Gene Symbol: Meig1
Description: meiosis expressed gene 1
Alias: MLZ-278, Meg1, meiosis-expressed gene 1 protein, protein expressed in male leptotene and zygotene spermatocytes 278
Species: mouse
Products:     Meig1

Top Publications

  1. Ever L, Steiner R, Shalom S, Don J. Two alternatively spliced Meig1 messenger RNA species are differentially expressed in the somatic and in the germ-cell compartments of the testis. Cell Growth Differ. 1999;10:19-26 pubmed
    Previous studies regarding the transcriptional pattern of the murine Meig1 gene (formally designated meg1) suggested that its transcription is restricted to germ cells at the first meiotic prophase, in both primary spermatocytes and ..
  2. Wang G, Zhang J, Moskophidis D, Mivechi N. Targeted disruption of the heat shock transcription factor (hsf)-2 gene results in increased embryonic lethality, neuronal defects, and reduced spermatogenesis. Genesis. 2003;36:48-61 pubmed
    ..These findings suggest that hsf2 has a major function in controlling expression of genes important for embryonic development and maintenance of sperm production. ..
  3. Don J, Wolgemuth D. Identification and characterization of the regulated pattern of expression of a novel mouse gene, meg1, during the meiotic cell cycle. Cell Growth Differ. 1992;3:495-505 pubmed
    The gene designated meg1 (meiosis expressed gene) is a new mouse gene identified during a search for mammalian genes potentially involved in meiotic processes...
  4. Don J, Winer M, Wolgemuth D. Developmentally regulated expression during gametogenesis of the murine gene meg1 suggests a role in meiosis. Mol Reprod Dev. 1994;38:16-23 pubmed
    Previous studies have shown that in adult male mice, expression of the meg1 gene is restricted to meiotic and early postmeiotic testicular germ cells...
  5. Zhang Z, Kostetskii I, Moss S, Jones B, Ho C, Wang H, et al. Haploinsufficiency for the murine orthologue of Chlamydomonas PF20 disrupts spermatogenesis. Proc Natl Acad Sci U S A. 2004;101:12946-51 pubmed
    ..The 35-kDa PF20 protein was shown to bind to meiosis-expressed gene 1 (MEIG1), a chromosome/chromatin-binding protein initially expressed during meiosis but retained in the germ cell nucleus ..
  6. Zhang Z, Shen X, Gude D, Wilkinson B, Justice M, Flickinger C, et al. MEIG1 is essential for spermiogenesis in mice. Proc Natl Acad Sci U S A. 2009;106:17055-60 pubmed publisher
    ..kDa, testis-specific isoform derived from the Spag16 gene, was found to bind to meiosis expressed gene 1 product (MEIG1), a protein originally thought to play a role in meiosis...
  7. Zhang L, Shang X, Li H, Shi Y, Li W, Teves M, et al. Characterization of membrane occupation and recognition nexus repeat containing 3, meiosis expressed gene 1 binding partner, in mouse male germ cells. Asian J Androl. 2015;17:86-93 pubmed publisher
    ..Meiosis expressed gene 1 (MEIG1) plays an essential role in the regulation of spermiogenesis...
  8. Salzberg Y, Eldar T, Karminsky O, Itach S, Pietrokovski S, Don J. Meig1 deficiency causes a severe defect in mouse spermatogenesis. Dev Biol. 2010;338:158-67 pubmed publisher
    b>Meig1 is a mouse gene, abundantly expressed in the testis. It encodes two alternative transcripts that are expressed differentially in the somatic and germinal compartments of the testis...
  9. Teves M, Jha K, Song J, Nagarkatti Gude D, Herr J, Foster J, et al. Germ cell-specific disruption of the Meig1 gene causes impaired spermiogenesis in mice. Andrology. 2013;1:37-46 pubmed publisher
    Meiosis expressed gene 1 (Meig1) was originally identified in a search for mammalian genes potentially involved in meiosis. Seven mouse Meig1 transcripts with the same coding region, but different 5'-UTRs, have been identified...

More Information


  1. Watanabe D, Sawada K, Koshimizu U, Kagawa T, Nishimune Y. Characterization of male meiotic germ cell-specific antigen (Meg 1) by monoclonal antibody TRA 369 in mice. Mol Reprod Dev. 1992;33:307-12 pubmed
    ..Thus this is a differentiation-specific antigen in male meiotic germ cells, and mAb TRA 369 is a useful tool to study the regulation of germ cell differentiation and to define germ cell development in a molecular level. ..
  2. Miyoshi N, Wagatsuma H, Wakana S, Shiroishi T, Nomura M, Aisaka K, et al. Identification of an imprinted gene, Meg3/Gtl2 and its human homologue MEG3, first mapped on mouse distal chromosome 12 and human chromosome 14q. Genes Cells. 2000;5:211-20 pubmed
    ..However, this result will provide a good basis for the further investigation of several important imprinted genes in this chromosomal region. ..
  3. Kogo H, Kowa Sugiyama H, Yamada K, Bolor H, Tsutsumi M, Ohye T, et al. Screening of genes involved in chromosome segregation during meiosis I: toward the identification of genes responsible for infertility in humans. J Hum Genet. 2010;55:293-9 pubmed publisher
    ..These 726 candidates for human infertility genes might serve as a useful resource for next-generation sequencing combined with exon capture by microarray...
  4. Li W, Tang W, Teves M, Zhang Z, Zhang L, Li H, et al. A MEIG1/PACRG complex in the manchette is essential for building the sperm flagella. Development. 2015;142:921-30 pubmed publisher
    ..Yeast two-hybrid studies revealed that meiosis-expressed gene 1 (MEIG1) and Parkin co-regulated gene (PACRG) interact, and that sperm-associated antigen 16, which encodes an axoneme ..