Gene Symbol: MCM9
Description: minichromosome maintenance 9 homologous recombination repair factor
Alias: 9030408O17Rik, Gm235, Mcmdc1, DNA helicase MCM9, DNA replication licensing factor MCM9, mini-chromosome maintenance deficient 9, mini-chromosome maintenance deficient domain-containing protein 1, minichromosome maintenance complex component 9, minichromosome maintenance deficient domain containing 1
Luo Y, Schimenti J. MCM9 deficiency delays primordial germ cell proliferation independent of the ATM pathway. Genesis. 2015;53:678-84 pubmed publisher
..genetic studies of DDR pathways that underlie germ cell depletion in mice mutant for minichromosome maintenance 9 (Mcm9), a gene that plays a role in homologous recombination repair (HRR)...
Lutzmann M, Maiorano D, Mechali M. Identification of full genes and proteins of MCM9, a novel, vertebrate-specific member of the MCM2-8 protein family. Gene. 2005;362:51-6 pubmed
..Here we report the complete identification of a novel member of this family, the MCM9 protein. Like MCM8, MCM9 is only present in the genome of higher eukaryotes...
Lamberti A, Sanges C, Chambery A, Migliaccio N, Rosso F, Di Maro A, et al
. Analysis of interaction partners for eukaryotic translation elongation factor 1A M-domain by functional proteomics. Biochimie. 2011;93:1738-46 pubmed publisher
..Interestingly, a co-localization of SORBS2 and eEF1A was evidenced at level of plasma membrane, thus suggesting the involvement of eEF1A1 in novel key signal transduction complexes. ..
Hartford S, Luo Y, Southard T, Min I, Lis J, Schimenti J. Minichromosome maintenance helicase paralog MCM9 is dispensible for DNA replication but functions in germ-line stem cells and tumor suppression. Proc Natl Acad Sci U S A. 2011;108:17702-7 pubmed publisher
..Many eukaryotes have a divergent paralog, MCM9, that was reported to be essential for loading MCM2-7 onto replication origins in the Xenopus oocyte extract system...
O Driscoll M. The pathological consequences of impaired genome integrity in humans; disorders of the DNA replication machinery. J Pathol. 2017;241:192-207 pubmed publisher
..Copyright © 2016 Pathological Society of Great Britain and Ireland. Published by John Wiley & Sons, Ltd. ..
Yoshida K. Identification of a novel cell-cycle-induced MCM family protein MCM9. Biochem Biophys Res Commun. 2005;331:669-74 pubmed
..Here we identified a novel MCM family gene, MCM9, by using bioinformatics. Human, mouse, and rat MCM9 showed approximately 90-91% total-amino acid identity...
Lutzmann M, Grey C, Traver S, Ganier O, Maya Mendoza A, Ranisavljevic N, et al
. MCM8- and MCM9-deficient mice reveal gametogenesis defects and genome instability due to impaired homologous recombination. Mol Cell. 2012;47:523-34 pubmed publisher
We generated knockout mice for MCM8 and MCM9 and show that deficiency for these genes impairs homologous recombination (HR)-mediated DNA repair during gametogenesis and somatic cells cycles...
Park J, Long D, Lee K, Abbas T, Shibata E, Negishi M, et al
. The MCM8-MCM9 complex promotes RAD51 recruitment at DNA damage sites to facilitate homologous recombination. Mol Cell Biol. 2013;33:1632-44 pubmed publisher
The minichromosome maintenance protein homologs MCM8 and MCM9 have previously been implicated in DNA replication elongation and prereplication complex (pre-RC) formation, respectively...