Gene Symbol: Med12
Description: mediator complex subunit 12
Alias: 230kDa, Mopa, OPA-1, Tnrc11, Trap230, mediator of RNA polymerase II transcription subunit 12, OPA-containing protein 1, mediator of RNA polymerase II transcription, subunit 12 homolog, thyroid hormone receptor-associated protein complex 230 kDa component, trinucleotide repeat containing 11 (THR-associated protein), trinucleotide repeat containing 11 (THR-associated protein, 230 kDa subunit), trinucleotide repeat-containing gene 11 protein
Species: mouse
Products:     Med12

Top Publications

  1. Duboule D, Haenlin M, Galliot B, Mohier E. DNA sequences homologous to the Drosophila opa repeat are present in murine mRNAs that are differentially expressed in fetuses and adult tissues. Mol Cell Biol. 1987;7:2003-6 pubmed
    ..However, unlike Drosophila, such repeated sequences were not found within the murine homeo-boxes containing genes of the Hox-1 complex. ..
  2. Vogl M, Reiprich S, Küspert M, Kosian T, Schrewe H, Nave K, et al. Sox10 cooperates with the mediator subunit 12 during terminal differentiation of myelinating glia. J Neurosci. 2013;33:6679-90 pubmed publisher
    ..glial expression programs, we identified and characterized a physical and functional link between Sox10 and the Med12 subunit of the Mediator complex that serves as a conserved multiprotein interphase between transcription factors ..
  3. Malik S, Guermah M, Yuan C, Wu W, Yamamura S, Roeder R. Structural and functional organization of TRAP220, the TRAP/mediator subunit that is targeted by nuclear receptors. Mol Cell Biol. 2004;24:8244-54 pubmed
    ..The implications of these observations are discussed in terms of our present understanding of coactivator function. ..
  4. Rocha P, Bleiss W, Schrewe H. Mosaic expression of Med12 in female mice leads to exencephaly, spina bifida, and craniorachischisis. Birth Defects Res A Clin Mol Teratol. 2010;88:626-32 pubmed publisher
    A precise temporal and spatial regulation of gene expression is necessary to achieve neural tube closure. Med12, a subunit of the mediator complex, can bind transcription factors and modulate expression of their target genes...
  5. Ishihara T, Ban Ishihara R, Maeda M, Matsunaga Y, Ichimura A, Kyogoku S, et al. Dynamics of mitochondrial DNA nucleoids regulated by mitochondrial fission is essential for maintenance of homogeneously active mitochondria during neonatal heart development. Mol Cell Biol. 2015;35:211-23 pubmed publisher
    ..Thus, the dynamics of mtDNA nucleoids regulated by mitochondrial fission is required for neonatal cardiomyocyte development by promoting homogeneous distribution of active mitochondria throughout the cardiomyocytes. ..
  6. Kim N, Livi C, Yew P, Boyer T. Mediator subunit Med12 contributes to the maintenance of neural stem cell identity. BMC Dev Biol. 2016;16:17 pubmed publisher
    The RNA polymerase II transcriptional Mediator subunit Med12 is broadly implicated in vertebrate brain development, and genetic variation in human MED12 is associated with X-linked intellectual disability and neuropsychiatric disorders...
  7. Mittal P, Shin Y, Yatsenko S, Castro C, Surti U, Rajkovic A. Med12 gain-of-function mutation causes leiomyomas and genomic instability. J Clin Invest. 2015;125:3280-4 pubmed publisher
    ..Mediator complex subunit 12 (MED12) exon 2 variants are associated with uterine leiomyomas; however, the causality of MED12 variants, their genetic ..
  8. Papadopoulou T, Kaymak A, Sayols S, Richly H. Dual role of Med12 in PRC1-dependent gene repression and ncRNA-mediated transcriptional activation. Cell Cycle. 2016;15:1479-93 pubmed publisher
    ..One means of controlling the function of Mediator is provided by the binding of the Cdk8 module (Med12, Cdk8, Ccnc and Med13) to the core Mediator...
  9. Philibert R, King B, Winfield S, Cook E, Lee Y, Stubblefield B, et al. Association of an X-chromosome dodecamer insertional variant allele with mental retardation. Mol Psychiatry. 1998;3:303-9 pubmed
    ..001) and treatment with antidepressants (P < 0.001). We conclude that the presence of this 12-bp variant confers significant susceptibility for mental retardation. ..

More Information


  1. Ge K, Guermah M, Yuan C, Ito M, Wallberg A, Spiegelman B, et al. Transcription coactivator TRAP220 is required for PPAR gamma 2-stimulated adipogenesis. Nature. 2002;417:563-7 pubmed
    ..These data indicate that TRAP220 acts, via the TRAP complex, as a PPAR gamma(2)-selective coactivator and, accordingly, that it is specific for one fibroblast differentiation pathway (adipogenesis) relative to another (myogenesis). ..
  2. Tutter A, Kowalski M, Baltus G, Iourgenko V, Labow M, Li E, et al. Role for Med12 in regulation of Nanog and Nanog target genes. J Biol Chem. 2009;284:3709-18 pubmed publisher
    ..b>Med12 is part of a subcomplex of four proteins associated with the core Mediator complex and has been found to function ..
  3. Aranda Orgilles B, Saldaña Meyer R, Wang E, Trompouki E, Fassl A, Lau S, et al. MED12 Regulates HSC-Specific Enhancers Independently of Mediator Kinase Activity to Control Hematopoiesis. Cell Stem Cell. 2016;19:784-799 pubmed publisher
    ..We show that MED12, a member of the Mediator kinase module, is an essential regulator of HSC homeostasis, as in vivo deletion of ..
  4. Kagey M, Newman J, Bilodeau S, Zhan Y, Orlando D, van Berkum N, et al. Mediator and cohesin connect gene expression and chromatin architecture. Nature. 2010;467:430-5 pubmed publisher
    ..Mediator and cohesin co-occupy different promoters in different cells, thus generating cell-type-specific DNA loops linked to the gene expression program of each cell. ..
  5. Huang S, Hölzel M, Knijnenburg T, Schlicker A, Roepman P, McDermott U, et al. MED12 controls the response to multiple cancer drugs through regulation of TGF-β receptor signaling. Cell. 2012;151:937-50 pubmed publisher
    ..We used a large-scale RNAi screen to identify MED12, a component of the transcriptional MEDIATOR complex that is mutated in cancers, as a determinant of response to ..
  6. Li N, Fassl A, Chick J, Inuzuka H, Li X, Mansour M, et al. Cyclin C is a haploinsufficient tumour suppressor. Nat Cell Biol. 2014;16:1080-91 pubmed publisher
    ..We also describe point mutations in human T-ALL that render cyclin-C-CDK unable to phosphorylate ICN1. Hence, tumour cells may develop different strategies to evade inhibition by cyclin C. ..
  7. Thomas Claudepierre A, Robert I, Rocha P, Raviram R, Schiavo E, Heyer V, et al. Mediator facilitates transcriptional activation and dynamic long-range contacts at the IgH locus during class switch recombination. J Exp Med. 2016;213:303-12 pubmed publisher
    ..Nevertheless, little is known about the underlying mechanisms. In this study, we show that Med1 and Med12, two subunits of the mediator complex implicated in transcription initiation and long-range enhancer/promoter loop ..