Gene Symbol: Masp1
Description: mannan-binding lectin serine peptidase 1
Alias: AW048060, CCPII, Crarf, Masp1/3, mannan-binding lectin serine protease 1, MASP-1, complement factor MASP-3, complement-activating component of Ra-reactive factor, mannose-binding lectin-associated serine protease 1, mannose-binding protein-associated serine protease, ra-reactive factor serine protease p100, raRF, serine protease 5
Species: mouse
Products:     Masp1

Top Publications

  1. Iwaki D, Kanno K, Takahashi M, Endo Y, Matsushita M, Fujita T. The role of mannose-binding lectin-associated serine protease-3 in activation of the alternative complement pathway. J Immunol. 2011;187:3751-8 pubmed publisher
    ..These results suggested that MASP-3 complexed with MBL is converted to an active form by incubation with bacterial targets, and that activated MASP-3 triggered the initial activation step of the alternative complement pathway. ..
  2. Takahashi M, Iwaki D, Kanno K, Ishida Y, Xiong J, Matsushita M, et al. Mannose-binding lectin (MBL)-associated serine protease (MASP)-1 contributes to activation of the lectin complement pathway. J Immunol. 2008;180:6132-8 pubmed
    ..In this study, a MASP-1- and MASP-3-deficient mouse model (MASP1/3(-/-)) was generated by a gene targeting strategy to investigate the roles of MASP-1 and MASP-3 in the lectin ..
  3. Banda N, Takahashi M, Levitt B, Glogowska M, Nicholas J, Takahashi K, et al. Essential role of complement mannose-binding lectin-associated serine proteases-1/3 in the murine collagen antibody-induced model of inflammatory arthritis. J Immunol. 2010;185:5598-606 pubmed publisher
    Gene-targeted mice deficient in the complement mannose-binding lectin-associated serine protease-1 and -3 (MASP1/3(-/-)) express only the zymogen of factor D (pro-factor D [pro-Df]), a necessary component of the alternative pathway (AP)...
  4. Takahashi M, Ishida Y, Iwaki D, Kanno K, Suzuki T, Endo Y, et al. Essential role of mannose-binding lectin-associated serine protease-1 in activation of the complement factor D. J Exp Med. 2010;207:29-37 pubmed publisher
    ..In this study, we generated a MASP-1- and MASP-3-deficient mouse model (Masp1/3-/-) and found that no activation of the alternative pathway was observed in Masp1/3-/- serum...
  5. Arend W, Mehta G, Antonioli A, Takahashi M, Takahashi K, Stahl G, et al. Roles of adipocytes and fibroblasts in activation of the alternative pathway of complement in inflammatory arthritis in mice. J Immunol. 2013;190:6423-33 pubmed publisher
    ..These results demonstrate that pathogenic activation of the AP can occur in the joint through immune complexes adherent to cartilage and the local production of necessary AP proteins by adipocytes and FLS. ..
  6. Takada F, Seki N, Matsuda Y, Takayama Y, Kawakami M. Localization of the genes for the 100-kDa complement-activating components of Ra-reactive factor (CRARF and Crarf) to human 3q27-q28 and mouse 16B2-B3. Genomics. 1995;25:757-9 pubmed
    ..and mouse genes for the complement-activating component (P100) of Ra-reactive factor, a novel bactericidal factor (CRARF and Crarf), were mapped to R-banded metaphase chromosomes by fluorescence in situ hybridization with human and ..
  7. Camerer E, Barker A, Duong D, Ganesan R, Kataoka H, Cornelissen I, et al. Local protease signaling contributes to neural tube closure in the mouse embryo. Dev Cell. 2010;18:25-38 pubmed publisher
    ..Together, our results suggest a role for protease-activated receptor signaling in neural tube closure and identify a local protease network that may trigger Par2 signaling and monitor and regulate epithelial integrity in this context. ..
  8. Takahashi K, Chang W, Takahashi M, Pavlov V, Ishida Y, La Bonte L, et al. Mannose-binding lectin and its associated proteases (MASPs) mediate coagulation and its deficiency is a risk factor in developing complications from infection, including disseminated intravascular coagulation. Immunobiology. 2011;216:96-102 pubmed publisher
    ..Infected MBL null mice also develop liver injury. These findings suggest that MBL deficiency may manifest into DIC and organ failure during infectious diseases. ..
  9. Adamiak M, Abdelbaset Ismail A, Suszynska M, Abdel Latif A, Ratajczak J, Ratajczak M. Novel evidence that the mannan-binding lectin pathway of complement activation plays a pivotal role in triggering mobilization of hematopoietic stem/progenitor cells by activation of both the complement and coagulation cascades. Leukemia. 2017;31:262-265 pubmed publisher

More Information


  1. Banda N, Mehta G, Kjaer T, Takahashi M, Schaack J, Morrison T, et al. Essential role for the lectin pathway in collagen antibody-induced arthritis revealed through use of adenovirus programming complement inhibitor MAp44 expression. J Immunol. 2014;193:2455-68 pubmed publisher
    ..Our study provides conclusive evidence that an intact complement LP is essential to initiate CAIA, and that MAp44 may be an appropriate treatment for inflammatory arthritis. ..
  2. Banda N, Acharya S, Scheinman R, Mehta G, Coulombe M, Takahashi M, et al. Mannan-Binding Lectin-Associated Serine Protease 1/3 Cleavage of Pro-Factor D into Factor D In Vivo and Attenuation of Collagen Antibody-Induced Arthritis through Their Targeted Inhibition by RNA Interference-Mediated Gene Silencing. J Immunol. 2016;197:3680-3694 pubmed
    ..Thus, MASP-1/3 represent a new therapeutic target for the treatment of RA, likely through both direct effects on the lectin pathway and indirectly through the alternative pathway. ..
  3. Stover C, Lynch N, Dahl M, Hanson S, Takahashi M, Frankenberger M, et al. Murine serine proteases MASP-1 and MASP-3, components of the lectin pathway activation complex of complement, are encoded by a single structural gene. Genes Immun. 2003;4:374-84 pubmed
    ..Furthermore, we demonstrate the evolutionary conservation of MASP-3 mRNA in cDNA transcripts from guinea pig, rabbit, pufferfish, and cow. ..
  4. Lawson P, Reid K. A novel PCR-based technique using expressed sequence tags and gene homology for murine genetic mapping: localization of the complement genes. Int Immunol. 2000;12:231-40 pubmed
    ..These results provide new insights into the evolution of this group of proteins. ..
  5. Ruseva M, Takahashi M, Fujita T, Pickering M. C3 dysregulation due to factor H deficiency is mannan-binding lectin-associated serine proteases (MASP)-1 and MASP-3 independent in vivo. Clin Exp Immunol. 2014;176:84-92 pubmed publisher
    ..Our data indicate that MASP-1 and MASP-3 are not essential for alternative pathway activation in complete FH deficiency. ..
  6. Krogh S, Holt C, Steffensen R, Funck K, Høyem P, Laugesen E, et al. Plasma levels of MASP-1, MASP-3 and MAp44 in patients with type 2 diabetes: influence of glycaemic control, body composition and polymorphisms in the MASP1 gene. Clin Exp Immunol. 2017;189:103-112 pubmed publisher
    ..We hypothesized that single nucleotide polymorphisms (SNPs) in the MASP1 gene may contribute to altered plasma levels of the belonging gene products; MASP-1, MASP-3 and mannan-binding ..
  7. Endo Y, Takahashi M, Nakao M, Saiga H, Sekine H, Matsushita M, et al. Two lineages of mannose-binding lectin-associated serine protease (MASP) in vertebrates. J Immunol. 1998;161:4924-30 pubmed
    ..Furthermore, the presence of MASP or MASP-like sequences in most vertebrate species suggests that the lectin pathway functions extensively in vertebrates and that its origin is traced back to the invertebrate stage...
  8. La Bonte L, Pavlov V, Tan Y, Takahashi K, Takahashi M, Banda N, et al. Mannose-binding lectin-associated serine protease-1 is a significant contributor to coagulation in a murine model of occlusive thrombosis. J Immunol. 2012;188:885-91 pubmed publisher
    ..Taken together, these findings indicate that MBL/MASP complexes, and specifically MASP-1, play a key role in thrombus formation in vitro and in vivo. ..
  9. Møller Kristensen M, Thiel S, Sjoholm A, Matsushita M, Jensenius J. Cooperation between MASP-1 and MASP-2 in the generation of C3 convertase through the MBL pathway. Int Immunol. 2007;19:141-9 pubmed
  10. Liu Y, Endo Y, Homma S, Kanno K, Yaginuma H, Fujita T. Ficolin A and ficolin B are expressed in distinct ontogenic patterns and cell types in the mouse. Mol Immunol. 2005;42:1265-73 pubmed
    ..Thus, the different spatial-temporal expression patterns of ficolins A and B suggest that these molecules play distinct roles in the prenatal and postnatal stages. ..
  11. Banda N, Takahashi M, Takahashi K, Stahl G, Hyatt S, Glogowska M, et al. Mechanisms of mannose-binding lectin-associated serine proteases-1/3 activation of the alternative pathway of complement. Mol Immunol. 2011;49:281-9 pubmed publisher
    ..We conclude that MASP-1 does not require binding to MBL-A, MBL-C, or FCN-A to activate the AP. MASP-1 may cleave pro-Df into mature Df through binding to FCN-B or to an unknown protein, or may function as an unbound soluble protein. ..
  12. Gorelik A, Sapir T, Haffner Krausz R, Olender T, Woodruff T, Reiner O. Developmental activities of the complement pathway in migrating neurons. Nat Commun. 2017;8:15096 pubmed publisher
    ..The complement pathway converges to cleave C3. Here we show that key proteins in the lectin arm of this pathway, MASP1, MASP2 and C3, are expressed in the developing cortex and that neuronal migration is impaired in knockout and ..
  13. Takahashi A, Takayama Y, Hatsuse H, Kawakami M. Presence of a serine protease in the complement-activating component of the complement-dependent bactericidal factor, RaRF, in mouse serum. Biochem Biophys Res Commun. 1993;190:681-7 pubmed
    ..The full sequence was found to have characteristics of a serine protease and exhibited 29% and 30% homologies with those of light chains of the C1r and C1s subcomponents of complement, respectively. ..
  14. Takayama Y, Takada F, Takahashi A, Kawakami M. A 100-kDa protein in the C4-activating component of Ra-reactive factor is a new serine protease having module organization similar to C1r and C1s. J Immunol. 1994;152:2308-16 pubmed
    Ra-reactive factor (RaRF), a C-dependent bactericidal factor in mice, is composed of one polysaccharide-binding component and one C4/C2-activating component...