Gene Symbol: Mef2b
Description: myocyte enhancer factor 2B
Alias: AI451606, myocyte-specific enhancer factor 2B
Species: mouse
Products:     Mef2b

Top Publications

  1. Allen D, Weber J, Sycuro L, Leinwand L. Myocyte enhancer factor-2 and serum response factor binding elements regulate fast Myosin heavy chain transcription in vivo. J Biol Chem. 2005;280:17126-34 pubmed
    ..Together, these data demonstrate that the quantitative differences in MyHC expression in mouse skeletal muscle have evolved at least in part through the elimination of positive-acting transcription factor binding sites. ..
  2. Lyons G, Micales B, Schwarz J, Martin J, Olson E. Expression of mef2 genes in the mouse central nervous system suggests a role in neuronal maturation. J Neurosci. 1995;15:5727-38 pubmed
    ..Since the molecular mechanisms that regulate neuron differentiation are unknown, we propose that the MEF2 factors are likely to play an important role in this process. ..
  3. Hidaka K, Morisaki T, Byun S, Hashido K, Toyama K, Mukai T. The MEF2B homologue differentially expressed in mouse embryonal carcinoma cells. Biochem Biophys Res Commun. 1995;213:555-60 pubmed those of human MEF2A and MEF2D, another domain sequence was similar but not identical to that of human MEF2B. While the transcription of MEF2A and MEF2D was up-regulated during differentiation of P19 cells, the MEF2B ..
  4. Molkentin J, Firulli A, Black B, Martin J, Hustad C, Copeland N, et al. MEF2B is a potent transactivator expressed in early myogenic lineages. Mol Cell Biol. 1996;16:3814-24 pubmed
    ..been shown to bind an A/T-rich DNA sequence in the control regions of numerous muscle-specific genes, whereas MEF2B was reported to be unable to bind this sequence unless the carboxyl terminus was deleted...
  5. Olson E, Perry M, Schulz R. Regulation of muscle differentiation by the MEF2 family of MADS box transcription factors. Dev Biol. 1995;172:2-14 pubmed
  6. Vetere G, Restivo L, Cole C, Ross P, Ammassari Teule M, Josselyn S, et al. Spine growth in the anterior cingulate cortex is necessary for the consolidation of contextual fear memory. Proc Natl Acad Sci U S A. 2011;108:8456-60 pubmed publisher
    ..Together, these data strengthen the causal link between cortical structural remodeling and memory consolidation and, further, identify MEF2 as a key regulator of these processes. ..
  7. Estrella N, Desjardins C, Nocco S, Clark A, Maksimenko Y, Naya F. MEF2 transcription factors regulate distinct gene programs in mammalian skeletal muscle differentiation. J Biol Chem. 2015;290:1256-68 pubmed publisher
    ..Whereas MEF2A is absolutely required for proper myoblast differentiation, MEF2B, -C, and -D were found to be dispensable for this process...
  8. Vong L, Bi W, O Connor Halligan K, Li C, Cserjesi P, Schwarz J. MEF2C is required for the normal allocation of cells between the ventricular and sinoatrial precursors of the primary heart field. Dev Dyn. 2006;235:1809-21 pubmed
    ..factor, tbx5, was ectopically expressed in the primitive ventricle and ventricle-specific splicing of mef2b was lost, suggesting that the mutant ventricle had acquired atrial-specific characteristics...
  9. Morisaki T, Sermsuvitayawong K, Byun S, Matsuda Y, Hidaka K, Morisaki H, et al. Mouse Mef2b gene: unique member of MEF2 gene family. J Biochem. 1997;122:939-46 pubmed
    ..To better understand the mouse Mef2 gene family, the mouse Mef2b gene, which was found to be expressed in undifferentiated embryonal cells, was characterized...

More Information


  1. Friday B, Mitchell P, Kegley K, Pavlath G. Calcineurin initiates skeletal muscle differentiation by activating MEF2 and MyoD. Differentiation. 2003;71:217-27 pubmed
    ..These results demonstrate that calcineurin regulates skeletal muscle differentiation by activating MEF2 and MyoD transcription factors leading to the induction of myogenin expression. ..
  2. Arnold M, Kim Y, Czubryt M, Phan D, McAnally J, Qi X, et al. MEF2C transcription factor controls chondrocyte hypertrophy and bone development. Dev Cell. 2007;12:377-89 pubmed
    ..These findings reveal unexpected commonalities in the mechanisms governing muscle, cardiovascular, and bone development with respect to their regulation by MEF2 and class II HDACs. ..
  3. Ferrari S, Molinari S, Melchionna R, Cusella De Angelis M, Battini R, De Angelis L, et al. Absence of MEF2 binding to the A/T-rich element in the muscle creatine kinase (MCK) enhancer correlates with lack of early expression of the MCK gene in embryonic mammalian muscle. Cell Growth Differ. 1997;8:23-34 pubmed
    ..We propose that phosphorylation of MEF2 regulates its activity and represents an important aspect of the mechanism controlling stage-specific transcription during skeletal myogenesis. ..
  4. Kao H, Verdel A, Tsai C, Simon C, Juguilon H, Khochbin S. Mechanism for nucleocytoplasmic shuttling of histone deacetylase 7. J Biol Chem. 2001;276:47496-507 pubmed
    ..The data also show that the cellular concentration of factors such as 14-3-3, CaMK I, and other yet unknown molecules may determine the subcellular localization of an individual HDAC member in a cell type and HDAC-specific manner. ..
  5. Lin X, Shah S, Bulleit R. The expression of MEF2 genes is implicated in CNS neuronal differentiation. Brain Res Mol Brain Res. 1996;42:307-16 pubmed
    ..These observations suggest that MEF2 molecules may be an important factor involved in CNS neuron differentiation similar to their role in muscle differentiation. ..
  6. Gregoire S, Xiao L, Nie J, Zhang X, Xu M, Li J, et al. Histone deacetylase 3 interacts with and deacetylates myocyte enhancer factor 2. Mol Cell Biol. 2007;27:1280-95 pubmed
    ..These results reveal an unexpected role for HDAC3 and suggest a novel pathway through which MEF2 activity is controlled in vivo. ..
  7. Von Both I, Silvestri C, Erdemir T, Lickert H, Walls J, Henkelman R, et al. Foxh1 is essential for development of the anterior heart field. Dev Cell. 2004;7:331-45 pubmed
    ..Thus, Foxh1 and Nkx2-5 functionally interact and are essential for development of the AHF and its derivatives, the RV and OFT, in response to TGFbeta-like signals. ..
  8. She H, Yang Q, Mao Z. Neurotoxin-induced selective ubiquitination and regulation of MEF2A isoform in neuronal stress response. J Neurochem. 2012;122:1203-10 pubmed publisher
  9. Lin Q, Schwarz J, Bucana C, Olson E. Control of mouse cardiac morphogenesis and myogenesis by transcription factor MEF2C. Science. 1997;276:1404-7 pubmed
    ..Thus, MEF2C is an essential regulator of cardiac myogenesis and right ventricular development. ..
  10. Naya F, Wu C, Richardson J, Overbeek P, Olson E. Transcriptional activity of MEF2 during mouse embryogenesis monitored with a MEF2-dependent transgene. Development. 1999;126:2045-52 pubmed
    ..The discordance between MEF2 mRNA expression and MEF2 transcriptional activity in nonmuscle cell types of embryos and adults also supports the notion that post-transcriptional mechanisms regulate the expression of MEF2 proteins. ..
  11. Lazaro J, Bailey P, Lassar A. Cyclin D-cdk4 activity modulates the subnuclear localization and interaction of MEF2 with SRC-family coactivators during skeletal muscle differentiation. Genes Dev. 2002;16:1792-805 pubmed
  12. Ross R, Navankasattusas S, Harvey R, Chien K. An HF-1a/HF-1b/MEF-2 combinatorial element confers cardiac ventricular specificity and established an anterior-posterior gradient of expression. Development. 1996;122:1799-809 pubmed
    ..The patterned expression of this transgene may provide a model system in which to investigate the cues that dictate anterior-posterior (right ventricle/left ventricle) gradients during mammalian heart development. ..