Mecom

Summary

Gene Symbol: Mecom
Description: MDS1 and EVI1 complex locus
Alias: D630039M04Rik, Evi-1, Evi1, Jbo, Mds, Mds1, Mds1-Evi1, Prdm3, Znfpr1b1, MDS1 and EVI1 complex locus protein, MDS1 and EVI1 complex locus protein EVI1, MDS1 and EVI1 complex locus protein MDS1, ecotropic viral integration site 1, ecotropic virus integration site 1 protein, myelodysplasia syndrome 1 protein homolog
Species: mouse
Products:     Mecom

Top Publications

  1. Chakraborty S, Senyuk V, Sitailo S, Chi Y, Nucifora G. Interaction of EVI1 with cAMP-responsive element-binding protein-binding protein (CBP) and p300/CBP-associated factor (P/CAF) results in reversible acetylation of EVI1 and in co-localization in nuclear speckles. J Biol Chem. 2001;276:44936-43 pubmed
    b>EVI1 is a very complex protein with two domains of zinc fingers and is inappropriately expressed in many types of human myeloid leukemias...
  2. Palmer S, Brouillet J, Kilbey A, Fulton R, Walker M, Crossley M, et al. Evi-1 transforming and repressor activities are mediated by CtBP co-repressor proteins. J Biol Chem. 2001;276:25834-40 pubmed
    Ectopic production of the EVI1 transcriptional repressor zinc finger protein is seen in 4--6% of human acute myeloid leukemias...
  3. Du Y, Jenkins N, Copeland N. Insertional mutagenesis identifies genes that promote the immortalization of primary bone marrow progenitor cells. Blood. 2005;106:3932-9 pubmed
    ..More than half of the lines have MSCV insertions at Evi1 or Prdm16. These loci encode transcription factor homologs and are validated human myeloid leukemia genes...
  4. Hoyt P, Bartholomew C, Davis A, Yutzey K, Gamer L, Potter S, et al. The Evi1 proto-oncogene is required at midgestation for neural, heart, and paraxial mesenchyme development. Mech Dev. 1997;65:55-70 pubmed
    The ecotropic viral integration site-1 (Evi1) locus was initially identified as a common site of retroviral integration in myeloid tumors of the AKXD-23 recombinant inbred mouse strain...
  5. Bartholomew C, Morishita K, Askew D, Buchberg A, Jenkins N, Copeland N, et al. Retroviral insertions in the CB-1/Fim-3 common site of integration activate expression of the Evi-1 gene. Oncogene. 1989;4:529-34 pubmed
    ..These results demonstrate that the CB-1/Fim-3 and Evi-1 loci constitute a large genomic region in which viral integrations activate the transcription of a new potential myeloid transforming gene. ..
  6. Bard Chapeau E, Jeyakani J, Kok C, Müller J, Chua B, Gunaratne J, et al. Ecotopic viral integration site 1 (EVI1) regulates multiple cellular processes important for cancer and is a synergistic partner for FOS protein in invasive tumors. Proc Natl Acad Sci U S A. 2012;109:2168-73 pubmed publisher
    b>Ecotropic viral integration site 1 (EVI1) is an oncogenic dual domain zinc finger transcription factor that plays an essential role in the regulation of hematopoietic stem cell renewal, and its overexpression in myeloid leukemia and ..
  7. Yoshimi A, Goyama S, Watanabe Okochi N, Yoshiki Y, Nannya Y, Nitta E, et al. Evi1 represses PTEN expression and activates PI3K/AKT/mTOR via interactions with polycomb proteins. Blood. 2011;117:3617-28 pubmed publisher
    Evi1 (ecotropic viral integration site 1) is essential for proliferation of hematopoietic stem cells and implicated in the development of myeloid disorders...
  8. Chi Y, Senyuk V, Chakraborty S, Nucifora G. EVI1 promotes cell proliferation by interacting with BRG1 and blocking the repression of BRG1 on E2F1 activity. J Biol Chem. 2003;278:49806-11 pubmed
    b>EVI1 is a complex protein required for embryogenesis and inappropriately expressed in many types of human myeloid leukemia...
  9. Yuasa H, Oike Y, Iwama A, Nishikata I, Sugiyama D, Perkins A, et al. Oncogenic transcription factor Evi1 regulates hematopoietic stem cell proliferation through GATA-2 expression. EMBO J. 2005;24:1976-87 pubmed
    The ecotropic viral integration site-1 (Evi1) is an oncogenic transcription factor in murine and human myeloid leukemia...
  10. Parkinson N, Hardisty Hughes R, Tateossian H, Tsai H, Brooker D, Morse S, et al. Mutation at the Evi1 locus in Junbo mice causes susceptibility to otitis media. PLoS Genet. 2006;2:e149 pubmed
    ..identified the causal mutation, a missense change in the C-terminal zinc finger region of the transcription factor Evi1. This protein is expressed in middle ear basal epithelial cells, fibroblasts, and neutrophil leukocytes at ..

Detail Information

Publications77

  1. Chakraborty S, Senyuk V, Sitailo S, Chi Y, Nucifora G. Interaction of EVI1 with cAMP-responsive element-binding protein-binding protein (CBP) and p300/CBP-associated factor (P/CAF) results in reversible acetylation of EVI1 and in co-localization in nuclear speckles. J Biol Chem. 2001;276:44936-43 pubmed
    b>EVI1 is a very complex protein with two domains of zinc fingers and is inappropriately expressed in many types of human myeloid leukemias...
  2. Palmer S, Brouillet J, Kilbey A, Fulton R, Walker M, Crossley M, et al. Evi-1 transforming and repressor activities are mediated by CtBP co-repressor proteins. J Biol Chem. 2001;276:25834-40 pubmed
    Ectopic production of the EVI1 transcriptional repressor zinc finger protein is seen in 4--6% of human acute myeloid leukemias...
  3. Du Y, Jenkins N, Copeland N. Insertional mutagenesis identifies genes that promote the immortalization of primary bone marrow progenitor cells. Blood. 2005;106:3932-9 pubmed
    ..More than half of the lines have MSCV insertions at Evi1 or Prdm16. These loci encode transcription factor homologs and are validated human myeloid leukemia genes...
  4. Hoyt P, Bartholomew C, Davis A, Yutzey K, Gamer L, Potter S, et al. The Evi1 proto-oncogene is required at midgestation for neural, heart, and paraxial mesenchyme development. Mech Dev. 1997;65:55-70 pubmed
    The ecotropic viral integration site-1 (Evi1) locus was initially identified as a common site of retroviral integration in myeloid tumors of the AKXD-23 recombinant inbred mouse strain...
  5. Bartholomew C, Morishita K, Askew D, Buchberg A, Jenkins N, Copeland N, et al. Retroviral insertions in the CB-1/Fim-3 common site of integration activate expression of the Evi-1 gene. Oncogene. 1989;4:529-34 pubmed
    ..These results demonstrate that the CB-1/Fim-3 and Evi-1 loci constitute a large genomic region in which viral integrations activate the transcription of a new potential myeloid transforming gene. ..
  6. Bard Chapeau E, Jeyakani J, Kok C, Müller J, Chua B, Gunaratne J, et al. Ecotopic viral integration site 1 (EVI1) regulates multiple cellular processes important for cancer and is a synergistic partner for FOS protein in invasive tumors. Proc Natl Acad Sci U S A. 2012;109:2168-73 pubmed publisher
    b>Ecotropic viral integration site 1 (EVI1) is an oncogenic dual domain zinc finger transcription factor that plays an essential role in the regulation of hematopoietic stem cell renewal, and its overexpression in myeloid leukemia and ..
  7. Yoshimi A, Goyama S, Watanabe Okochi N, Yoshiki Y, Nannya Y, Nitta E, et al. Evi1 represses PTEN expression and activates PI3K/AKT/mTOR via interactions with polycomb proteins. Blood. 2011;117:3617-28 pubmed publisher
    Evi1 (ecotropic viral integration site 1) is essential for proliferation of hematopoietic stem cells and implicated in the development of myeloid disorders...
  8. Chi Y, Senyuk V, Chakraborty S, Nucifora G. EVI1 promotes cell proliferation by interacting with BRG1 and blocking the repression of BRG1 on E2F1 activity. J Biol Chem. 2003;278:49806-11 pubmed
    b>EVI1 is a complex protein required for embryogenesis and inappropriately expressed in many types of human myeloid leukemia...
  9. Yuasa H, Oike Y, Iwama A, Nishikata I, Sugiyama D, Perkins A, et al. Oncogenic transcription factor Evi1 regulates hematopoietic stem cell proliferation through GATA-2 expression. EMBO J. 2005;24:1976-87 pubmed
    The ecotropic viral integration site-1 (Evi1) is an oncogenic transcription factor in murine and human myeloid leukemia...
  10. Parkinson N, Hardisty Hughes R, Tateossian H, Tsai H, Brooker D, Morse S, et al. Mutation at the Evi1 locus in Junbo mice causes susceptibility to otitis media. PLoS Genet. 2006;2:e149 pubmed
    ..identified the causal mutation, a missense change in the C-terminal zinc finger region of the transcription factor Evi1. This protein is expressed in middle ear basal epithelial cells, fibroblasts, and neutrophil leukocytes at ..
  11. Watanabe Okochi N, Yoshimi A, Sato T, Ikeda T, Kumano K, Taoka K, et al. The shortest isoform of C/EBP?, liver inhibitory protein (LIP), collaborates with Evi1 to induce AML in a mouse BMT model. Blood. 2013;121:4142-55 pubmed publisher
    b>Ecotropic viral integration site 1 (Evi1) is one of the master regulators in the development of acute myeloid leukemia (AML) and myelodysplastic syndrome...
  12. Kataoka K, Sato T, Yoshimi A, Goyama S, Tsuruta T, Kobayashi H, et al. Evi1 is essential for hematopoietic stem cell self-renewal, and its expression marks hematopoietic cells with long-term multilineage repopulating activity. J Exp Med. 2011;208:2403-16 pubmed publisher
    b>Ecotropic viral integration site 1 (Evi1), a transcription factor of the SET/PR domain protein family, is essential for the maintenance of hematopoietic stem cells (HSCs) in mice and is overexpressed in several myeloid malignancies...
  13. Tanaka T, Nishida J, Mitani K, Ogawa S, Yazaki Y, Hirai H. Evi-1 raises AP-1 activity and stimulates c-fos promoter transactivation with dependence on the second zinc finger domain. J Biol Chem. 1994;269:24020-6 pubmed
    ..We constructed deletion mutants of Evi-1 and investigated the functions of these domains. It was shown that the second zinc finger domain is essential for the activation of AP-1 and transactivation of the c-fos promoter. ..
  14. Morishita K, Parker D, Mucenski M, Jenkins N, Copeland N, Ihle J. Retroviral activation of a novel gene encoding a zinc finger protein in IL-3-dependent myeloid leukemia cell lines. Cell. 1988;54:831-40 pubmed
    ..This represents the first demonstration of the retroviral activation of a gene encoding a zinc finger protein and the first implication for a member of this gene family in the transformation of hematopoietic cells. ..
  15. Arai S, Yoshimi A, Shimabe M, Ichikawa M, Nakagawa M, Imai Y, et al. Evi-1 is a transcriptional target of mixed-lineage leukemia oncoproteins in hematopoietic stem cells. Blood. 2011;117:6304-14 pubmed publisher
    ..Our findings indicate that Evi-1 is one of the targets of MLL oncoproteins and is selectively activated in hematopoietic stem cell-derived MLL leukemic cells. ..
  16. Cheeseman M, Tyrer H, Williams D, Hough T, Pathak P, Romero M, et al. HIF-VEGF pathways are critical for chronic otitis media in Junbo and Jeff mouse mutants. PLoS Genet. 2011;7:e1002336 pubmed publisher
    ..Our analysis of the Junbo and Jeff mutants highlights the role of hypoxia and HIF-mediated pathways, and we conclude that targeting molecules in HIF-VEGF signaling pathways has therapeutic potential in the treatment of chronic OM. ..
  17. Funabiki T, Kreider B, Ihle J. The carboxyl domain of zinc fingers of the Evi-1 myeloid transforming gene binds a consensus sequence of GAAGATGAG. Oncogene. 1994;9:1575-81 pubmed
    ..Although Evi-1 contains potential transcriptional activation domains, it was not able to activate gene transcription from CAT constructs containing the consensus sequence. ..
  18. Perkins A, Mercer J, Jenkins N, Copeland N. Patterns of Evi-1 expression in embryonic and adult tissues suggest that Evi-1 plays an important regulatory role in mouse development. Development. 1991;111:479-87 pubmed
    ..Expression in the limb occurs at the highest levels from 9.5 to 12.5 days, is present in both hind and forelimbs, is absent at the apical ectodermal ridge, and does not appear to establish a gradient.(ABSTRACT TRUNCATED AT 250 WORDS) ..
  19. Dickstein J, Senyuk V, Premanand K, Laricchia Robbio L, Xu P, Cattaneo F, et al. Methylation and silencing of miRNA-124 by EVI1 and self-renewal exhaustion of hematopoietic stem cells in murine myelodysplastic syndrome. Proc Natl Acad Sci U S A. 2010;107:9783-8 pubmed publisher
    By expressing EVI1 in murine bone marrow (BM), we previously described a myelodysplastic syndrome (MDS) model characterized by pancytopenia, dysmegakaryopoiesis, dyserythropoiesis, and BM failure...
  20. Mucenski M, Taylor B, Copeland N, Jenkins N. Chromosomal location of Evi-1, a common site of ecotropic viral integration in AKXD murine myeloid tumors. Oncogene Res. 1988;2:219-33 pubmed
    ..These results suggest that Evi-1 represents a new locus involved in myeloid disease. ..
  21. Mucenski M, Taylor B, Ihle J, Hartley J, Morse H, Jenkins N, et al. Identification of a common ecotropic viral integration site, Evi-1, in the DNA of AKXD murine myeloid tumors. Mol Cell Biol. 1988;8:301-8 pubmed
    ..We designated this locus Evi-1 (ecotropic viral integration site 1)...
  22. Morishita K, Parganas E, Douglass E, Ihle J. Unique expression of the human Evi-1 gene in an endometrial carcinoma cell line: sequence of cDNAs and structure of alternatively spliced transcripts. Oncogene. 1990;5:963-71 pubmed
    ..The possible basis for the unique expression of the Evi-1 gene by HEC-1 cells could not be determined by karyotype or Southern blot analysis. ..
  23. Xu X, Woo C, Steere R, Lee B, Huang Y, Wu J, et al. EVI1 acts as an inducible negative-feedback regulator of NF-?B by inhibiting p65 acetylation. J Immunol. 2012;188:6371-80 pubmed publisher
    ..The molecular mechanisms underlying the tight regulation of inflammation remain largely unknown. Ecotropic viral integration site 1 (EVI1), a proto-oncogene and zinc finger transcription factor, plays important roles in normal ..
  24. Bordereaux D, Fichelson S, Tambourin P, Gisselbrecht S. Alternative splicing of the Evi-1 zinc finger gene generates mRNAs which differ by the number of zinc finger motifs. Oncogene. 1990;5:925-7 pubmed
    ..This was confirmed by Northern blot analysis and S1 mapping experiments. Therefore, the Evi-1 gene codes potentially for at least two proteins of 1042 and 718 amino acids differing in the numbers of their zinc-finger motifs. ..
  25. Yatsula B, Lin S, Read A, Poholek A, Yates K, Yue D, et al. Identification of binding sites of EVI1 in mammalian cells. J Biol Chem. 2005;280:30712-22 pubmed
    The leukemia-associated protein EVI1 possesses seven zinc fingers within an N-terminal domain (amino acids 1-250) that binds to GACAAGATA...
  26. Hirai H. The transcription factor Evi-1. Int J Biochem Cell Biol. 1999;31:1367-71 pubmed
    ..In the aspect of potential therapeutic approaches, some pharmaceutical drugs or antisense oligonucleotides that repress Evi-1 expression would be useful for the treatment of Evi-1-induced neoplastic tumors. ..
  27. Goyama S, Yamamoto G, Shimabe M, Sato T, Ichikawa M, Ogawa S, et al. Evi-1 is a critical regulator for hematopoietic stem cells and transformed leukemic cells. Cell Stem Cell. 2008;3:207-20 pubmed publisher
    ..Thus, Evi-1 is a common and critical regulator essential for proliferation of embryonic/adult HSCs and transformed leukemic cells. ..
  28. Matsugi T, Morishita K, Ihle J. Identification, nuclear localization, and DNA-binding activity of the zinc finger protein encoded by the Evi-1 myeloid transforming gene. Mol Cell Biol. 1990;10:1259-64 pubmed
    ..These antisera primarily detected a 145-kilodalton nuclear protein that bound double-stranded DNA. Binding was inhibited by chelating agents and partially restored by zinc ions. ..
  29. Shimabe M, Goyama S, Watanabe Okochi N, Yoshimi A, Ichikawa M, Imai Y, et al. Pbx1 is a downstream target of Evi-1 in hematopoietic stem/progenitors and leukemic cells. Oncogene. 2009;28:4364-74 pubmed publisher
    ..These results indicate that Pbx1 is a target gene of Evi-1 involved in Evi-1-mediated leukemogenesis. ..
  30. Laricchia Robbio L, Nucifora G. Significant increase of self-renewal in hematopoietic cells after forced expression of EVI1. Blood Cells Mol Dis. 2008;40:141-7 pubmed
    b>EVI1 was first identified as a preferential integration site of ecotropic retroviruses in the MDS1/EVI1 genomic locus leading to myeloid tumors in susceptible mice...
  31. Cardona M, Simonson O, Oprea I, Moreno P, Silva Lara M, Mohamed A, et al. A murine model of acute myeloid leukemia with Evi1 overexpression and autocrine stimulation by an intracellular form of GM-CSF in DA-3 cells. Leuk Lymphoma. 2016;57:183-92 pubmed publisher
    The poor treatment response of acute myeloid leukemia (AML) overexpressing high-risk oncogenes such as EVI1, demands specific animal models for new treatment evaluations...
  32. Norrander J, Larsson M, Stahl S, Hoog C, Linck R. Expression of ciliary tektins in brain and sensory development. J Neurosci. 1998;18:8912-8 pubmed
    ..The evolutionary conservation of tektins and their association with tubulin in cilia and centriole formation make them important and useful molecular targets for the study of neural development. ..
  33. Alliston T, Ko T, Cao Y, Liang Y, Feng X, Chang C, et al. Repression of bone morphogenetic protein and activin-inducible transcription by Evi-1. J Biol Chem. 2005;280:24227-37 pubmed
    ..In this way, Evi-1 acts as a general Smad corepressor to inhibit TGF-beta-, activin-, and BMP-inducible transcription. ..
  34. Perkins A, Kim J. Zinc fingers 1-7 of EVI1 fail to bind to the GATA motif by itself but require the core site GACAAGATA for binding. J Biol Chem. 1996;271:1104-10 pubmed
    b>EVI1 is a zinc finger oncoprotein that binds via fingers 1-7 to the sequence GACAAGATAA. The target genes on which EVI1 acts are unknown...
  35. Malik M, Jividen K, Padmakumar V, Cataisson C, Li L, Lee J, et al. Inducible NOS-induced chloride intracellular channel 4 (CLIC4) nuclear translocation regulates macrophage deactivation. Proc Natl Acad Sci U S A. 2012;109:6130-5 pubmed publisher
    ..In mice, genetically null for CLIC4, the number of phagocytosing macrophages stimulated by LPS is reduced. Thus, iNOS-induced nuclear CLIC4 is an essential part of the macrophage deactivation program. ..
  36. Clarke M, Volpe G, Sheriff L, Walton D, Ward C, Wei W, et al. Transcriptional regulation of SPROUTY2 by MYB influences myeloid cell proliferation and stem cell properties by enhancing responsiveness to IL-3. Leukemia. 2017;31:957-966 pubmed publisher
    ..MYB acts on MAPK signaling by directly regulating transcription of the gene encoding the negative modulator SPRY2. This mechanistic insight points to pathways that might be targeted therapeutically in MPN. ..
  37. Kobayashi H, Kobayashi C, Nakamura Ishizu A, Karigane D, Haeno H, Yamamoto K, et al. Bacterial c-di-GMP affects hematopoietic stem/progenitors and their niches through STING. Cell Rep. 2015;11:71-84 pubmed publisher
    ..Our results define machinery underlying the dynamic regulation of HSPCs and their niches during bacterial infection through c-di-GMP/STING signaling. ..
  38. Sayadi A, Jeyakani J, Seet S, Wei C, Bourque G, Bard F, et al. Functional features of EVI1 and EVI1Δ324 isoforms of MECOM gene in genome-wide transcription regulation and oncogenicity. Oncogene. 2016;35:2311-21 pubmed publisher
    The MDS1 and ecotropic viral integration site 1 (EVI1) complex locus (MECOM) gene encodes several transcription factor variants including MDS1-EVI1, EVI1 and EVI1Δ324...
  39. Boualia S, Gaitan Y, Tremblay M, Sharma R, Cardin J, Kania A, et al. A core transcriptional network composed of Pax2/8, Gata3 and Lim1 regulates key players of pro/mesonephros morphogenesis. Dev Biol. 2013;382:555-66 pubmed publisher
  40. Sato T, Goyama S, Kataoka K, Nasu R, Tsuruta Kishino T, Kagoya Y, et al. Evi1 defines leukemia-initiating capacity and tyrosine kinase inhibitor resistance in chronic myeloid leukemia. Oncogene. 2014;33:5028-38 pubmed publisher
    ..b>Ecotropic viral integration site 1 (EVI1), a key transcription factor in HSC regulation, is known to predict poor outcomes in myeloid ..
  41. Pinheiro I, Margueron R, Shukeir N, Eisold M, Fritzsch C, Richter F, et al. Prdm3 and Prdm16 are H3K9me1 methyltransferases required for mammalian heterochromatin integrity. Cell. 2012;150:948-60 pubmed publisher
    ..We developed a biochemical assay and used in vivo analyses in mouse embryonic fibroblasts to identify Prdm3 and Prdm16 as redundant H3K9me1-specific KMTs that direct cytoplasmic H3K9me1 methylation...
  42. Spensberger D, Delwel R. A novel interaction between the proto-oncogene Evi1 and histone methyltransferases, SUV39H1 and G9a. FEBS Lett. 2008;582:2761-7 pubmed publisher
    The transcription factor ecotropic viral integration site 1 (Evi1) is associated with acute myeloid leukemia (AML) and myelodysplastic syndrome (MDS) in patients due to chromosomal aberration of chromosome 3...
  43. Ishibashi J, Firtina Z, Rajakumari S, Wood K, Conroe H, Steger D, et al. An Evi1-C/EBP? complex controls peroxisome proliferator-activated receptor ?2 gene expression to initiate white fat cell differentiation. Mol Cell Biol. 2012;32:2289-99 pubmed publisher
    ..We show here that the zinc finger protein Evi1 increases in preadipocytes at the onset of differentiation prior to increases in PPAR? levels...
  44. Rodriguez Garcia M, Kozak C, Morgan R, Fernandez M. Mouse annexin V chromosomal localization, cDNA sequence conservation, and molecular evolution. Genomics. 1996;31:151-7 pubmed
    ..Comparison of nine species of ANX5 led to an estimation of the unit evolutionary mutation rate at 1% aa replacements every 8 million years, comparable to other annexins. ..
  45. Deng X, Cao Y, Liu Y, Li F, Sambandam K, Rajaraman S, et al. Overexpression of Evi-1 oncoprotein represses TGF-? signaling in colorectal cancer. Mol Carcinog. 2013;52:255-264 pubmed publisher
    ..We have also identified a novel Evi-1 transcript, Evi-1e, as the major Evi-1 transcript expressed in human CRCs. ..
  46. Boualia S, Gaitan Y, Murawski I, Nadon R, Gupta I, Bouchard M. Vesicoureteral reflux and other urinary tract malformations in mice compound heterozygous for Pax2 and Emx2. PLoS ONE. 2011;6:e21529 pubmed publisher
    ..As both genes are located on human chromosome 10q, which is lost in a proportion of VUR patients, these findings may help understand VUR and CAKUT in humans. ..
  47. Zhang Y, Stehling Sun S, Lezon Geyda K, Juneja S, Coillard L, Chatterjee G, et al. PR-domain-containing Mds1-Evi1 is critical for long-term hematopoietic stem cell function. Blood. 2011;118:3853-61 pubmed publisher
    The Mds1 and Evi1 complex locus (Mecom) gives rise to several alternative transcripts implicated in leukemogenesis. However, the contribution that Mecom-derived gene products make to normal hematopoiesis remains largely unexplored...
  48. Ashworth A, Denny P. Zinc finger protein genes in the mouse genome. Mamm Genome. 1991;1:196-200 pubmed
  49. Maicas M, Vázquez I, Alis R, Marcotegui N, Urquiza L, Cortés Lavaud X, et al. The MDS and EVI1 complex locus (MECOM) isoforms regulate their own transcription and have different roles in the transformation of hematopoietic stem and progenitor cells. Biochim Biophys Acta. 2017;1860:721-729 pubmed publisher
    Transcriptional activation of the EVI1 oncogene (3q26) leads to aggressive forms of human acute myeloid leukemia (AML). However, the mechanism of EVI1-mediated leukemogenesis has not been fully elucidated...
  50. Copeland N, Jenkins N. Retroviral integration in murine myeloid tumors to identify Evi-1, a novel locus encoding a zinc-finger protein. Adv Cancer Res. 1990;54:141-57 pubmed
  51. Broad T, Burkin D, Cambridge L, Lewis P, Maher D, Ansari H, et al. Four human chromosome 3q and four human chromosome 21 loci map onto sheep chromosome 1q. Mamm Genome. 1995;6:202-5 pubmed
    ..ceruloplasmin (CP), sucrase isomaltase (SI), glucose transporter 2 (GLUT2), and ectopic viral integration site 1 (EVI1)...
  52. Pandey K, Adamson M, Gu Y, Kozak C. Genetic mapping of the gene encoding guanylate cyclase-A/atrial natriuretic factor receptor (Npra) to mouse chromosome 3. Mamm Genome. 1994;5:520-2 pubmed
  53. Wimmer K, Vinatzer U, Zwirn P, Fonatsch C, Wieser R. Comparative expression analysis of the antagonistic transcription factors EVI1 and MDS1-EVI1 in murine tissues and during in vitro hematopoietic differentiation. Biochem Biophys Res Commun. 1998;252:691-6 pubmed
    An alternative form of the transcription factor EVI1, MDS1-EVI1, which previously had been believed to exist only in the context of leukemic fusion mRNAs, has recently been shown to be expressed also in normal human tissues...
  54. White D, Unwin R, Bindels E, Pierce A, Teng H, Muter J, et al. Phosphorylation of the leukemic oncoprotein EVI1 on serine 196 modulates DNA binding, transcriptional repression and transforming ability. PLoS ONE. 2013;8:e66510 pubmed publisher
    The EVI1 (ecotropic viral integration site 1) gene at 3q26 codes for a transcriptional regulator with an essential role in haematopoiesis...
  55. Spitkovsky D, Royer Pokora B, Delius H, Kisseljov F, Jenkins N, Gilbert D, et al. Tissue restricted expression and chromosomal localization of the YB-1 gene encoding a 42 kD nuclear CCAAT binding protein. Nucleic Acids Res. 1992;20:797-803 pubmed
    ..Finally, we have identified four YB-1 related loci in the mouse genome and have mapped these loci to four different mouse chromosomes by interspecific backcross analysis. ..
  56. Huang J, Wang Y, Liu F, Liu Y, Zhao C, Guo Y, et al. EVI1 promotes cell proliferation in HBx-induced hepatocarcinogenesis as a critical transcription factor regulating lncRNAs. Oncotarget. 2016;7:21887-99 pubmed publisher
    ..expressed lncRNAs in the livers of HBx transgenic mice by bioinformatics prediction, and found that ecotropic viral integration site 1 (Evi1) was a potential main transcription regulator...
  57. Bindels E, Havermans M, Lugthart S, Erpelinck C, Wocjtowicz E, Krivtsov A, et al. EVI1 is critical for the pathogenesis of a subset of MLL-AF9-rearranged AMLs. Blood. 2012;119:5838-49 pubmed publisher
    The proto-oncogene EVI1 (ecotropic viral integration site-1), located on chromosome band 3q26, is aberrantly expressed in human acute myeloid leukemia (AML) with 3q26 rearrangements...
  58. Senyuk V, Premanand K, Xu P, Qian Z, Nucifora G. The oncoprotein EVI1 and the DNA methyltransferase Dnmt3 co-operate in binding and de novo methylation of target DNA. PLoS ONE. 2011;6:e20793 pubmed publisher
    b>EVI1 has pleiotropic functions during murine embryogenesis and its targeted disruption leads to prenatal death by severely affecting the development of virtually all embryonic organs...
  59. Roy P, Reavey E, Rayne M, Roy S, Abed El Baky M, Ishii Y, et al. Enhanced sensitivity to hydrogen peroxide-induced apoptosis in Evi1 transformed Rat1 fibroblasts due to repression of carbonic anhydrase III. FEBS J. 2010;277:441-52 pubmed publisher
    b>EVI1 is a nuclear zinc finger protein essential to normal development, which participates in acute myeloid leukaemia progression and transforms Rat1 fibroblasts...
  60. Spensberger D, Vermeulen M, Le Guezennec X, Beekman R, van Hoven A, Bindels E, et al. Myeloid transforming protein Evi1 interacts with methyl-CpG binding domain protein 3 and inhibits in vitro histone deacetylation by Mbd3/Mi-2/NuRD. Biochemistry. 2008;47:6418-26 pubmed publisher
    The ecotropic viral integration site 1 ( Evi1) gene encodes a putative transcription regulator, which is aberrantly expressed in acute myeloid leukemias (AML) with chromosomal abnormalities involving the 3q26 locus...
  61. Nagamachi A, Htun P, Ma F, Miyazaki K, Yamasaki N, Kanno M, et al. A 5' untranslated region containing the IRES element in the Runx1 gene is required for angiogenesis, hematopoiesis and leukemogenesis in a knock-in mouse model. Dev Biol. 2010;345:226-36 pubmed publisher
    ..the roles of the IRES element in Runx1 function, we generated knock-in mice for either wild-type Runx1 or Runx1/Evi1, a Runx1 fusion protein identified in human leukemia...
  62. Okazaki T, Yoshida B, Avraham K, Wang H, Wuenschell C, Jenkins N, et al. Molecular diversity of the SCG10/stathmin gene family in the mouse. Genomics. 1993;18:360-73 pubmed
    ..These data are consistent with the idea that the neuron-specific SCG10 gene evolved by duplication and modification of the more broadly expressed stathmin/Lap18 gene. ..
  63. Wieser R. The oncogene and developmental regulator EVI1: expression, biochemical properties, and biological functions. Gene. 2007;396:346-57 pubmed
    The EVI1 gene codes for a zinc finger transcription factor with important roles both in normal development and in leukemogenesis...
  64. Buchberg A, Jenkins N, Copeland N. Localization of the murine macrophage colony-stimulating factor gene to chromosome 3 using interspecific backcross analysis. Genomics. 1989;5:363-7 pubmed
    ..The location of Csfm also identifies yet another mouse chromosome that shares synteny with human chromosome 5q, a region involved in several different types of myeloid disease. ..
  65. Nishikawa S, Arai S, Masamoto Y, Kagoya Y, Toya T, Watanabe Okochi N, et al. Thrombopoietin/MPL signaling confers growth and survival capacity to CD41-positive cells in a mouse model of Evi1 leukemia. Blood. 2014;124:3587-96 pubmed publisher
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