Gene Symbol: Mc5r
Description: melanocortin 5 receptor
Alias: melanocortin receptor 5, MC5-R
Species: mouse
Products:     Mc5r

Top Publications

  1. Chen W, Kelly M, Opitz Araya X, Thomas R, Low M, Cone R. Exocrine gland dysfunction in MC5-R-deficient mice: evidence for coordinated regulation of exocrine gland function by melanocortin peptides. Cell. 1997;91:789-98 pubmed
    ..These data show a requirement for the MC5-R in multiple exocrine glands for the production of numerous products, indicative of a coordinated system for regulation of exocrine gland function by melanocortin peptides. ..
  2. Maier H, Meixner M, Hartmann D, Sandhoff R, Wang Eckhardt L, Zöller I, et al. Normal fur development and sebum production depends on fatty acid 2-hydroxylase expression in sebaceous glands. J Biol Chem. 2011;286:25922-34 pubmed publisher
    ..These results underline the importance of the sebaceous glands and suggest a role of specific sebaceous gland or sebum lipids, synthesized by FA2H, in the hair follicle homeostasis. ..
  3. Nimura M, Udagawa J, Hatta T, Hashimoto R, Otani H. Spatial and temporal patterns of expression of melanocortin type 2 and 5 receptors in the fetal mouse tissues and organs. Anat Embryol (Berl). 2006;211:109-17 pubmed
    ..5 to E12.5 and from E13.5 to E18.5, respectively, while melanocortin type 5 receptors (MC5R) was not detected. In the mesonephros, MC2R and MC5R were expressed from E11.5 to E12...
  4. Sebag J, Hinkle P. Opposite effects of the melanocortin-2 (MC2) receptor accessory protein MRAP on MC2 and MC5 receptor dimerization and trafficking. J Biol Chem. 2009;284:22641-8 pubmed publisher
    ..These results establish that MRAP forms stable complexes with two different melanocortin receptors, facilitating surface expression of MC2 receptor but disrupting dimerization and surface localization of MC5 receptor. ..
  5. Morgan C, Thomas R, Cone R. Melanocortin-5 receptor deficiency promotes defensive behavior in male mice. Horm Behav. 2004;45:58-63 pubmed
    ..We assessed mice made deficient in the gene for the melanocortin-5 receptor (MC5R) to determine its role in pheromone-regulated behavior...
  6. Logan D, Bryson Richardson R, Pagán K, Taylor M, Currie P, Jackson I. The structure and evolution of the melanocortin and MCH receptors in fish and mammals. Genomics. 2003;81:184-91 pubmed
    ..Zebrafish have six melanocortin receptors, including two MC5R orthologues, while Fugu, lacking MC3R, has only four...
  7. Horsley V, O Carroll D, Tooze R, Ohinata Y, Saitou M, Obukhanych T, et al. Blimp1 defines a progenitor population that governs cellular input to the sebaceous gland. Cell. 2006;126:597-609 pubmed
  8. Labbe O, Desarnaud F, Eggerickx D, Vassart G, Parmentier M. Molecular cloning of a mouse melanocortin 5 receptor gene widely expressed in peripheral tissues. Biochemistry. 1994;33:4543-9 pubmed
    ..07 +/- 0.13 nM) and endowed with a pharmacological profile similar to that of the melanocyte MSH (MC1) receptor, but characterized by a broad tissue distribution.(ABSTRACT TRUNCATED AT 250 WORDS) ..
  9. Møller C, Raun K, Jacobsen M, Pedersen T, Holst B, Conde Frieboes K, et al. Characterization of murine melanocortin receptors mediating adipocyte lipolysis and examination of signalling pathways involved. Mol Cell Endocrinol. 2011;341:9-17 pubmed publisher
    ..So far, 5 different subtypes have been described (MC1R-MC5R) and of these MC2R and MC5R have been proposed to act directly in adipocytes and regulate lipolysis in rodents...

More Information


  1. Caldwell H, Lepri J. Disruption of the fifth melanocortin receptor alters the urinary excretion of aggression-modifying pheromones in male house mice. Chem Senses. 2002;27:91-4 pubmed
    ..These results are consistent with the hypothesis that activation of the fifth melanocortin receptor in the preputial glands of male house mice causes excretion of urinary pheromones that delay aggressive responses by other males. ..
  2. Hendrich B, Abbott C, McQueen H, Chambers D, Cross S, Bird A. Genomic structure and chromosomal mapping of the murine and human Mbd1, Mbd2, Mbd3, and Mbd4 genes. Mamm Genome. 1999;10:906-12 pubmed
    ..The Mbd1 and Mbd2 genes, in contrast, map together to murine and human Chromosomes (Chrs)18. The Mbd3 and Mbd4 genes map to murine Chrs 10 and 6, respectively, while the human MBD3 and MBD4 genes map to Chrs 19 and 3, respectively. ..
  3. Zemel M. Agouti/melanocortin interactions with leptin pathways in obesity. Nutr Rev. 1998;56:271-4 pubmed
    ..Both of these actions occur via a Ca(2+)-dependent mechanism, suggesting that modulation of adipocyte Ca2+ transport may be a key target for further investigation. ..
  4. Lee D, Taylor A. Both MC5r and A2Ar are required for protective regulatory immunity in the spleen of post-experimental autoimmune uveitis in mice. J Immunol. 2013;191:4103-11 pubmed publisher
    The ocular microenvironment uses a poorly defined mela5 receptor (MC5r)-dependent pathway to recover immune tolerance following intraocular inflammation...
  5. Gantz I, Shimoto Y, Konda Y, Miwa H, Dickinson C, Yamada T. Molecular cloning, expression, and characterization of a fifth melanocortin receptor. Biochem Biophys Res Commun. 1994;200:1214-20 pubmed
    ..Northern blot analysis demonstrated the expression of mMC5R mRNA in mouse skeletal muscle, lung, spleen, and brain. ..
  6. Lee D, Taylor A. Following EAU recovery there is an associated MC5r-dependent APC induction of regulatory immunity in the spleen. Invest Ophthalmol Vis Sci. 2011;52:8862-7 pubmed publisher
    ..Induction of this regulatory immunity is dependent on the expression of the melanocortin 5 receptor (MC5r)...
  7. Kiefer L, Veal J, Mountjoy K, Wilkison W. Melanocortin receptor binding determinants in the agouti protein. Biochemistry. 1998;37:991-7 pubmed
    ..These agouti variants with altered receptor selectivity may be useful in determining the role of melanocortin receptors in diabetes and obesity. ..
  8. Fathi Z, Iben L, Parker E. Cloning, expression, and tissue distribution of a fifth melanocortin receptor subtype. Neurochem Res. 1995;20:107-13 pubmed
    ..Lower but detectable levels of MC5 mRNA are also found in RT2-2 retinal neuronal cells, lung, testis, spleen, heart, kidney, and liver. ..
  9. O Shaughnessy P, Fleming L, Jackson G, Hochgeschwender U, Reed P, Baker P. Adrenocorticotropic hormone directly stimulates testosterone production by the fetal and neonatal mouse testis. Endocrinology. 2003;144:3279-84 pubmed
    ..Results show that both LH and ACTH can regulate testicular steroidogenesis during fetal development in the mouse and suggest that fetal Leydig cells, but not adult Leydig cells, are sensitive to ACTH stimulation. ..
  10. Rodrigues A, Almeida H, Gouveia A. Alpha-MSH signalling via melanocortin 5 receptor promotes lipolysis and impairs re-esterification in adipocytes. Biochim Biophys Acta. 2013;1831:1267-75 pubmed
    ..The aim of the current study was to investigate the role of melanocortin 5 receptor (MC5R) on alpha-melanocyte-stimulating hormone (alpha-MSH)-induced lipolysis in 3T3-L1 adipocytes...
  11. Schioth H, Fredriksson A, Carlsson C, Yook P, Muceniece R, Wikberg J. Evidence indicating that the extracellular loops of the mouse MC5 receptor do not participate in ligand binding. Mol Cell Endocrinol. 1998;139:109-15 pubmed
    ..Comparison of the wild type mMC5 receptor with the hMC5 receptor showed that it has the same potency order for the MSH peptides but considerably higher affinity than the hMC5 receptor. ..
  12. Jun D, Na K, Kim W, Kwak D, Kwon E, Yoon J, et al. Melanocortins induce interleukin 6 gene expression and secretion through melanocortin receptors 2 and 5 in 3T3-L1 adipocytes. J Mol Endocrinol. 2010;44:225-36 pubmed publisher
    ..Of the five MCRs that have been cloned, MC2R and MC5R are expressed during adipocyte differentiation...
  13. Etori M, Yonekubo K, Sato E, Mizukami K, Hirahara K, Karasuyama H, et al. Melanocortin receptors 1 and 5 might mediate inhibitory effects of ?-melanocyte-stimulating hormone on antigen-induced chronic allergic skin inflammation in IgE transgenic mice. J Invest Dermatol. 2012;132:1925-7 pubmed publisher
  14. Rodrigues A, Almeida H, Gouveia A. Melanocortin 5 receptor signaling and internalization: role of MAPK/ERK pathway and ?-arrestins 1/2. Mol Cell Endocrinol. 2012;361:69-79 pubmed publisher
    The Melanocortin 5 receptor (MC5R) is a G-protein coupled receptor (GPCR) that exhibits high affinity for ?-MSH...
  15. Lute B, Jou W, Lateef D, Goldgof M, Xiao C, Piñol R, et al. Biphasic effect of melanocortin agonists on metabolic rate and body temperature. Cell Metab. 2014;20:333-45 pubmed publisher
    ..a profound, transient hypometabolism/hypothermia that is preserved in mice lacking any one of Mc1r, Mc3r, Mc4r, or Mc5r. Three other melanocortin agonists also caused hypothermia, which is actively achieved via seeking a cool ..
  16. Korstanje R, Desai J, Lazar G, King B, Rollins J, Spurr M, et al. Quantitative trait loci affecting phenotypic variation in the vacuolated lens mouse mutant, a multigenic mouse model of neural tube defects. Physiol Genomics. 2008;35:296-304 pubmed publisher
    ..Bioinformatics and protein modeling suggest that these variants may be functional. Our studies further establish vl as a multigenic mouse model for NTDs and identify additional QTL that interact with Gpr161 to regulate neurulation. ..
  17. Morgan C, Cone R. Melanocortin-5 receptor deficiency in mice blocks a novel pathway influencing pheromone-induced aggression. Behav Genet. 2006;36:291-300 pubmed
    The rodent preputial gland secretes aggression-promoting pheromones and expresses melanocortin-5 receptor (MC5R), but the functional relationship is poorly understood...
  18. Schioth H, Muceniece R, Szardenings M, Prusis P, Wikberg J. Evidence indicating that the TM4, EL2, and TM5 of the melanocortin 3 receptor Do not participate in ligand binding. Biochem Biophys Res Commun. 1996;229:687-92 pubmed
    ..The data provide further evidence, that the mutated regions may not participate at all in ligand binding, as indicated by modelling experiments and homology comparison. ..