Gene Symbol: Mesp1
Description: mesoderm posterior 1
Alias: bHLHc5, mesoderm posterior protein 1
Species: mouse
Products:     Mesp1

Top Publications

  1. Dominguez Frutos E, Vendrell V, Alvarez Y, Zelarayan L, López Hernández I, Ros M, et al. Tissue-specific requirements for FGF8 during early inner ear development. Mech Dev. 2009;126:873-81 pubmed publisher
    ..This study underlines the crucial role of a defined Fgf8 expression pattern controlling inner ear formation in vertebrates. ..
  2. Bondue A, Lapouge G, Paulissen C, Semeraro C, Iacovino M, Kyba M, et al. Mesp1 acts as a master regulator of multipotent cardiovascular progenitor specification. Cell Stem Cell. 2008;3:69-84 pubmed publisher
    ..Using mouse ESCs in which gene expression can be temporally regulated, we have found that transient expression of Mesp1 dramatically accelerates and enhances multipotent cardiovascular progenitor specification through an intrinsic and ..
  3. Bildsoe H, Loebel D, Jones V, Hor A, Braithwaite A, Chen Y, et al. The mesenchymal architecture of the cranial mesoderm of mouse embryos is disrupted by the loss of Twist1 function. Dev Biol. 2013;374:295-307 pubmed publisher
    ..0. To dissect the function of Twist1 in the cranial mesoderm beyond mid-gestation, we used Mesp1-Cre to delete Twist1 in the anterior mesoderm, which includes the progenitors of the cranial mesoderm...
  4. Randall V, McCue K, Roberts C, Kyriakopoulou V, Beddow S, Barrett A, et al. Great vessel development requires biallelic expression of Chd7 and Tbx1 in pharyngeal ectoderm in mice. J Clin Invest. 2009;119:3301-10 pubmed publisher
    ..We could not rescue PAA morphogenesis by restoring neural crest Chd7 expression. Rather, biallelic expression of Chd7 and Tbx1 in the pharyngeal ectoderm was required for normal PAA development...
  5. Watanabe Y, Miyagawa Tomita S, Vincent S, Kelly R, Moon A, Buckingham M. Role of mesodermal FGF8 and FGF10 overlaps in the development of the arterial pole of the heart and pharyngeal arch arteries. Circ Res. 2010;106:495-503 pubmed publisher
  6. Kitajima S, Takagi A, Inoue T, Saga Y. MesP1 and MesP2 are essential for the development of cardiac mesoderm. Development. 2000;127:3215-26 pubmed
    The transcription factors, MesP1 and MesP2, sharing an almost identical bHLH motif, have an overlapping expression pattern during gastrulation and somitogenesis...
  7. Ieda M, Fu J, Delgado Olguin P, Vedantham V, Hayashi Y, Bruneau B, et al. Direct reprogramming of fibroblasts into functional cardiomyocytes by defined factors. Cell. 2010;142:375-86 pubmed publisher
    ..Reprogramming of endogenous or explanted fibroblasts might provide a source of cardiomyocytes for regenerative approaches. ..
  8. David R, Brenner C, Stieber J, Schwarz F, Brunner S, Vollmer M, et al. MesP1 drives vertebrate cardiovascular differentiation through Dkk-1-mediated blockade of Wnt-signalling. Nat Cell Biol. 2008;10:338-45 pubmed publisher
    ..A candidate cardiovascular-fate inducer is the bHLH transcription factor MesP1. As one of the earliest markers, it is expressed specifically in almost all cardiovascular precursors and is ..
  9. Xu H, Viola A, Zhang Z, Gerken C, Lindsay Illingworth E, Baldini A. Tbx1 regulates population, proliferation and cell fate determination of otic epithelial cells. Dev Biol. 2007;302:670-82 pubmed
    ..We conclude that the main functions of Tbx1 in the inner ear are to control, cell-autonomously, contribution, size and fate of a large population of otic epithelial cells, and, cell non-autonomously, cochlear morphogenesis. ..

More Information


  1. Harel I, Nathan E, Tirosh Finkel L, Zigdon H, Guimarães Camboa N, Evans S, et al. Distinct origins and genetic programs of head muscle satellite cells. Dev Cell. 2009;16:822-32 pubmed publisher
    ..We used fate-mapping techniques in avian and mouse models to show that trunk (Pax3(+)) and cranial (MesP1(+)) skeletal muscle and satellite cells derive from separate genetic lineages...
  2. Lindsley R, Gill J, Murphy T, Langer E, Cai M, Mashayekhi M, et al. Mesp1 coordinately regulates cardiovascular fate restriction and epithelial-mesenchymal transition in differentiating ESCs. Cell Stem Cell. 2008;3:55-68 pubmed publisher
    ..In contrast to many inactive factors, we found that mesoderm posterior 1 (Mesp1) promoted mesoderm development independently of Wnt signaling...
  3. Xu H, Chen L, Baldini A. In vivo genetic ablation of the periotic mesoderm affects cell proliferation survival and differentiation in the cochlea. Dev Biol. 2007;310:329-40 pubmed
    ..This model provides a striking demonstration of the essential role played by the periotic mesenchyme in the organogenesis of the cochlea. ..
  4. Zhang Z, Cerrato F, Xu H, Vitelli F, Morishima M, Vincentz J, et al. Tbx1 expression in pharyngeal epithelia is necessary for pharyngeal arch artery development. Development. 2005;132:5307-15 pubmed
    ..We also thereby demonstrate conclusively that the role of Tbx1 in fourth PAA development is cell non-autonomous...
  5. Saga Y, Hata N, Kobayashi S, Magnuson T, Seldin M, Taketo M. MesP1: a novel basic helix-loop-helix protein expressed in the nascent mesodermal cells during mouse gastrulation. Development. 1996;122:2769-78 pubmed
    ..A novel gene thus isolated is designated as Mesp1 and encodes a possible transcription factor MesP1 containing a basic helix-loop-helix motif...
  6. Saga Y, Miyagawa Tomita S, Takagi A, Kitajima S, Miyazaki J, Inoue T. MesP1 is expressed in the heart precursor cells and required for the formation of a single heart tube. Development. 1999;126:3437-47 pubmed
    The Mesp1 gene encodes the basic HLH protein MesP1 which is expressed in the mesodermal cell lineage during early gastrulation. Disruption of the Mesp1 gene leads to aberrant heart morphogenesis, resulting in cardia bifida...
  7. Zhang Z, Huynh T, Baldini A. Mesodermal expression of Tbx1 is necessary and sufficient for pharyngeal arch and cardiac outflow tract development. Development. 2006;133:3587-95 pubmed
    ..Thus, the mesodermal transcription program is not only crucial for cardiovascular development, but is also key in the development and patterning of pharyngeal endoderm. ..
  8. Yoshida T, Vivatbutsiri P, Morriss Kay G, Saga Y, Iseki S. Cell lineage in mammalian craniofacial mesenchyme. Mech Dev. 2008;125:797-808 pubmed publisher
    ..lineage tracing experiments in mouse embryos, using the permanent genetic markers Wnt1-cre for neural crest and Mesp1-cre for mesoderm, combined with the Rosa26 reporter. At the end of neural crest cell migration (E9...
  9. Haraguchi S, Kitajima S, Takagi A, Takeda H, Inoue T, Saga Y. Transcriptional regulation of Mesp1 and Mesp2 genes: differential usage of enhancers during development. Mech Dev. 2001;108:59-69 pubmed
    b>Mesp1 and Mesp2 encode bHLH-type transcription factors, Mesp1 and Mesp2, respectively. The expression of both genes is observed in the nascent mesoderm, and subsequently in the rostral presomitic mesoderm...
  10. Pane L, Zhang Z, Ferrentino R, Huynh T, Cutillo L, Baldini A. Tbx1 is a negative modulator of Mef2c. Hum Mol Genet. 2012;21:2485-96 pubmed publisher
    ..Overall, our study uncovered a target of Tbx1 with critical developmental roles, so highlighting the power of the dosage gradient approach that we used. ..
  11. Chen Y, Moon A, Gaufo G. Influence of mesodermal Fgf8 on the differentiation of neural crest-derived postganglionic neurons. Dev Biol. 2012;361:125-36 pubmed publisher
  12. Chan S, Shi X, Toyama A, Arpke R, Dandapat A, Iacovino M, et al. Mesp1 patterns mesoderm into cardiac, hematopoietic, or skeletal myogenic progenitors in a context-dependent manner. Cell Stem Cell. 2013;12:587-601 pubmed publisher
    b>Mesp1 is regarded as the master regulator of cardiovascular development, initiating the cardiac transcription factor cascade to direct the generation of cardiac mesoderm...
  13. Lescroart F, Hamou W, Francou A, Théveniau Ruissy M, Kelly R, Buckingham M. Clonal analysis reveals a common origin between nonsomite-derived neck muscles and heart myocardium. Proc Natl Acad Sci U S A. 2015;112:1446-51 pubmed publisher
    ..By linking neck muscle and heart development, our findings highlight the importance of cardiopharyngeal mesoderm in the evolution of the vertebrate heart and neck and in the pathophysiology of human congenital disease. ..
  14. Hanna L, Foreman R, Tarasenko I, Kessler D, Labosky P. Requirement for Foxd3 in maintaining pluripotent cells of the early mouse embryo. Genes Dev. 2002;16:2650-61 pubmed
    ..These results establish Foxd3 as a factor required for the maintenance of progenitor cells in the mammalian embryo. ..
  15. Devine W, Wythe J, George M, Koshiba Takeuchi K, Bruneau B. Early patterning and specification of cardiac progenitors in gastrulating mesoderm. elife. 2014;3: pubmed publisher
    ..Here we show, using clonal genetic fate mapping, that Mesp1+ cells in gastrulating mesoderm are rapidly specified into committed cardiac precursors fated for distinct ..
  16. Choudhary B, Zhou J, Li P, Thomas S, Kaartinen V, Sucov H. Absence of TGFbeta signaling in embryonic vascular smooth muscle leads to reduced lysyl oxidase expression, impaired elastogenesis, and aneurysm. Genesis. 2009;47:115-21 pubmed publisher
    ..In mutant tissue, lysyl oxidase expression was substantially reduced, which may contribute to the observed pathology. ..
  17. Shen H, Cavallero S, Estrada K, Sandovici I, Kumar S, Makita T, et al. Extracardiac control of embryonic cardiomyocyte proliferation and ventricular wall expansion. Cardiovasc Res. 2015;105:271-8 pubmed publisher
    ..Each involves instructive cues that originate outside the heart and thereby act on the epicardium in an endocrine manner, a mode of regulation that is mostly unknown in embryogenesis. ..
  18. Powers S, Taniguchi K, Yen W, Melhuish T, Shen J, Walsh C, et al. Tgif1 and Tgif2 regulate Nodal signaling and are required for gastrulation. Development. 2010;137:249-59 pubmed publisher
    ..Together, these data show that Tgif function is required for gastrulation, and provide the first clear evidence that Tgifs limit the transcriptional response to Nodal signaling during early embryogenesis. ..
  19. Chabab S, Lescroart F, Rulands S, Mathiah N, Simons B, Blanpain C. Uncovering the Number and Clonal Dynamics of Mesp1 Progenitors during Heart Morphogenesis. Cell Rep. 2016;14:1-10 pubmed publisher
    The heart arises from distinct sources of cardiac progenitors that independently express Mesp1 during gastrulation...
  20. Zhang R, Cao P, Yang Z, Wang Z, Wu J, Chen Y, et al. Heparan Sulfate Biosynthesis Enzyme, Ext1, Contributes to Outflow Tract Development of Mouse Heart via Modulation of FGF Signaling. PLoS ONE. 2015;10:e0136518 pubmed publisher
    ..Our results collectively indicate that Ext1 is crucial for outflow tract formation in distinct progenitor cells, and heparan sulfate modulates FGF signaling during early heart development. ..
  21. Lescroart F, Chabab S, Lin X, Rulands S, Paulissen C, Rodolosse A, et al. Early lineage restriction in temporally distinct populations of Mesp1 progenitors during mammalian heart development. Nat Cell Biol. 2014;16:829-40 pubmed publisher
    ..b>Mesp1 has been proposed to mark the most primitive multipotent cardiac progenitors common for both heart fields...
  22. David R, Jarsch V, Schwarz F, Nathan P, Gegg M, Lickert H, et al. Induction of MesP1 by Brachyury(T) generates the common multipotent cardiovascular stem cell. Cardiovasc Res. 2011;92:115-22 pubmed publisher
    ..progenitor cells are characterized and induced by the expression of the transcription factor mesoderm posterior1 (MesP1) in vertebrate embryos and murine embryonic stem cells...
  23. Liu Y, Chen L, Diaz A, Benham A, Xu X, Wijaya C, et al. Mesp1 Marked Cardiac Progenitor Cells Repair Infarcted Mouse Hearts. Sci Rep. 2016;6:31457 pubmed publisher
    b>Mesp1 directs multipotential cardiovascular cell fates, even though it's transiently induced prior to the appearance of the cardiac progenitor program...
  24. van den Ameele J, Tiberi L, Bondue A, Paulissen C, Herpoel A, Iacovino M, et al. Eomesodermin induces Mesp1 expression and cardiac differentiation from embryonic stem cells in the absence of Activin. EMBO Rep. 2012;13:355-62 pubmed publisher
    ..Eomes also rapidly induces the expression of Mesp1, a key regulator of cardiovascular differentiation, and directly binds to regulatory sequences of Mesp1...
  25. Bildsoe H, Fan X, Wilkie E, Ashoti A, Jones V, Power M, et al. Transcriptional targets of TWIST1 in the cranial mesoderm regulate cell-matrix interactions and mesenchyme maintenance. Dev Biol. 2016;418:189-203 pubmed publisher
  26. Okamura Y, Saga Y. Pofut1 is required for the proper localization of the Notch receptor during mouse development. Mech Dev. 2008;125:663-73 pubmed publisher
    ..We propose that altered trafficking pathways may account for the abnormal accumulation of the Notch1 receptor in the endoplasmic reticulum in Pofut1-null mouse embryos. ..
  27. Beckers J, Schlautmann N, Gossler A. The mouse rib-vertebrae mutation disrupts anterior-posterior somite patterning and genetically interacts with a Delta1 null allele. Mech Dev. 2000;95:35-46 pubmed
    ..However, fine genetic mapping places rv into an interval on chromosome seven that does not contain a gene encoding a known component of the Notch signaling pathway. ..
  28. Takahashi Y, Yasuhiko Y, Kitajima S, Kanno J, Saga Y. Appropriate suppression of Notch signaling by Mesp factors is essential for stripe pattern formation leading to segment boundary formation. Dev Biol. 2007;304:593-603 pubmed
    b>Mesp1 and Mesp2 are homologous transcription factors that are co-expressed in the anterior presomitic mesoderm (PSM) during mouse somitogenesis...
  29. Furtado M, Solloway M, Jones V, Costa M, Biben C, Wolstein O, et al. BMP/SMAD1 signaling sets a threshold for the left/right pathway in lateral plate mesoderm and limits availability of SMAD4. Genes Dev. 2008;22:3037-49 pubmed publisher
    ..We conclude that BMP/SMAD1 signaling sets a bilateral, repressive threshold for NODAL-dependent Nodal activation in LPM, limiting availability of SMAD4. This repressive threshold is essential for bistable output of the LR system. ..
  30. Yoon J, Moon R, Wold B. The bHLH class protein pMesogenin1 can specify paraxial mesoderm phenotypes. Dev Biol. 2000;222:376-91 pubmed
    ..rostral to the pMesogenin1 domain strongly upregulate expression of pMesogenin's closest known paralogs, MesP1 and MesP2 (Thylacine1/2 in Xenopus)...
  31. Wu S. Mesp1 at the heart of mesoderm lineage specification. Cell Stem Cell. 2008;3:1-2 pubmed publisher
    ..In this issue of Cell Stem Cell, Lindsley et al. (2008) and Bondue et al. (2008) use embryonic stem cells to identify a key role for Mesp1 in this process.
  32. Sasaki N, Kiso M, Kitagawa M, Saga Y. The repression of Notch signaling occurs via the destabilization of mastermind-like 1 by Mesp2 and is essential for somitogenesis. Development. 2011;138:55-64 pubmed publisher
    ..Surprisingly, this function of Mesp2 is found to be independent of its function as a transcription factor. Together, these data demonstrate that Mesp2 is a novel component involved in the suppression of Notch target genes...
  33. Jiang Z, Zhu L, Hu L, Slesnick T, Pautler R, Justice M, et al. Zic3 is required in the extra-cardiac perinodal region of the lateral plate mesoderm for left-right patterning and heart development. Hum Mol Genet. 2013;22:879-89 pubmed publisher
  34. Kume T, Jiang H, Topczewska J, Hogan B. The murine winged helix transcription factors, Foxc1 and Foxc2, are both required for cardiovascular development and somitogenesis. Genes Dev. 2001;15:2470-82 pubmed
    ..shows that Foxc1 and Foxc2 are both required for transcription in the anterior presomitic mesoderm of paraxis, Mesp1, Mesp2, Hes5, and Notch1, and for the formation of sharp boundaries of Dll1, Lfng, and ephrinB2 expression...
  35. Soibam B, Benham A, Kim J, Weng K, Yang L, Xu X, et al. Genome-Wide Identification of MESP1 Targets Demonstrates Primary Regulation Over Mesendoderm Gene Activity. Stem Cells. 2015;33:3254-65 pubmed publisher
    b>MESP1 is considered the first sign of the nascent cardiac mesoderm and plays a critical role in the appearance of cardiac progenitors, while exhibiting a transient expression in the developing embryo...
  36. Miquerol L, Bellon A, Moreno N, Beyer S, Meilhac S, Buckingham M, et al. Resolving cell lineage contributions to the ventricular conduction system with a Cx40-GFP allele: a dual contribution of the first and second heart fields. Dev Dyn. 2013;242:665-77 pubmed publisher
    ..The mammalian VCS is comprised of cells derived from two lineages, supporting a dual contribution of first and second heart field progenitor cells. ..
  37. Dykes I, van Bueren K, Ashmore R, Floss T, Wurst W, Szumska D, et al. HIC2 is a novel dosage-dependent regulator of cardiac development located within the distal 22q11 deletion syndrome region. Circ Res. 2014;115:23-31 pubmed publisher
    ..Conditional targeting indicated a requirement for Hic2 within the Nkx2.5+ and Mesp1+ cardiovascular progenitor lineages. Microarray analysis revealed increased expression of Bmp10...
  38. Kasberg A, Brunskill E, Steven Potter S. SP8 regulates signaling centers during craniofacial development. Dev Biol. 2013;381:312-23 pubmed publisher
    ..These results show that Sp8 primarily functions to promote Fgf expression in the ANR and OP signaling centers that drive the survival, proliferation, and differentiation of the NC and paraxial mesoderm that make the face. ..
  39. Payne S, Burney M, McCue K, Popal N, Davidson S, Anderson R, et al. A critical role for the chromatin remodeller CHD7 in anterior mesoderm during cardiovascular development. Dev Biol. 2015;405:82-95 pubmed publisher
    ..We present evidence for an additional requirement for CHD7 activity in the Mesp1-expressing anterior mesoderm during heart development...
  40. Milgrom Hoffman M, Harrelson Z, Ferrara N, Zelzer E, Evans S, Tzahor E. The heart endocardium is derived from vascular endothelial progenitors. Development. 2011;138:4777-87 pubmed publisher
    ..distinct cardiovascular progenitor populations; FLK1 is required in vivo for formation of the endocardium in the Mesp1 and Tie2 lineages, but not in the Isl1 lineage...
  41. Cioffi S, Martucciello S, Fulcoli F, Bilio M, Ferrentino R, Nusco E, et al. Tbx1 regulates brain vascularization. Hum Mol Genet. 2014;23:78-89 pubmed publisher
    ..2DS patients and to evaluate whether some of the anatomical and functional brain anomalies in patients may have a microvascular origin. ..
  42. Asahina K, Zhou B, Pu W, Tsukamoto H. Septum transversum-derived mesothelium gives rise to hepatic stellate cells and perivascular mesenchymal cells in developing mouse liver. Hepatology. 2011;53:983-95 pubmed publisher
    ..A cell lineage analysis using MesP1(Cre) /Rosa26lacZ(flox) mice identifies the mesodermal origin of the STM, HSCs, and perivascular mesenchymal cells (..
  43. Saga Y, Hata N, Koseki H, Taketo M. Mesp2: a novel mouse gene expressed in the presegmented mesoderm and essential for segmentation initiation. Genes Dev. 1997;11:1827-39 pubmed
    We isolated a novel bHLH protein gene Mesp2 (for mesoderm posterior 2) that cross-hybridizes with Mesp1 expressed in the early mouse mesoderm...
  44. Harel I, Maezawa Y, Avraham R, Rinon A, Ma H, Cross J, et al. Pharyngeal mesoderm regulatory network controls cardiac and head muscle morphogenesis. Proc Natl Acad Sci U S A. 2012;109:18839-44 pubmed publisher
    ..We suggest that PM-derived cardiogenesis and myogenesis are network properties rather than properties specific to individual PM members. These findings shed new light on the developmental underpinnings of congenital defects. ..
  45. Kitajima S, Miyagawa Tomita S, Inoue T, Kanno J, Saga Y. Mesp1-nonexpressing cells contribute to the ventricular cardiac conduction system. Dev Dyn. 2006;235:395-402 pubmed
    Previous fate mapping analysis, using Cre recombinase driven by the Mesp1 locus, revealed that Mesp1 is expressed in almost all of the precursors of the cardiovascular system, including the endothelium, endocardium, myocardium, and ..
  46. Feridooni T, Hotchkiss A, Remley Carr S, Saga Y, Pasumarthi K. Cardiomyocyte specific ablation of p53 is not sufficient to block doxorubicin induced cardiac fibrosis and associated cytoskeletal changes. PLoS ONE. 2011;6:e22801 pubmed publisher
    ..Further, these results support a role for p53 independent apoptotic pathways leading to Dox induced myocardial damage and highlight the importance of vascular lesions in Dox induced cardiotoxicity. ..
  47. Papangeli I, Scambler P. Tbx1 genetically interacts with the transforming growth factor-?/bone morphogenetic protein inhibitor Smad7 during great vessel remodeling. Circ Res. 2013;112:90-102 pubmed publisher
    ..Tbx1 acts upstream of Smad7 controlling vascular smooth muscle and extracellular matrix investment of the fourth arch artery. ..
  48. Tyser R, Miranda A, Chen C, Davidson S, Srinivas S, Riley P. Calcium handling precedes cardiac differentiation to initiate the first heartbeat. elife. 2016;5: pubmed publisher
    ..NCX1 blockade impacted on CaMKII signalling to down-regulate cardiac gene expression, leading to impaired differentiation and failed crescent maturation. ..
  49. Liang Q, Xu C, Chen X, Li X, Lu C, Zhou P, et al. The roles of Mesp family proteins: functional diversity and redundancy in differentiation of pluripotent stem cells and mammalian mesodermal development. Protein Cell. 2015;6:553-561 pubmed publisher
    Mesp family proteins comprise two members named mesodermal posterior 1 (Mesp1) and mesodermal posterior 2 (Mesp2). Both Mesp1 and Mesp2 are transcription factors and they share an almost identical basic helix-loop-helix motif...
  50. Cho A, Tang Y, Davila J, Deng S, Chen L, Miller E, et al. Calcineurin signaling regulates neural induction through antagonizing the BMP pathway. Neuron. 2014;82:109-124 pubmed publisher
    ..As a result, FGF-activated CaN signaling opposes BMP signaling during gastrulation, thereby promoting neural induction and the development of anterior structures. ..
  51. Osipovich A, Gangula R, Vianna P, Magnuson M. Setd5 is essential for mammalian development and the co-transcriptional regulation of histone acetylation. Development. 2016;143:4595-4607 pubmed
    ..These findings suggest that SETD5 functions in a manner similar to yeast Set3p and Drosophila UpSET, and that it is essential for regulating histone acetylation during gene transcription. ..
  52. Rothova M, Thompson H, Lickert H, Tucker A. Lineage tracing of the endoderm during oral development. Dev Dyn. 2012;241:1183-91 pubmed publisher
  53. Dastjerdi A, Robson L, Walker R, Hadley J, Zhang Z, Rodriguez Niedenführ M, et al. Tbx1 regulation of myogenic differentiation in the limb and cranial mesoderm. Dev Dyn. 2007;236:353-63 pubmed
    ..Finally, analysis of the Tbx1-mesoderm-specific knockout mouse demonstrated the cell autonomous requirement for Tbx1 during myocyte development in the cranial mesoderm. ..
  54. Kang J, Gu Y, Li P, Johnson B, Sucov H, Thomas P. PDGF-A as an epicardial mitogen during heart development. Dev Dyn. 2008;237:692-701 pubmed publisher
    ..Indeed, our results demonstrate the presence of additional mitogens that may have such an overlapping role. ..
  55. Sun J, Ting M, Ishii M, Maxson R. Msx1 and Msx2 function together in the regulation of primordial germ cell migration in the mouse. Dev Biol. 2016;417:11-24 pubmed publisher
    ..These phenotypes are also evident in a Mesp1-Cre-mediated mesoderm-specific mutant line of Msx1 and Msx2...
  56. Komada Y, Yamane T, Kadota D, Isono K, Takakura N, Hayashi S, et al. Origins and properties of dental, thymic, and bone marrow mesenchymal cells and their stem cells. PLoS ONE. 2012;7:e46436 pubmed publisher
    ..Using double-transgenic mouse systems encoding P0-Cre, Wnt1-Cre, Mesp1-Cre, and Rosa26EYFP, which enabled us to trace NC-derived or mesoderm-derived cells as YFP-expressing cells, we ..
  57. Mukhopadhyay M, Teufel A, Yamashita T, Agulnick A, Chen L, Downs K, et al. Functional ablation of the mouse Ldb1 gene results in severe patterning defects during gastrulation. Development. 2003;130:495-505 pubmed
    ..The expression of several Wnt inhibitors is curtailed in the mutant, suggesting that Wnt pathways may be involved in axial patterning regulated by Ldb1. ..
  58. Saga Y. Genetic rescue of segmentation defect in MesP2-deficient mice by MesP1 gene replacement. Mech Dev. 1998;75:53-66 pubmed
    Gene knock-out and knock-in strategies are employed to investigate the function of MesP1. MesP1 belongs to the same family of bHLH transcription factors as MesP2...
  59. Lania G, Zhang Z, Huynh T, Caprio C, Moon A, Vitelli F, et al. Early thyroid development requires a Tbx1-Fgf8 pathway. Dev Biol. 2009;328:109-17 pubmed publisher
    ..Thus, we have established that a Tbx1->Fgf8 pathway in the pharyngeal mesoderm is a key size regulator of mammalian thyroid. ..
  60. He F, Soriano P. Dysregulated PDGFRα signaling alters coronal suture morphogenesis and leads to craniosynostosis through endochondral ossification. Development. 2017;144:4026-4036 pubmed publisher
    ..Our results thus identify a novel mechanism underlying calvarial development in craniosynostosis. ..
  61. Ivanovitch K, Temiño S, Torres M. Live imaging of heart tube development in mouse reveals alternating phases of cardiac differentiation and morphogenesis. elife. 2017;6: pubmed publisher
    ..These results reveal tissue-level coordination between morphogenesis and differentiation during HT formation and provide a new framework to understand heart development. ..
  62. Perea Gomez A, Lawson K, Rhinn M, Zakin L, Brulet P, Mazan S, et al. Otx2 is required for visceral endoderm movement and for the restriction of posterior signals in the epiblast of the mouse embryo. Development. 2001;128:753-65 pubmed
  63. Yasuhiko Y, Kitajima S, Takahashi Y, Oginuma M, Kagiwada H, Kanno J, et al. Functional importance of evolutionally conserved Tbx6 binding sites in the presomitic mesoderm-specific enhancer of Mesp2. Development. 2008;135:3511-9 pubmed publisher
    ..These results demonstrate that there is significant evolutionary conservation of Mesp regulatory mechanisms between fish and mice...
  64. Abboud N, Moore Morris T, Hiriart E, Yang H, Bezerra H, Gualazzi M, et al. A cohesin-OCT4 complex mediates Sox enhancers to prime an early embryonic lineage. Nat Commun. 2015;6:6749 pubmed publisher
    ..SALL4 concomitantly mobilizes the polycomb complexes at the Soxs loci. Thus, OCT4/SALL4-driven cohesin- and polycombs-mediated changes in higher-order chromatin structure mediate instruction of early cell fate in embryonic cells. ..
  65. Vincent S, Mayeuf Louchart A, Watanabe Y, Brzezinski J, Miyagawa Tomita S, Kelly R, et al. Prdm1 functions in the mesoderm of the second heart field, where it interacts genetically with Tbx1, during outflow tract morphogenesis in the mouse embryo. Hum Mol Genet. 2014;23:5087-101 pubmed publisher
    ..Our results identify PRDM1 as a potential modifier of phenotypic severity in TBX1 haploinsufficient DiGeorge syndrome patients. ..
  66. Kataoka H, Hayashi M, Kobayashi K, Ding G, Tanaka Y, Nishikawa S. Region-specific Etv2 ablation revealed the critical origin of hemogenic capacity from Hox6-positive caudal-lateral primitive mesoderm. Exp Hematol. 2013;41:567-581.e9 pubmed publisher
  67. MacDonald S, Bamforth S, Chen C, Farthing C, Franklyn A, Broadbent C, et al. Epiblastic Cited2 deficiency results in cardiac phenotypic heterogeneity and provides a mechanism for haploinsufficiency. Cardiovasc Res. 2008;79:448-57 pubmed publisher
    ..Cardiac malformation associated with Cited2 haploinsufficiency may occur by reducing expression of key Cited2 targets such as Pitx2c. ..
  68. Gopalakrishnan S, Comai G, Sambasivan R, Francou A, Kelly R, Tajbakhsh S. A Cranial Mesoderm Origin for Esophagus Striated Muscles. Dev Cell. 2015;34:694-704 pubmed publisher
    ..These findings have important implications in understanding esophageal dysfunctions, including dysphagia, and congenital disorders, such as DiGeorge syndrome. ..
  69. Lua I, Li Y, Pappoe L, Asahina K. Myofibroblastic Conversion and Regeneration of Mesothelial Cells in Peritoneal and Liver Fibrosis. Am J Pathol. 2015;185:3258-73 pubmed publisher
    ..The CG treatment also induced myofibroblastic conversion of MCs in the liver. Lineage tracing with Mesp1-Cre mice revealed that Mesp1(+) mesoderm gave rise to liver MCs but not peritoneal MCs...
  70. Liang D, Wang X, Mittal A, Dhiman S, Hou S, Degenhardt K, et al. Mesodermal expression of integrin α5β1 regulates neural crest development and cardiovascular morphogenesis. Dev Biol. 2014;395:232-44 pubmed publisher
    ..To investigate the role of integrin α5β1 in cardiovascular development, we used the Mesp1(Cre) knock-in strain of mice to ablate integrin α5 in the anterior mesoderm, which gives rise to all of the ..
  71. Kaucka M, Ivashkin E, Gyllborg D, Zikmund T, Tesarova M, Kaiser J, et al. Analysis of neural crest-derived clones reveals novel aspects of facial development. Sci Adv. 2016;2:e1600060 pubmed publisher
    ..These cellular mechanisms resemble the strategy behind limb bud morphogenesis, suggesting the possibility of common principles and deep homology between facial and limb outgrowth. ..
  72. Flore G, Cioffi S, Bilio M, Illingworth E. Cortical Development Requires Mesodermal Expression of Tbx1, a Gene Haploinsufficient in 22q11.2 Deletion Syndrome. Cereb Cortex. 2017;27:2210-2225 pubmed publisher
    ..Finally, we show that mesoderm-specific inactivation of Tbx1 is sufficient to recapitulate the brain phenotype indicating that Tbx1 exerts a cell nonautonomous role in cortical development from the mesoderm. ..
  73. Barrantes I, Elia A, Wunsch K, Hrabe de Angelis M, Mak T, Rossant J, et al. Interaction between Notch signalling and Lunatic fringe during somite boundary formation in the mouse. Curr Biol. 1999;9:470-80 pubmed
    ..The Dll1, Notch1 and RBPJkappa mutations disrupt the expression of Lunatic fringe (L-fng), Jagged1, Mesp1, Mesp2 and Hes5 in the PSM. Furthermore, expression of EphA4, mCer 1 and uncx4...
  74. David R, Stieber J, Fischer E, Brunner S, Brenner C, Pfeiler S, et al. Forward programming of pluripotent stem cells towards distinct cardiovascular cell types. Cardiovasc Res. 2009;84:263-72 pubmed publisher
    ..Our recent work demonstrated that MesP1 represents a master regulator sufficient to induce cardiovasculogenesis in pluripotent cells...
  75. Yu S, Poe B, SCHWARZ M, Elliot S, Albertine K, Fenton S, et al. Fetal and postnatal lung defects reveal a novel and required role for Fgf8 in lung development. Dev Biol. 2010;347:92-108 pubmed publisher
  76. Czajkowski M, Rassek C, Lenhard D, Bröhl D, Birchmeier C. Divergent and conserved roles of Dll1 signaling in development of craniofacial and trunk muscle. Dev Biol. 2014;395:307-16 pubmed publisher
    ..Thus, Dll1 functions in satellite cell homing and Pax7 expression diverge in cranial- and somite-derived muscle. ..
  77. Dilg D, Saleh R, Phelps S, Rose Y, Dupays L, Murphy C, et al. HIRA Is Required for Heart Development and Directly Regulates Tnni2 and Tnnt3. PLoS ONE. 2016;11:e0161096 pubmed publisher
    ..Thus, we show here that HIRA has locus-specific effects on gene expression and that histone chaperone activity is vital for normal heart development, impinging on pathways regulated by an established cardiac transcription factor. ..
  78. Chan S, Hagen H, Swanson S, Stewart R, Boll K, Aho J, et al. Development of Bipotent Cardiac/Skeletal Myogenic Progenitors from MESP1+ Mesoderm. Stem Cell Reports. 2016;6:26-34 pubmed publisher
    ..We describe an embryonic stem cell-based system in which MESP1 drives a PDGFRA+ population with dual cardiac and skeletal muscle differentiation potential, and gene expression ..
  79. Li P, Pashmforoush M, Sucov H. Mesodermal retinoic acid signaling regulates endothelial cell coalescence in caudal pharyngeal arch artery vasculogenesis. Dev Biol. 2012;361:116-24 pubmed publisher
  80. Watanabe Y, Zaffran S, Kuroiwa A, Higuchi H, Ogura T, Harvey R, et al. Fibroblast growth factor 10 gene regulation in the second heart field by Tbx1, Nkx2-5, and Islet1 reveals a genetic switch for down-regulation in the myocardium. Proc Natl Acad Sci U S A. 2012;109:18273-80 pubmed publisher
    ..Our findings provide a paradigm for transcriptional mechanisms that underlie the changes in regulatory networks during the transition from progenitor state to that of the differentiated tissue. ..
  81. Kokubo H, Tomita Miyagawa S, Hamada Y, Saga Y. Hesr1 and Hesr2 regulate atrioventricular boundary formation in the developing heart through the repression of Tbx2. Development. 2007;134:747-55 pubmed
    ..Furthermore, we find that the expression of Hesr1 and Hesr2 is independent of Notch2 signaling. Taken together, our data demonstrate that Hesr1 and Hesr2 play crucial roles in AV boundary formation through the suppression of Tbx2. ..
  82. O Reilly V, Lopes Floro K, Shi H, Chapman B, Preis J, James A, et al. Gene-environment interaction demonstrates the vulnerability of the embryonic heart. Dev Biol. 2014;391:99-110 pubmed publisher
    ..Importantly, these findings extend our understanding of the roles of Hif1α in cardiovascular development. ..
  83. Dykes I, van Bueren K, Scambler P. HIC2 regulates isoform switching during maturation of the cardiovascular system. J Mol Cell Cardiol. 2018;114:29-37 pubmed publisher
    ..We propose that HIC2 regulates a switching event within both the contractile machinery of cardiomyocytes and the oxygen carrying systems during the developmental period where demands on cardiac loading change rapidly. ..