Gene Symbol: Mboat7
Description: membrane bound O-acyltransferase domain containing 7
Alias: 5730589L02Rik, BB1, Leng4, Lpiat, Lpiat1, mBB1, lysophospholipid acyltransferase 7, 1-acylglycerophosphatidylinositol O-acyltransferase, LPLAT 7, O-acyltransferase domain-containing protein 7, bladder and breast carcinoma-overexpressed gene 1 protein, leukocyte receptor cluster (LRC) member 4, leukocyte receptor cluster member 4, lysophosphatidylinositol acyltransferase, lysophosphatidylinositol acyltransferase 1, m-mboa-7, membrane-bound O-acyltransferase domain-containing protein 7
Species: mouse
Products:     Mboat7

Top Publications

  1. Lee H, Inoue T, Imae R, Kono N, Shirae S, Matsuda S, et al. Caenorhabditis elegans mboa-7, a member of the MBOAT family, is required for selective incorporation of polyunsaturated fatty acids into phosphatidylinositol. Mol Biol Cell. 2008;19:1174-84 pubmed
    ..LysoPI acyltransferase (LPIAT) is thought to catalyze formation of AA-containing PI; however, the gene that encodes this enzyme has not yet been ..
  2. Vogel P, Read R, Hansen G, Payne B, Small D, Sands A, et al. Congenital hydrocephalus in genetically engineered mice. Vet Pathol. 2012;49:166-81 pubmed publisher
    ..The likely underlying cause in the remaining 4 lines (RIKEN 4930444A02, Celsr2, Mboat7, and transgenic FZD3) was not determined, but it is possible that some of these could also have ciliary defects...
  3. Lee H, Inoue T, Sasaki J, Kubo T, Matsuda S, Nakasaki Y, et al. LPIAT1 regulates arachidonic acid content in phosphatidylinositol and is required for cortical lamination in mice. Mol Biol Cell. 2012;23:4689-700 pubmed publisher
    ..Here we show that lysophosphatidylinositol acyltransferase 1 (LPIAT1, also known as MBOAT7), the closest mammalian homologue, plays a crucial role in brain ..
  4. Daigo Y, Takayama I, Ward S, Sanders K, Fujino M. Isolation of novel mouse genes that were differentially expressed in W/W(V) mouse fundus. J Gastroenterol. 2004;39:238-41 pubmed
    ..Expression of another five genes was decreased in W/W(V) mice: BB1 (overexpressed in bladder and breast carcinoma), HTATIP/CPLA2 (HIV-1 TAT interactive protein/cytosolic ..
  5. Anderson K, Kielkowska A, Durrant T, Juvin V, Clark J, Stephens L, et al. Lysophosphatidylinositol-acyltransferase-1 (LPIAT1) is required to maintain physiological levels of PtdIns and PtdInsP(2) in the mouse. PLoS ONE. 2013;8:e58425 pubmed publisher
    We disrupted the gene encoding lysophosphatidylinositol-acyltransferase-1 (LPIAT1) in the mouse with the aim of understanding its role in determining cellular phosphoinositide content...
  6. Hirata Y, Yamamori N, Kono N, Lee H, Inoue T, Arai H. Identification of small subunit of serine palmitoyltransferase a as a lysophosphatidylinositol acyltransferase 1-interacting protein. Genes Cells. 2013;18:397-409 pubmed publisher
    b>Lysophosphatidylinositol acyltransferase 1 (LPIAT1), also known as MBOAT7, is a phospholipid acyltransferase that selectively incorporates arachidonic acid (AA) into the sn-2 position of phosphatidylinositol (PI)...
  7. Tabe S, Hikiji H, Ariyoshi W, Hashidate Yoshida T, Shindou H, Okinaga T, et al. Lysophosphatidylethanolamine acyltransferase 1/membrane-bound O-acyltransferase 1 regulates morphology and function of P19C6 cell-derived neurons. FASEB J. 2016;30:2591-601 pubmed publisher
    ..Shindou, H., Okinaga, T., Shimizu, T., Tominaga, K., Nishihara, T. Lysophosphatidylethanolamine acyltransferase 1/membrane-bound O-acyltransferase 1 regulates morphology and function of P19C6 cell-derived neurons. ..