Med7

Summary

Gene Symbol: Med7
Description: mediator complex subunit 7
Alias: 1110063B05Rik, Crsp33, Crsp9, mediator of RNA polymerase II transcription subunit 7, CRSP complex subunit 9, cofactor required for Sp1 transcriptional activation subunit 9, cofactor required for Sp1 transcriptional activation, subunit 9, 33kDa
Species: mouse
Products:     Med7

Top Publications

  1. Sasaki N, Nagaoka S, Itoh M, Izawa M, Konno H, Carninci P, et al. Characterization of gene expression in mouse blastocyst using single-pass sequencing of 3995 clones. Genomics. 1998;49:167-79 pubmed
    ..Although the human EST project is considered to represent roughly half of all genes, our findings indicate that many early stage developmental genes remain to be identified. ..
  2. Jiang Y, Veschambre P, Erdjument Bromage H, Tempst P, Conaway J, Conaway R, et al. Mammalian mediator of transcriptional regulation and its possible role as an end-point of signal transduction pathways. Proc Natl Acad Sci U S A. 1998;95:8538-43 pubmed
    ..of transcriptional regulation on the basis of the following: homologs of two subunits of yeast Mediator, Srb7 and Med7, copurify with the complex; peptide sequencing reveals, in addition, homologs of the yeast Mediator subunits Rgr1 ..
  3. Malik S, Guermah M, Yuan C, Wu W, Yamamura S, Roeder R. Structural and functional organization of TRAP220, the TRAP/mediator subunit that is targeted by nuclear receptors. Mol Cell Biol. 2004;24:8244-54 pubmed
    ..The implications of these observations are discussed in terms of our present understanding of coactivator function. ..
  4. Kagey M, Newman J, Bilodeau S, Zhan Y, Orlando D, van Berkum N, et al. Mediator and cohesin connect gene expression and chromatin architecture. Nature. 2010;467:430-5 pubmed publisher
    ..Mediator and cohesin co-occupy different promoters in different cells, thus generating cell-type-specific DNA loops linked to the gene expression program of each cell. ..