Mbp

Summary

Gene Symbol: Mbp
Description: myelin basic protein
Alias: C76307, Hmbpr, R75289, golli-mbp, mld, shi, myelin A1 protein, myelin deficient, shiverer
Species: mouse

Top Publications

  1. pmc BMP signaling mutant mice exhibit glial cell maturation defects
    Jill See
    Department of Research Neurology, Children s Hospital of Philadelphia, Philadelphia, PA 19104, USA
    Mol Cell Neurosci 35:171-82. 2007
  2. pmc Oligodendroglial modulation of fast axonal transport in a mouse model of hereditary spastic paraplegia
    Julia M Edgar
    Applied Neurobiology Group, Institute of Comparative Medicine, University of Glasgow, Scotland, UK
    J Cell Biol 166:121-31. 2004
  3. ncbi Common developmental requirement for Olig function indicates a motor neuron/oligodendrocyte connection
    Q Richard Lu
    Department of Cancer Biology, Dana Farber Cancer Institute, Harvard Medical School, 44 Binney Street, Boston, MA 02115, USA
    Cell 109:75-86. 2002
  4. ncbi Krox-20 controls myelination in the peripheral nervous system
    P Topilko
    Unité 368 de l Institut National de la Santé et de la Recherche Médicale, Ecole Normale Superieure, Paris, France
    Nature 371:796-9. 1994
  5. ncbi Axonal swellings and degeneration in mice lacking the major proteolipid of myelin
    I Griffiths
    Applied Neurobiology Group, Department of Veterinary Clinical Studies, University of Glasgow, Glasgow G61 1QH, Scotland, UK
    Science 280:1610-3. 1998
  6. pmc Statistical diffusion tensor histology reveals regional dysmyelination effects in the shiverer mouse mutant
    J Michael Tyszka
    Biological Imaging Center, Division of Biology, California Institute of Technology, 2Q Broad 114 96, 1200 E California Blvd, Pasadena, CA 91125, USA
    Neuroimage 29:1058-65. 2006
  7. ncbi K+ channel distribution and clustering in developing and hypomyelinated axons of the optic nerve
    M N Rasband
    Department of Biochemistry and Biophysics, University of Rochester Medical Center, Rochester, NY 14642, USA
    J Neurocytol 28:319-31. 1999
  8. ncbi Molecular genetic analysis of myelin-deficient mice: shiverer mutant mice show deletion in gene(s) coding for myelin basic protein
    M Kimura
    J Neurochem 44:692-6. 1985
  9. ncbi Immunochemical studies of myelin basic protein in shiverer mouse devoid of major dense line of myelin
    P Dupouey
    Neurosci Lett 12:113-8. 1979
  10. ncbi Formation of compact myelin is required for maturation of the axonal cytoskeleton
    S T Brady
    University of Texas Southwestern Medical Center, Department of Cell Biology and Neuroscience, Dallas, Texas 75235 9039, USA
    J Neurosci 19:7278-88. 1999

Scientific Experts

Detail Information

Publications97

  1. pmc BMP signaling mutant mice exhibit glial cell maturation defects
    Jill See
    Department of Research Neurology, Children s Hospital of Philadelphia, Philadelphia, PA 19104, USA
    Mol Cell Neurosci 35:171-82. 2007
    ....
  2. pmc Oligodendroglial modulation of fast axonal transport in a mouse model of hereditary spastic paraplegia
    Julia M Edgar
    Applied Neurobiology Group, Institute of Comparative Medicine, University of Glasgow, Scotland, UK
    J Cell Biol 166:121-31. 2004
    ..Our data demonstrate a novel role for oligodendrocytes in the local regulation of axonal function and have implications for the axonal loss associated with secondary progressive multiple sclerosis...
  3. ncbi Common developmental requirement for Olig function indicates a motor neuron/oligodendrocyte connection
    Q Richard Lu
    Department of Cancer Biology, Dana Farber Cancer Institute, Harvard Medical School, 44 Binney Street, Boston, MA 02115, USA
    Cell 109:75-86. 2002
    ..Neither Olig gene is required for astrocytes. These findings, together with fate mapping analysis of Olig-expressing cells, indicate that oligodendrocytes are derived from Olig-specified progenitors that give rise also to neurons...
  4. ncbi Krox-20 controls myelination in the peripheral nervous system
    P Topilko
    Unité 368 de l Institut National de la Santé et de la Recherche Médicale, Ecole Normale Superieure, Paris, France
    Nature 371:796-9. 1994
    ..Therefore Krox-20 is likely to control a set of genes required for completion of myelination in the peripheral nervous system...
  5. ncbi Axonal swellings and degeneration in mice lacking the major proteolipid of myelin
    I Griffiths
    Applied Neurobiology Group, Department of Veterinary Clinical Studies, University of Glasgow, Glasgow G61 1QH, Scotland, UK
    Science 280:1610-3. 1998
    ..Similar swellings were absent in dysmyelinated shiverer mice, which lack myelin basic protein (MBP), but recurred in MBP*PLP double mutants...
  6. pmc Statistical diffusion tensor histology reveals regional dysmyelination effects in the shiverer mouse mutant
    J Michael Tyszka
    Biological Imaging Center, Division of Biology, California Institute of Technology, 2Q Broad 114 96, 1200 E California Blvd, Pasadena, CA 91125, USA
    Neuroimage 29:1058-65. 2006
    b>Shiverer is an important model of central nervous system dysmyelination characterized by a deletion in the gene encoding myelin basic protein with relevance to human dysmyelinating and demyelinating diseases...
  7. ncbi K+ channel distribution and clustering in developing and hypomyelinated axons of the optic nerve
    M N Rasband
    Department of Biochemistry and Biophysics, University of Rochester Medical Center, Rochester, NY 14642, USA
    J Neurocytol 28:319-31. 1999
    ..Developmental studies in hypomyelinating Shiverer mice revealed dramatically disrupted axoglial junctions, aberrant Na(+) channel clusters, and little or no ..
  8. ncbi Molecular genetic analysis of myelin-deficient mice: shiverer mutant mice show deletion in gene(s) coding for myelin basic protein
    M Kimura
    J Neurochem 44:692-6. 1985
    The gene expression of myelin basic proteins (MBPs) in shiverer mutant mice was investigated by the Northern and Southern hybridization techniques...
  9. ncbi Immunochemical studies of myelin basic protein in shiverer mouse devoid of major dense line of myelin
    P Dupouey
    Neurosci Lett 12:113-8. 1979
    The myelin-deficient mutant Shiverer (Shi/Shi) lacks basic protein (MBP) in the myelin of its central nervous system (CNS)...
  10. ncbi Formation of compact myelin is required for maturation of the axonal cytoskeleton
    S T Brady
    University of Texas Southwestern Medical Center, Department of Cell Biology and Neuroscience, Dallas, Texas 75235 9039, USA
    J Neurosci 19:7278-88. 1999
    ..1992), but little is known about effects of oligodendrocytes on CNS axons. The shiverer mutant mouse has a deletion in the myelin basic protein gene that eliminates compact myelin in the CNS...
  11. ncbi Cutting edge: myelin basic protein-specific cytotoxic T cell tolerance is maintained in vivo by a single dominant epitope in H-2k mice
    E S Huseby
    Department of Immunology, University of Washington, Seattle 98195, USA
    J Immunol 163:1115-8. 1999
    ..We demonstrate here that myelin basic protein (MBP) is processed in vivo by the MHC class I pathway leading to a MBP79-87/Kk complex...
  12. ncbi Coronin 3 and its role in murine brain morphogenesis
    Andreas Hasse
    Center for Biochemistry and Center of Molecular Medicine Cologne, Medical Faculty, University of Cologne, Joseph Stelzmann Strasse 52, D 50931 Koeln, Germany
    Eur J Neurosci 21:1155-68. 2005
    ..Full-length coronin 3 among other areas localized to outgrowing neurites, whereas truncated proteins efficiently suppressed neurite formation. Our results favour a role for coronin 3 in neuron morphogenesis and possibly migration...
  13. pmc Recombination within the myelin basic protein gene created the dysmyelinating shiverer mouse mutation
    S M Molineaux
    Proc Natl Acad Sci U S A 83:7542-6. 1986
    b>Shiverer (shi) is an autosomal recessive mutation in the mouse characterized by an almost total lack of central nervous system myelin...
  14. ncbi The effect of the shiverer mutation on myelin basic protein expression in homozygous and heterozygous mouse brain
    E Barbarese
    J Neurochem 40:1680-6. 1983
    We report (a) that the shiverer mutation has pleiotropic phenotypic effects on myelin basic protein expression in the CNS of homozygous (shi/shi) mice and (b) that each of the effects of the shiverer allele is expressed co-dominantly with ..
  15. ncbi Absence of the major dense line in myelin of the mutant mouse "shiverer"
    A Privat
    Neurosci Lett 12:107-12. 1979
    The myelin of the central nervous system (CNS) of the mutant mouse Shiverer is characterized by the absence of the major dense line (MDL)...
  16. ncbi High incidence of spontaneous autoimmune encephalomyelitis in immunodeficient anti-myelin basic protein T cell receptor transgenic mice
    J J Lafaille
    Howard Hughes Medical Institute, Department of Biology, Massachusetts Institute of Technology, Cambridge 02139
    Cell 78:399-408. 1994
    We have generated TCR transgenic mice (T/R+) specific for myelin basic protein (MBP) and crossed them to RAG-1-deficient mice to obtain mice (T/R-) that have T cells expressing the transgenic TCR but no other lymphocytes...
  17. ncbi Oligodendrocyte population dynamics and the role of PDGF in vivo
    A R Calver
    MRC Laboratory for Molecular Cell Biology and Department of Biology, University College London, United Kingdom
    Neuron 20:869-82. 1998
    ..Therefore, cell survival controls override proliferation controls for determining the final number and distribution of mature oligodendrocytes...
  18. ncbi Regulatory T cells maintain long-term tolerance to myelin basic protein by inducing a novel, dynamic state of T cell tolerance
    Sarah E Cabbage
    Molecular and Cellular Biology Program, Department of Immunology, University of Washington, Seattle, WA 98195, USA
    J Immunol 178:887-96. 2007
    ..of multiple sclerosis involves a breakdown in T cell tolerance to myelin proteins like myelin basic protein (MBP)...
  19. ncbi The transmembrane semaphorin Sema4D/CD100, an inhibitor of axonal growth, is expressed on oligodendrocytes and upregulated after CNS lesion
    Caroline Moreau-Fauvarque
    Institut National de la Santé et de la Recherche Médicale U106, Hopital de la Salpetriere, 75013 Paris, France
    J Neurosci 23:9229-39. 2003
    ..This upregulation was transient because from 1 month after the lesion, Sema4D expression was back to its normal level. These results indicate that Sema4D is a novel inhibitory factor for axonal regeneration expressed in myelin...
  20. ncbi Combinatorial profiles of oligodendrocyte-selective classes of transcriptional regulators differentially modulate myelin basic protein gene expression
    Solen Gokhan
    Institute for Brain Disorders and Neural Regeneration, Albert Einstein College of Medicine, Bronx, New York 10461, USA
    J Neurosci 25:8311-21. 2005
    ....
  21. ncbi Loss of p27Kip1 function results in increased proliferative capacity of oligodendrocyte progenitors but unaltered timing of differentiation
    P Casaccia-Bonnefil
    Molecular Neurobiology, Skirball Institute for Biomolecular Medicine at NYU Medical Center, New York, NY 10016, USA nyu edu
    Development 126:4027-37. 1999
    ....
  22. ncbi Neurological mouse mutants and the genes of myelin
    K A Nave
    Zentrum fur Molekulare Biologie, Universitat Heidelberg, Germany
    J Neurosci Res 38:607-12. 1994
    ..b>Shiverer, jimpy, Trembler, and protein zero (P0)-deficient mice demonstrate the overall function of myelination and have ..
  23. ncbi CD8+ T cells maintain tolerance to myelin basic protein by 'epitope theft'
    Antoine Perchellet
    Department of Immunology, University of Washington, Box 357650, Seattle, Washington 98195, USA
    Nat Immunol 5:606-14. 2004
    ..with different affinities for the H-2K(k)-restricted myelin basic protein epitope consisting of amino acids 79-87 (MBP(79-87)). We observed both thymic deletion and peripheral tolerance in the lower-affinity T cells...
  24. ncbi Assembly of CNS myelin in the absence of proteolipid protein
    M Klugmann
    Zentrum für Molekulare Biologie ZMBH University of Heidelburg, Federal Republic of Germany
    Neuron 18:59-70. 1997
    ..Dysmyelination and oligodendrocyte death emerge as an epiphenomenon of other PLP mutations and have been uncoupled in the PLP null allele from the risk of premature myelin breakdown...
  25. ncbi An oligodendrocyte-specific zinc-finger transcription regulator cooperates with Olig2 to promote oligodendrocyte differentiation
    Shu Zong Wang
    Center for Developmental Biology and Kent Waldrep Foundation Center for Basic Neuroscience Research on Nerve Growth and Regeneration, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA
    Development 133:3389-98. 2006
    ..Its expression increases in parallel with that of major myelin genes Mbp and Plp1. Zfp488 is a nuclear protein that possesses transcriptional repression activity...
  26. ncbi Control of oligodendrocyte differentiation by the Nkx2.2 homeodomain transcription factor
    Y Qi
    Department of Anatomical Sciences and Neurobiology, School of Medicine, University of Louisville, Louisville, KY 40292, USA
    Development 128:2723-33. 2001
    ..We show that Nkx2.2 is also expressed in mammalian oligodendrocyte progenitors and that the differentiation of MBP-positive and PLP-DM20-positive oligodendrocytes is dramatically retarded in Nkx2...
  27. pmc Terminal differentiation of myelin-forming oligodendrocytes depends on the transcription factor Sox10
    C Claus Stolt
    Institut fur Biochemie, Universitat Erlangen Nurnberg, 91054 Erlangen, Germany
    Genes Dev 16:165-70. 2002
    ..Sox10 directly regulates myelin gene expression in oligodendrocytes, but does not control erbB3 expression as in peripheral glia. Sox10 thus functions in peripheral and central glia at different stages and through different mechanisms...
  28. ncbi The POU factor Oct-6 and Schwann cell differentiation
    M Jaegle
    Medical Genetics Center, Department of Cell Biology and Genetics, Erasmus University, Post Office Box 1738, 3000 DR Rotterdam, Netherlands
    Science 273:507-10. 1996
    ..Thus, Oct-6 appears to be required for the transition of promyelin cells to myelinating cells. Once these cells progress past this point, Oct-6 is no longer required, and myelination occurs normally...
  29. ncbi Changes in microtubule stability and density in myelin-deficient shiverer mouse CNS axons
    L L Kirkpatrick
    Department of Cell Biology, University of Texas Southwestern Medical Center, Dallas, Texas 75235, USA
    J Neurosci 21:2288-97. 2001
    ..and CNS myelination have equivalent effects on axons, neurofilaments, and microtubules in CNS, myelin-deficient shiverer axons were examined...
  30. pmc Opalin, a transmembrane sialylglycoprotein located in the central nervous system myelin paranodal loop membrane
    Fumio Yoshikawa
    Laboratory for Molecular Neurogenesis and Laboratory for Neural Architecture, RIKEN Brain Science Institute, Wako, Japan
    J Biol Chem 283:20830-40. 2008
    ..These results suggest a role for highly sialylglycosylated Opalin in an intermembranous function of the myelin paranodal loops in the central nervous system...
  31. ncbi Hypomorphic Sox10 alleles reveal novel protein functions and unravel developmental differences in glial lineages
    Silke Schreiner
    Institut fur Biochemie, Emil Fischer Zentrum, Universitat Erlangen, Fahrstrasse 17, D 91054 Erlangen, Germany
    Development 134:3271-81. 2007
    ....
  32. doi Replacement of mouse Sox10 by the Drosophila ortholog Sox100B provides evidence for co-option of SoxE proteins into vertebrate-specific gene-regulatory networks through altered expression
    François Cossais
    Institut fur Biochemie, Emil Fischer Zentrum, Universitat Erlangen, Fahrstrasse 17, D 91054 Erlangen, Germany
    Dev Biol 341:267-81. 2010
    ....
  33. ncbi Replacement of the Sox10 transcription factor by Sox8 reveals incomplete functional equivalence
    Susanne Kellerer
    Institut fur Biochemie, Universitat Erlangen, Fahrstrasse 17, D 91054 Erlangen, Germany
    Development 133:2875-86. 2006
    ..We conclude that the extent of functional equivalence depends on the tissue and that, despite their relatedness, Sox8 and Sox10 have more unique functions than previously appreciated...
  34. pmc The class III POU domain protein Brn-1 can fully replace the related Oct-6 during schwann cell development and myelination
    Ralf P Friedrich
    Institut fur Biochemie, Universitat Erlangen, Fahrstrasse 17, 91054 Erlangen, Germany
    Mol Cell Biol 25:1821-9. 2005
    ..Similar to Oct-6, Brn-1 down-regulated its own expression at later stages of myelination. Thus, class III POU domain proteins can fully replace each other in Schwann cell development...
  35. pmc Calcineurin/NFAT signaling is required for neuregulin-regulated Schwann cell differentiation
    Shih Chu Kao
    Howard Hughes Medical Institute, Stanford University, Stanford, CA 94305, USA
    Science 323:651-4. 2009
    ..Our studies demonstrate that calcineurin and NFAT are essential for neuregulin and ErbB signaling, neural crest diversification, and differentiation of Schwann cells...
  36. ncbi Electron paramagnetic resonance spectroscopy and molecular modelling of the interaction of myelin basic protein (MBP) with calmodulin (CaM)-diversity and conformational adaptability of MBP CaM-targets
    Eugenia Polverini
    Istituto Nazionale per la Fisica della Materia, Dipartimento di Fisica, Universita di Parma, Parco Area delle Scienze 7 A, 43100 Parma, Italy
    J Struct Biol 148:353-69. 2004
    ..data, and the predictions of CaM-binding motifs using the Calmodulin Target Database (), three main segments of MBP were suggested for the interaction...
  37. ncbi Dual origin of spinal oligodendrocyte progenitors and evidence for the cooperative role of Olig2 and Nkx2.2 in the control of oligodendrocyte differentiation
    Hui Fu
    Department of Anatomical Sciences and Neurobiology, School of Medicine, University of Louisville, Louisville, KY 40292, USA
    Development 129:681-93. 2002
    ..In support of this suggestion, inhibition of expression of these two transcription factors in culture by antisense oligonucleotides has an additive inhibitory effect on OLP differentiation and proteolipid protein (PLP) gene expression...
  38. pmc Heterogeneous nuclear ribonucleoprotein (hnRNP) F is a novel component of oligodendroglial RNA transport granules contributing to regulation of myelin basic protein (MBP) synthesis
    Robin White
    Department of Biology, Molecular Cell Biology, Johannes Gutenberg University of Mainz, Bentzelweg 3, 55128 Mainz, Germany
    J Biol Chem 287:1742-54. 2012
    Myelin basic protein (MBP) is a major component of central nervous system (CNS) myelin. The absence of MBP results in the loss of almost all compact myelin in the CNS...
  39. pmc Leucine-rich repeat kinase 2 (LRRK2)/PARK8 possesses GTPase activity that is altered in familial Parkinson's disease R1441C/G mutants
    Xianting Li
    Departments of Neurology and Neuroscience, Mount Sinai School of Medicine, New York, USA
    J Neurochem 103:238-47. 2007
    ..The distinctive levels of kinase/GTPase activity in brain LRRK2 may help explain LRRK2-associated neuronal functions or dysfunctions in the pathogenesis of PD...
  40. doi Control of glial precursor cell development in the mouse optic nerve by sonic hedgehog from retinal ganglion cells
    Gabriel D Dakubo
    Ottawa Health Research Institute, Ottawa, ON, Canada K1H 8L6
    Brain Res 1228:27-42. 2008
    ..RGC-derived Shh signalling isthus necessary in vivo for maintenance of astrocyte proliferation, affecting both axo-glial and normal glial cell development in the optic nerve...
  41. ncbi Swift entry of myelin-specific T lymphocytes into the central nervous system in spontaneous autoimmune encephalomyelitis
    Glaucia C Furtado
    Molecular Pathogenesis Program, Kimmel Center for Biology and Medicine of the Skirball Institute, New York University School of Medicine, New York, NY 10016, USA
    J Immunol 181:4648-55. 2008
    ..Using a model of spontaneous EAE, we demonstrated that myelin basic protein (MBP)-specific CD4(+) T cells up-regulate activation markers in the CNS-draining cervical lymph nodes at a time when ..
  42. ncbi Developmental abnormalities of myelin basic protein expression in fyn knock-out brain reveal a role of Fyn in posttranscriptional regulation
    Zifan Lu
    Department of Pharmacology, Emory University School of Medicine, Atlanta, Georgia 30322, USA
    J Biol Chem 280:389-95. 2005
    ..affect the expression of mRNAs that encode myelin structural proteins, including that for the myelin basic protein (MBP), until postnatal day 13 (P13)...
  43. pmc Isolation and function of mouse tissue resident vascular precursors marked by myelin protein zero
    Yoshiaki Kubota
    Department of Cell Differentiation, The Sakaguchi Laboratory, School of Medicine, Keio University, Shinjuku ku, Tokyo 160 8582, Japan
    J Exp Med 208:949-60. 2011
    ..Thus, in postnatal mice, although growing vessels are formed primarily by angiogenesis from preexisting vessels, a minor population of arterial endothelia may be derived from tissue-resident vascular precursor cells...
  44. pmc Automated discrimination of brain pathological state attending to complex structural brain network properties: the shiverer mutant mouse case
    Yasser Iturria-Medina
    Neuroimaging Department, Cuban Neuroscience Center, La Habana, Cuba
    PLoS ONE 6:e19071. 2011
    ..Here, we aimed to investigate whether possible brain structural network differences in the shiverer mouse mutant, a relevant animal model of myelin related diseases, can reflect intrinsic individual brain ..
  45. ncbi Quaking*shiverer double-mutant mice survive for at least 100 days with no CNS myelin
    M K Wolf
    Department of Cell Biology, University of Massachusetts Medical School, Worcester, MA 01655, USA
    Dev Neurosci 21:483-90. 1999
    ..We demonstrate that quaking*shiverer double-mutant mice can survive for at least 100 days without any CNS myelin whatsoever...
  46. ncbi The protooncogene Ski controls Schwann cell proliferation and myelination
    Suzana Atanasoski
    Institute of Cell Biology, Department of Biology, Swiss Federal Institute of Technology, ETH Honggerberg, Zurich, Switzerland
    Neuron 43:499-511. 2004
    ..The myelination-regulating transcription factor Oct6 is involved in a complex modulatory relationship with Ski. We conclude that Ski is a crucial signal in Schwann cell development and myelination...
  47. ncbi Novel myosin heavy chain encoded by murine dilute coat colour locus
    J A Mercer
    Mammalian Genetics Laboratory, NCI Frederick Cancer Research and Development Center, Maryland 21702
    Nature 349:709-13. 1991
    ..These results suggest an important role for the dilute gene product in the elaboration, maintenance, or function of cellular processes of melanocytes and neurons...
  48. ncbi SoxD proteins influence multiple stages of oligodendrocyte development and modulate SoxE protein function
    C Claus Stolt
    Institut fur Biochemie, Emil Fischer Zentrum, Universitat Erlangen, D 91054 Erlangen, Germany
    Dev Cell 11:697-709. 2006
    ..Our studies reveal a complex regulatory network between different groups of Sox proteins that is essential for proper progression of oligodendrocyte development...
  49. ncbi Gli3 mutation rescues the generation, but not the differentiation, of oligodendrocytes in Shh mutants
    Min Tan
    Department of Anatomical Sciences and Neurobiology, School of Medicine, University of Louisville, Louisville, KY 40292, USA
    Brain Res 1067:158-63. 2006
    ....
  50. ncbi Activation of myelin genes during transdifferentiation from melanoma to glial cell phenotype
    Shalom G Slutsky
    Department of Molecular Genetics, Weizmann Institute of Science, Rehovot 76100, Israel
    J Biol Chem 278:8960-8. 2003
    ..fused to its soluble receptor (IL6RIL6), causes induction of myelin genes such as myelin basic protein (MBP) and myelin protein zero (Po) in embryonic dorsal root ganglia Schwann cells...
  51. ncbi Evidence for motoneuron lineage-specific regulation of Olig2 in the vertebrate neural tube
    Tao Sun
    Department of Pediatric Oncology, Dana Farber Cancer Institute and Harvard Medical School, 44 Binney Street, Boston, MA 02115, USA
    Dev Biol 292:152-64. 2006
    ..Our findings indicate complex regulation of Olig2 by stage- and lineage-specific regulatory elements. They further suggest that transcriptional regulation of Olig2 is involved in segregation of pMN neuroblasts...
  52. ncbi Neurosteroid progesterone is up-regulated in the brain of jimpy and shiverer mice
    C Le Goascogne
    INSERM U 488, Bicetre, France
    Glia 29:14-24. 2000
    Concentrations of neurosteroids have been measured in the brains of postnatal myelin mutants jimpy (jp) and shiverer (shi) mice and of their normal controls...
  53. ncbi A novel transcript overlapping the myelin basic protein gene
    B Grima
    Centre de Biologie Cellulaire du CNRS, ERS 28, Ivry Seine, France
    J Neurochem 59:2318-23. 1992
    ..We have isolated a hemopoietic MBP-related (HMBPR) cDNA clone from a mouse bone marrow cDNA library screened with an MBP cDNA probe...
  54. ncbi (Na+ + K+)-adenosinetriphosphatase in the brain of Shiverer (Shi/Shi) mice
    H J Sheedlo
    Department of Neurology, University of Michigan, Ann Arbor 48109
    Neurochem Res 12:1081-6. 1987
    The myelin-deficient Shiverer (Shi/Shi) mutant mouse may be a useful model in assessing the dependence of brain (Na+ + K+)-ATPase concentration and composition on myelin membrane formation...
  55. ncbi Peripheral nervous system of shiverer mutant mice: developmental change of myelin components and immunohistochemical demonstration of the absence of MBP and presence of P2 protein
    K Mikoshiba
    Brain Res 283:71-9. 1983
    Peripheral nerves of the shiverer mouse, which are characterized by the absence of major dense lines and myelin basic proteins in CNS myelin, were analyzed...
  56. ncbi Expression of a novel transcript of the myelin basic protein gene
    K Kitamura
    Mental Retardation Research Center, UCLA Medical School 90024
    J Neurochem 54:2032-41. 1990
    A cDNA (M41) corresponding to a mouse myelin basic protein (MBP) mRNA with a longer 5'-untranslated region than predicted from earlier studies of MBP gene structure has been isolated and characterized...
  57. ncbi Compact myelin exists in the absence of basic protein in the shiverer mutant mouse
    D A Kirschner
    Nature 283:207-10. 1980
  58. ncbi A survey of neurological mutant mice. II. Lipid composition of myelinated tissue in possible myelin mutants
    A L Ganser
    Department of Neuroscience, Children s Hospital, Boston, Mass
    Dev Neurosci 10:123-40. 1988
    ..abstract truncated at 400 words)..
  59. ncbi Comparison of the distribution of Na+,K+-ATPase and myelin-associated glycoprotein (MAG) in the optic nerve, spinal cord and trigeminal ganglion of shiverer (shi/shi) and control (+/+) mice
    H J Sheedlo
    Brain Res 415:105-14. 1987
    ..sections of the spinal cord, optic nerve and trigeminal ganglion of adult control (+/+) and CNS myelin-deficient shiverer (shi/shi) mice...
  60. ncbi Myelin deficient mice: expression of myelin basic protein and generation of mice with varying levels of myelin
    B Popko
    Cell 48:713-21. 1987
    Mice homozygous for the mutation myelin deficient (mld), an allele of shiverer, exhibit decreased CNS myelination, tremors, and convulsions of progressively increasing severity leading to an early death...
  61. ncbi Alternative splicing accounts for the four forms of myelin basic protein
    F de Ferra
    Cell 43:721-7. 1985
    We have isolated cDNA clones encoding the four different forms of mouse myelin basic protein (MBP) and have analyzed the structure of the MBP gene...
  62. ncbi Oligodendrocytes of the jimpy phenotype can be partially restored by environmental factors in vivo
    F Lachapelle
    U134 INSERM, Hopital de la Salpetriere, Paris, France
    J Neurosci Res 29:235-43. 1991
    Cross-transplantations of neural tissue between jimpy (jp) shiverer (shi) and normal mice have been performed under heterochronic conditions...
  63. ncbi Molecular characterization of the murine mutation myelin deficient
    B Popko
    Department of Biochemistry and Biophysics, University of North Carolina, Chapel Hill 27599
    Epilepsy Res Suppl 4:275-82. 1991
  64. ncbi Regulation of myelin basic protein gene transcription in normal and shiverer mutant mice
    M Wiktorowicz
    Division of Molecular Immunology and Neurobiology, Samuel Lunenfeld Research Institute of Mount Sinai Hospital, Toronto, Canada
    Dev Neurosci 13:143-50. 1991
    ..mRNA and total transcripts from the myelin basic protein gene in brains from mice of wild-type and homozygous shiverer genotypes at several ages spanning postnatal development...
  65. ncbi Shiverer jimpy double mutant mice. V. Correlation of genotype and myelin proteins
    A Sinclair
    Department of Neurology, Childrens Hospital, Boston, Mass
    Dev Neurosci 13:138-42. 1991
    ..the levels of myelin basic protein (MBP) and proteolipid protein (PLP) in the brains of mice bred to carry both the shi/shi and jp/Y hypomyelination defects...
  66. ncbi A multipoint genetic linkage map of mouse chromosome 18
    K R Johnson
    Jackson Laboratory, Bar Harbor, Maine 04609
    Genomics 13:1143-9. 1992
    ..3-Tpi-10-11.8-(Egr-1, Hmg17-rs9)-2.1-Fgfa-2.2-Grl-1-10.1-(Cdx-1, Csfmr, Pdgfrb, Pdea, Rps14)-2.1-Adrb-2-22.9-Mbp. Pgk-1rs5, Tpi-10, Hmg17-rs9, and Rps14 had not been previously mapped in the mouse; Egr-1 had only been ..
  67. ncbi Chromosomal localization of the murine genes for the alpha- and beta-subunits of calcium/calmodulin-dependent protein kinase II
    M Danciger
    Jules Stein Eye Institute, UCLA School of Medicine 90024
    Mamm Genome 3:122-5. 1992
  68. ncbi Effects of carbonic anhydrase II (CAII) deficiency on CNS structure and function in the myelin-deficient CAII-deficient double mutant mouse
    W Cammer
    Department of Neurology, Albert Einstein College of Medicine, Bronx, New York 10461, USA
    J Neurosci Res 40:451-7. 1995
    ..Since myelin basic protein also takes part in myelin compaction, we bred double CAII-deficient, myelin-deficient (Mld) mutant mice, in which the adults would have some compact myelin sheaths and a partial deficiency in myelin basic ..
  69. ncbi Membrane adhesion and other functions for the myelin basic proteins
    S M Staugaitis
    Department of Pathology, Columbia Presbyterian Medical Center, New York, USA
    Bioessays 18:13-8. 1996
    ..We now think that while the major MBPs are intracellular adhesion molecules, some of the quantitatively less abundant isoforms that are expressed very early in development may have regulatory effects on the myelination program...
  70. ncbi Myelin basic protein is necessary for the regulation of myelin-associated glycoprotein expression in mouse oligodendroglia
    J Nakahara
    Department of Neurobiology, Tokyo Metropolitan Institute of Gerontology, 35 2 Sakaecho, Itabashi ku, 173 0015, Tokyo, Japan
    Neurosci Lett 298:163-6. 2001
    ..We propose here that myelin basic protein (MBP) is prerequisite, which is more diffusely expressed than MAG in early stages of myelination...
  71. ncbi Regulation of cytoskeleton by myelin components: studies on shiverer oligodendrocytes carrying an Mbp transgene
    C A Dyer
    Department of Biomedical Sciences, E K Shriver Center, Waltham, Mass, USA
    Dev Neurosci 19:395-409. 1997
    Oligodendrocytes from the shiverer mutant mouse are missing most of the myelin basic protein (Mbp) gene. In axon-free cultures, they produce membrane sheets with abnormally assembled microtubule and actin-based structures...
  72. ncbi Functional analysis in vivo of the double mutant mouse deficient in both proteolipid protein (PLP) and myelin basic protein (MBP) in the central nervous system
    W Stoffel
    Institute of Biochemistry, D 50931 Köln, Germany
    Cell Tissue Res 289:195-206. 1997
    ..Neuromotor activity and coordination are considerably improved compared to the shiverer trait.
  73. ncbi Evidence that some oligodendrocyte progenitors in the developing optic pathway express the plp gene
    M L Fanarraga
    Department of Anatomy and Cell Biology, University of Cantabria, Santander, Spain
    Glia 18:282-92. 1996
    ..Small unbranched cells expressing DM-20 but not myelin basic protein (MBP) and probably representing progenitors were detectable by immunostaining in similar locations...
  74. ncbi Myelin basic protein gene expression in neurons: developmental and regional changes in protein targeting within neuronal nuclei, cell bodies, and processes
    C F Landry
    Mental Retardation Research Center, Neuropsychiatric Institute, University of California at Los Angeles School of Medicine, California 90024, USA
    J Neurosci 16:2452-62. 1996
    The myelin basic protein (MBP) gene is part of the golli-mbp gene complex...
  75. ncbi Vacuolar myelopathy in transgenic mice expressing human immunodeficiency virus type 1 proteins under the regulation of the myelin basic protein gene promoter
    G Goudreau
    Laboratory of Molecular Biology, Clinical Research Institute of Montreal, Quebec, Canada
    Nat Med 2:655-61. 1996
    ..This animal model provides in vivo evidence linking the expression of HIV-1 proteins in oligodendrocytes to the spinal cord damage found in vacuolar myelopathy...
  76. ncbi Myelin mutants: new models and new observations
    K F Lunn
    Department of Medical Sciences, School of Veterinary Medicine, University of Wisconsin Madison 53706, USA
    Microsc Res Tech 32:183-203. 1995
    ..These findings underscore the complexity of the myelination process and highlight the numerous ways in which it can be disrupted...
  77. ncbi Cerebellar soluble lectin and its glycoprotein ligands in the developing brain of control and dysmyelinating mutant mice
    W X Li
    Unite de Neurobiologie Cellulaire, Moleculaire et Clinique, INSERM U, 134, Hopital de la Salpetriere, Paris, France
    Neurochem Int 22:125-33. 1993
    ..glycoprotein ligands were studied using immunoblotting and affinoblotting techniques in the forebrain of quaking, shiverer and jimpy dysmyelinating mutant mice and their respective control littermates during the postnatal development...
  78. ncbi Generation and analysis of normal and shiverer temperature-sensitive immortalized cell lines exhibiting phenotypic characteristics of oligodendrocytes at several stages of differentiation
    L M Foster
    Mental Retardation Research Center, UCLA School of Medicine 90024
    Dev Neurosci 15:100-9. 1993
    ..19 separate oligodendroglial cell lines, 10 derived from normal mice and 9 derived from the neurological mutant shiverer, which is missing a large segment of the myelin basic protein gene...
  79. pmc Normal basal laminas are realized on dystrophic Schwann cells in dystrophic in equilibrium shiverer chimera nerves
    A C Peterson
    J Cell Biol 99:1831-7. 1984
    ..To explore the pathogenesis of this abnormality we have exploited a dystrophic in equilibrium shiverer mouse chimera preparation in which both the basal lamina phenotype and the genotype of myelin-forming Schwann ..
  80. ncbi Pax-2 expression defines a subset of GABAergic interneurons and their precursors in the developing murine cerebellum
    S M Maricich
    Alzheimer Research Laboratory, Case Western Reserve University School of Medicine, 10900 Euclid Avenue, Cleveland, Ohio 44106, USA
    J Neurobiol 41:281-94. 1999
    ..Finally, our data support the hypothesis that the basket and stellate cells arise from neuronally restricted, migratory precursors located in the early postnatal cerebellar white matter...
  81. ncbi Transferrin in the central nervous system of the shiverer mouse myelin mutant
    J R Connor
    Department of Neuroscience and Anatomy, Milton S Hershey Medical Center, Pennsylvania State University, Hershey 17033
    J Neurosci Res 36:501-7. 1993
    ..In this study the shiverer mouse mutant in which the oligodendrocyte population is numerically normal, but has both quantitatively ..
  82. ncbi Shiverer: an autosomal recessive mutant mouse with myelin deficiency
    G F Chernoff
    J Hered 72:128. 1981
    b>Shiverer is an autosomal recessive trait in the mouse characterized by early generalized tremors that become prominent in the hindquarters with age...
  83. pmc A hypomorphic allele of Tsc2 highlights the role of TSC1/TSC2 in signaling to AKT and models mild human TSC2 alleles
    Kristen Pollizzi
    Translational Medicine Division, Department of Medicine, Brigham and Women s Hospital, Boston, MA 02115, USA
    Hum Mol Genet 18:2378-87. 2009
    ..Tsc2-del3 mice also serve as a model for hypomorphic TSC2 missense mutations reported in TSC patients...
  84. ncbi Chromosomal assignments of 17 structural genes and 11 related DNA fragments in rats (Rattus norvegicus) by Southern blot analysis of rat x mouse somatic cell hybrid clones
    M Yasue
    Institute of Laboratory Animals, Faculty of Medicine, Kyoto University, Japan
    Genomics 12:659-64. 1992
    ..ATP1A1, ATP1A2, ATP1A3, B2M, GSTP, and SMST; 5 mouse genes, Ncam, Ngfg, Pim-1, Tcp-1, and Trp53; and 5 human genes, MBP, MYB, NEFM, SCN2A, and TCRGC1, 17 structural genes including 15 newly assigned genes and 11 related DNA fragments ..
  85. ncbi Junctional region of the myelin basic protein-specific T cell receptor beta chain in mice
    B Kalman
    Department of Neurology, Thomas Jefferson University, Philadelphia, PA 19107 5083, USA
    J Neuroimmunol 59:195-9. 1995
    ..existence of both conserved and diverse amino acid sequences in the junctional regions of the myelin basic protein (MBP)-specific T cell receptors (TCR) in mice is presented...
  86. ncbi H-2 S region determined polymorphic variants of the C4, Slp, C2, and B complement proteins: a compilation
    J P Atkinson
    Immunogenetics 16:617-23. 1982
  87. ncbi Targeted expression of Cre recombinase to myelinating cells of the central nervous system in transgenic mice
    M Niwa-Kawakita
    INSERM U434, Fondation Jean Dausset CEPH, Paris, France
    Genesis 26:127-9. 2000
  88. ncbi Failure of central nervous system myelination in MBP/c-myc transgenic mice: evidence for c-myc cytotoxicity
    N A Jensen
    Department of Medical Biochemistry, University of Aarhus, Denmark
    Oncogene 16:2123-9. 1998
    ..The MBP/c-myc transgenic mice developed severe neurological disturbances characterized by action tremors and recurrent ..
  89. pmc A quantitative survey of gravity receptor function in mutant mouse strains
    Sherri M Jones
    Department of Communication Sciences and Disorders, East Carolina University, Greenville, NC 27858, USA
    J Assoc Res Otolaryngol 6:297-310. 2005
    ..Interestingly, some heterozygote groups also showed abnormalities in one or more VsEP response parameters, suggesting that vestibular dysfunction, although less severe, may be present in some heterozygous animals...
  90. pmc Genetic mapping of the mouse c-fms proto-oncogene to chromosome 18
    M D Hoggan
    Laboratory of Molecular Microbiology, National Institute of Allergy and Infectious Diseases, Bethesda, Maryland 20892
    J Virol 62:1055-6. 1988
    ..Results demonstrate that Fms, the genetic locus containing this sequence, maps to mouse chromosome 18. Mouse Fms is thus not linked to the same set of genes involved in growth regulation that human FMS is linked to...
  91. ncbi Myelin basic protein functions as a microtubule stabilizing protein in differentiated oligodendrocytes
    M R Galiano
    CIQUIBIC Dpto Química Biológica, Facultad Ciencias Quimicas, Haya de la Torre S N, Cordoba, Argentina
    J Neurosci Res 84:534-41. 2006
    ..Additionally, STOP suppression in oligodendrocytes derived from shiverer mice that lack MBP led to the complete suppression of microtubule cold stability at all stages of cell ..
  92. ncbi In situ expression of PLP/DM-20, MBP, and CNP during embryonic and postnatal development of the jimpy mutant and of transgenic mice overexpressing PLP
    F Peyron
    Laboratoire de Neurobiologie Cellulaire Moléculaire et Clinique, INSERM U 134, Universite P and M Curie, Hopital de la Salpetriere, Paris, France
    J Neurosci Res 50:190-201. 1997
    We analyzed by in situ hybridization the spatiotemporal expression of dm-20, myelin basic protein (MBP) and 2'-3' cyclic nucleotide phosphodiesterase (CNP) during embryonic and postnatal development of the normal mouse and two plp/dm-20 ..
  93. ncbi Expression of the tight junction protein ZO-1 in the olfactory system: presence of ZO-1 on olfactory sensory neurons and glial cells
    F Miragall
    Institut fur Anatomie, Universitat Regensburg, Germany
    J Comp Neurol 341:433-48. 1994
    ..Our results provide further evidence that ZO-1 serves functions unrelated to the tight junction complex and indicate molecular heterogeneity of these cell-cell contacts...
  94. pmc Identification of a cDNA coding for a fifth form of myelin basic protein in mouse
    S Newman
    Proc Natl Acad Sci U S A 84:886-90. 1987
    ..The primary sequences of four molecular mass variants (14, 17, 18.5, and 21.5 kDa) of the mouse myelin basic protein (MBP) have recently been determined through analysis of cDNA clones of their mRNAs...
  95. ncbi Distinct hypomyelinated phenotypes in MBP-SV40 large T transgenic mice
    N A Jensen
    Division of Biology, California Institute of Technology, Pasadena
    J Neurosci Res 34:257-64. 1993
    ..of transgenic mice were generated expressing the SV40 large T-antigen under control of the myelin basic protein (MBP) promoter...
  96. ncbi Sodium channel density in hypomyelinated brain increased by myelin basic protein gene deletion
    J L Noebels
    Department of Neurology, Division of Neuroscience, Baylor College of Medicine, Houston, Texas 77030
    Nature 352:431-4. 1991
    ..We have found that large caliber fibre pathways in the brain of the mutant mouse shiverer (shi, gene on chromosome 18), whose developmental fate of myelination is averted by deletion of five exons in the ..
  97. ncbi Expression of the ceramide galactosyltransferase gene during myelination of the mouse nervous system. Comparison with the genes encoding myelin basic proteins, choline kinase and CTP:phosphocholine cytidylyltransferase
    B Garbay
    Laboratoire de Biogenese Membranaire, URA CNRS 1811, IBGC du CNRS, Universite de Bordeaux II, France
    Brain Res Dev Brain Res 83:119-24. 1994
    ..On the other hand, the expression of the CGT gene is similar to that of the MBP gene in the CNS and the PNS...

Research Grants64

  1. Synthesis and Assembly of Basic Proteins into Myelin.
    Anthony Campagnoni; Fiscal Year: 2007
    ..These studies are relevant to demyelinating diseases, like MS and leukodystrophies, and will enhance our understanding of myelination, remyelination and the effects of hypomyelination on neural function. ..
  2. PROTEIN SYNTHESIS INITIATION IN ANIMAL CELLS
    Bansidhar Datta; Fiscal Year: 2002
    ..This research is expected to provide valuable information regarding the mechanism of protein synthesis initiation in normal, cancerous, and virus- infected animal cells. ..
  3. A Combination Trial of Copaxone Plus Estriol in RRMS
    Rhonda Voskuhl; Fiscal Year: 2009
    ..Safety measures (blood tests and gynecologic evaluations) will also be followed. The overall goal of this study will be the development of an oral treatment, estriol, for RRMS. ..
  4. NO DAMAGE TO FOLATE CYCLE IN THE CENTRAL NERVOUS SYSTEM
    Kenneth Hensley; Fiscal Year: 2005
    ..abstract_text> ..
  5. Protective Effect of Pregnancy Doses of Estrogens in EAE
    Rhonda Voskuhl; Fiscal Year: 2005
    ..abstract_text> ..
  6. Role of sex chromosomes in gender differences in EAE
    Rhonda Voskuhl; Fiscal Year: 2004
    ..On the other hand, if immune measures differ between genotypes (XX vs. XY) within a given phenotype, we will conclude that gender differences in immune measures are due to both sex hormones and sex chromosomes. ..
  7. MicroRNA Function in the Development of the Cerebral Cortex
    Tao Sun; Fiscal Year: 2010
    ..The success of our project should yield significant insights into the etiology of human mental disorders, which can be caused by mutations of not only coding genes but also noncoding molecules such as microRNAs. ..
  8. Synthesis and Assembly of Basic Proteins into Myelin.
    Anthony Campagnoni; Fiscal Year: 2009
    ..These studies are relevant to demyelinating diseases, like MS and leukodystrophies, and will enhance our understanding of myelination, remyelination and the effects of hypomyelination on neural function. ..
  9. A Combination Trial of Copaxone Plus Estriol in RRMS
    Rhonda Voskuhl; Fiscal Year: 2009
    ..Safety measures (blood tests and gynecologic evaluations) will also be followed. The overall goal of this study will be the development of an oral treatment, estriol, for RRMS. ..
  10. The Effect of Sex Chromosomes on Immune Responses
    Rhonda Voskuhl; Fiscal Year: 2009
    ..cytokine production of lymph node cells (LNCs) from SJL mice immunized with the autoantigen myelin basic protein (MBP)...
  11. Sex Chromosome Effects in Lupus
    Rhonda Voskuhl; Fiscal Year: 2007
    ..This disease was chosen in light of the 9:1 female preponderance of the human disease system lupus erythematosus. ..
  12. Golli-MBP Gene Expression in the Nervous System
    Anthony Campagnoni; Fiscal Year: 2007
    The golli proteins are one of two families of proteins produced from the MBP gene with more ubiquitous expression than the classic MBP family...
  13. The Effect of Sex Chromosomes on Immune Responses
    Rhonda Voskuhl; Fiscal Year: 2007
    ..cytokine production of lymph node cells (LNCs) from SJL mice immunized with the autoantigen myelin basic protein (MBP)...
  14. SYNTHESIS AND ASSEMBLY OF BASIC PROTEINS INTO MYELIN
    Anthony Campagnoni; Fiscal Year: 2003
    ..e. the myelin basic protein (MBP) and proteolipid protein (PLP) genes, has begun to change in view of new information about their structure, ..
  15. SYNTHESIS AND ASSEMBLY OF BASIC PROTEINS IN MYELIN
    Anthony Campagnoni; Fiscal Year: 1993
    ..We have been successful at immortalizing oligodendrocytes from normal and shiverer mice with a retrovirus containing a temperature sensitive SV40 large T antigen oncogene, many of which may be ..
  16. SYNTHESIS AND ASSEMBLY OF BASIC PROTEINS IN MYELIN
    Anthony Campagnoni; Fiscal Year: 1999
    ..We have been successful at immortalizing oligodendrocytes from normal and shiverer mice with a retrovirus containing a temperature sensitive SV40 large T antigen oncogene, many of which may be ..
  17. GENETIC ELEMENTS REGULATING MYELIN GENE EXPRESSION
    Anthony Campagnoni; Fiscal Year: 2001
    DESCRIPTION: The Golli-mbp gene encodes two families of proteins, the Golli proteins and the myelin basic proteins...
  18. SYNTHESIS AND ASSEMBLY OF BASIC PROTEINS IN MYELIN
    Anthony Campagnoni; Fiscal Year: 1992
    ..The overall objective of the proposed work is to examine, in detail, the expression of myelin basic protein (MBP) genes in normal mice and in dysmyelinating mutants which we have shown to have altered MBP metabolism...