taken together, these data provide strong evidence for Norrin playing an important role in female reproductive tissues. ..
  27. Fukasawa M, Morita S, Kimura M, Horii T, Ochiya T, Hatada I. Genomic imprinting in Dicer1-hypomorphic mice. Cytogenet Genome Res. 2006;113:138-43 pubmed
    ..We did not observe any abnormality in the allelic expression of imprinted genes in these mice or their offspring, suggesting that reduced expression of Dicer1 did not significantly affect the maintenance and reprogramming of imprinting. ..
  28. Anunciado Koza R, Manuel J, Mynatt R, Zhang J, Kozak L, Koza R. Diet-induced adipose tissue expansion is mitigated in mice with a targeted inactivation of mesoderm specific transcript (Mest). PLoS ONE. 2017;12:e0179879 pubmed publisher
    Interindividual variation of white adipose tissue (WAT) expression of mesoderm specific transcript (Mest), a paternally-expressed imprinted gene belonging to the α/β-hydrolase fold protein family, becomes apparent among genetically ..
  29. Jung H, Lee S, Jho E. Mest/Peg1 inhibits Wnt signalling through regulation of LRP6 glycosylation. Biochem J. 2011;436:263-9 pubmed publisher
    b>Mest (mesoderm-specific transcript)/Peg1 (paternally expressed gene 1) is an imprinted gene that plays important roles in embryo development, although its biochemical role has not been determined...
  30. Hu M, Zhao Z, TuanMu L, Wei H, Gao F, Li L, et al. Analysis of imprinted gene expression and implantation in haploid androgenetic mouse embryos. Andrologia. 2015;47:102-8 pubmed publisher
    ..ability of haploid androgenetic mouse embryos, and to analyse the expression of imprinted genes Igf2r, Asb4 and Mest in haploid androgenetic/gynogenetic blastocysts, we produced the haploid mouse embryos using the enucleation ..
  31. Venkatesh D, Park K, Harrington A, Miceli Libby L, Yoon J, Liaw L. Cardiovascular and hematopoietic defects associated with Notch1 activation in embryonic Tie2-expressing populations. Circ Res. 2008;103:423-31 pubmed publisher
    ..Cardiovascular lineages are sensitive to an imbalance in Notch signaling, with aberrant activation reflecting a vascular phenotype comparable to a loss-of-function Notch1 mutation...
  32. Gambardella L, Hemberger M, Hughes B, Zudaire E, Andrews S, Vermeren S. PI3K signaling through the dual GTPase-activating protein ARAP3 is essential for developmental angiogenesis. Sci Signal. 2010;3:ra76 pubmed publisher
    ..Our work delineates a previously unknown signaling pathway that controls angiogenesis immediately downstream of PI3K? through ARAP3 to the Rho and Arf family of small GTPases. ..
  33. Manuel M, Martynoga B, Yu T, West J, Mason J, Price D. The transcription factor Foxg1 regulates the competence of telencephalic cells to adopt subpallial fates in mice. Development. 2010;137:487-97 pubmed publisher
    ..These findings indicate that, in addition to regulating the production of ventralising signals, Foxg1 acts cell-autonomously in the telencephalon to ensure that cells develop the competence to adopt ventral identities. ..
  34. Chandler R, Brennan J, Schisler J, Serber D, Patterson C, Magnuson T. ARID1a-DNA interactions are required for promoter occupancy by SWI/SNF. Mol Cell Biol. 2013;33:265-80 pubmed publisher
    ..These findings support the model wherein cooperative interactions among intrinsic subunit-chromatin interaction domains and sequence-specific transcription factors drive SWI/SNF recruitment. ..
  35. Obata Y, Kaneko ishino T, Koide T, Takai Y, Ueda T, Domeki I, et al. Disruption of primary imprinting during oocyte growth leads to the modified expression of imprinted genes during embryogenesis. Development. 1998;125:1553-60 pubmed
    ..leads to the modified expression of imprinted genes and this parthenogenetic phenotype, we have examined Peg1/Mest, Igf2, Peg3, Snrpn, H19, Igf2r and excess p57KIP2...
  36. Rakoczy J, Zhang Z, Bowling F, Dawson P, Simmons D. Loss of the sulfate transporter Slc13a4 in placenta causes severe fetal abnormalities and death in mice. Cell Res. 2015;25:1273-6 pubmed publisher
  37. Kanwar Y, Kumar A, Ota K, Lin S, Wada J, Chugh S, et al. Identification of developmentally regulated mesodermal-specific transcript in mouse embryonic metanephros. Am J Physiol Renal Physiol. 2002;282:F953-65 pubmed
    Mesodermal-specific cDNA or transcript (MEST) was identified by suppression subtractive hybridization-PCR of cDNA isolated from embryonic day 13 vs. newborn mice kidneys...
  38. Himes K, Koppes E, Chaillet J. Generalized disruption of inherited genomic imprints leads to wide-ranging placental defects and dysregulated fetal growth. Dev Biol. 2013;373:72-82 pubmed publisher
  39. Hiramuki Y, Sato T, Furuta Y, Surani M, Sehara Fujisawa A. Mest but Not MiR-335 Affects Skeletal Muscle Growth and Regeneration. PLoS ONE. 2015;10:e0130436 pubmed publisher
    ..In this study, we examined whether Mest, one of paternally expressed imprinted genes that regulates body size during development, and miR-335 located in ..
  40. Screen M, Dean W, Cross J, Hemberger M. Cathepsin proteases have distinct roles in trophoblast function and vascular remodelling. Development. 2008;135:3311-20 pubmed publisher
    ..Our findings provide evidence for the highly specialized functions of closely related cysteine cathepsin proteases in extra-embryonic development, and reinforce their importance for a successful outcome of pregnancy. ..
  41. Nikonova L, Koza R, Mendoza T, Chao P, Curley J, Kozak L. Mesoderm-specific transcript is associated with fat mass expansion in response to a positive energy balance. FASEB J. 2008;22:3925-37 pubmed publisher
    A 50-fold variation in mRNA and protein levels of the mesoderm-specific transcript gene (Mest) in white fat of C57BL/6J (B6) mice fed an obesogenic diet is positively correlated with expansion of fat mass...
  42. Shi W, Lefebvre L, Yu Y, Otto S, Krella A, Orth A, et al. Loss-of-imprinting of Peg1 in mouse interspecies hybrids is correlated with altered growth. Genesis. 2004;39:65-72 pubmed
    ..We show here that LOI of the strictly paternally expressed gene Peg1 (also called Mest) occurs in F1 hybrids between Mus musculus (MMU) and M. spretus (MSP)...
  43. Hata K, Okano M, Lei H, Li E. Dnmt3L cooperates with the Dnmt3 family of de novo DNA methyltransferases to establish maternal imprints in mice. Development. 2002;129:1983-93 pubmed
    ..Together, our findings suggest that Dnmt3L may cooperate with Dnmt3 family methyltransferases to carry out de novo methylation of maternally imprinted genes in oocytes. ..
  44. Lee H, Choi N, Lee S, Ko K, Hwang T, Han D, et al. Epigenetic alteration of imprinted genes during neural differentiation of germline-derived pluripotent stem cells. Epigenetics. 2016;11:177-83 pubmed publisher
    ..The androgenetic patterns of H19, Snrpn, and Mest were maintained even after differentiation of gPS cells into NSCs (gPS-NSCs), whereas the fully unmethylated status ..
  45. Shi W, van den Hurk J, Alamo Bethencourt V, Mayer W, Winkens H, Ropers H, et al. Choroideremia gene product affects trophoblast development and vascularization in mouse extra-embryonic tissues. Dev Biol. 2004;272:53-65 pubmed
    ..spretus X-chromosome rather than a modifier effect. Our results demonstrate that Chm is essential for diploid trophoblast development and plays a role in the vascularization in placenta and yolk sac. ..
  46. Ineson J, Stayner C, Hazlett J, Slobbe L, Robson E, Legge M, et al. Somatic reactivation of expression of the silent maternal Mest allele and acquisition of normal reproductive behaviour in a colony of Peg1/Mest mutant mice. J Reprod Dev. 2012;58:490-500 pubmed
    ..In humans and mice the Peg1/Mest gene (Mest) is maternally repressed, and paternally expressed...
  47. Nishita Y, Yoshida I, Sado T, Takagi N. Genomic imprinting and chromosomal localization of the human MEST gene. Genomics. 1996;36:539-42 pubmed
    We have isolated a human homologue (MEST) of the mouse mesoderm-specific transcript (Mest) gene that shares about 70% nucleotide sequence homology...
  48. Su D, Gudas L. Retinoic acid receptor gamma activates receptor tyrosine kinase Tie1 gene transcription through transcription factor GATA4 in F9 stem cells. Exp Hematol. 2008;36:624-41 pubmed publisher
    ..An understanding of RAR specificity in RA signaling should result in insights into hematopoietic stem cell signaling and potentially in improved therapies for several human diseases. ..
  49. Kamei Y, Suganami T, Kohda T, Ishino F, Yasuda K, Miura S, et al. Peg1/Mest in obese adipose tissue is expressed from the paternal allele in an isoform-specific manner. FEBS Lett. 2007;581:91-6 pubmed
    Paternally expressed 1 (Peg1)/mesoderm specific transcript (Mest) is an imprinted gene, which is only transcribed from the paternal (father's) allele...
  50. Kobayashi S, Wagatsuma H, Ono R, Ichikawa H, Yamazaki M, Tashiro H, et al. Mouse Peg9/Dlk1 and human PEG9/DLK1 are paternally expressed imprinted genes closely located to the maternally expressed imprinted genes: mouse Meg3/Gtl2 and human MEG3. Genes Cells. 2000;5:1029-37 pubmed
    ..Because of its homology to mammalian Delta homologues, PEG9/DLK1 may contribute to the scoliosis phenotype observed in maternal uniparental disomy 14 (mUPD14) patients. ..
  51. Finkielstain G, Forcinito P, Lui J, Barnes K, Marino R, Makaroun S, et al. An extensive genetic program occurring during postnatal growth in multiple tissues. Endocrinology. 2009;150:1791-800 pubmed publisher
    ..As examples, we focused on three growth-promoting genes, Igf2, Mest, and Peg3, that were markedly down-regulated with age...
  52. Faisal M, Kim H, Kim J. Sexual differences of imprinted genes' expression levels. Gene. 2014;533:434-8 pubmed publisher
  53. Withington S, Scott A, Saunders D, Lopes Floro K, Preis J, Michalicek J, et al. Loss of Cited2 affects trophoblast formation and vascularization of the mouse placenta. Dev Biol. 2006;294:67-82 pubmed
    ..We conclude that Cited2 is required for normal placental development and vascularisation, and hence for embryo viability. ..
  54. Kanwar Y, Pan X, Lin S, Kumar A, Wada J, Haas C, et al. Imprinted mesodermal specific transcript (MEST) and H19 genes in renal development and diabetes. Kidney Int. 2003;63:1658-70 pubmed
    Imprinted genes, mesodermal specific cDNA or transcript (MEST) and H19, are implicated in peri-implantation embryogenesis, and their expression was assessed in embryonic kidneys undergoing glucose-induced dysmorphogenesis...
  55. Miyoshi N, Wagatsuma H, Wakana S, Shiroishi T, Nomura M, Aisaka K, et al. Identification of an imprinted gene, Meg3/Gtl2 and its human homologue MEG3, first mapped on mouse distal chromosome 12 and human chromosome 14q. Genes Cells. 2000;5:211-20 pubmed
    ..However, this result will provide a good basis for the further investigation of several important imprinted genes in this chromosomal region. ..
  56. Wada J, Kumar A, Ota K, Wallner E, Batlle D, Kanwar Y. Representational difference analysis of cDNA of genes expressed in embryonic kidney. Kidney Int. 1997;51:1629-38 pubmed
  57. Oh McGinnis R, Bogutz A, Lee K, Higgins M, Lefebvre L. Rescue of placental phenotype in a mechanistic model of Beckwith-Wiedemann syndrome. BMC Dev Biol. 2010;10:50 pubmed publisher
    ..When the IC2KO mutation is paternally inherited, epigenetic silencing is lost in the region and the DelTel7 lethality is rescued in compound heterozygotes, leading to viable DelTel7/IC2KO mice...
  58. Seibt J, Armant O, Le Digarcher A, Castro D, Ramesh V, Journot L, et al. Expression at the imprinted dlk1-gtl2 locus is regulated by proneural genes in the developing telencephalon. PLoS ONE. 2012;7:e48675 pubmed publisher
    ..This raises the possibility that the transcripts of this selective locus participate in the biological effects of proneural genes in the developing telencephalon. ..
  59. Okada T, Okumura Y, Motoyama J, Ogawa M. FGF8 signaling patterns the telencephalic midline by regulating putative key factors of midline development. Dev Biol. 2008;320:92-101 pubmed publisher
  60. Rodriguez T, Sparrow D, Scott A, Withington S, Preis J, Michalicek J, et al. Cited1 is required in trophoblasts for placental development and for embryo growth and survival. Mol Cell Biol. 2004;24:228-44 pubmed
    ..We conclude that Cited1 is required in trophoblasts for normal placental development and subsequently for embryo viability. ..