Mef2c

Summary

Gene Symbol: Mef2c
Description: myocyte enhancer factor 2C
Alias: 5430401D19Rik, 9930028G15Rik, AV011172, Mef2, myocyte-specific enhancer factor 2C
Species: mouse
Products:     Mef2c

Top Publications

  1. Kwon C, Arnold J, Hsiao E, Taketo M, Conklin B, Srivastava D. Canonical Wnt signaling is a positive regulator of mammalian cardiac progenitors. Proc Natl Acad Sci U S A. 2007;104:10894-9 pubmed
    ..Together, these data provide in vivo and in vitro evidence that canonical Wnt signaling promotes the expansion of cardiac progenitors and differentiation of cardiomyocytes. ..
  2. Lin Q, Schwarz J, Bucana C, Olson E. Control of mouse cardiac morphogenesis and myogenesis by transcription factor MEF2C. Science. 1997;276:1404-7 pubmed
    ..The murine MEF2C gene is expressed in heart precursor cells before formation of the linear heart tube...
  3. Cobos I, Borello U, Rubenstein J. Dlx transcription factors promote migration through repression of axon and dendrite growth. Neuron. 2007;54:873-88 pubmed
  4. Edmondson D, Lyons G, Martin J, Olson E. Mef2 gene expression marks the cardiac and skeletal muscle lineages during mouse embryogenesis. Development. 1994;120:1251-63 pubmed
    ..of muscle gene expression in vivo, we analyzed by in situ hybridization the expression patterns of the Mef2a, Mef2c and Mef2d genes during mouse embryogenesis. We first detected MEF2C expression at day 7.5 postcoitum (p.c...
  5. Lyons I, Parsons L, Hartley L, Li R, Andrews J, Robb L, et al. Myogenic and morphogenetic defects in the heart tubes of murine embryos lacking the homeo box gene Nkx2-5. Genes Dev. 1995;9:1654-66 pubmed
    ..The data demonstrate that Nkx2-5 is essential for normal heart morphogenesis, myogenesis, and function. Furthermore, this gene is a component of a genetic pathway required for myogenic specialization of the ventricles. ..
  6. Potthoff M, Wu H, Arnold M, Shelton J, Backs J, McAnally J, et al. Histone deacetylase degradation and MEF2 activation promote the formation of slow-twitch myofibers. J Clin Invest. 2007;117:2459-67 pubmed
    ..histone deacetylase (HDAC) proteins, which function as transcriptional repressors of the myocyte enhancer factor 2 (MEF2) transcription factor, fail to accumulate in the soleus, a slow muscle, compared with fast muscles (e.g...
  7. Verzi M, McCulley D, De Val S, Dodou E, Black B. The right ventricle, outflow tract, and ventricular septum comprise a restricted expression domain within the secondary/anterior heart field. Dev Biol. 2005;287:134-45 pubmed
    ..In this study, we used regulatory elements from the mouse mef2c gene to direct the expression of Cre recombinase exclusively in the anterior heart field and its derivatives in ..
  8. Laforest B, Nemer M. GATA5 interacts with GATA4 and GATA6 in outflow tract development. Dev Biol. 2011;358:368-78 pubmed publisher
    ..of several transcription factors important for endocardial and myocardial cell differentiation, such as Tbx20, Mef2c, Hey1 and Hand2, was reduced in compound heterozygote embryos...
  9. Naya F, Wu C, Richardson J, Overbeek P, Olson E. Transcriptional activity of MEF2 during mouse embryogenesis monitored with a MEF2-dependent transgene. Development. 1999;126:2045-52 pubmed
    The four members of the MEF2 family of MADS-box transcription factors, MEF2-A, MEF2-B, MEF2-C and MEF2-D, are expressed in overlapping patterns in developing muscle and neural cell lineages during embryogenesis...

More Information

Publications79

  1. Dodou E, Verzi M, Anderson J, Xu S, Black B. Mef2c is a direct transcriptional target of ISL1 and GATA factors in the anterior heart field during mouse embryonic development. Development. 2004;131:3931-42 pubmed
    ..The MADS domain transcription factor MEF2C is required for proper formation of the cardiac outflow tract and right ventricle, suggesting a key role in ..
  2. De Val S, Anderson J, Heidt A, Khiem D, Xu S, Black B. Mef2c is activated directly by Ets transcription factors through an evolutionarily conserved endothelial cell-specific enhancer. Dev Biol. 2004;275:424-34 pubmed
    ..b>Mef2c is expressed very early in the development of the endothelium, and genetic studies in mice have demonstrated that ..
  3. Potthoff M, Arnold M, McAnally J, Richardson J, Bassel Duby R, Olson E. Regulation of skeletal muscle sarcomere integrity and postnatal muscle function by Mef2c. Mol Cell Biol. 2007;27:8143-51 pubmed
    ..Here we show that skeletal muscle-specific deletion of Mef2c in mice results in disorganized myofibers and perinatal lethality...
  4. Wang D, Valdez M, McAnally J, Richardson J, Olson E. The Mef2c gene is a direct transcriptional target of myogenic bHLH and MEF2 proteins during skeletal muscle development. Development. 2001;128:4623-33 pubmed
    ..the mechanisms that regulate MEF2 gene expression during skeletal muscle development, we analyzed the mouse Mef2c gene for cis-regulatory elements that direct expression in the skeletal muscle lineage in vivo...
  5. Tanaka M, Chen Z, Bartunkova S, Yamasaki N, Izumo S. The cardiac homeobox gene Csx/Nkx2.5 lies genetically upstream of multiple genes essential for heart development. Development. 1999;126:1269-80 pubmed
    ..hybridization studies demonstrated that, among 20 candidate genes examined, expression of ANF, BNP, MLC2V, N-myc, MEF2C, HAND1 and Msx2 was disturbed in the mutant heart...
  6. Zhang P, Wong C, Liu D, Finegold M, Harper J, Elledge S. p21(CIP1) and p57(KIP2) control muscle differentiation at the myogenin step. Genes Dev. 1999;13:213-24 pubmed
  7. Ferrari S, Molinari S, Melchionna R, Cusella De Angelis M, Battini R, De Angelis L, et al. Absence of MEF2 binding to the A/T-rich element in the muscle creatine kinase (MCK) enhancer correlates with lack of early expression of the MCK gene in embryonic mammalian muscle. Cell Growth Differ. 1997;8:23-34 pubmed
    ..In contrast, no binding activity to the MEF2 site was observed with embryonic nuclear extract...
  8. Zeisberg E, Ma Q, Juraszek A, Moses K, Schwartz R, Izumo S, et al. Morphogenesis of the right ventricle requires myocardial expression of Gata4. J Clin Invest. 2005;115:1522-31 pubmed
    ..Our results demonstrate a general role of myocardial Gata4 in regulating cardiomyocyte proliferation and a specific, stage-dependent role in regulating the morphogenesis of the RV and the atrioventricular canal. ..
  9. Dy P, Wang W, Bhattaram P, Wang Q, Wang L, Ballock R, et al. Sox9 directs hypertrophic maturation and blocks osteoblast differentiation of growth plate chondrocytes. Dev Cell. 2012;22:597-609 pubmed publisher
    ..Sox9 protein outlives Sox9 RNA in upper hypertrophic chondrocytes, where it contributes with Mef2c to directly activate the major marker of these cells, Col10a1...
  10. Lu J, McKinsey T, Zhang C, Olson E. Regulation of skeletal myogenesis by association of the MEF2 transcription factor with class II histone deacetylases. Mol Cell. 2000;6:233-44 pubmed
    Skeletal muscle differentiation is controlled by associations between myogenic basic-helix-loop-helix and MEF2 transcription factors...
  11. Takeuchi J, Mileikovskaia M, Koshiba Takeuchi K, Heidt A, Mori A, Arruda E, et al. Tbx20 dose-dependently regulates transcription factor networks required for mouse heart and motoneuron development. Development. 2005;132:2463-74 pubmed
    ..and right ventricle, which derive from the anterior heart field (AHF), and decreased expression of Nkx2-5 and Mef2c, transcription factors required for AHF formation...
  12. Chen S, Loffler K, Chen D, Stallcup M, Muscat G. The coactivator-associated arginine methyltransferase is necessary for muscle differentiation: CARM1 coactivates myocyte enhancer factor-2. J Biol Chem. 2002;277:4324-33 pubmed
    ..that CARM1 and the SRC cofactor GRIP-1 cooperatively stimulate the activity of myocyte enhancer factor-2C (MEF2C). Moreover, there are direct interactions among MEF2C, GRIP-1, and CARM1...
  13. Molkentin J, Li L, Olson E. Phosphorylation of the MADS-Box transcription factor MEF2C enhances its DNA binding activity. J Biol Chem. 1996;271:17199-204 pubmed
    ..We show that serine 59 located between the MADS and MEF2 domains of MEF2C is phosphorylated in vivo and can be phosphorylated in vitro by casein kinase-II (CKII)...
  14. Bi W, Drake C, Schwarz J. The transcription factor MEF2C-null mouse exhibits complex vascular malformations and reduced cardiac expression of angiopoietin 1 and VEGF. Dev Biol. 1999;211:255-67 pubmed
    ..Targeted deletion of the MEF2C gene, in particular, revealed its importance for early cardiogenesis (Q. Lin et al., 1997, Science 276, 1404-1407)...
  15. Kozhemyakina E, Cohen T, Yao T, Lassar A. Parathyroid hormone-related peptide represses chondrocyte hypertrophy through a protein phosphatase 2A/histone deacetylase 4/MEF2 pathway. Mol Cell Biol. 2009;29:5751-62 pubmed publisher
    ..demonstrate that PTHrP or forskolin administration can block induction of collagen X-luciferase by exogenous Runx2, MEF2, and Smad1 in transfected chondrocytes...
  16. Dressel U, Bailey P, Wang S, Downes M, Evans R, Muscat G. A dynamic role for HDAC7 in MEF2-mediated muscle differentiation. J Biol Chem. 2001;276:17007-13 pubmed
    The overlapping expression profile of MEF2 and the class-II histone deacetylase, HDAC7, led us to investigate the functional interaction and relationship between these regulatory proteins...
  17. Arnold M, Kim Y, Czubryt M, Phan D, McAnally J, Qi X, et al. MEF2C transcription factor controls chondrocyte hypertrophy and bone development. Dev Cell. 2007;12:377-89 pubmed
    Chondrocyte hypertrophy is essential for endochondral bone development. Unexpectedly, we discovered that MEF2C, a transcription factor that regulates muscle and cardiovascular development, controls bone development by activating the gene ..
  18. L honoré A, Rana V, Arsic N, Franckhauser C, Lamb N, Fernandez A. Identification of a new hybrid serum response factor and myocyte enhancer factor 2-binding element in MyoD enhancer required for MyoD expression during myogenesis. Mol Biol Cell. 2007;18:1992-2001 pubmed
    ..shift assay, chromatin immunoprecipitation, and microinjection analyses show this element is a hybrid SRF- and MEF2 Binding (SMB) sequence where myocyte enhancer factor 2 (MEF2) complexes can compete out binding of SRF at the onset ..
  19. Angelelli C, Magli A, Ferrari D, Ganassi M, Matafora V, Parise F, et al. Differentiation-dependent lysine 4 acetylation enhances MEF2C binding to DNA in skeletal muscle cells. Nucleic Acids Res. 2008;36:915-28 pubmed
    ..In the present report, we provide evidence for a novel regulatory mechanism of MEF2C activity, which occurs at the onset of skeletal muscle differentiation and is based on Lys4 acetylation...
  20. McKinsey T, Zhang C, Lu J, Olson E. Signal-dependent nuclear export of a histone deacetylase regulates muscle differentiation. Nature. 2000;408:106-11 pubmed
    Members of the myocyte enhancer factor-2 (MEF2) family of transcription factors associate with myogenic basic helix-loop-helix transcription factors such as MyoD to activate skeletal myogenesis...
  21. Zhu B, Gulick T. Phosphorylation and alternative pre-mRNA splicing converge to regulate myocyte enhancer factor 2C activity. Mol Cell Biol. 2004;24:8264-75 pubmed
    ..In MEF2C alone, alternative splice acceptors in the last exon give forms that include or exclude a short domain that we ..
  22. Lazaro J, Bailey P, Lassar A. Cyclin D-cdk4 activity modulates the subnuclear localization and interaction of MEF2 with SRC-family coactivators during skeletal muscle differentiation. Genes Dev. 2002;16:1792-805 pubmed
    ..We have found that cyclin D-cdk activity blocks the association of MEF2C with the coactivator protein GRIP-1 and thereby inhibits the activity of MEF2...
  23. Li H, Radford J, Ragusa M, Shea K, McKercher S, Zaremba J, et al. Transcription factor MEF2C influences neural stem/progenitor cell differentiation and maturation in vivo. Proc Natl Acad Sci U S A. 2008;105:9397-402 pubmed publisher
    ..that myocyte enhancer factor 2 (MEF2) transcription factors act as effectors of neurogenesis in the brain, with MEF2C the predominant isoform in developing cerebrocortex...
  24. Ieda M, Fu J, Delgado Olguin P, Vedantham V, Hayashi Y, Bruneau B, et al. Direct reprogramming of fibroblasts into functional cardiomyocytes by defined factors. Cell. 2010;142:375-86 pubmed publisher
    ..Here, we report that a combination of three developmental transcription factors (i.e., Gata4, Mef2c, and Tbx5) rapidly and efficiently reprogrammed postnatal cardiac or dermal fibroblasts directly into ..
  25. Mjaatvedt C, Yamamura H, Capehart A, Turner D, Markwald R. The Cspg2 gene, disrupted in the hdf mutant, is required for right cardiac chamber and endocardial cushion formation. Dev Biol. 1998;202:56-66 pubmed
  26. Chen J, Krane M, Deutsch M, Wang L, Rav Acha M, Gregoire S, et al. Inefficient reprogramming of fibroblasts into cardiomyocytes using Gata4, Mef2c, and Tbx5. Circ Res. 2012;111:50-5 pubmed publisher
    ..To assess the efficiency of direct fibroblast reprogramming via viral overexpression of GATA4, Mef2c, and Tbx5 (GMT)...
  27. Pu W, Ishiwata T, Juraszek A, Ma Q, Izumo S. GATA4 is a dosage-sensitive regulator of cardiac morphogenesis. Dev Biol. 2004;275:235-44 pubmed
    ..Surprisingly, expression levels of the putative GATA4 target genes ANF, BNP, MEF2C, Nkx2-5, cyclin D2, and BMP4 were unchanged in mutant hearts, suggesting that GATA4 is not a dose-limiting ..
  28. Barbosa A, Kim M, Ertunc M, Adachi M, Nelson E, McAnally J, et al. MEF2C, a transcription factor that facilitates learning and memory by negative regulation of synapse numbers and function. Proc Natl Acad Sci U S A. 2008;105:9391-6 pubmed publisher
    ..We show that deletion of the MEF2C transcription factor in the CNS of mice impairs hippocampal-dependent learning and memory...
  29. Laforest B, Andelfinger G, Nemer M. Loss of Gata5 in mice leads to bicuspid aortic valve. J Clin Invest. 2011;121:2876-87 pubmed publisher
    ..Mice with mutated Gata5 alleles represent unique models to dissect the mechanisms underlying degenerative aortic valve disease and to develop much-needed preventive and therapeutic interventions. ..
  30. Martin J, Schwarz J, Olson E. Myocyte enhancer factor (MEF) 2C: a tissue-restricted member of the MEF-2 family of transcription factors. Proc Natl Acad Sci U S A. 1993;90:5282-6 pubmed
    ..These results suggest that the MEF-2 site is a target for a diverse family of proteins that regulates transcription in a variety of cell types. ..
  31. Martin J, Miano J, Hustad C, Copeland N, Jenkins N, Olson E. A Mef2 gene that generates a muscle-specific isoform via alternative mRNA splicing. Mol Cell Biol. 1994;14:1647-56 pubmed
    ..Mammalian MEF2 proteins have been shown previously to be encoded by three genes, Mef2, xMef2, and Mef2c, each of which gives rise to multiple alternatively spliced transcripts...
  32. Lyons G, Micales B, Schwarz J, Martin J, Olson E. Expression of mef2 genes in the mouse central nervous system suggests a role in neuronal maturation. J Neurosci. 1995;15:5727-38 pubmed
    ..b>Mef2C mRNA was first detected in a ventral portion of the telencephalon at 11.5 d postcoitum (p.c.). By 13.5 d p.c...
  33. Akhtar M, Kim M, Adachi M, Morris M, Qi X, Richardson J, et al. In vivo analysis of MEF2 transcription factors in synapse regulation and neuronal survival. PLoS ONE. 2012;7:e34863 pubmed publisher
    ..The role of MEF2 isoforms in the brain has been studied using in vitro manipulations with only MEF2C examined in vivo...
  34. Lin Q, Lu J, Yanagisawa H, Webb R, Lyons G, Richardson J, et al. Requirement of the MADS-box transcription factor MEF2C for vascular development. Development. 1998;125:4565-74 pubmed
    ..The MADS-box transcription factor MEF2C is expressed in developing endothelial cells and smooth muscle cells (SMCs), as well as in surrounding mesenchyme, ..
  35. Kobayashi N, Goto K, Horiguchi K, Nagata M, Kawata M, Miyazawa K, et al. c-Ski activates MyoD in the nucleus of myoblastic cells through suppression of histone deacetylases. Genes Cells. 2007;12:375-85 pubmed
    ..by a transcription factor complex containing proteins of the MyoD family and the myocyte enhancer factor 2 (MEF2) family. c-Ski acts on the MyoD-MEF2 complex and modulates the activity of MyoD in myogenin promoter regulation...
  36. Lu K, Evans S, Hirano S, Liu F. Dual role for Islet-1 in promoting striatonigral and repressing striatopallidal genetic programs to specify striatonigral cell identity. Proc Natl Acad Sci U S A. 2014;111:E168-77 pubmed publisher
    ..The dual action of developmental control by Isl1 in promoting appropriate striatonigral but repressing inappropriate striatopallidal genetic profiles may ensure sharpening of the striatonigral identity during development. ..
  37. Lockhart M, Wirrig E, Phelps A, Ghatnekar A, Barth J, Norris R, et al. Mef2c regulates transcription of the extracellular matrix protein cartilage link protein 1 in the developing murine heart. PLoS ONE. 2013;8:e57073 pubmed publisher
    ..The cardiac transcription factor Mef2c is involved in the regulation of gene expression in cardiac and skeletal muscle cell lineages...
  38. Barnes R, Harris I, Jaehnig E, Sauls K, Sinha T, Rojas A, et al. MEF2C regulates outflow tract alignment and transcriptional control of Tdgf1. Development. 2016;143:774-9 pubmed publisher
    ..Here, we inactivated the gene encoding the transcription factor MEF2C in the AHF in mice...
  39. Chen H, Shi S, Acosta L, Li W, Lu J, Bao S, et al. BMP10 is essential for maintaining cardiac growth during murine cardiogenesis. Development. 2004;131:2219-31 pubmed
    ..g. NKX2.5 and MEF2C) in the developing myocardium at mid-gestation...
  40. Xu W, Edmondson D, Evrard Y, Wakamiya M, Behringer R, Roth S. Loss of Gcn5l2 leads to increased apoptosis and mesodermal defects during mouse development. Nat Genet. 2000;26:229-32 pubmed
    ..Our studies are the first to demonstrate that specific acetyltransferases are required for cell survival and mesoderm formation during mammalian development. ..
  41. Kolodziejczyk S, Wang L, Balazsi K, DeRepentigny Y, Kothary R, Megeney L. MEF2 is upregulated during cardiac hypertrophy and is required for normal post-natal growth of the myocardium. Curr Biol. 1999;9:1203-6 pubmed
    ..Transgenic mice expressing a dominant-negative form of MEF2C displayed attenuated post-natal growth of the myocardium...
  42. Prall O, Menon M, Solloway M, Watanabe Y, Zaffran S, Bajolle F, et al. An Nkx2-5/Bmp2/Smad1 negative feedback loop controls heart progenitor specification and proliferation. Cell. 2007;128:947-59 pubmed
  43. Kemler D, Dahley O, Roßwag S, Litfin M, Kassel O. The LIM domain protein nTRIP6 acts as a co-repressor for the transcription factor MEF2C in myoblasts. Sci Rep. 2016;6:27746 pubmed publisher
    The transcription factor Myocyte enhancer factor 2C (MEF2C) plays a key role in the late differentiation of skeletal muscle progenitor cells, the so-called myoblasts...
  44. Bruneau B, Bao Z, Tanaka M, Schott J, Izumo S, Cepko C, et al. Cardiac expression of the ventricle-specific homeobox gene Irx4 is modulated by Nkx2-5 and dHand. Dev Biol. 2000;217:266-77 pubmed
    ..Irx4 gene expression was also assessed in embryos with aberrant cardiac development: mice lacking RXRalpha or MEF2c have normal Irx4 expression, but mice lacking the homeobox transcription factor Nkx2-5 (Csx) have markedly reduced ..
  45. Rajkovich K, Loerwald K, Hale C, Hess C, Gibson J, Huber K. Experience-Dependent and Differential Regulation of Local and Long-Range Excitatory Neocortical Circuits by Postsynaptic Mef2c. Neuron. 2017;93:48-56 pubmed publisher
    ..Here, we demonstrate that the activity-dependent transcription factor, Myocyte enhancer factor-2C (Mef2c), differentially regulates development of local versus long-range excitatory synaptic inputs onto layer 2/3 ..
  46. Phan D, Rasmussen T, Nakagawa O, McAnally J, Gottlieb P, Tucker P, et al. BOP, a regulator of right ventricular heart development, is a direct transcriptional target of MEF2C in the developing heart. Development. 2005;132:2669-78 pubmed
    ..These regions of the heart are severely hypoplastic in mutant mice lacking the myocyte enhancer factor 2C (MEF2C) and BOP transcription factors, suggesting that these cardiogenic regulatory factors may act in a common pathway ..
  47. Weinert S, Bergmann N, Luo X, Erdmann B, Gotthardt M. M line-deficient titin causes cardiac lethality through impaired maturation of the sarcomere. J Cell Biol. 2006;173:559-70 pubmed
  48. Zhu B, Ramachandran B, Gulick T. Alternative pre-mRNA splicing governs expression of a conserved acidic transactivation domain in myocyte enhancer factor 2 factors of striated muscle and brain. J Biol Chem. 2005;280:28749-60 pubmed
    ..Despite a location between the p38 MAPK docking domain and Thr phosphoacceptors of MEF2A and MEF2C, inclusion of beta does not influence responses of these factors to this signaling pathway...
  49. Hennebry A, Berry C, Siriett V, O Callaghan P, Chau L, Watson T, et al. Myostatin regulates fiber-type composition of skeletal muscle by regulating MEF2 and MyoD gene expression. Am J Physiol Cell Physiol. 2009;296:C525-34 pubmed publisher
    ..Results revealed reduced MEF2C protein in Mstn(-/-) muscle and myoblast nuclear extracts...
  50. Trajkovski M, Ahmed K, Esau C, Stoffel M. MyomiR-133 regulates brown fat differentiation through Prdm16. Nat Cell Biol. 2012;14:1330-5 pubmed
    ..and subcutaneous white adipose tissue (SAT) as a result of decreased expression of its transcriptional regulator Mef2. miR-133 directly targets and negatively regulates PRDM16, and inhibition of miR-133 or Mef2 promotes ..
  51. Wei L, Imanaka Yoshida K, Wang L, Zhan S, Schneider M, DeMayo F, et al. Inhibition of Rho family GTPases by Rho GDP dissociation inhibitor disrupts cardiac morphogenesis and inhibits cardiomyocyte proliferation. Development. 2002;129:1705-14 pubmed
    ..These results reveal new biological functions for Rho family proteins as essential determinants of cell proliferation signals at looping and chamber maturation stages in mammalian cardiac development. ..
  52. Garry D, Yang Q, Bassel Duby R, Williams R. Persistent expression of MNF identifies myogenic stem cells in postnatal muscles. Dev Biol. 1997;188:280-94 pubmed
    ..These data identify MNF as a marker of quiescent satellite cells and suggest that downstream genes controlled by MNF serve to modulate proliferative growth or differentiation in this unique cell population. ..
  53. Black B, Ligon K, Zhang Y, Olson E. Cooperative transcriptional activation by the neurogenic basic helix-loop-helix protein MASH1 and members of the myocyte enhancer factor-2 (MEF2) family. J Biol Chem. 1996;271:26659-63 pubmed
    ..shown to activate skeletal muscle transcription in collaboration with members of the myocyte enhancer factor-2 (MEF2) family of MCM1-agamous-deficiens-serum response factor (MADS)-box transcription factors, which are expressed in ..
  54. Wang X, Merritt A, Seyfried J, Guo C, Papadakis E, Finegan K, et al. Targeted deletion of mek5 causes early embryonic death and defects in the extracellular signal-regulated kinase 5/myocyte enhancer factor 2 cell survival pathway. Mol Cell Biol. 2005;25:336-45 pubmed
    ..Overall, this is the first study to rigorously establish the role of MEK5 in vivo as an activator of ERK5 and as an essential regulator of cell survival that is required for normal embryonic development. ..
  55. Kuratomi S, Ohmori Y, Ito M, Shimazaki K, Muramatsu S, Mizukami H, et al. The cardiac pacemaker-specific channel Hcn4 is a direct transcriptional target of MEF2. Cardiovasc Res. 2009;83:682-7 pubmed publisher
    ..Subsequent mutation analysis revealed that the Hcn4 enhancer function was dependent on myocyte enhancer factor-2 (MEF2) and activator protein-1 (AP1) binding sequences located in CNS13...
  56. Takemori H, Katoh Hashimoto Y, Nakae J, Olson E, Okamoto M. Inactivation of HDAC5 by SIK1 in AICAR-treated C2C12 myoblasts. Endocr J. 2009;56:121-30 pubmed
    ..These observations suggest that GSK-3 beta and SIK1 may play important roles in the regulation of PGC-1alpha gene expression by inactivating HDAC5 followed by activation of MEF2C.
  57. Nakajima K, Inagawa M, Uchida C, Okada K, Tane S, Kojima M, et al. Coordinated regulation of differentiation and proliferation of embryonic cardiomyocytes by a jumonji (Jarid2)-cyclin D1 pathway. Development. 2011;138:1771-82 pubmed publisher
    ..Thus, a Jmj-cyclin D1 pathway coordinately regulates proliferation and differentiation of cardiomyocytes. ..
  58. Konno T, Chen D, Wang L, Wakimoto H, Teekakirikul P, Nayor M, et al. Heterogeneous myocyte enhancer factor-2 (Mef2) activation in myocytes predicts focal scarring in hypertrophic cardiomyopathy. Proc Natl Acad Sci U S A. 2010;107:18097-102 pubmed publisher
    ..To determine if hypertrophic signals activated myocyte enhancer factor-2 (Mef2), we studied mice carrying the HCM mutation, myosin heavy-chain Arg403Gln, (MHC(403/+)) and an Mef2-dependent ?-..
  59. Harrington A, Raissi A, Rajkovich K, Berto S, Kumar J, Molinaro G, et al. MEF2C regulates cortical inhibitory and excitatory synapses and behaviors relevant to neurodevelopmental disorders. elife. 2016;5: pubmed publisher
    Numerous genetic variants associated with MEF2C are linked to autism, intellectual disability (ID) and schizophrenia (SCZ) - a heterogeneous collection of neurodevelopmental disorders with unclear pathophysiology...
  60. Xia S, Li X, Johnson T, Seidel C, Wallace D, Li R. Polycystin-dependent fluid flow sensing targets histone deacetylase 5 to prevent the development of renal cysts. Development. 2010;137:1075-84 pubmed publisher
    ..Here, we found that myocyte enhancer factor 2C (MEF2C) and histone deacetylase 5 (HDAC5), two key regulators of cardiac hypertrophy, are targets of polycystin-dependent ..
  61. Valdez M, Richardson J, Klein W, Olson E. Failure of Myf5 to support myogenic differentiation without myogenin, MyoD, and MRF4. Dev Biol. 2000;219:287-98 pubmed
  62. Gu X, Fu C, Lin L, Liu S, Su X, Li A, et al. miR-124 and miR-9 mediated downregulation of HDAC5 promotes neurite development through activating MEF2C-GPM6A pathway. J Cell Physiol. 2018;233:673-687 pubmed publisher
    ..the neuronal membrane glycoprotein GPM6A (M6a) is a direct target gene of HDAC5 regulated transcriptional factor MEF2C. HDAC5 inhibits neurite elongation, acting at least partially via a MEF2C/M6a signaling pathway...
  63. Furtado M, Costa M, Pranoto E, Salimova E, Pinto A, Lam N, et al. Cardiogenic genes expressed in cardiac fibroblasts contribute to heart development and repair. Circ Res. 2014;114:1422-34 pubmed publisher
  64. Paciorkowski A, Traylor R, Rosenfeld J, Hoover J, Harris C, Winter S, et al. MEF2C Haploinsufficiency features consistent hyperkinesis, variable epilepsy, and has a role in dorsal and ventral neuronal developmental pathways. Neurogenetics. 2013;14:99-111 pubmed publisher
    b>MEF2C haploinsufficiency syndrome is an emerging neurodevelopmental disorder associated with intellectual disability, autistic features, epilepsy, and abnormal movements...
  65. Hsiao S, Chen S. Myogenic regulatory factors regulate M-cadherin expression by targeting its proximal promoter elements. Biochem J. 2010;428:223-33 pubmed publisher
    ..Taken together, these observations identify a molecular mechanism by which MRFs regulate M-cadherin expression directly to ensure the terminal differentiation of myoblasts. ..
  66. Schwieger M, Schuler A, Forster M, Engelmann A, Arnold M, Delwel R, et al. Homing and invasiveness of MLL/ENL leukemic cells is regulated by MEF2C. Blood. 2009;114:2476-88 pubmed publisher
    ..Among the targeted genes, we identified Mef2c, encoding a MCM1-agamous-deficiens-serum response factor transcription factor, and confirmed that overexpression ..
  67. Andersen D, Laborda J, Baladron V, Kassem M, Sheikh S, Jensen C. Dual role of delta-like 1 homolog (DLK1) in skeletal muscle development and adult muscle regeneration. Development. 2013;140:3743-53 pubmed publisher
    ..Collectively, our results suggest a novel and surprising dual biological function of DLK1 as an enhancer of muscle development, but as an inhibitor of adult muscle regeneration. ..
  68. Panda A, Abdelmohsen K, Yoon J, Martindale J, Yang X, Curtis J, et al. RNA-binding protein AUF1 promotes myogenesis by regulating MEF2C expression levels. Mol Cell Biol. 2014;34:3106-19 pubmed publisher
    ..differentiation into myotubes, RNP immunoprecipitation (RIP) analysis indicated that AUF1 binds prominently to Mef2c (myocyte enhancer factor 2c) mRNA, which encodes the key myogenic transcription factor MEF2C...
  69. Karamboulas C, Dakubo G, Liu J, De Repentigny Y, Yutzey K, Wallace V, et al. Disruption of MEF2 activity in cardiomyoblasts inhibits cardiomyogenesis. J Cell Sci. 2006;119:4315-21 pubmed
    ..Drosophila Mef2 is essential for Drosophila heart development, however, neither MEF2C nor MEF2B are essential for the early stages of murine cardiomyogenesis...
  70. Fan X, Hou N, Fan K, Yuan J, Mo X, Deng Y, et al. Geft is dispensable for the development of the second heart field. BMB Rep. 2012;45:153-8 pubmed
    ..Cre-mediated deletion of the Geft gene in heart using Mef2c-Cre transgenic mice resulted in a dramatic decrease of Geft expression...