Mbp

Summary

Gene Symbol: Mbp
Description: myelin basic protein
Alias: C76307, Hmbpr, R75289, golli-mbp, jve, mld, shi, myelin basic protein, Golli-Mbp, myelin A1 protein, myelin deficient, shiverer
Species: mouse
Products:     Mbp

Top Publications

  1. Way S, McKenna J, Mietzsch U, Reith R, Wu H, Gambello M. Loss of Tsc2 in radial glia models the brain pathology of tuberous sclerosis complex in the mouse. Hum Mol Genet. 2009;18:1252-65 pubmed publisher
  2. Topilko P, Schneider Maunoury S, Levi G, Baron van Evercooren A, Chennoufi A, Seitanidou T, et al. Krox-20 controls myelination in the peripheral nervous system. Nature. 1994;371:796-9 pubmed
    ..myelin-associated glycoprotein, late myelin gene products are absent, including those for protein zero and myelin basic protein. Therefore Krox-20 is likely to control a set of genes required for completion of myelination in the ..
  3. Majava V, Wang C, Myllykoski M, Kangas S, Kang S, Hayashi N, et al. Structural analysis of the complex between calmodulin and full-length myelin basic protein, an intrinsically disordered molecule. Amino Acids. 2010;39:59-71 pubmed publisher
    b>Myelin basic protein (MBP) is present between the cytoplasmic leaflets of the compact myelin membrane in both the peripheral and central nervous systems, and characterized to be intrinsically disordered in solution...
  4. Stolt C, Lommes P, Friedrich R, Wegner M. Transcription factors Sox8 and Sox10 perform non-equivalent roles during oligodendrocyte development despite functional redundancy. Development. 2004;131:2349-58 pubmed
    ..Resulting differences in protein amounts might be a main reason for the weaker impact of Sox8 on oligodendrocyte development and for unidirectional compensation of the Sox8 loss by Sox10. ..
  5. Nave K. Neurological mouse mutants and the genes of myelin. J Neurosci Res. 1994;38:607-12 pubmed
    ..b>Shiverer, jimpy, Trembler, and protein zero (P0)-deficient mice demonstrate the overall function of myelination and have ..
  6. Ahmed M, Bamm V, Harauz G, Ladizhansky V. Solid-state NMR spectroscopy of membrane-associated myelin basic protein--conformation and dynamics of an immunodominant epitope. Biophys J. 2010;99:1247-55 pubmed publisher
    b>Myelin basic protein (MBP) maintains the tight multilamellar compaction of the myelin sheath in the central nervous system through peripheral binding of adjacent lipid bilayers of oligodendrocytes...
  7. Kosaras B, Kirschner D. Radial component of CNS myelin: junctional subunit structure and supramolecular assembly. J Neurocytol. 1990;19:187-99 pubmed
    ..g., shiverer, transgenic shiverer, myelin deficient and jimpy mutant mice); isolated CNS myelin, which has been shown by X-ray diffraction to be more stable than ..
  8. Qi Y, Cai J, Wu Y, Wu R, Lee J, Fu H, et al. Control of oligodendrocyte differentiation by the Nkx2.2 homeodomain transcription factor. Development. 2001;128:2723-33 pubmed
    ..We show that Nkx2.2 is also expressed in mammalian oligodendrocyte progenitors and that the differentiation of MBP-positive and PLP-DM20-positive oligodendrocytes is dramatically retarded in Nkx2...
  9. Klugmann M, Schwab M, Pühlhofer A, Schneider A, Zimmermann F, Griffiths I, et al. Assembly of CNS myelin in the absence of proteolipid protein. Neuron. 1997;18:59-70 pubmed
    ..quot; Dysmyelination and oligodendrocyte death emerge as an epiphenomenon of other PLP mutations and have been uncoupled in the PLP null allele from the risk of premature myelin breakdown. ..
  10. Griffiths I, Klugmann M, Anderson T, Yool D, Thomson C, Schwab M, et al. Axonal swellings and degeneration in mice lacking the major proteolipid of myelin. Science. 1998;280:1610-3 pubmed
    ..Similar swellings were absent in dysmyelinated shiverer mice, which lack myelin basic protein (MBP), but recurred in MBP*PLP double mutants...

Detail Information

Publications68

  1. Way S, McKenna J, Mietzsch U, Reith R, Wu H, Gambello M. Loss of Tsc2 in radial glia models the brain pathology of tuberous sclerosis complex in the mouse. Hum Mol Genet. 2009;18:1252-65 pubmed publisher
  2. Topilko P, Schneider Maunoury S, Levi G, Baron van Evercooren A, Chennoufi A, Seitanidou T, et al. Krox-20 controls myelination in the peripheral nervous system. Nature. 1994;371:796-9 pubmed
    ..myelin-associated glycoprotein, late myelin gene products are absent, including those for protein zero and myelin basic protein. Therefore Krox-20 is likely to control a set of genes required for completion of myelination in the ..
  3. Majava V, Wang C, Myllykoski M, Kangas S, Kang S, Hayashi N, et al. Structural analysis of the complex between calmodulin and full-length myelin basic protein, an intrinsically disordered molecule. Amino Acids. 2010;39:59-71 pubmed publisher
    b>Myelin basic protein (MBP) is present between the cytoplasmic leaflets of the compact myelin membrane in both the peripheral and central nervous systems, and characterized to be intrinsically disordered in solution...
  4. Stolt C, Lommes P, Friedrich R, Wegner M. Transcription factors Sox8 and Sox10 perform non-equivalent roles during oligodendrocyte development despite functional redundancy. Development. 2004;131:2349-58 pubmed
    ..Resulting differences in protein amounts might be a main reason for the weaker impact of Sox8 on oligodendrocyte development and for unidirectional compensation of the Sox8 loss by Sox10. ..
  5. Nave K. Neurological mouse mutants and the genes of myelin. J Neurosci Res. 1994;38:607-12 pubmed
    ..b>Shiverer, jimpy, Trembler, and protein zero (P0)-deficient mice demonstrate the overall function of myelination and have ..
  6. Ahmed M, Bamm V, Harauz G, Ladizhansky V. Solid-state NMR spectroscopy of membrane-associated myelin basic protein--conformation and dynamics of an immunodominant epitope. Biophys J. 2010;99:1247-55 pubmed publisher
    b>Myelin basic protein (MBP) maintains the tight multilamellar compaction of the myelin sheath in the central nervous system through peripheral binding of adjacent lipid bilayers of oligodendrocytes...
  7. Kosaras B, Kirschner D. Radial component of CNS myelin: junctional subunit structure and supramolecular assembly. J Neurocytol. 1990;19:187-99 pubmed
    ..g., shiverer, transgenic shiverer, myelin deficient and jimpy mutant mice); isolated CNS myelin, which has been shown by X-ray diffraction to be more stable than ..
  8. Qi Y, Cai J, Wu Y, Wu R, Lee J, Fu H, et al. Control of oligodendrocyte differentiation by the Nkx2.2 homeodomain transcription factor. Development. 2001;128:2723-33 pubmed
    ..We show that Nkx2.2 is also expressed in mammalian oligodendrocyte progenitors and that the differentiation of MBP-positive and PLP-DM20-positive oligodendrocytes is dramatically retarded in Nkx2...
  9. Klugmann M, Schwab M, Pühlhofer A, Schneider A, Zimmermann F, Griffiths I, et al. Assembly of CNS myelin in the absence of proteolipid protein. Neuron. 1997;18:59-70 pubmed
    ..quot; Dysmyelination and oligodendrocyte death emerge as an epiphenomenon of other PLP mutations and have been uncoupled in the PLP null allele from the risk of premature myelin breakdown. ..
  10. Griffiths I, Klugmann M, Anderson T, Yool D, Thomson C, Schwab M, et al. Axonal swellings and degeneration in mice lacking the major proteolipid of myelin. Science. 1998;280:1610-3 pubmed
    ..Similar swellings were absent in dysmyelinated shiverer mice, which lack myelin basic protein (MBP), but recurred in MBP*PLP double mutants...
  11. Brady S, Witt A, Kirkpatrick L, de Waegh S, Readhead C, Tu P, et al. Formation of compact myelin is required for maturation of the axonal cytoskeleton. J Neurosci. 1999;19:7278-88 pubmed
    ..The shiverer mutant mouse has a deletion in the myelin basic protein gene that eliminates compact myelin in the CNS...
  12. Finzsch M, Stolt C, Lommes P, Wegner M. Sox9 and Sox10 influence survival and migration of oligodendrocyte precursors in the spinal cord by regulating PDGF receptor alpha expression. Development. 2008;135:637-46 pubmed publisher
    ..We thus conclude that Sox9 and Sox10 are required in a functionally redundant manner in oligodendrocyte precursors for PDGF-dependent survival and migration. ..
  13. Polverini E, Boggs J, Bates I, Harauz G, Cavatorta P. Electron paramagnetic resonance spectroscopy and molecular modelling of the interaction of myelin basic protein (MBP) with calmodulin (CaM)-diversity and conformational adaptability of MBP CaM-targets. J Struct Biol. 2004;148:353-69 pubmed
    The classic 18.5 kDa isoform of murine myelin basic protein (mMBP) has been shown to bind calmodulin (CaM) strongly and specifically in vitro...
  14. Fu H, Qi Y, Tan M, Cai J, Takebayashi H, Nakafuku M, et al. Dual origin of spinal oligodendrocyte progenitors and evidence for the cooperative role of Olig2 and Nkx2.2 in the control of oligodendrocyte differentiation. Development. 2002;129:681-93 pubmed
    ..In support of this suggestion, inhibition of expression of these two transcription factors in culture by antisense oligonucleotides has an additive inhibitory effect on OLP differentiation and proteolipid protein (PLP) gene expression. ..
  15. Bamm V, De Avila M, Smith G, Ahmed M, Harauz G. Structured functional domains of myelin basic protein: cross talk between actin polymerization and Ca(2+)-dependent calmodulin interaction. Biophys J. 2011;101:1248-56 pubmed publisher
    The 18.5-kDa myelin basic protein (MBP), the most abundant isoform in human adult myelin, is a multifunctional, intrinsically disordered protein that maintains compact assembly of the sheath...
  16. Kimura M, Inoko H, Katsuki M, Ando A, Sato T, Hirose T, et al. Molecular genetic analysis of myelin-deficient mice: shiverer mutant mice show deletion in gene(s) coding for myelin basic protein. J Neurochem. 1985;44:692-6 pubmed
    The gene expression of myelin basic proteins (MBPs) in shiverer mutant mice was investigated by the Northern and Southern hybridization techniques...
  17. Ioannidou K, Anderson K, Strachan D, Edgar J, Barnett S. Time-lapse imaging of the dynamics of CNS glial-axonal interactions in vitro and ex vivo. PLoS ONE. 2012;7:e30775 pubmed publisher
    ..cord to which exogenous GFP-labelled murine cells were added, and ii) ex vivo imaging of the spinal cord of shiverer (Mbp mutant) mice, transplanted with GFP-labelled murine neurospheres...
  18. Foster L, Landry C, Phan T, Campagnoni A. Conditionally immortalized oligodendrocyte cell lines migrate to different brain regions and elaborate 'myelin-like' membranes after transplantation into neonatal shiverer mouse brains. Dev Neurosci. 1995;17:160-70 pubmed
    ..lines, representing a spectrum of different stages of oligodendrocyte maturation, were transplanted into neonatal shiverer mouse brains and examined for their ability to survive, multiply, and migrate in vivo...
  19. Bamm V, Ahmed M, Harauz G. Interaction of myelin basic protein with actin in the presence of dodecylphosphocholine micelles. Biochemistry. 2010;49:6903-15 pubmed publisher
    The 18.5 kDa myelin basic protein (MBP), the most abundant splice isoform in human adult myelin, is a multifunctional, intrinsically disordered protein that maintains compact assembly of the myelin sheath in the central nervous system...
  20. Calver A, Hall A, Yu W, Walsh F, Heath J, Betsholtz C, et al. Oligodendrocyte population dynamics and the role of PDGF in vivo. Neuron. 1998;20:869-82 pubmed
    ..Therefore, cell survival controls override proliferation controls for determining the final number and distribution of mature oligodendrocytes. ..
  21. Yoshikawa F, Sato Y, Tohyama K, Akagi T, Hashikawa T, Nagakura Takagi Y, et al. Opalin, a transmembrane sialylglycoprotein located in the central nervous system myelin paranodal loop membrane. J Biol Chem. 2008;283:20830-40 pubmed publisher
    ..These results suggest a role for highly sialylglycosylated Opalin in an intermembranous function of the myelin paranodal loops in the central nervous system. ..
  22. Bates I, Feix J, Boggs J, Harauz G. An immunodominant epitope of myelin basic protein is an amphipathic alpha-helix. J Biol Chem. 2004;279:5757-64 pubmed
    b>Myelin basic protein is a candidate autoantigen in multiple sclerosis. One of its dominant antigenic epitopes is segment Pro85 to Pro96 (human sequence numbering, corresponding to Pro82 to Pro93 in the mouse)...
  23. Friedrich R, Schlierf B, Tamm E, Bösl M, Wegner M. The class III POU domain protein Brn-1 can fully replace the related Oct-6 during schwann cell development and myelination. Mol Cell Biol. 2005;25:1821-9 pubmed
    ..Similar to Oct-6, Brn-1 down-regulated its own expression at later stages of myelination. Thus, class III POU domain proteins can fully replace each other in Schwann cell development. ..
  24. Jaegle M, Mandemakers W, Broos L, Zwart R, Karis A, Visser P, et al. The POU factor Oct-6 and Schwann cell differentiation. Science. 1996;273:507-10 pubmed
    ..Thus, Oct-6 appears to be required for the transition of promyelin cells to myelinating cells. Once these cells progress past this point, Oct-6 is no longer required, and myelination occurs normally. ..
  25. Foster L, Phan T, Verity A, Bredesen D, Campagnoni A. Generation and analysis of normal and shiverer temperature-sensitive immortalized cell lines exhibiting phenotypic characteristics of oligodendrocytes at several stages of differentiation. Dev Neurosci. 1993;15:100-9 pubmed
    ..normal mice and 9 derived from the neurological mutant shiverer, which is missing a large segment of the myelin basic protein gene...
  26. Vassall K, Bessonov K, De Avila M, Polverini E, Harauz G. The effects of threonine phosphorylation on the stability and dynamics of the central molecular switch region of 18.5-kDa myelin basic protein. PLoS ONE. 2013;8:e68175 pubmed publisher
    The classic isoforms of myelin basic protein (MBP) are essential for the formation and maintenance of myelin in the central nervous system of higher vertebrates...
  27. Ye F, Chen Y, Hoang T, Montgomery R, Zhao X, Bu H, et al. HDAC1 and HDAC2 regulate oligodendrocyte differentiation by disrupting the beta-catenin-TCF interaction. Nat Neurosci. 2009;12:829-38 pubmed publisher
    ..Thus, crosstalk between HDAC1/2 and the canonical Wnt signaling pathway mediated by TCF7L2 serves as a regulatory mechanism for oligodendrocyte differentiation. ..
  28. Galiano M, Andrieux A, Deloulme J, Bosc C, Schweitzer A, Job D, et al. Myelin basic protein functions as a microtubule stabilizing protein in differentiated oligodendrocytes. J Neurosci Res. 2006;84:534-41 pubmed
    b>Myelin basic protein (MBP) is an oligodendrocyte-specific protein essential for oligodendrocyte morphogenesis at late stages of cell differentiation...
  29. Harauz G, Ladizhansky V, Boggs J. Structural polymorphism and multifunctionality of myelin basic protein. Biochemistry. 2009;48:8094-104 pubmed publisher
    ..of oligodendrocyte lineage (golli) gives rise to a variety of developmentally regulated splice isoforms of myelin basic protein (MBP), denoted golli for early forms and classic for later ones...
  30. Edgar J, McLaughlin M, Yool D, Zhang S, Fowler J, Montague P, et al. Oligodendroglial modulation of fast axonal transport in a mouse model of hereditary spastic paraplegia. J Cell Biol. 2004;166:121-31 pubmed
    ..Our data demonstrate a novel role for oligodendrocytes in the local regulation of axonal function and have implications for the axonal loss associated with secondary progressive multiple sclerosis...
  31. Kao S, Wu H, Xie J, Chang C, Ranish J, Graef I, et al. Calcineurin/NFAT signaling is required for neuregulin-regulated Schwann cell differentiation. Science. 2009;323:651-4 pubmed publisher
    ..Our studies demonstrate that calcineurin and NFAT are essential for neuregulin and ErbB signaling, neural crest diversification, and differentiation of Schwann cells. ..
  32. Cossais F, Sock E, Hornig J, Schreiner S, Kellerer S, Bösl M, et al. Replacement of mouse Sox10 by the Drosophila ortholog Sox100B provides evidence for co-option of SoxE proteins into vertebrate-specific gene-regulatory networks through altered expression. Dev Biol. 2010;341:267-81 pubmed publisher
  33. Smith G, Chen L, Bamm V, Dutcher J, Harauz G. The interaction of zinc with membrane-associated 18.5 kDa myelin basic protein: an attenuated total reflectance-Fourier transform infrared spectroscopic study. Amino Acids. 2010;39:739-50 pubmed publisher
    b>Myelin basic protein (MBP) is an essential structural protein required for tight compaction of the myelin sheath of the central nervous system, and belongs to the family of intrinsically disordered proteins...
  34. Cabbage S, Huseby E, Sather B, Brabb T, Liggitt D, Goverman J. Regulatory T cells maintain long-term tolerance to myelin basic protein by inducing a novel, dynamic state of T cell tolerance. J Immunol. 2007;178:887-96 pubmed
    The pathogenesis of multiple sclerosis involves a breakdown in T cell tolerance to myelin proteins like myelin basic protein (MBP)...
  35. Casaccia Bonnefil P, Hardy R, Teng K, Levine J, Koff A, Chao M. Loss of p27Kip1 function results in increased proliferative capacity of oligodendrocyte progenitors but unaltered timing of differentiation. Development. 1999;126:4027-37 pubmed
    ..QKI) to identify embryonic glial progenitors, NG2 to identify neonatal oligodendrocyte progenitors, and myelin basic protein to label differentiated oligodendrocytes, we found an increased number of proliferating QKI- and NG2-..
  36. Dyer C, Philibotte T, Wolf M, Billings Gagliardi S. Myelin basic protein mediates extracellular signals that regulate microtubule stability in oligodendrocyte membrane sheets. J Neurosci Res. 1994;39:97-107 pubmed
    ..In this report, wild type and myelin basic protein (MBP)-deficient shiverer oligodendrocytes were used to study the possible relationships between these ..
  37. Tyszka J, Readhead C, Bearer E, Pautler R, Jacobs R. Statistical diffusion tensor histology reveals regional dysmyelination effects in the shiverer mouse mutant. Neuroimage. 2006;29:1058-65 pubmed
    ..important model of central nervous system dysmyelination characterized by a deletion in the gene encoding myelin basic protein with relevance to human dysmyelinating and demyelinating diseases...
  38. Cossais F, Wahlbuhl M, Kriesch J, Wegner M. SOX10 structure-function analysis in the chicken neural tube reveals important insights into its role in human neurocristopathies. Hum Mol Genet. 2010;19:2409-20 pubmed publisher
    ..This contributes to the phenotypic variability of human SOX10 mutations. ..
  39. Stolt C, Lommes P, Sock E, Chaboissier M, Schedl A, Wegner M. The Sox9 transcription factor determines glial fate choice in the developing spinal cord. Genes Dev. 2003;17:1677-89 pubmed
  40. Stolt C, Schlierf A, Lommes P, Hillgärtner S, Werner T, Kosian T, et al. SoxD proteins influence multiple stages of oligodendrocyte development and modulate SoxE protein function. Dev Cell. 2006;11:697-709 pubmed
    ..Our studies reveal a complex regulatory network between different groups of Sox proteins that is essential for proper progression of oligodendrocyte development. ..
  41. Schreiner S, Cossais F, Fischer K, Scholz S, Bösl M, Holtmann B, et al. Hypomorphic Sox10 alleles reveal novel protein functions and unravel developmental differences in glial lineages. Development. 2007;134:3271-81 pubmed
  42. Lu Q, Sun T, Zhu Z, Ma N, Garcia M, Stiles C, et al. Common developmental requirement for Olig function indicates a motor neuron/oligodendrocyte connection. Cell. 2002;109:75-86 pubmed
    ..Neither Olig gene is required for astrocytes. These findings, together with fate mapping analysis of Olig-expressing cells, indicate that oligodendrocytes are derived from Olig-specified progenitors that give rise also to neurons. ..
  43. Dupouey P, Jacque C, Bourre J, Cesselin F, Privat A, Baumann N. Immunochemical studies of myelin basic protein in shiverer mouse devoid of major dense line of myelin. Neurosci Lett. 1979;12:113-8 pubmed
    The myelin-deficient mutant Shiverer (Shi/Shi) lacks basic protein (MBP) in the myelin of its central nervous system (CNS)...
  44. Moreau Fauvarque C, Kumanogoh A, Camand E, Jaillard C, Barbin G, Boquet I, et al. The transmembrane semaphorin Sema4D/CD100, an inhibitor of axonal growth, is expressed on oligodendrocytes and upregulated after CNS lesion. J Neurosci. 2003;23:9229-39 pubmed
    ..This upregulation was transient because from 1 month after the lesion, Sema4D expression was back to its normal level. These results indicate that Sema4D is a novel inhibitory factor for axonal regeneration expressed in myelin. ..
  45. Privat A, Jacque C, Bourre J, Dupouey P, Baumann N. Absence of the major dense line in myelin of the mutant mouse "shiverer". Neurosci Lett. 1979;12:107-12 pubmed
    The myelin of the central nervous system (CNS) of the mutant mouse Shiverer is characterized by the absence of the major dense line (MDL)...
  46. Vogl M, Reiprich S, Küspert M, Kosian T, Schrewe H, Nave K, et al. Sox10 cooperates with the mediator subunit 12 during terminal differentiation of myelinating glia. J Neurosci. 2013;33:6679-90 pubmed publisher
    ..We conclude that Sox10 functions during terminal differentiation of myelinating glia, at least in part by Med12-dependent recruitment of the Mediator complex. ..
  47. Rasband M, Trimmer J, Peles E, Levinson S, Shrager P. K+ channel distribution and clustering in developing and hypomyelinated axons of the optic nerve. J Neurocytol. 1999;28:319-31 pubmed
    ..Developmental studies in hypomyelinating Shiverer mice revealed dramatically disrupted axoglial junctions, aberrant Na(+) channel clusters, and little or no ..
  48. Huseby E, Ohlen C, Goverman J. Cutting edge: myelin basic protein-specific cytotoxic T cell tolerance is maintained in vivo by a single dominant epitope in H-2k mice. J Immunol. 1999;163:1115-8 pubmed
    ..We demonstrate here that myelin basic protein (MBP) is processed in vivo by the MHC class I pathway leading to a MBP79-87/Kk complex...
  49. Perchellet A, Stromnes I, Pang J, Goverman J. CD8+ T cells maintain tolerance to myelin basic protein by 'epitope theft'. Nat Immunol. 2004;5:606-14 pubmed
    b>Myelin basic protein-specific CD8(+) T cells can induce central nervous system autoimmunity; however, immune tolerance prevents these autoreactive cells from causing disease...
  50. Stolt C, Rehberg S, Ader M, Lommes P, Riethmacher D, Schachner M, et al. Terminal differentiation of myelin-forming oligodendrocytes depends on the transcription factor Sox10. Genes Dev. 2002;16:165-70 pubmed
    ..Sox10 directly regulates myelin gene expression in oligodendrocytes, but does not control erbB3 expression as in peripheral glia. Sox10 thus functions in peripheral and central glia at different stages and through different mechanisms. ..
  51. Dyer C, Philibotte T, Billings Gagliardi S, Wolf M. Cytoskeleton in myelin-basic-protein-deficient shiverer oligodendrocytes. Dev Neurosci. 1995;17:53-62 pubmed
    ..Here we use the shiverer mutant mouse, which is missing a large segment of the myelin basic protein (MBP) gene, to investigate the possible role in cytoskeletal assembly of an MBP gene product or of other ..
  52. Hoffmann S, Hos D, Küspert M, Lang R, Lovell Badge R, Wegner M, et al. Stem cell factor Sox2 and its close relative Sox3 have differentiation functions in oligodendrocytes. Development. 2014;141:39-50 pubmed publisher
    ..This study presents one of the few cases in which SoxB1 proteins, including the stem cell factor Sox2, are associated with differentiation rather than precursor functions. ..
  53. Kellerer S, Schreiner S, Stolt C, Scholz S, Bösl M, Wegner M. Replacement of the Sox10 transcription factor by Sox8 reveals incomplete functional equivalence. Development. 2006;133:2875-86 pubmed
    ..We conclude that the extent of functional equivalence depends on the tissue and that, despite their relatedness, Sox8 and Sox10 have more unique functions than previously appreciated. ..
  54. Smith G, Seymour L, Boggs J, Harauz G. The 21.5-kDa isoform of myelin basic protein has a non-traditional PY-nuclear-localization signal. Biochem Biophys Res Commun. 2012;422:670-5 pubmed publisher
    The predominant 18.5-kDa classic myelin basic protein (MBP) is mainly responsible for compaction of the myelin sheath in the central nervous system, but is multifunctional, having numerous interactions with Ca(2+)-calmodulin, actin, ..
  55. Roach A, Boylan K, Horvath S, Prusiner S, Hood L. Characterization of cloned cDNA representing rat myelin basic protein: absence of expression in brain of shiverer mutant mice. Cell. 1983;34:799-806 pubmed
    ..A synthetic DNA probe synthesized based on reverse translation of the amino acid sequence of rat myelin basic protein (MBP) was used to select two cDNA clones encoding MBP. A 1...
  56. Smith G, De Avila M, Paez P, Spreuer V, Wills M, Jones N, et al. Proline substitutions and threonine pseudophosphorylation of the SH3 ligand of 18.5-kDa myelin basic protein decrease its affinity for the Fyn-SH3 domain and alter process development and protein localization in oligodendrocytes. J Neurosci Res. 2012;90:28-47 pubmed publisher
    ..The classic 18.5-kDa MBP isoform has a proline-rich region comprising amino acids 92-99 (murine sequence -T(92)PRTPPPS(99)-) that contains a ..
  57. Lafaille J, Nagashima K, Katsuki M, Tonegawa S. High incidence of spontaneous autoimmune encephalomyelitis in immunodeficient anti-myelin basic protein T cell receptor transgenic mice. Cell. 1994;78:399-408 pubmed
    We have generated TCR transgenic mice (T/R+) specific for myelin basic protein (MBP) and crossed them to RAG-1-deficient mice to obtain mice (T/R-) that have T cells expressing the transgenic TCR but no other lymphocytes...
  58. Zujovic V, Thibaud J, Bachelin C, Vidal M, Deboux C, Coulpier F, et al. Boundary cap cells are peripheral nervous system stem cells that can be redirected into central nervous system lineages. Proc Natl Acad Sci U S A. 2011;108:10714-9 pubmed publisher
  59. Gokhan S, Marin Husstege M, Yung S, Fontanez D, Casaccia Bonnefil P, Mehler M. Combinatorial profiles of oligodendrocyte-selective classes of transcriptional regulators differentially modulate myelin basic protein gene expression. J Neurosci. 2005;25:8311-21 pubmed
    ..Transient transfections of these precise combinatorial codes with a luciferase reporter gene driven by the myelin basic protein promoter define how changes in the molecular composition of these transcriptional complexes modulate myelin ..
  60. Wang S, Dulin J, Wu H, Hurlock E, Lee S, Jansson K, et al. An oligodendrocyte-specific zinc-finger transcription regulator cooperates with Olig2 to promote oligodendrocyte differentiation. Development. 2006;133:3389-98 pubmed
    ..Its expression increases in parallel with that of major myelin genes Mbp and Plp1. Zfp488 is a nuclear protein that possesses transcriptional repression activity...
  61. Homchaudhuri L, De Avila M, Nilsson S, Bessonov K, Smith G, Bamm V, et al. Secondary structure and solvent accessibility of a calmodulin-binding C-terminal segment of membrane-associated myelin basic protein. Biochemistry. 2010;49:8955-66 pubmed publisher
    b>Myelin basic protein (MBP), specifically the 18.5 kDa isoform, is a peripheral membrane protein and a major component of mammalian central nervous system myelin...
  62. Finzsch M, Schreiner S, Kichko T, Reeh P, Tamm E, Bösl M, et al. Sox10 is required for Schwann cell identity and progression beyond the immature Schwann cell stage. J Cell Biol. 2010;189:701-12 pubmed publisher
    ..Schwann cells failed to develop beyond the immature stage and were unable to maintain identity. Thus, our study identifies a novel cause for peripheral neuropathies in patients with SOX10 mutations. ..
  63. Aggarwal S, Snaidero N, Pähler G, Frey S, Sanchez P, Zweckstetter M, et al. Myelin membrane assembly is driven by a phase transition of myelin basic proteins into a cohesive protein meshwork. PLoS Biol. 2013;11:e1001577 pubmed publisher
    ..Here, we show that myelin basic protein drives myelin biogenesis using weak forces arising from its inherent capacity to phase separate...
  64. Barbarese E, Nielson M, Carson J. The effect of the shiverer mutation on myelin basic protein expression in homozygous and heterozygous mouse brain. J Neurochem. 1983;40:1680-6 pubmed
    We report (a) that the shiverer mutation has pleiotropic phenotypic effects on myelin basic protein expression in the CNS of homozygous (shi/shi) mice and (b) that each of the effects of the shiverer allele is expressed co-dominantly with ..
  65. Smith G, Samborska B, Hawley S, Klaiman J, Gillis T, Jones N, et al. Nucleus-localized 21.5-kDa myelin basic protein promotes oligodendrocyte proliferation and enhances neurite outgrowth in coculture, unlike the plasma membrane-associated 18.5-kDa isoform. J Neurosci Res. 2013;91:349-62 pubmed publisher
    The classic myelin basic protein (MBP) family of central nervous system (CNS) myelin arises from transcription start site 3 of the Golli (gene of oligodendrocyte lineage) complex and comprises splice isoforms ranging in nominal molecular ..
  66. Sugimori M, Nagao M, Parras C, Nakatani H, Lebel M, Guillemot F, et al. Ascl1 is required for oligodendrocyte development in the spinal cord. Development. 2008;135:1271-81 pubmed publisher
    ..Thus, Ascl1 regulates multiple aspects of oligodendrocyte development in the spinal cord. ..
  67. Boggs J, Homchaudhuri L, Ranagaraj G, Liu Y, Smith G, Harauz G. Interaction of myelin basic protein with cytoskeletal and signaling proteins in cultured primary oligodendrocytes and N19 oligodendroglial cells. BMC Res Notes. 2014;7:387 pubmed publisher
    The classic myelin basic protein (MBP) isoforms are intrinsically-disordered proteins of 14-21...