Mbl2

Summary

Gene Symbol: Mbl2
Description: mannose-binding lectin (protein C) 2
Alias: L-MBP, MBL, MBL-C, MBP-C, mannose-binding protein C, RA-reactive factor P28A subunit, RARF/P28A, mannan-binding protein, mannose binding lectin (C), mannose binding lectin, liver (C)
Species: mouse

Top Publications

  1. ncbi Molecular characterization of the mouse mannose-binding proteins. The mannose-binding protein A but not C is an acute phase reactant
    K Sastry
    Division of Hematology Oncology, Children s Hospital, Boston, MA
    J Immunol 147:692-7. 1991
  2. pmc Mannose-binding lectin enhances Toll-like receptors 2 and 6 signaling from the phagosome
    W K Eddie Ip
    Laboratory of Developmental Immunology, Department of Pediatrics, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA
    J Exp Med 205:169-81. 2008
  3. pmc Deficiency of mannose-binding lectin greatly increases antibody response in a mouse model of vaccination
    Hilde Kari Guttormsen
    Channing Laboratory, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, 181 Longwood Avenue, Boston, MA 02115, USA
    Clin Immunol 130:264-71. 2009
  4. doi Macrophage-specific expression of mannose-binding lectin controls atherosclerosis in low-density lipoprotein receptor-deficient mice
    Robert A Matthijsen
    Department of Surgery, Maastricht University Medical Centre and School for Nutrition and Metabolism, Maastricht, Netherlands
    Circulation 119:2188-95. 2009
  5. pmc Mannan-binding lectin deficiency modulates the humoral immune response dependent on the genetic environment
    Marieta Ruseva
    Department of Medical Microbiology and Immunology, University of Aarhus, Denmark
    Immunology 127:279-88. 2009
  6. ncbi Mannose-binding lectin is a regulator of inflammation that accompanies myocardial ischemia and reperfusion injury
    Mary C Walsh
    Center for Experimental Therapeutics and Reperfusion Injury, Brigham and Women s Hospital, Harvard Medical School, Boston MA 02115, USA
    J Immunol 175:541-6. 2005
  7. ncbi Mannan-binding lectin recognizes structures on ischaemic reperfused mouse kidneys and is implicated in tissue injury
    M Møller-Kristensen
    Department of Medical Microbiology and Immunology, University of Aarhus, Denmark
    Scand J Immunol 61:426-34. 2005
  8. ncbi Gastrointestinal ischemia-reperfusion injury is lectin complement pathway dependent without involving C1q
    Melanie L Hart
    Center for Experimental Therapeutics and Reperfusion Injury, Anesthesiology, Perioperative and Pain Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    J Immunol 174:6373-80. 2005
  9. pmc Mechanisms of mannose-binding lectin-associated serine proteases-1/3 activation of the alternative pathway of complement
    Nirmal K Banda
    Division of Rheumatology, Departments of Medicine and Immunology, University of Colorado School of Medicine, Aurora, CO 80045, USA
    Mol Immunol 49:281-9. 2011
  10. pmc Mannan-binding lectin modulates the response to HSV-2 infection
    M Gadjeva
    Department of Medical Microbiology and Immunology, University of Aarhus, Aarhus, Denmark
    Clin Exp Immunol 138:304-11. 2004

Research Grants

  1. Innate Immunity in the Clearance of Influenza A Virus Infected Apoptotic Cells
    Kazue Takahashi; Fiscal Year: 2008
  2. Transgenic Rod Development and Function
    Baerbel Rohrer; Fiscal Year: 2005
  3. NOT1 in stress tolerance of Cryptococcus neoformans
    John Panepinto; Fiscal Year: 2005
  4. ROD NEURODEGENERATIVE AND PROTECTIVE GENES
    Baerbel Rohrer; Fiscal Year: 2005
  5. INTERACTION OF CLQ ON PHAGOCYTIC CELLS
    Andrea Joan Tenner; Fiscal Year: 2010

Scientific Experts

  • Rinke Stienstra
  • S Thiel
  • John Panepinto
  • Yuichi Endo
  • Barbel Rohrer
  • Kazue Takahashi
  • M W Turner
  • Denise Hilfiker-Kleiner
  • Franz Petry
  • M Møller-Kristensen
  • L M Stuart
  • ANDREA TENNER
  • M Gadjeva
  • W K Eddie Ip
  • Gerard Chaouat
  • Gregory L Stahl
  • Vasile I Pavlov
  • Nirmal K Banda
  • V Michael Holers
  • Laura R La Bonte
  • Teizo Fujita
  • R Alan B Ezekowitz
  • Michael C Carroll
  • Youssif M Ali
  • Minoru Takahashi
  • Lei Shi
  • William P Arend
  • Marc N Busche
  • Clifford Kim
  • A K Yadav
  • Jonathan M Ciencewicki
  • Shushimita Shushimita
  • Chenhui Zou
  • Ying S Tan
  • Shihui Sun
  • Christine von Toerne
  • Stefan Bidula
  • Hui Fang Zhou
  • Takashi Miwa
  • J A Ostergaard
  • Wilhelm J Schwaeble
  • Bronwyn M Gunn
  • Antonio Gigliotti Rothfuchs
  • Sabine Pfister
  • Magdalena Glogowska
  • N K Banda
  • Santiago F Gonzalez
  • Brandon Renner
  • Wei Chuan Chang
  • Alvaro Cervera
  • Jens C Jensenius
  • G L Stahl
  • Hilde Kari Guttormsen
  • Da Ming Zuo
  • Marieta Ruseva
  • Robert A Matthijsen
  • Joshua M Thurman
  • Elizabeth A Moulton
  • Phoebe H Yager
  • Kathrin Held
  • M N Busche
  • Alan Ezekowitz
  • Sidonia Mihai
  • Kei Ono
  • Rodney K Chan
  • Mary C Walsh
  • Melanie L Hart
  • Russell P Rother
  • Cory M Hogaboam
  • Bryan T MacDonald
  • Zachary R McCaw
  • Alexandra Castillejos
  • T Madan
  • Steven R Kleeberger
  • Jens Christian Jensenius
  • Magali Saint-Geniez
  • Kip M Connor
  • Daniel Diaz-Aguilar
  • H Chaudhari
  • P K Shah
  • Kaylee E Smith
  • Jianying Li
  • Kirsten C Verhein
  • Pierre R Bushel
  • Kevin Gerrish
  • Ron W F de Bruin
  • Frank J M F Dor
  • Erin E McClure
  • Jan N M Ijzermans
  • William B Gorsuch

Detail Information

Publications71

  1. ncbi Molecular characterization of the mouse mannose-binding proteins. The mannose-binding protein A but not C is an acute phase reactant
    K Sastry
    Division of Hematology Oncology, Children s Hospital, Boston, MA
    J Immunol 147:692-7. 1991
    ..The expression of both mannose-binding proteins A and C mRNA is restricted to the liver under basal and stress conditions...
  2. pmc Mannose-binding lectin enhances Toll-like receptors 2 and 6 signaling from the phagosome
    W K Eddie Ip
    Laboratory of Developmental Immunology, Department of Pediatrics, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA
    J Exp Med 205:169-81. 2008
    ..Furthermore, we demonstrate that this cooperation occurs within the phagosome, emphasizing the importance of engulfment in providing the appropriate cellular environment to facilitate the synergy between these defense pathways...
  3. pmc Deficiency of mannose-binding lectin greatly increases antibody response in a mouse model of vaccination
    Hilde Kari Guttormsen
    Channing Laboratory, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, 181 Longwood Avenue, Boston, MA 02115, USA
    Clin Immunol 130:264-71. 2009
    Mannose-binding lectin (MBL), a pattern recognition innate immune molecule, selectively binds distinct chemical patterns, including carbohydrates expressed on Group B streptococcus (GBS)...
  4. doi Macrophage-specific expression of mannose-binding lectin controls atherosclerosis in low-density lipoprotein receptor-deficient mice
    Robert A Matthijsen
    Department of Surgery, Maastricht University Medical Centre and School for Nutrition and Metabolism, Maastricht, Netherlands
    Circulation 119:2188-95. 2009
    With consideration of the central role of the innate immune system in atherogenesis and mannose-binding lectin (MBL) as an innate regulator of immunity, the role of MBL in experimental and human atherosclerosis was assessed.
  5. pmc Mannan-binding lectin deficiency modulates the humoral immune response dependent on the genetic environment
    Marieta Ruseva
    Department of Medical Microbiology and Immunology, University of Aarhus, Denmark
    Immunology 127:279-88. 2009
    Mannan-binding lectin (MBL) is a plasma protein implicated in innate immune defence against a broad range of microorganisms, including viruses...
  6. ncbi Mannose-binding lectin is a regulator of inflammation that accompanies myocardial ischemia and reperfusion injury
    Mary C Walsh
    Center for Experimental Therapeutics and Reperfusion Injury, Brigham and Women s Hospital, Harvard Medical School, Boston MA 02115, USA
    J Immunol 175:541-6. 2005
    The mannose-binding lectin (MBL), a circulating pattern recognition molecule, recognizes a wide range of infectious agents with resultant initiation of the complement cascade in an Ab-independent manner...
  7. ncbi Mannan-binding lectin recognizes structures on ischaemic reperfused mouse kidneys and is implicated in tissue injury
    M Møller-Kristensen
    Department of Medical Microbiology and Immunology, University of Aarhus, Denmark
    Scand J Immunol 61:426-34. 2005
    ..are exposed due to the ischaemia may be recognized by pattern recognition molecules such as mannan-binding lectin (MBL), inducing complement activation...
  8. ncbi Gastrointestinal ischemia-reperfusion injury is lectin complement pathway dependent without involving C1q
    Melanie L Hart
    Center for Experimental Therapeutics and Reperfusion Injury, Anesthesiology, Perioperative and Pain Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    J Immunol 174:6373-80. 2005
    ..The role of the classical and lectin complement pathways in GI/R injury was evaluated using C1q-deficient (C1q KO), MBL-A/C-deficient (MBL-null), complement factor 2- and factor B-deficient (C2/fB KO), and wild-type (WT) mice...
  9. pmc Mechanisms of mannose-binding lectin-associated serine proteases-1/3 activation of the alternative pathway of complement
    Nirmal K Banda
    Division of Rheumatology, Departments of Medicine and Immunology, University of Colorado School of Medicine, Aurora, CO 80045, USA
    Mol Immunol 49:281-9. 2011
    ..MASP are believed to require binding to mannose binding lectins (MBL) or ficolins (FCN) to carry out their biological activities...
  10. pmc Mannan-binding lectin modulates the response to HSV-2 infection
    M Gadjeva
    Department of Medical Microbiology and Immunology, University of Aarhus, Aarhus, Denmark
    Clin Exp Immunol 138:304-11. 2004
    ..g. mannan-binding lectin (MBL)...
  11. pmc Mannose-binding lectin-deficient mice are susceptible to infection with Staphylococcus aureus
    Lei Shi
    Laboratory of Developmental Immunology, Department of Pediatrics, Massachusetts General Hospital, Harvard Medical School, 55 Fruit Street, JRG 1402, Boston, MA 02114, USA
    J Exp Med 199:1379-90. 2004
    ..aureus. The mannose-binding lectin (MBL, also known as mannose-binding protein) is an oligomeric serum molecule that recognizes carbohydrates decorating a ..
  12. pmc Relative roles of complement factor 3 and mannose-binding lectin in host defense against infection
    Kazue Takahashi
    Laboratory of Developmental Immunology, Department of Pediatrics, Massachusetts General Hospital, Harvard Medical School, 55 Fruit Street, GRJ 1402, Boston, MA 02114, USA
    Infect Immun 73:8188-93. 2005
    ..is initiated by the classical, alternative, or lectin pathway, with the latter requiring mannose-binding lectin (MBL, also known as mannose-binding protein)...
  13. doi Increased susceptibility of complement factor B/C2 double knockout mice and mannan-binding lectin knockout mice to systemic infection with Candida albicans
    Kathrin Held
    Institute of Medical Microbiology and Hygiene, Johannes Gutenberg University Mainz, Augustusplatz Hochhaus, D 55101 Mainz, Germany
    Mol Immunol 45:3934-41. 2008
    ..of mice deficient in complement factor B and C2 (Bf/C2-/-), C1q (C1qa-/-), and mannan-binding lectin (MBL)-A (MBL-A) and MBL-C (MBL-A/C-/-) to systemic infection with C. albicans. Animals were infected i.p. with 10(8)C...
  14. ncbi Characterization of murine mannose-binding protein genes Mbl1 and Mbl2 reveals features common to other collectin genes
    R Sastry
    Department of Pathology, Boston University School of Medicine, Massachusetts 02118, USA
    Mamm Genome 6:103-10. 1995
    ..In this study, the two genes encoding MBP in mice--Mbl1 and Mbl2--have been isolated and their exon-intron structure studied to understand their evolutionary relationship to the ..
  15. pmc Burn injury reveals altered phenotype in mannan-binding lectin-deficient mice
    Mette Møller-Kristensen
    Laboratory of Developmental Immunology, Department of Pediatrics, Harvard Medical School, Boston, Massachusetts, USA
    J Invest Dermatol 127:1524-31. 2007
    ..The pattern recognition molecule, mannan-binding lectin (MBL), plays an important role in the first-line host defense against infectious agents...
  16. pmc Deficiency of mannose-binding lectin greatly increases susceptibility to postburn infection with Pseudomonas aeruginosa
    Mette Møller-Kristensen
    Laboratory of Developmental Immunology, Department of Pediatrics, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA
    J Immunol 176:1769-75. 2006
    ..response that includes influx of phagocytes and serum factors, such as complement and mannose-binding lectin (MBL), which is a broad-spectrum pattern recognition molecule that plays a key role in innate immunity...
  17. ncbi L-MBP is expressed in epithelial cells of mouse small intestine
    Kazuhide Uemura
    Department of Biological Chemistry, Core Research for Science and Technology Project, Japan Science and Technology Corp, Graduate School of Pharmaceutical Sciences, Kyoto University, Japan
    J Immunol 169:6945-50. 2002
    The mannan-binding proteins (L-MBP and S-MBP, also denoted MBL-C and MBL-A), mainly produced in liver and existing in liver and serum, play important roles in the innate immunity against a variety of pathogens...
  18. ncbi Characterization and quantification of mouse mannan-binding lectins (MBL-A and MBL-C) and study of acute phase responses
    H Liu
    Department of Medical Microbiology and Immunology, University of Aarhus, Aarhus, Denmark
    Scand J Immunol 53:489-97. 2001
    Rat monoclonal antibodies (MoAbs) against mouse mannan-binding lectin (MBL)-A and MBL-C were generated and assays for MBL-A and MBL-C were constructed. This allowed for the quantitative analysis of both proteins for the first time...
  19. doi Mannose-binding lectin is required for the effective clearance of apoptotic cells by adipose tissue macrophages during obesity
    Rinke Stienstra
    Nutrition, Metabolism and Genomics Group, Wageningen University, Wageningen, the Netherlands Department of Medicine, Radboud University Medical Centre, Nijmegen, The Netherlands Nijmegen Institute for Infection, Inflammation and Immunity N4i, Radboud University Medical Centre, Nijmegen, The Netherlands
    Diabetes 63:4143-53. 2014
    ..Mannose-binding lectin (MBL), a soluble mediator of innate immunity, promotes phagocytosis and alters macrophage function...
  20. pmc Human mannose-binding lectin inhibitor prevents myocardial injury and arterial thrombogenesis in a novel animal model
    Vasile I Pavlov
    Department of Anesthesiology, Perioperative and Pain Medicine, Center for Experimental Therapeutics and Reperfusion Injury, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts
    Am J Pathol 185:347-55. 2015
    ..Serum MBL2 concentrations averaged approximately 3 μg/mL in MBL2(+/+)Mbl1(-/-)Mbl2(-/-) [MBL2 knock in (KI)] mice...
  21. pmc Mannan-Binding Lectin Is Involved in the Protection against Renal Ischemia/Reperfusion Injury by Dietary Restriction
    Shushimita Shushimita
    Department of Surgery, Division of Transplant Surgery, Erasmus MC, University Medical Center, Rotterdam, The Netherlands
    PLoS ONE 10:e0137795. 2015
    ..We recently showed that Mannan-binding lectin (MBL), the initiator of the lectin pathway of complement activation, plays a pivotal role in renal I/RI...
  22. pmc Fibrinogen-specific antibody induces abdominal aortic aneurysm in mice through complement lectin pathway activation
    Hui Fang Zhou
    Division of Rheumatology, Department of Medicine, and Division of Vascular Surgery, Department of Surgery, Washington University in St Louis, St Louis, MO 63124
    Proc Natl Acad Sci U S A 110:E4335-44. 2013
    ..Our findings support the concept that an autoimmune process directed at aortic wall self-antigens may play a central role in the immunopathogenesis of AAA. ..
  23. pmc Intradermal immunization with wall teichoic acid (WTA) elicits and augments an anti-WTA IgG response that protects mice from methicillin-resistant Staphylococcus aureus infection independent of mannose-binding lectin status
    Kazue Takahashi
    Department of Pediatrics, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, United States of America
    PLoS ONE 8:e69739. 2013
    ..were to investigate the immune response to intradermal immunization with wall teichoic acid (WTA) and the effect of MBL deficiency in a murine model of infection with methicillin-resistant Staphylococcus aureus (MRSA)...
  24. pmc Essential role of complement mannose-binding lectin-associated serine proteases-1/3 in the murine collagen antibody-induced model of inflammatory arthritis
    Nirmal K Banda
    Division of Rheumatology, University of Colorado School of Medicine, Aurora, CO 80045, USA
    J Immunol 185:5598-606. 2010
    ....
  25. doi Continuous glycoprotein-130-mediated signal transducer and activator of transcription-3 activation promotes inflammation, left ventricular rupture, and adverse outcome in subacute myocardial infarction
    Denise Hilfiker-Kleiner
    Department of Cardiology and Angiology, Medical School Hannover, Hannover, Germany
    Circulation 122:145-55. 2010
    ..By analyzing cardiomyocyte-specific gp130(Y757F) mutant mice, we investigated the effect of disturbed gp130 signaling after myocardial infarction...
  26. doi Expression and localization of collectins in feto-maternal tissues of human first trimester spontaneous abortion and abortion prone mouse model
    A K Yadav
    National Institute for Research in Reproductive Health, Indian Council of Medical Research, Jehangir Merwanji Street, Parel, Mumbai 400012, India
    Immunobiology 221:260-8. 2016
    ..Immunostaining for SP-D and MBL proteins was positive in placental and decidual tissues...
  27. pmc Endogenous and natural complement inhibitor attenuates myocardial injury and arterial thrombogenesis
    Vasile I Pavlov
    Center for Experimental Therapeutics and Reperfusion Injury, Department of Anesthesiology, Perioperative and Pain Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston MA 02115, USA
    Circulation 126:2227-35. 2012
    ..Thus, we hypothesized that the endogenous mannose-binding lectin (MBL)/ficolin-associated protein-1 (MAP-1) that inhibits complement activation in vitro also could be an in vivo ..
  28. pmc The alternative complement pathway aids in vascular regression during the early stages of a murine model of proliferative retinopathy
    Clifford Kim
    Angiogenesis Laboratory, Massachusetts Eye and Ear Infirmary, Boston, Massachusetts, USA Department of Ophthalmology, Harvard Medical School, Boston, Massachusetts, USA and Schepens Eye Research Institute, Boston, Massachusetts, USA
    FASEB J 30:1300-5. 2016
    ....
  29. pmc Effects of mannose-binding lectin on pulmonary gene expression and innate immune inflammatory response to ozone
    Jonathan M Ciencewicki
    Immunity, Inflammation, and Disease Laboratory, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina
    Am J Physiol Lung Cell Mol Physiol 311:L280-91. 2016
    ..We hypothesized that mannose-binding lectin (MBL), an innate immunity serum protein, contributes to the proinflammatory events caused by ozone-mediated activation ..
  30. doi Inhibition of complement activation alleviates acute lung injury induced by highly pathogenic avian influenza H5N1 virus infection
    Shihui Sun
    1 State Key Laboratory of Pathogen and Biosecurity, Beijing Institute of Microbiology and Epidemiology, Beijing, China
    Am J Respir Cell Mol Biol 49:221-30. 2013
    ..caused by excessive complement activation, as demonstrated by deposition of C3, C5b-9, and mannose-binding lectin (MBL)-C in lung tissue, and by up-regulation of MBL-associated serine protease-2 and the complement receptors C3aR and ..
  31. pmc Absence of mannose-binding lectin prevents hyperglycemic cardiovascular complications
    Vasile I Pavlov
    Center for Experimental Therapeutics and Reperfusion Injury, Department of Anesthesiology, Perioperative and Pain Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
    Am J Pathol 180:104-12. 2012
    ..that cardiomyopathy and vasculopathy resulting from acute hyperglycemia are dependent on mannose-binding lectin (MBL) and lectin complement pathway activation...
  32. pmc Mannose-binding lectin-associated serine protease-1 is a significant contributor to coagulation in a murine model of occlusive thrombosis
    Laura R La Bonte
    Department of Anesthesiology, Perioperative and Pain Medicine, Center for Experimental Therapeutics and Reperfusion Injury, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    J Immunol 188:885-91. 2012
    ..In contrast, mannose-binding lectin (MBL)-null and MBL-associated serine protease (MASP)-1/-3 knockout (KO) mice had significantly decreased FeCl(3)-induced ..
  33. pmc Mannose binding lectin is required for alphavirus-induced arthritis/myositis
    Bronwyn M Gunn
    Department of Microbiology and Immunology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, United States of America
    PLoS Pathog 8:e1002586. 2012
    ..activation pathways mediate disease progression after infection, and we have identified the mannose binding lectin (MBL) pathway, but not the classical or alternative complement activation pathways, as essential for development of RRV-..
  34. pmc The lectin pathway of complement activation is a critical component of the innate immune response to pneumococcal infection
    Youssif M Ali
    Department of Infection, Immunity and Inflammation, University of Leicester, Leicester, United Kingdom
    PLoS Pathog 8:e1002793. 2012
    ..demonstrate that mouse ficolin A, human L-ficolin, and collectin 11 in both species, but not mannan-binding lectin (MBL), are the pattern recognition molecules that drive lectin pathway activation on the surface of S. pneumoniae...
  35. pmc Mannose-binding lectin regulates host resistance and pathology during experimental infection with Trypanosoma cruzi
    Antonio Gigliotti Rothfuchs
    Immunobiology Section, Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USA
    PLoS ONE 7:e47835. 2012
    Mannose-binding lectin (MBL) is a humoral pattern-recognition molecule important for host defense...
  36. doi Apoe, Mbl2, and Psp plasma protein levels correlate with diabetic phenotype in NZO mice--an optimized rapid workflow for SRM-based quantification
    Christine von Toerne
    Research Unit Protein Science, Helmholtz Zentrum Munchen, German Research Center for Environmental Health, Neuherberg, Germany
    J Proteome Res 12:1331-43. 2013
    ..We could demonstrate that apolipoprotein E (Apoe), mannose-binding lectin 2 (Mbl2), and parotid secretory protein (Psp) are present at significantly different quantities in depleted plasma of ..
  37. doi Diabetes-induced changes in mannan-binding lectin levels and complement activation in a mouse model of type 1 diabetes
    J A Ostergaard
    The Medical Research Laboratories, Department of Clinical Medicine, Faculty of Health, Aarhus University, Aarhus C, Denmark
    Scand J Immunol 77:187-94. 2013
    Circulating mannan-binding lectin (MBL) levels are elevated in type 1 diabetes. Further, high MBL levels are associated with the development of diabetic nephropathy...
  38. pmc Role of ficolin-A and lectin complement pathway in the innate defense against pathogenic Aspergillus species
    Stefan Bidula
    Norwich Medical School, University of East Anglia, Norwich, United Kingdom
    Infect Immun 81:1730-40. 2013
    ..In contrast, the collectin mannose binding lectin C (MBL-C) but not MBL-A led to efficient lectin pathway activation on A. fumigatus in the absence of ficolin-A...
  39. pmc Blocking properdin, the alternative pathway, and anaphylatoxin receptors ameliorates renal ischemia-reperfusion injury in decay-accelerating factor and CD59 double-knockout mice
    Takashi Miwa
    Department of Pharmacology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA
    J Immunol 190:3552-9. 2013
    ..Further, they demonstrate a critical role for properdin and support its therapeutic targeting in renal IRI...
  40. ncbi Mannose-binding lectin-deficient mice display defective apoptotic cell clearance but no autoimmune phenotype
    Lynda M Stuart
    Laboratory of Developmental Immunology, Harvard Department of Pediatrics, Massachusetts General Hospital, Boston, MA 02114, USA
    J Immunol 174:3220-6. 2005
    Mannose-binding lectin (MBL) is a circulating serum protein that is sequestered to sites of inflammation and infection...
  41. doi Sox17-dependent gene expression and early heart and gut development in Sox17-deficient mouse embryos
    Sabine Pfister
    Embryology Unit, Children s Medical Research Institute, New South Wales, Australia
    Int J Dev Biol 55:45-58. 2011
    ..This is associated with the defective development of the heart in the mutant embryos, which is accompanied by localised loss of Myocd-expressing cardiogenic progenitors and the malformation of the anterior intestinal portal...
  42. ncbi Hypomorphic expression of Dkk1 in the doubleridge mouse: dose dependence and compensatory interactions with Lrp6
    Bryan T MacDonald
    Department of Human Genetics, University of Michigan, Ann Arbor, MI 48109 0618, USA
    Development 131:2543-52. 2004
    ..These compensatory interactions between Dkk1 and Lrp6 demonstrate the importance of correctly balancing positive and negative regulation of Wnt signaling during mammalian development...
  43. ncbi Mannose-binding lectin deficiency alters the development of fungal asthma: effects on airway response, inflammation, and cytokine profile
    Cory M Hogaboam
    Department of Pathology, University of Michigan Medical School, Ann Arbor, MI 48109 0602, USA
    J Leukoc Biol 75:805-14. 2004
    ..Herein, we examined the role of mannose-binding lectin (MBL), a complement-activating plasma protein, during pulmonary innate and allergic immune responses directed against A...
  44. ncbi Membrane receptors for soluble defense collagens
    A J Tenner
    Department of Molecular Biology and Biochemistry, University of California, Irvine, CA 92697 3900, USA
    Curr Opin Immunol 11:34-41. 1999
    ....
  45. pmc A novel membrane protein is a mouse mammary tumor virus receptor
    T V Golovkina
    Department of Microbiology Cancer Center, University of Pennsylvania, Philadelphia 19104 6142, USA
    J Virol 72:3066-71. 1998
    ..The MTVR sequence clone is unique, shows no homology to known membrane proteins, and is transcribed in many tissues...
  46. ncbi Mart1 is located on mouse chromosome 19 and is excluded as a candidate for ep and ru
    A Wright
    Laboratory for Genetic Disease Research, National Center for Human Genome, Research, National Institutes of Health, Bethesda, Maryland 20892, USA
    Mamm Genome 8:377-8. 1997
  47. ncbi Mannose-binding lectin: the pluripotent molecule of the innate immune system
    M W Turner
    Immunobiology Unit, Institute of Child Health, London, UK
    Immunol Today 17:532-40. 1996
  48. ncbi Characterization of a novel member of the macrophage mannose receptor type C lectin family
    K Wu
    Department of Molecular Oncology, Genentech, Inc, South San Francisco, California 94080, USA
    J Biol Chem 271:21323-30. 1996
    ..Finally, in situ hybridization analysis demonstrated that the transcript encoding this lectin was found in a number of highly endothelialized sites as well as in chondrocytes in cartilaginous regions of the embryo...
  49. ncbi The murine mannose-binding protein genes (Mbl 1 and Mbl 2) localize to chromosomes 14 and 19
    R A White
    Section of Genetics, Children s Mercy Hospital UMKC School of Medicine 64108
    Mamm Genome 5:807-9. 1994
  50. ncbi Mouse Zp1 encodes a zona pellucida protein homologous to egg envelope proteins in mammals and fish
    O Epifano
    Laboratory of Cellular and Developmental Biology, NIDDK, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Biol Chem 270:27254-8. 1995
    ....
  51. ncbi cDNAs and deduced amino acid sequences of subunits in the binding component of mouse bactericidal factor, Ra-reactive factor: similarity to mannose-binding proteins
    S Kuge
    Department of Molecular Biology, School of Medicine, Kitasato University, Kanagawa Ken, Japan
    Biochemistry 31:6943-50. 1992
    ..Southern and Northern blotting analyses using these cDNAs indicated that the P28a and P28b polypeptides are the products of two unique mouse genes which are expressed in hepatic cells...
  52. pmc Complement activation pathways in murine immune complex-induced arthritis and in C3a and C5a generation in vitro
    N K Banda
    Division of Rheumatology, University of Colorado Denver, Aurora, CO 80045, USA
    Clin Exp Immunol 159:100-8. 2010
    ..We conclude that neither the CP nor LP alone is capable of mediating CAIA in vivo and that mouse sera exhibits a high level of IgG-induced C5a generation in vitro through either the CP or AP...
  53. doi Binding and activation of human and mouse complement by Cryptosporidium parvum (Apicomplexa) and susceptibility of C1q- and MBL-deficient mice to infection
    Franz Petry
    Institute of Medical Microbiology and Hygiene, Johannes Gutenberg University Mainz, Augustusplatz Hochhaus, D 55101 Mainz, Germany
    Mol Immunol 45:3392-400. 2008
    ..Using real-time PCR, parasite development could be demonstrated in adult mice lacking mannan-binding lectin (MBL-A/C-/-) but not in mice lacking complement factor C1q (C1qA-/-) or in wild type C57BL/6 mice...
  54. doi Mannose binding lectin gene deficiency increases susceptibility to traumatic brain injury in mice
    Phoebe H Yager
    Department of Pediatric Critical Care Medicine, Massachusetts General Hospital, Harvard Medical School, Charlestown, Massachusetts 2129, USA
    J Cereb Blood Flow Metab 28:1030-9. 2008
    Mannose binding lectin (MBL) initiates complement activation and exacerbates tissue damage after systemic ischemia/reperfusion...
  55. ncbi Pathogenic complement activation in collagen antibody-induced arthritis in mice requires amplification by the alternative pathway
    Nirmal K Banda
    Division of Rheumatology B115, University of Colorado at Denver and Health Sciences Center, Aurora, CO 80045, USA
    J Immunol 179:4101-9. 2007
    ..These results indicate that the alternative pathway amplification loop, with its ability to greatly enhance C3 activation, is necessary to mediate inflammatory arthritis induced by adherent immune complexes...
  56. doi Lessons learned from murine models of mannose-binding lectin deficiency
    Kazue Takahashi
    Programs of Developmental Immunology, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA
    Biochem Soc Trans 36:1487-90. 2008
    b>MBL (mannose-binding lectin) is a pattern recognition molecule and a component of innate immunity, the first line of the host defence system against foreign bodies and pathogens...
  57. pmc Surviving mousepox infection requires the complement system
    Elizabeth A Moulton
    Rheumatology Division, Department of Medicine, Washington University School of Medicine, Saint Louis, MO, USA
    PLoS Pathog 4:e1000249. 2008
    ..In summary, the complement system acts in the first few minutes, hours, and days to control this poxviral infection until the adaptive immune response can react, and loss of this system results in lethal infection...
  58. pmc Binding of serum mannan binding lectin to a cell integrity-defective Cryptococcus neoformans ccr4Delta mutant
    John C Panepinto
    University of Illinois at Chicago, Section of Infectious Diseases, Chicago, IL 60612, USA
    Infect Immun 75:4769-79. 2007
    Mannan binding lectin (MBL) is an innate immune mediator belonging to the collectin family known to bind to the surfaces of many viruses, bacteria, and fungi...
  59. ncbi The alternative pathway of complement activation is critical for blister induction in experimental epidermolysis bullosa acquisita
    Sidonia Mihai
    Department of Dermatology, University of Lubeck, Lubeck, Germany, and Department of Pediatrics, Laboratory of Developmental Immunology, Massachusetts General Hospital, Boston 02115, USA
    J Immunol 178:6514-21. 2007
    ....
  60. doi Protective role of mouse MBL-C on intestinal mucosa during Shigella flexneri invasion
    Da Ming Zuo
    Department of Immunology, School of Basic Medical Sciences, Southern Medical University, Guangzhou, Guangdong, People s Republic of China
    Int Immunol 21:1125-34. 2009
    Mannan-binding lectin (MBL) is a C-type serum lectin, which is believed to play an important role in the innate immunity against a variety of pathogens...
  61. pmc Myocardial ischemia and reperfusion injury is dependent on both IgM and mannose-binding lectin
    Marc N Busche
    Department of Anesthesiology, Perioperative and Pain Medicine, Center for Experimental Therapeutics and Reperfusion Injury, Brigham and Women s Hospital, Boston, MA 02115, USA
    Am J Physiol Heart Circ Physiol 297:H1853-9. 2009
    ..Several recent studies from our laboratory demonstrated the importance of mannose-binding lectin (MBL) as the initiation pathway for complement activation and the resulting pathological effects following MI/R...
  62. pmc Mannose-binding lectin plays a critical role in myocardial ischaemia and reperfusion injury in a mouse model of diabetes
    M N Busche
    Center for Experimental Therapeutics and Reperfusion Injury, Department of Anesthesiology, Perioperative and Pain Medicine, Brigham and Women s Hospital, Harvard Medical School, 75 Francis Street, Thorn 705, Boston, MA 02115, USA
    Diabetologia 51:1544-51. 2008
    ..We hypothesised a significant role for mannose-binding lectin (MBL) in cardiomyopathies associated with hyperglycaemia.
  63. doi Early regulators in abortion and implications for a preeclampsia model
    Gerard Chaouat
    Unité 782 INSERM, Hôpital Antoine Béclère et Université Paris Sud Orsay, 92141 Clamart Cedex, France gerard
    J Reprod Immunol 82:131-40. 2009
    ..The complement regulator mannan binding lectin-A (MBL-A), but not MBL-C, was present on day 4.5 pc especially after mating with DBA/2 males...
  64. pmc Genetically-defined deficiency of mannose-binding lectin is associated with protection after experimental stroke in mice and outcome in human stroke
    Alvaro Cervera
    Comprehensive Stroke Center, Hospital Clinic, Institut d Investigacions Biomediques August Pi i Sunyer IDIBAPS, Medical School, University of Barcelona, Barcelona, Spain
    PLoS ONE 5:e8433. 2010
    ..The latter is initiated by mannose-binding lectin (MBL) and MBL-associated serine proteases (MASPs)...
  65. pmc Capture of influenza by medullary dendritic cells via SIGN-R1 is essential for humoral immunity in draining lymph nodes
    Santiago F Gonzalez
    The Immune Disease Institute and Program in Cellular and Molecular Medicine, Children s Hospital, Department of Pediatrics, Harvard Medical School, Boston, Massachusetts, USA
    Nat Immunol 11:427-34. 2010
    ..Thus, our results have important implications for the generation of durable humoral immunity to viral pathogens through vaccination...
  66. doi Interactions of ficolin and mannose-binding lectin with fibrinogen/fibrin augment the lectin complement pathway
    Yuichi Endo
    Department of Immunology, Fukushima Medical University School of Medicine, Fukushima, Japan
    J Innate Immun 2:33-42. 2010
    Ficolin and mannose-binding lectin (MBL) are animal lectins that are involved in innate immunity by initiating the lectin complement pathway...
  67. ncbi The differing roles of the classical and mannose-binding lectin complement pathways in the events following skeletal muscle ischemia-reperfusion
    Rodney K Chan
    Department of Surgery and Pediatrics, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    J Immunol 177:8080-5. 2006
    ..pathway had been assumed to be the major pathway of activation leading to injury, the mannose-binding lectin (MBL) pathway might also play a contributing role...
  68. pmc B cell subsets contribute to renal injury and renal protection after ischemia/reperfusion
    Brandon Renner
    Department of Medicine, University of Colorado Denver School of Medicine, Denver, CO 80045, USA
    J Immunol 185:4393-400. 2010
    ..However, nonperitoneal B cells attenuate renal injury after I/R, possibly through the production of IL-10...
  69. ncbi Mannose-binding lectin augments the uptake of lipid A, Staphylococcus aureus, and Escherichia coli by Kupffer cells through increased cell surface expression of scavenger receptor A
    Kei Ono
    Department of Biochemistry, Sapporo Medical University School of Medicine, Sapporo, Japan
    J Immunol 177:5517-23. 2006
    We investigated roles of scavenger receptor A (SR-A) and mannose-binding lectin (MBL) in the uptake of endotoxin and bacteria by Kupffer cells...
  70. pmc Lack of the pattern recognition molecule mannose-binding lectin increases susceptibility to influenza A virus infection
    Wei Chuan Chang
    Department of Pediatrics, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA
    BMC Immunol 11:64. 2010
    Mannose-binding lectin (MBL), a pattern recognition innate immune molecule, inhibits influenza A virus infection in vitro. MBL deficiency due to gene polymorphism in humans has been associated with infection susceptibility...
  71. pmc The alternative pathway is required, but not alone sufficient, for retinal pathology in mouse laser-induced choroidal neovascularization
    Barbel Rohrer
    Department of Ophthalmology, Medical University of South Carolina, Charleston, SC 29425, United States
    Mol Immunol 48:e1-8. 2011
    ..First, single-gene knockouts were analyzed and compared to wild type mice; C1q(-/-) (no CP), MBL(-/-) (no LP), and CFB(-/-) (no AP)...

Research Grants5

  1. Innate Immunity in the Clearance of Influenza A Virus Infected Apoptotic Cells
    Kazue Takahashi; Fiscal Year: 2008
    ..The focus of this proposal is mannose-binding lectin (MBL), a serum protein of the innate immune system that recognizes not only pathogens, including viruses, but also ..
  2. Transgenic Rod Development and Function
    Baerbel Rohrer; Fiscal Year: 2005
    ..However, more importantly, it will provide avenues for studying gene defects at the single cell level not only in the retina, but in other systems as well. ..
  3. NOT1 in stress tolerance of Cryptococcus neoformans
    John Panepinto; Fiscal Year: 2005
    ..Exploring the NOT1 dependent stress response may reveal novel virulence factors in C. neoformans. ..
  4. ROD NEURODEGENERATIVE AND PROTECTIVE GENES
    Baerbel Rohrer; Fiscal Year: 2005
    ..We expect to isolate common downstream target genes that are activated both during degeneration and neuroprotection. ..
  5. INTERACTION OF CLQ ON PHAGOCYTIC CELLS
    Andrea Joan Tenner; Fiscal Year: 2010
    ..Therapeutic targeting of these "biosensors", exemplified by C1q/MBL and the cell surface molecules/complexes that transfer the signals to the cell, should facilitate more effective ..