Med24

Summary

Gene Symbol: Med24
Description: mediator complex subunit 24
Alias: 911GSE, AU040102, AW547152, D11Ertd307e, DRIP100, Gse2, Pparb2, Pparbp2, R75526, Thrap4, Trap100, mediator of RNA polymerase II transcription subunit 24, genetic suppressor element 2, mTRAP100, peroxisome proliferation activation receptor binding protein 2, thyroid hormone receptor associated protein 4, thyroid hormone receptor-associated protein 100 kDa, thyroid hormone receptor-associated protein complex 100 kDa component
Species: mouse
Products:     Med24

Top Publications

  1. Malik S, Roeder R. Dynamic regulation of pol II transcription by the mammalian Mediator complex. Trends Biochem Sci. 2005;30:256-63 pubmed
    ..In addition, the compositional complexity of the Mediator allows for assimilation of other diverse signals such as those emanating from repressors and other coactivators. ..
  2. Malik S, Guermah M, Yuan C, Wu W, Yamamura S, Roeder R. Structural and functional organization of TRAP220, the TRAP/mediator subunit that is targeted by nuclear receptors. Mol Cell Biol. 2004;24:8244-54 pubmed
    ..The implications of these observations are discussed in terms of our present understanding of coactivator function. ..
  3. Zhang J, Fondell J. Identification of mouse TRAP100: a transcriptional coregulatory factor for thyroid hormone and vitamin D receptors. Mol Endocrinol. 1999;13:1130-40 pubmed
    ..Here we present the mouse cDNA for the 100-kDa component of the TRAP complex (mTRAP100)...
  4. Gustafsson C, Samuelsson T. Mediator--a universal complex in transcriptional regulation. Mol Microbiol. 2001;41:1-8 pubmed
    ..As an appendix to this review, we have created a database, MEDB, in which we have compiled information about all the S. cerevisiae Mediator subunits and their homologues in other eukaryotic cells (http://bio.lundberg.gu.se/medb/). ..
  5. Kagey M, Newman J, Bilodeau S, Zhan Y, Orlando D, van Berkum N, et al. Mediator and cohesin connect gene expression and chromatin architecture. Nature. 2010;467:430-5 pubmed publisher
    ..Mediator and cohesin co-occupy different promoters in different cells, thus generating cell-type-specific DNA loops linked to the gene expression program of each cell. ..
  6. Hasegawa N, Sumitomo A, Fujita A, Aritome N, Mizuta S, Matsui K, et al. Mediator subunits MED1 and MED24 cooperatively contribute to pubertal mammary gland development and growth of breast carcinoma cells. Mol Cell Biol. 2012;32:1483-95 pubmed publisher
    ..Here, we provide evidence that the MED24-containing submodule of Mediator functionally communicates specifically with MED1 in pubertal mammary gland ..
  7. Xu Y, Guo W, Li P, Zhang Y, Zhao M, Fan Z, et al. Long-Range Chromosome Interactions Mediated by Cohesin Shape Circadian Gene Expression. PLoS Genet. 2016;12:e1005992 pubmed publisher
    ..This study provided a novel insight into the relationship between circadian transcriptome and the high-order chromosome structure. ..
  8. Gudkov A, Kazarov A, Thimmapaya R, Axenovich S, Mazo I, Roninson I. Cloning mammalian genes by expression selection of genetic suppressor elements: association of kinesin with drug resistance and cell immortalization. Proc Natl Acad Sci U S A. 1994;91:3744-8 pubmed
  9. Ito M, Okano H, Darnell R, Roeder R. The TRAP100 component of the TRAP/Mediator complex is essential in broad transcriptional events and development. EMBO J. 2002;21:3464-75 pubmed
    ..Genetic ablation of the murine TRAP100 component of this complex has revealed that it is not essential for cell viability per se...

More Information

Publications10

  1. Spies N, Smith C, Rodriguez J, Baker J, Batzoglou S, Sidow A. Constraint and divergence of global gene expression in the mammalian embryo. elife. 2015;4:e05538 pubmed publisher
    ..The widespread effect of maternal and embryonic genotype in conjunction with the purifying selection we uncovered suggests that embryogenesis is an important and understudied reservoir of phenotypic variation. ..