mast cell protease 8


Gene Symbol: mast cell protease 8
Description: mast cell protease 8
Alias: BB139338, MMCP-8, mast cell protease 8
Species: mouse
Products:     mast cell protease 8

Top Publications

  1. Lunderius C, Hellman L. Characterization of the gene encoding mouse mast cell protease 8 (mMCP-8), and a comparative analysis of hematopoietic serine protease genes. Immunogenetics. 2001;53:225-32 pubmed
    ..We present here the nucleotide sequence of the gene encoding mouse mast cell protease 8 (mMCP-8)...
  2. Lihua L, Yoshikawa S, Ohta T, Horiguchi K, Kawano Y, Ohtsu H, et al. Large particulate allergens can elicit mast cell-mediated anaphylaxis without exit from blood vessels as efficiently as do small soluble allergens. Biochem Biophys Res Commun. 2015;467:70-5 pubmed publisher
  3. Sullivan B, Liang H, Bando J, WU D, Cheng L, McKerrow J, et al. Genetic analysis of basophil function in vivo. Nat Immunol. 2011;12:527-35 pubmed publisher
    ..Although targeted deletion of IL-4 and IL-13 in either CD4(+) T cells or basophils had a minimal effect on worm clearance, deletion from both lineages demonstrated a nonredundant role for basophil cytokines in primary helminth immunity...
  4. Egawa M, Mukai K, Yoshikawa S, Iki M, Mukaida N, Kawano Y, et al. Inflammatory monocytes recruited to allergic skin acquire an anti-inflammatory M2 phenotype via basophil-derived interleukin-4. Immunity. 2013;38:570-80 pubmed publisher
    ..Thus, inflammatory monocytes can be converted from being proinflammatory to anti-inflammatory under the influence of basophils in allergic reactions...
  5. Gallwitz M, Reimer J, Hellman L. Expansion of the mast cell chymase locus over the past 200 million years of mammalian evolution. Immunogenetics. 2006;58:655-69 pubmed
    ..These findings indicate that all chymase locus genes are derived from a single ancestor that was present more than 200 million years ago. ..
  6. Gallwitz M, Hellman L. Rapid lineage-specific diversification of the mast cell chymase locus during mammalian evolution. Immunogenetics. 2006;58:641-54 pubmed
    ..These findings illustrate the importance of gene duplications in conferring rapid changes in mammalian genomes. ..
  7. Ho C, Chhabra A, Starkl P, Schnorr P, Wilmes S, Moraga I, et al. Decoupling the Functional Pleiotropy of Stem Cell Factor by Tuning c-Kit Signaling. Cell. 2017;168:1041-1052.e18 pubmed publisher
    ..The approach of biasing cell activation by tuning signaling thresholds and outputs has applications to many dimeric receptor-ligand systems. ..
  8. Cheng L, Sullivan B, Retana L, Allen C, Liang H, Locksley R. IgE-activated basophils regulate eosinophil tissue entry by modulating endothelial function. J Exp Med. 2015;212:513-24 pubmed publisher
    ..Thus, basophils are gatekeepers that link adaptive immunity with innate effector programs by altering access to tissue sites by activation-induced interactions with the endothelium. ..
  9. Pellefigues C, Dema B, Lamri Y, Saidoune F, Chavarot N, Lohéac C, et al. Prostaglandin D2 amplifies lupus disease through basophil accumulation in lymphoid organs. Nat Commun. 2018;9:725 pubmed publisher
    ..Our study identifies the PGD2/PTGDR axis as a ready-to-use therapeutic modality in SLE. ..

More Information


  1. Gallwitz M, Enoksson M, Hellman L. Expression profile of novel members of the rat mast cell protease (rMCP)-2 and (rMCP)-8 families, and functional analyses of mouse mast cell protease (mMCP)-8. Immunogenetics. 2007;59:391-405 pubmed
    ..Thus, the substrate specificity of mMCP-8 may be too narrow to be detected with the employed methods, or the enzyme may require a substrate conformation that is not provided by the analyzed peptides. ..
  2. Lützelschwab C, Huang M, Kullberg M, Aveskogh M, Hellman L. Characterization of mouse mast cell protease-8, the first member of a novel subfamily of mouse mast cell serine proteases, distinct from both the classical chymases and tryptases. Eur J Immunol. 1998;28:1022-33 pubmed
    ..This latter is in clear contrast to what has been observed in the rat where the MMCP-8 homologues, RMCP-8, -9 and -10, can be considered as true mucosal MC proteases. ..
  3. Reber L, Marichal T, Mukai K, Kita Y, Tokuoka S, Roers A, et al. Selective ablation of mast cells or basophils reduces peanut-induced anaphylaxis in mice. J Allergy Clin Immunol. 2013;132:881-8.e1-11 pubmed publisher
    ..The neutrophilia in Kit(W-sh/W-sh) mice might influence the responses of these mice in this PIA model. ..
  4. Pozniak C, Sengupta Ghosh A, Gogineni A, Hanson J, Lee S, Larson J, et al. Dual leucine zipper kinase is required for excitotoxicity-induced neuronal degeneration. J Exp Med. 2013;210:2553-67 pubmed publisher
  5. Abram C, Roberge G, Hu Y, Lowell C. Comparative analysis of the efficiency and specificity of myeloid-Cre deleting strains using ROSA-EYFP reporter mice. J Immunol Methods. 2014;408:89-100 pubmed publisher
    ..By focusing on myeloid subsets, we directly compare the relative efficiency and specificity of myeloid deletion in these strains under steady-state conditions. ..
  6. Rönnberg E, Calounova G, Guss B, Lundequist A, Pejler G. Granzyme D is a novel murine mast cell protease that is highly induced by multiple pathways of mast cell activation. Infect Immun. 2013;81:2085-94 pubmed publisher
    ..Together, these findings identify granzyme D as a novel murine mast cell protease and implicate granzyme D in settings where mast cells are activated, such as bacterial infection and allergy. ..
  7. Wada T, Ishiwata K, Koseki H, Ishikura T, Ugajin T, Ohnuma N, et al. Selective ablation of basophils in mice reveals their nonredundant role in acquired immunity against ticks. J Clin Invest. 2010;120:2867-75 pubmed publisher acquired tick resistance, mice expressing the human diphtheria toxin receptor under the control of the mast cell protease 8 (Mcpt8) promoter were generated...
  8. Lee L, Ji M, Sinha M, Dong M, Ren X, Wang Y, et al. Determinants of Divergent Adaptive Immune Responses after Airway Sensitization with Ligands of Toll-Like Receptor 5 or Toll-Like Receptor 9. PLoS ONE. 2016;11:e0167693 pubmed publisher
    ..Thus, the cell types that responded to TLR ligands were a critical determinant of the innate cytokines produced and the character of the resulting adaptive immune response in the airways. ..
  9. Tsutsui H, Yamanishi Y, Ohtsuka H, Sato S, Yoshikawa S, Karasuyama H. The Basophil-specific Protease mMCP-8 Provokes an Inflammatory Response in the Skin with Microvascular Hyperpermeability and Leukocyte Infiltration. J Biol Chem. 2017;292:1061-1067 pubmed publisher
    ..Particularly, mouse mast cell protease 8 (mMCP-8) is specifically expressed by basophils but not mast cells despite its name...