Gene Symbol: Marco
Description: macrophage receptor with collagenous structure
Alias: AI323439, Ly112, Scara2, macrophage receptor MARCO
Species: mouse
Products:     Marco

Top Publications

  1. Granucci F, Petralia F, Urbano M, Citterio S, Di Tota F, Santambrogio L, et al. The scavenger receptor MARCO mediates cytoskeleton rearrangements in dendritic cells and microglia. Blood. 2003;102:2940-7 pubmed
    Macrophage receptor with collagenous structure (MARCO) is a scavenger receptor expressed in peritoneal macrophages and in a subpopulation of macrophages in the marginal zone of the spleen and in the medullary cord of lymph nodes...
  2. Arredouani M, Yang Z, Ning Y, Qin G, Soininen R, Tryggvason K, et al. The scavenger receptor MARCO is required for lung defense against pneumococcal pneumonia and inhaled particles. J Exp Med. 2004;200:267-72 pubmed
    Alveolar macrophages (AMs) express the class A scavenger receptor macrophage receptor with collagenous structure (MARCO), but its role in vivo in lung defense against bacteria and environmental particles has not been studied...
  3. Ghosh S, Gregory D, Smith A, Kobzik L. MARCO regulates early inflammatory responses against influenza: a useful macrophage function with adverse outcome. Am J Respir Cell Mol Biol. 2011;45:1036-44 pubmed publisher
    Lung macrophages use the scavenger receptor MARCO to bind and ingest bacteria, particulate matter, and post cellular debris. We investigated the role of MARCO in influenza A virus (IAV) pneumonia...
  4. Dahl M, Bauer A, Arredouani M, Soininen R, Tryggvason K, Kleeberger S, et al. Protection against inhaled oxidants through scavenging of oxidized lipids by macrophage receptors MARCO and SR-AI/II. J Clin Invest. 2007;117:757-64 pubmed
    ..macrophages (AMs) express the class A scavenger receptors (SRAs) macrophage receptor with collagenous structure (MARCO) and scavenger receptor AI/II (SRA-I/II), which recognize oxidized lipids and provide innate defense against ..
  5. Brännström A, Sankala M, Tryggvason K, Pikkarainen T. Arginine residues in domain V have a central role for bacteria-binding activity of macrophage scavenger receptor MARCO. Biochem Biophys Res Commun. 2002;290:1462-9 pubmed
    b>MARCO is a bacteria-binding macrophage-specific scavenger receptor that plays a role in innate immune response...
  6. Mukhopadhyay S, Varin A, Chen Y, Liu B, Tryggvason K, Gordon S. SR-A/MARCO-mediated ligand delivery enhances intracellular TLR and NLR function, but ligand scavenging from cell surface limits TLR4 response to pathogens. Blood. 2011;117:1319-28 pubmed publisher
    ..The class-A scavenger receptors SR-A (scavenger receptor A) and MARCO (macrophage receptor with collagenous structure) are 2 well-characterized phagocytic receptors that are unable to ..
  7. Elomaa O, Kangas M, Sahlberg C, Tuukkanen J, Sormunen R, Liakka A, et al. Cloning of a novel bacteria-binding receptor structurally related to scavenger receptors and expressed in a subset of macrophages. Cell. 1995;80:603-9 pubmed
  8. Chen Y, Pikkarainen T, Elomaa O, Soininen R, Kodama T, Kraal G, et al. Defective microarchitecture of the spleen marginal zone and impaired response to a thymus-independent type 2 antigen in mice lacking scavenger receptors MARCO and SR-A. J Immunol. 2005;175:8173-80 pubmed
    The macrophage scavenger receptor macrophage receptor with a collagenous structure (MARCO) is expressed in mice by the marginal zone macrophages of the spleen and by macrophages of the medullary cords of lymph nodes, as well as the ..
  9. Komine H, Kuhn L, Matsushita N, MULE J, Pilon Thomas S. Examination of MARCO activity on dendritic cell phenotype and function using a gene knockout mouse. PLoS ONE. 2013;8:e67795 pubmed publisher
    We have reported the upregulation of MARCO, a member of the class A scavenger receptor family, on the surface of murine and human dendritic cells (DCs) pulsed with tumor lysates...

More Information


  1. Jozefowski S, Sulahian T, Arredouani M, Kobzik L. Role of scavenger receptor MARCO in macrophage responses to CpG oligodeoxynucleotides. J Leukoc Biol. 2006;80:870-9 pubmed
    The macrophage Class A scavenger receptor MARCO (macrophage receptor with a collagenous structure) functions as a pattern-recognition receptor for bacterial components, but its role in responses to CpG oligonucleotide sequences (CpG-ODN) ..
  2. Brown J, Swindle E, Kushnir Sukhov N, Holian A, Metcalfe D. Silica-directed mast cell activation is enhanced by scavenger receptors. Am J Respir Cell Mol Biol. 2007;36:43-52 pubmed
    ..scavenger receptors; then explored the involvement of SR-A and macrophage receptor with colleagenous structure (MARCO)...
  3. Jozefowski S, Arredouani M, Sulahian T, Kobzik L. Disparate regulation and function of the class A scavenger receptors SR-AI/II and MARCO. J Immunol. 2005;175:8032-41 pubmed
    The macrophage class A scavenger receptors, macrophage receptor with a collagenous structure (MARCO) and type I/II class A scavenger receptor (SR-AI/II), share structural features and roles in host defense, but little is known about ..
  4. Arredouani M, Franco F, Imrich A, Fedulov A, Lu X, Perkins D, et al. Scavenger Receptors SR-AI/II and MARCO limit pulmonary dendritic cell migration and allergic airway inflammation. J Immunol. 2007;178:5912-20 pubmed
    The class A scavenger receptors (SR-A) MARCO and SR-AI/II are expressed on lung macrophages (MPhis) and dendritic cells (DCs) and function in innate defenses against inhaled pathogens and particles...
  5. Bowdish D, Sakamoto K, Kim M, Kroos M, Mukhopadhyay S, Leifer C, et al. MARCO, TLR2, and CD14 are required for macrophage cytokine responses to mycobacterial trehalose dimycolate and Mycobacterium tuberculosis. PLoS Pathog. 2009;5:e1000474 pubmed publisher
    ..Herein, we demonstrate that the macrophage receptor with collagenous structure (MARCO), a class A scavenger receptor, is utilized preferentially to "tether" TDM to the macrophage and to ..
  6. MacLeod D, Nakatsuji T, Yamasaki K, Kobzik L, Gallo R. HSV-1 exploits the innate immune scavenger receptor MARCO to enhance epithelial adsorption and infection. Nat Commun. 2013;4:1963 pubmed publisher
    ..Here we demonstrate that a cell surface scavenger receptor, macrophage receptor with collagenous structure (MARCO), previously thought to enhance antiviral defense by enabling nucleic acid recognition, is usurped by herpes ..
  7. Bonilla D, Bhattacharya A, Sha Y, Xu Y, Xiang Q, Kan A, et al. Autophagy regulates phagocytosis by modulating the expression of scavenger receptors. Immunity. 2013;39:537-47 pubmed publisher
    ..had increased expression of two class A scavenger receptors: macrophage receptor with collagenous structure (MARCO) and macrophage scavenger receptor 1 (MSR1)...
  8. Hirano S, Kanno S. Macrophage Receptor with Collagenous Structure (MARCO) Is Processed by either Macropinocytosis or Endocytosis-Autophagy Pathway. PLoS ONE. 2015;10:e0142062 pubmed publisher
    The Macrophage Receptor with COllagenous structure (MARCO) protein is a plasma membrane receptor for un-opsonized or environmental particles on phagocytic cells...
  9. Thakur S, Beamer C, Migliaccio C, Holian A. Critical role of MARCO in crystalline silica-induced pulmonary inflammation. Toxicol Sci. 2009;108:462-71 pubmed publisher
    ..Although, previous studies established the macrophage receptor with collagenous structure (MARCO) as an important receptor for binding and uptake of crystalline silica particles in vitro, the role of MARCO in ..
  10. Elshourbagy N, Li X, Terrett J, Vanhorn S, Gross M, Adamou J, et al. Molecular characterization of a human scavenger receptor, human MARCO. Eur J Biochem. 2000;267:919-26 pubmed
    Murine MARCO has been identified recently in subsets of macrophages located in the peritoneum, marginal zone of the spleen, and the medullary cord of lymph nodes, where it has been proposed that it serves as a bacteria-binding receptor...
  11. Prabhudas M, Bowdish D, Drickamer K, Febbraio M, Herz J, Kobzik L, et al. Standardizing scavenger receptor nomenclature. J Immunol. 2014;192:1997-2006 pubmed publisher
    ..The purpose of this article is to describe the proposed mammalian nomenclature and classification developed at the workshop and to solicit additional feedback from the broader research community. ..
  12. Kellermayer Z, Lábadi A, Czompoly T, Arnold H, Balogh P. Absence of Nkx2-3 homeodomain transcription factor induces the formation of LYVE-1-positive endothelial cysts without lymphatic commitment in the spleen. J Histochem Cytochem. 2011;59:690-700 pubmed publisher
    ..structures are bordered with ER-TR7(+) fibroblastic reticular cells with small clusters of macrophages expressing MARCO and sialoadhesin...
  13. Rogers N, Lees M, Gabriel L, Maniati E, Rose S, Potter P, et al. A defect in Marco expression contributes to systemic lupus erythematosus development via failure to clear apoptotic cells. J Immunol. 2009;182:1982-90 pubmed publisher
    ..those strains with functional analyses to demonstrate that reduced expression of the innate scavenger receptor Marco (macrophage receptor with collagenous structure) is a primary event in BXSB mice, that reduced mRNA expression is ..
  14. Ordija C, Chiou T, Yang Z, DeLoid G, de Oliveira Valdo M, Wang Z, et al. Free actin impairs macrophage bacterial defenses via scavenger receptor MARCO interaction with reversal by plasma gelsolin. Am J Physiol Lung Cell Mol Physiol. 2017;312:L1018-L1028 pubmed publisher
    ..7 ± 50.7, or 52.7 ± 16.9; n = 5-6, P < 0.05]. In addition, actin binding was reduced in a MARCO/SR-AI/II-deficient cell line and by normal AMs obtained from MARCO-/- mice...
  15. Perez A, Wright M, Maugeais C, Braendli Baiocco A, Okamoto H, Takahashi A, et al. MARCO, a macrophage scavenger receptor highly expressed in rodents, mediates dalcetrapib-induced uptake of lipids by rat and mouse macrophages. Toxicol In Vitro. 2010;24:745-50 pubmed publisher
    ..chylomicrons was increased by LPS and associated with expression of MAcrophage Receptor with COllagenous domain (MARCO). MARCO was expressed at very low levels in human macrophages and was not inducible by LPS...
  16. Jawad S, Liu B, Li Z, Katamay R, Campos M, Wei L, et al. The role of macrophage class a scavenger receptors in a laser-induced murine choroidal neovascularization model. Invest Ophthalmol Vis Sci. 2013;54:5959-70 pubmed publisher
    ..Class A scavenger receptors, scavenger receptor-A (SR-A) and macrophage receptor with collagenous domain (MARCO), are expressed on macrophages and are associated with macrophage function...
  17. Herrmann M, Schafer C, Heiss A, Gräber S, Kinkeldey A, Büscher A, et al. Clearance of fetuin-A--containing calciprotein particles is mediated by scavenger receptor-A. Circ Res. 2012;111:575-84 pubmed publisher
    ..Biochemical studies showed that fetuin-A is essential for the formation of protein-mineral complexes, called calciprotein particles (CPPs). CPPs must be cleared from circulation to prevent local deposition and pathological calcification...
  18. Georgoudaki A, Prokopec K, Boura V, Hellqvist E, Sohn S, Östling J, et al. Reprogramming Tumor-Associated Macrophages by Antibody Targeting Inhibits Cancer Progression and Metastasis. Cell Rep. 2016;15:2000-11 pubmed publisher
    ..We have found that the pattern recognition scavenger receptor MARCO defines a subtype of suppressive TAMs and is linked to clinical outcome...
  19. MacLeod D, Nakatsuji T, Wang Z, Di Nardo A, Gallo R. Vaccinia virus binds to the scavenger receptor MARCO on the surface of keratinocytes. J Invest Dermatol. 2015;135:142-150 pubmed publisher
    ..The class A scavenger receptor known as MARCO (macrophage receptor with collagenous structure) is expressed on human and mouse keratinocytes and found to be ..
  20. Getts D, Terry R, Getts M, Deffrasnes C, Müller M, van Vreden C, et al. Therapeutic inflammatory monocyte modulation using immune-modifying microparticles. Sci Transl Med. 2014;6:219ra7 pubmed publisher
    ..inflammatory monocytes, in an opsonin-independent fashion, via the macrophage receptor with collagenous structure (MARCO)...
  21. Dorrington M, Roche A, Chauvin S, Tu Z, Mossman K, Weiser J, et al. MARCO is required for TLR2- and Nod2-mediated responses to Streptococcus pneumoniae and clearance of pneumococcal colonization in the murine nasopharynx. J Immunol. 2013;190:250-8 pubmed publisher
    ..Because the receptors scavenger receptor A (SRA), macrophage receptor with collagenous structure (MARCO), and mannose receptor (MR) have been identified as nonopsonic receptors for S...
  22. Varin A, Mukhopadhyay S, Herbein G, Gordon S. Alternative activation of macrophages by IL-4 impairs phagocytosis of pathogens but potentiates microbial-induced signalling and cytokine secretion. Blood. 2010;115:353-62 pubmed publisher
    ..IL-4Ralpha chain, but independent of Scavenger receptor A and macrophage receptor with collagenous structure (MARCO), 2 known receptors for N meningitidis...
  23. Beamer C, Holian A. Silica suppresses Toll-like receptor ligand-induced dendritic cell activation. FASEB J. 2008;22:2053-63 pubmed publisher
    ..Taken together, silica's ability to alter susceptibility to infection may be due to impaired inflammatory responses and reduced antibacterial activity. ..
  24. Gomes I, Palma L, Campos G, Lima J, DE Almeida T, DE Menezes J, et al. The scavenger receptor MARCO is involved in Leishmania major infection by CBA/J macrophages. Parasite Immunol. 2009;31:188-98 pubmed publisher
    ..The macrophage receptor with collagenous structure (MARCO) is a PRR that is preferably expressed by macrophages and is capable of binding Gram-positive and Gram-negative ..
  25. Chan I, Van Hoof D, Abramova M, Bilardello M, Mar E, Jorgensen B, et al. PEGylated IL-10 Activates Kupffer Cells to Control Hypercholesterolemia. PLoS ONE. 2016;11:e0156229 pubmed publisher
    ..Taken together these data suggest that PEG-rIL-10's cholesterol regulating biology is consistent between mice and humans. ..
  26. Thelen T, Hao Y, Medeiros A, Curtis J, Serezani C, Kobzik L, et al. The class A scavenger receptor, macrophage receptor with collagenous structure, is the major phagocytic receptor for Clostridium sordellii expressed by human decidual macrophages. J Immunol. 2010;185:4328-35 pubmed publisher
    ..sordellii phagocytosis. Soluble macrophage receptor with collagenous structure (MARCO) receptor prevented C...
  27. Hollifield M, Bou Ghanem E, de Villiers W, Garvy B. Scavenger receptor A dampens induction of inflammation in response to the fungal pathogen Pneumocystis carinii. Infect Immun. 2007;75:3999-4005 pubmed
    ..carinii infection than did wild-type mice. Together, these data indicate that SRA controls inflammatory cytokines produced by alveolar macrophages in the context of P. carinii infection...
  28. Kissick H, Dunn L, Ghosh S, Nechama M, Kobzik L, Arredouani M. The scavenger receptor MARCO modulates TLR-induced responses in dendritic cells. PLoS ONE. 2014;9:e104148 pubmed publisher
    The scavenger receptor MARCO mediates macrophage recognition and clearance of pathogens and their polyanionic ligands...
  29. Wu M, Gibbons J, DeLoid G, Bedugnis A, Thimmulappa R, Biswal S, et al. Immunomodulators targeting MARCO expression improve resistance to postinfluenza bacterial pneumonia. Am J Physiol Lung Cell Mol Physiol. 2017;313:L138-L153 pubmed publisher
    Downregulation of the alveolar macrophage (AM) receptor with collagenous structure (MARCO) leads to susceptibility to postinfluenza bacterial pneumonia, a major cause of morbidity and mortality...
  30. Maler M, Nielsen P, Stichling N, Cohen I, Ruzsics Z, Wood C, et al. Key Role of the Scavenger Receptor MARCO in Mediating Adenovirus Infection and Subsequent Innate Responses of Macrophages. MBio. 2017;8: pubmed publisher
    The scavenger receptor MARCO is expressed in several subsets of naive tissue-resident macrophages and has been shown to participate in the recognition of various bacterial pathogens...
  31. Petnicki Ocwieja T, Chung E, Acosta D, Ramos L, Shin O, Ghosh S, et al. TRIF mediates Toll-like receptor 2-dependent inflammatory responses to Borrelia burgdorferi. Infect Immun. 2013;81:402-10 pubmed publisher
    ..This appears to be due to the effects of MyD88 on phagocytosis via scavenger receptors, such as MARCO, which are not affected by the loss of TRIF...
  32. Pinheiro da Silva F, Aloulou M, Skurnik D, Benhamou M, Andremont A, Velasco I, et al. CD16 promotes Escherichia coli sepsis through an FcR gamma inhibitory pathway that prevents phagocytosis and facilitates inflammation. Nat Med. 2007;13:1368-74 pubmed
    ..the phagocytic receptor negatively regulated by FcRgamma on macrophages as the class A scavenger receptor MARCO. E. coli-FcgammaRIII interaction induces the recruitment of SHP-1 to MARCO, thereby inhibiting E...
  33. Hamilton R, Thakur S, Mayfair J, Holian A. MARCO mediates silica uptake and toxicity in alveolar macrophages from C57BL/6 mice. J Biol Chem. 2006;281:34218-26 pubmed
    ..The purpose of this study was to isolate which SRs (macrophage receptor with collagenous structure (MARCO), CD204, or CD36) were involved using a variety of SR single and double null mice...
  34. Shichita T, Ito M, Morita R, Komai K, Noguchi Y, Ooboshi H, et al. MAFB prevents excess inflammation after ischemic stroke by accelerating clearance of damage signals through MSR1. Nat Med. 2017;23:723-732 pubmed publisher
    ..peroxiredoxins (PRXs), and S100A8 and S100A9, were internalized through the class A scavenger receptors MSR1 and MARCO in vitro. In ischemic murine brain, DAMP internalization was largely mediated by MSR1...
  35. Neyen C, Plüddemann A, Mukhopadhyay S, Maniati E, Bossard M, Gordon S, et al. Macrophage scavenger receptor a promotes tumor progression in murine models of ovarian and pancreatic cancer. J Immunol. 2013;190:3798-805 pubmed publisher
    ..Our observations suggest that SR-A may be a potential drug target in the prevention of metastatic cancer progression. ..
  36. Murthy S, Larson Casey J, Ryan A, He C, Kobzik L, Carter A. Alternative activation of macrophages and pulmonary fibrosis are modulated by scavenger receptor, macrophage receptor with collagenous structure. FASEB J. 2015;29:3527-36 pubmed publisher
    ..The scavenger receptor, macrophage receptor with collagenous structure (MARCO), provides innate immune defense against inhaled particles and pathogens; however, a receptor for asbestos has not ..
  37. Rezaie P, Corbisiero V, Male D. Transient expression of MIDC-8 in the normal mouse brain. Neurosci Lett. 2005;377:189-94 pubmed
    ..immunohistochemically characterized the expression of mononuclear phagocyte markers CD14, CD36, CD68, CD204 and MARCO by parenchymal microglia in the developing and adult mouse brain...
  38. Kangas M, Brännström A, Elomaa O, Matsuda Y, Eddy R, Shows T, et al. Structure and chromosomal localization of the human and murine genes for the macrophage MARCO receptor. Genomics. 1999;58:82-9 pubmed
    ..The human and mouse genes were localized to syntenic regions on chromosomes 2 and 1, respectively, using fluorescence in situ hybridization. ..
  39. Jing J, Yang I, Hui L, Patel J, Evans C, Prikeris R, et al. Role of macrophage receptor with collagenous structure in innate immune tolerance. J Immunol. 2013;190:6360-7 pubmed publisher
    ..Macrophage receptor with collagenous structure (MARCO) is a scavenger receptor on the cell surface of macrophages that mediates opsonin-independent phagocytosis...
  40. Court N, Vasseur V, Vacher R, Fremond C, Shebzukhov Y, Yeremeev V, et al. Partial redundancy of the pattern recognition receptors, scavenger receptors, and C-type lectins for the long-term control of Mycobacterium tuberculosis infection. J Immunol. 2010;184:7057-70 pubmed publisher
    ..tuberculosis infection, in sharp contrast with the nonredundant, essential role of the TNF, IL-1, or IFN-gamma pathway for host resistance to M. tuberculosis. ..
  41. Komai K, Shichita T, Ito M, Kanamori M, Chikuma S, Yoshimura A. Role of scavenger receptors as damage-associated molecular pattern receptors in Toll-like receptor activation. Int Immunol. 2017;29:59-70 pubmed publisher
    ..These data suggest that scavenger receptors function as co-receptors along with TLRs for HMGB1 in M1-type inflammatory macrophages. ..
  42. Mukhopadhyay S, Chen Y, Sankala M, Peiser L, Pikkarainen T, Kraal G, et al. MARCO, an innate activation marker of macrophages, is a class A scavenger receptor for Neisseria meningitidis. Eur J Immunol. 2006;36:940-9 pubmed
    The scavenger receptor-A I/II (SR-A) and macrophage receptor with collagenous domain (MARCO) share a common domain organisation and ligand repertoire, including selected polyanions and gram-positive and -negative organisms, but differ in ..
  43. Chen Y, Wermeling F, Sundqvist J, Jonsson A, Tryggvason K, Pikkarainen T, et al. A regulatory role for macrophage class A scavenger receptors in TLR4-mediated LPS responses. Eur J Immunol. 2010;40:1451-60 pubmed publisher
    ..induces up-regulation of the class A scavenger receptors (SR) macrophage receptor with a collagenous structure (MARCO) and SR-A, which occurs, at least in the case of MARCO, via both MyD88-dependent and -independent pathways...
  44. Harvey C, Thimmulappa R, Sethi S, Kong X, Yarmus L, Brown R, et al. Targeting Nrf2 signaling improves bacterial clearance by alveolar macrophages in patients with COPD and in a mouse model. Sci Transl Med. 2011;3:78ra32 pubmed publisher
    ..Nrf2 increased phagocytic ability of macrophages by direct transcriptional up-regulation of the scavenger receptor MARCO. Disruption of Nrf2 or MARCO abrogated sulforaphane-mediated bacterial phagocytosis by COPD alveolar macrophages...
  45. Wermeling F, Chen Y, Pikkarainen T, Scheynius A, Winqvist O, Izui S, et al. Class A scavenger receptors regulate tolerance against apoptotic cells, and autoantibodies against these receptors are predictive of systemic lupus. J Exp Med. 2007;204:2259-65 pubmed
    ..Because the autoantibodies can be detected before onset of disease in mice, they could have predictive value as early indicators of SLE. ..