Masp2

Summary

Gene Symbol: Masp2
Description: mannan-binding lectin serine peptidase 2
Alias: MASP-2, MAp19, mannan-binding lectin serine protease 2, MBL-associated serine protease 2, mannose-binding protein-associated serine protease 2
Species: mouse
Products:     Masp2

Top Publications

  1. Iwaki D, Kanno K, Takahashi M, Endo Y, Matsushita M, Fujita T. The role of mannose-binding lectin-associated serine protease-3 in activation of the alternative complement pathway. J Immunol. 2011;187:3751-8 pubmed publisher
    ..These results suggested that MASP-3 complexed with MBL is converted to an active form by incubation with bacterial targets, and that activated MASP-3 triggered the initial activation step of the alternative complement pathway. ..
  2. Iwaki D, Kanno K, Takahashi M, Endo Y, Lynch N, Schwaeble W, et al. Small mannose-binding lectin-associated protein plays a regulatory role in the lectin complement pathway. J Immunol. 2006;177:8626-32 pubmed
    ..Therefore, MASP-2 is essential for the activation of C4 and sMAP plays a regulatory role in the activation of the lectin pathway. ..
  3. Takahashi M, Iwaki D, Kanno K, Ishida Y, Xiong J, Matsushita M, et al. Mannose-binding lectin (MBL)-associated serine protease (MASP)-1 contributes to activation of the lectin complement pathway. J Immunol. 2008;180:6132-8 pubmed
    ..From these results, we propose that MASP-1 contributes to the activation of the lectin pathway, probably through the activation of MASP-2. ..
  4. Ali Y, Lynch N, Haleem K, Fujita T, Endo Y, Hansen S, et al. The lectin pathway of complement activation is a critical component of the innate immune response to pneumococcal infection. PLoS Pathog. 2012;8:e1002793 pubmed publisher
    ..This study corroborates the essential function of MASP-2 in the lectin pathway and highlights the importance of MBL-independent lectin pathway activation in the host defense against pneumococci. ..
  5. Schwaeble W, Lynch N, Clark J, Marber M, Samani N, Ali Y, et al. Targeting of mannan-binding lectin-associated serine protease-2 confers protection from myocardial and gastrointestinal ischemia/reperfusion injury. Proc Natl Acad Sci U S A. 2011;108:7523-8 pubmed publisher
    ..The therapeutic effects of MASP-2 inhibition in this experimental model suggest the utility of anti-MASP-2 antibody therapy in reperfusion injury and other lectin pathway-mediated disorders. ..
  6. Freeley S, Popat R, Parmar K, Kolev M, Hunt B, Stover C, et al. Experimentally-induced anti-myeloperoxidase vasculitis does not require properdin, MASP-2 or bone marrow-derived C5. J Pathol. 2016;240:61-71 pubmed publisher
    ..2016 The Authors. The Journal of Pathology published by John Wiley & Sons Ltd on behalf of Pathological Society of Great Britain and Ireland. ..
  7. Stover C, Lynch N, Hanson S, Windbichler M, Gregory S, Schwaeble W. Organization of the MASP2 locus and its expression profile in mouse and rat. Mamm Genome. 2004;15:887-900 pubmed
    ..They comprise the genes for MASP-2/ MAp19, TAR DNA binding protein of 43 kDa, FRAP kinase, CDT6, Polymyositis-Scleroderma 100-kDa autoantigen, spermidine ..
  8. Banda N, Acharya S, Scheinman R, Mehta G, Takahashi M, Endo Y, et al. Deconstructing the Lectin Pathway in the Pathogenesis of Experimental Inflammatory Arthritis: Essential Role of the Lectin Ficolin B and Mannose-Binding Protein-Associated Serine Protease 2. J Immunol. 2017;199:1835-1845 pubmed publisher
    ..Finally, we also speculate that the residual disease seen in our studies is driven by the AP and/or the C2/C4 bypass pathway via the direct cleavage of C3 through an LP-dependent mechanism. ..
  9. Asgari E, Farrar C, Lynch N, Ali Y, Roscher S, Stover C, et al. Mannan-binding lectin-associated serine protease 2 is critical for the development of renal ischemia reperfusion injury and mediates tissue injury in the absence of complement C4. FASEB J. 2014;28:3996-4003 pubmed publisher
    ..Our study highlights the role of LP activation in renal IR injury and indicates that injury occurs through MASP-2-dependent activation events independent of C4. ..

More Information

Publications23

  1. Dib S, Xiao S, Miletic D, Robertson J. Gene targeting of mouse Tardbp negatively affects Masp2 expression. PLoS ONE. 2014;9:e95373 pubmed publisher
    ..was specifically designed to not overlap with Tardbp adjacent genes, the homologous recombination event affected the expression of a downstream gene, Masp2. This may explain the inability to obtain homozygote mice with targeted Tardbp.
  2. Sun S, Zhao G, Liu C, Wu X, Guo Y, Yu H, et al. Inhibition of complement activation alleviates acute lung injury induced by highly pathogenic avian influenza H5N1 virus infection. Am J Respir Cell Mol Biol. 2013;49:221-30 pubmed publisher
  3. Lawson P, Reid K. A novel PCR-based technique using expressed sequence tags and gene homology for murine genetic mapping: localization of the complement genes. Int Immunol. 2000;12:231-40 pubmed
    ..These results provide new insights into the evolution of this group of proteins. ..
  4. Møller Kristensen M, Thiel S, Sjoholm A, Matsushita M, Jensenius J. Cooperation between MASP-1 and MASP-2 in the generation of C3 convertase through the MBL pathway. Int Immunol. 2007;19:141-9 pubmed
  5. Farrar C, Tran D, Li K, Wu W, Peng Q, Schwaeble W, et al. Collectin-11 detects stress-induced L-fucose pattern to trigger renal epithelial injury. J Clin Invest. 2016;126:1911-25 pubmed publisher
    ..Given these results, we conclude that lectin complement pathway activation triggered by ligand-CL-11 interaction in postischemic tissue is a potent source of acute kidney injury and is amenable to sugar-specific blockade. ..
  6. Orsini F, Chrysanthou E, Dudler T, Cummings W, Takahashi M, Fujita T, et al. Mannan binding lectin-associated serine protease-2 (MASP-2) critically contributes to post-ischemic brain injury independent of MASP-1. J Neuroinflammation. 2016;13:213 pubmed publisher
  7. Endo Y, Takahashi M, Nakao M, Saiga H, Sekine H, Matsushita M, et al. Two lineages of mannose-binding lectin-associated serine protease (MASP) in vertebrates. J Immunol. 1998;161:4924-30 pubmed
    ..Furthermore, the presence of MASP or MASP-like sequences in most vertebrate species suggests that the lectin pathway functions extensively in vertebrates and that its origin is traced back to the invertebrate stage...
  8. Liu Y, Endo Y, Homma S, Kanno K, Yaginuma H, Fujita T. Ficolin A and ficolin B are expressed in distinct ontogenic patterns and cell types in the mouse. Mol Immunol. 2005;42:1265-73 pubmed
    ..Thus, the different spatial-temporal expression patterns of ficolins A and B suggest that these molecules play distinct roles in the prenatal and postnatal stages. ..
  9. Stover C, Thiel S, Lynch N, Schwaeble W. The rat and mouse homologues of MASP-2 and MAp19, components of the lectin activation pathway of complement. J Immunol. 1999;163:6848-59 pubmed
    ..activation, a serine protease of 76 kDa, termed MASP-2, and a MASP-2 related plasma protein of 19 kDa, termed MAp19. Upon activation of the MBL/MASPs/MAp19 complex, MASP-2 cleaves the fourth complement component C4, while the role ..
  10. Ali Y, Kenawy H, Muhammad A, Sim R, Andrew P, Schwaeble W. Human L-ficolin, a recognition molecule of the lectin activation pathway of complement, activates complement by binding to pneumolysin, the major toxin of Streptococcus pneumoniae. PLoS ONE. 2013;8:e82583 pubmed publisher
    ..This work elucidates the detailed interactions between PLY and complement and shows for the first time a specific role of the LP in PLY-mediated complement activation in human serum. ..
  11. Gorelik A, Sapir T, Haffner Krausz R, Olender T, Woodruff T, Reiner O. Developmental activities of the complement pathway in migrating neurons. Nat Commun. 2017;8:15096 pubmed publisher
    ..Here we show that key proteins in the lectin arm of this pathway, MASP1, MASP2 and C3, are expressed in the developing cortex and that neuronal migration is impaired in knockout and knockdown ..
  12. Takahashi M, Ishida Y, Iwaki D, Kanno K, Suzuki T, Endo Y, et al. Essential role of mannose-binding lectin-associated serine protease-1 in activation of the complement factor D. J Exp Med. 2010;207:29-37 pubmed publisher
    ..Thus, it is clear that MASP-1 is an essential protease of both the lectin and alternative complement pathways...
  13. Iwaki D, Fujita T. Production and purification of recombinants of mouse MASP-2 and sMAP. J Endotoxin Res. 2005;11:47-50 pubmed
    ..From these data, rsMAP and rMASP-2 generated in this study seem to be useful in analysis of the deficient mice. ..
  14. Endo Y, Nakazawa N, Liu Y, Iwaki D, Takahashi M, Fujita T, et al. Carbohydrate-binding specificities of mouse ficolin A, a splicing variant of ficolin A and ficolin B and their complex formation with MASP-2 and sMAP. Immunogenetics. 2005;57:837-44 pubmed
    ..These results suggest that ficolin A and its variant function as recognition molecules of the lectin pathway, and ficolin B plays a distinct role through its unique carbohydrate-binding specificity. ..