Gene Symbol: Mark3
Description: MAP/microtubule affinity regulating kinase 3
Alias: 1600015G02Rik, A430080F22Rik, C-TAK1, ETK-1, ETK1, Emk2, MPK10, MAP/microtubule affinity-regulating kinase 3, ELKL motif kinase 2, EMK-2, EMK2/MARK3 serine-threonine protein kinase, MPK-10
Species: mouse
Products:     Mark3

Top Publications

  1. Zhang Y, Maksakova I, Gagnier L, van de Lagemaat L, Mager D. Genome-wide assessments reveal extremely high levels of polymorphism of two active families of mouse endogenous retroviral elements. PLoS Genet. 2008;4:e1000007 pubmed publisher
    ..These extreme levels of polymorphism suggest that ERV insertions play a significant role in genetic drift of mouse lines...
  2. Gilardi Hebenstreit P, Nieto M, Frain M, Mattei M, Chestier A, Wilkinson D, et al. An Eph-related receptor protein tyrosine kinase gene segmentally expressed in the developing mouse hindbrain. Oncogene. 1992;7:2499-506 pubmed
    ..These data are consistent with a role of the Sek gene product in a signal transduction process involved in pattern formation in the hindbrain. ..
  3. Biesecker L, Gottschalk L, Emerson S. Identification of four murine cDNAs encoding putative protein kinases from primitive embryonic stem cells differentiated in vitro. Proc Natl Acad Sci U S A. 1993;90:7044-8 pubmed
    ..These genes are candidates for receptors or downstream effectors of cytokines that regulate self-renewal and lineage commitment in embryogenesis. ..
  4. Hanks S, Quinn A, Hunter T. The protein kinase family: conserved features and deduced phylogeny of the catalytic domains. Science. 1988;241:42-52 pubmed
    ..Phylogenetic mapping of the conserved protein kinase catalytic domains can serve as a useful first step in the functional characterization of these newly identified family members. ..
  5. Concepcion D, Flores García L, Hamilton B. Multipotent genetic suppression of retrotransposon-induced mutations by Nxf1 through fine-tuning of alternative splicing. PLoS Genet. 2009;5:e1000484 pubmed publisher
  6. Hezel A, Gurumurthy S, Granot Z, Swisa A, Chu G, Bailey G, et al. Pancreatic LKB1 deletion leads to acinar polarity defects and cystic neoplasms. Mol Cell Biol. 2008;28:2414-25 pubmed publisher
    ..These genetic studies provide in vivo evidence of a key role for LKB1 in the establishment of epithelial cell polarity that is vital for pancreatic acinar cell function and viability and for the suppression of neoplasia. ..
  7. Lennerz J, Hurov J, White L, Lewandowski K, Prior J, Planer G, et al. Loss of Par-1a/MARK3/C-TAK1 kinase leads to reduced adiposity, resistance to hepatic steatosis, and defective gluconeogenesis. Mol Cell Biol. 2010;30:5043-56 pubmed publisher
    ..Here, we report phenotypes of mice null for a second family member (Par-1a/MARK3/C-TAK1) that exhibit increased energy expenditure, reduced adiposity with unaltered glucose handling, and normal ..
  8. Wilks A. Two putative protein-tyrosine kinases identified by application of the polymerase chain reaction. Proc Natl Acad Sci U S A. 1989;86:1603-7 pubmed
    ..The PCR library was then screened by DNA sequencing for PTK-related sequences. Two sequences were identified that, on the basis of sequence comparison with known PTKs, may encode representatives of a new class of PTK. ..
  9. Muller J, Ory S, Copeland T, Piwnica Worms H, Morrison D. C-TAK1 regulates Ras signaling by phosphorylating the MAPK scaffold, KSR1. Mol Cell. 2001;8:983-93 pubmed

More Information


  1. Hartleben B, Schweizer H, Lübben P, Bartram M, Möller C, Herr R, et al. Neph-Nephrin proteins bind the Par3-Par6-atypical protein kinase C (aPKC) complex to regulate podocyte cell polarity. J Biol Chem. 2008;283:23033-8 pubmed publisher
  2. Kwan J, Sczaniecka A, Heidary Arash E, Nguyen L, Chen C, Ratkovic S, et al. DLG5 connects cell polarity and Hippo signaling protein networks by linking PAR-1 with MST1/2. Genes Dev. 2016;30:2696-2709 pubmed publisher
    ..MST1/2 and large tumor suppressor homologs 1/2 (LATS1/2), uses its scaffolding function to link MST1/2 with MARK3, and inhibits MST1/2 kinase activity...
  3. Tochio N, Koshiba S, Kobayashi N, Inoue M, Yabuki T, Aoki M, et al. Solution structure of the kinase-associated domain 1 of mouse microtubule-associated protein/microtubule affinity-regulating kinase 3. Protein Sci. 2006;15:2534-43 pubmed
    ..In this study, we determined the solution structure of the KA1 domain of mouse MARK3 by NMR spectroscopy...
  4. Wang C, You Z, Xia Q, Xiong T, Xia Y, Yao D. Upregulation of Mark3 and Rpgrip1 mRNA expression by jujuboside A in mouse hippocampus. Acta Pharmacol Sin. 2007;28:334-8 pubmed
    ..01 vs control) at a dosage of 80 mg/kg, and the genes MAP/microtubule affinity-regulating kinase3 (Mark3) and retinitis pigmentosa GTPase regulator interacting protein1 (Rpgrip1) were upregulated by JuA in the mouse ..
  5. Heisig J, Weber D, Englberger E, Winkler A, Kneitz S, Sung W, et al. Target gene analysis by microarrays and chromatin immunoprecipitation identifies HEY proteins as highly redundant bHLH repressors. PLoS Genet. 2012;8:e1002728 pubmed publisher
    ..These data clearly establish the three HEY bHLH factors as highly redundant transcriptional repressors in vitro and in vivo, which explains the combinatorial action observed in different tissues with overlapping expression. ..
  6. Calabrese G, Mesner L, Stains J, Tommasini S, Horowitz M, Rosen C, et al. Integrating GWAS and Co-expression Network Data Identifies Bone Mineral Density Genes SPTBN1 and MARK3 and an Osteoblast Functional Module. Cell Syst. 2017;4:46-59.e4 pubmed publisher
    ..We experimentally confirmed that two of the genes predicted to be causal, SPTBN1 and MARK3, are potentially responsible for the effects of GWAS loci on chromosomes 2p16.2 and 14q32.32, respectively...
  7. Schwarz T, Murphy S, Sohn C, Mansky K. C-TAK1 interacts with microphthalmia-associated transcription factor, Mitf, but not the related family member Tfe3. Biochem Biophys Res Commun. 2010;394:890-5 pubmed publisher