Mapt

Summary

Gene Symbol: Mapt
Description: microtubule-associated protein tau
Alias: AI413597, AW045860, Mtapt, Tau, microtubule-associated protein tau, PHF-tau, neurofibrillary tangle protein, paired helical filament-tau
Species: mouse

Top Publications

  1. pmc Analysis of tau phosphorylation and truncation in a mouse model of human tauopathy
    Patrice Delobel
    Medical Research Council Laboratory of Molecular Biology, Hills Road, Cambridge CB2 OQH, UK
    Am J Pathol 172:123-31. 2008
  2. ncbi Inhibition of neuronal maturation in primary hippocampal neurons from tau deficient mice
    H N Dawson
    Division of Neurology, Department of Medicine, Duke University, Durham, NC 27710 and OSV, Inc, Research Triangle Park, NC 27709, USA
    J Cell Sci 114:1179-87. 2001
  3. ncbi Sequestosome 1/p62 shuttles polyubiquitinated tau for proteasomal degradation
    Jeganathan Ramesh Babu
    Department of Biological Sciences, Program in Cell and Molecular Biosciences, Auburn University, AL 36849, USA
    J Neurochem 94:192-203. 2005
  4. pmc Tau reduction prevents Abeta-induced defects in axonal transport
    Keith A Vossel
    Gladstone Institute of Neurological Disease, San Francisco, CA 94158, USA
    Science 330:198. 2010
  5. pmc Expression of MeCP2 in postmitotic neurons rescues Rett syndrome in mice
    Sandra Luikenhuis
    Whitehead Institute for Biomedical Research, Massachusetts Institute of Technology, 9 Cambridge Center, Cambridge, MA 02142, USA
    Proc Natl Acad Sci U S A 101:6033-8. 2004
  6. ncbi Formation of tau inclusions in knock-in mice with familial Alzheimer disease (FAD) mutation of presenilin 1 (PS1)
    Kentaro Tanemura
    Laboratory for Alzheimer Disease and Neural Architecture, Brain Science Institute, RIKEN, Wako, Saitama 351 0198, Japan
    J Biol Chem 281:5037-41. 2006
  7. doi Performance of aβ1-40, aβ1-42, total tau, and phosphorylated tau as predictors of dementia in a cohort of patients with mild cognitive impairment
    Lucilla Parnetti
    Clinica Neurologica, Universita degli Studi di Perugia, Perugia, Italy
    J Alzheimers Dis 29:229-38. 2012
  8. ncbi Increased tau phosphorylation in apolipoprotein E4 transgenic mice is associated with activation of extracellular signal-regulated kinase: modulation by zinc
    Faith M Harris
    Gladstone Institute of Neurological Disease, University of California, San Francisco, California 94141 9100, USA
    J Biol Chem 279:44795-801. 2004
  9. doi Developmental expression of prion protein and its ligands stress-inducible protein 1 and vitronectin
    Glaucia N M Hajj
    Ludwig Institute for Cancer Research, São Paulo 01323 903, Brazil
    J Comp Neurol 517:371-84. 2009
  10. ncbi BAG-1 associates with Hsc70.Tau complex and regulates the proteasomal degradation of Tau protein
    Evan Elliott
    Department of Neurobiology, Weizmann Insitute of Science, Rehovot, Israel 76100
    J Biol Chem 282:37276-84. 2007

Research Grants

  1. MAP KINASE REGULATION OF MICROGLIAL ACTIVATION
    Narayan Bhat; Fiscal Year: 2004
  2. MAP KINASES IN OLIGODENDROCYTE CELL SIGNALING
    Narayan Bhat; Fiscal Year: 2005
  3. Neuroinflammation in Cholesterol-Induced AD Pathogenesis
    Narayan Bhat; Fiscal Year: 2009
  4. Proteome analysis in mice expressing P301L tau
    Irving Vega; Fiscal Year: 2005
  5. BIOLOGY OF ALZHEIMER PAIRED HELICAL FILAMENTS
    Virginia Lee; Fiscal Year: 2001
  6. ALZHEIMER PATHOPHYSIOLOGY IN HUMAN CATARACT FORMATION
    PETER FREDERIKSE; Fiscal Year: 2002
  7. MITOCHONDRIAL OXIDATIVE STRESS AND NEURODEGENERATION
    Simon Melov; Fiscal Year: 2004
  8. Mechanisms of Tau-Based Neurodegeneration
    Mark Forman; Fiscal Year: 2005
  9. Comparative Functional Genomics of Longevity Assurance
    Simon Melov; Fiscal Year: 2006
  10. Alzheimer disease biomarkers in lens
    Peter H Frederikse; Fiscal Year: 2010

Detail Information

Publications143 found, 100 shown here

  1. pmc Analysis of tau phosphorylation and truncation in a mouse model of human tauopathy
    Patrice Delobel
    Medical Research Council Laboratory of Molecular Biology, Hills Road, Cambridge CB2 OQH, UK
    Am J Pathol 172:123-31. 2008
    Recent evidence has suggested that truncation of tau protein at the caspase cleavage site D421 precedes hyperphosphorylation and may be necessary for the assembly of tau into filaments in Alzheimer's disease and other tauopathies...
  2. ncbi Inhibition of neuronal maturation in primary hippocampal neurons from tau deficient mice
    H N Dawson
    Division of Neurology, Department of Medicine, Duke University, Durham, NC 27710 and OSV, Inc, Research Triangle Park, NC 27709, USA
    J Cell Sci 114:1179-87. 2001
    Conflicting evidence supports a role for tau as an essential neuronal cytoskeletal protein or as a redundant protein whose function can be fulfilled by other microtubule-associated proteins...
  3. ncbi Sequestosome 1/p62 shuttles polyubiquitinated tau for proteasomal degradation
    Jeganathan Ramesh Babu
    Department of Biological Sciences, Program in Cell and Molecular Biosciences, Auburn University, AL 36849, USA
    J Neurochem 94:192-203. 2005
    ..Employing both in vitro and in vivo approaches, tau was found to be a substrate of the TRAF6, possessing lysine 63 polyubiquitin chains...
  4. pmc Tau reduction prevents Abeta-induced defects in axonal transport
    Keith A Vossel
    Gladstone Institute of Neurological Disease, San Francisco, CA 94158, USA
    Science 330:198. 2010
    Amyloid-β (Aβ) peptides, derived from the amyloid precursor protein, and the microtubule-associated protein tau are key pathogenic factors in Alzheimer's disease (AD). How exactly they impair cognitive functions is unknown...
  5. pmc Expression of MeCP2 in postmitotic neurons rescues Rett syndrome in mice
    Sandra Luikenhuis
    Whitehead Institute for Biomedical Research, Massachusetts Institute of Technology, 9 Cambridge Center, Cambridge, MA 02142, USA
    Proc Natl Acad Sci U S A 101:6033-8. 2004
    ..Expression of the Mecp2 transgene in postmitotic neurons resulted in symptoms of severe motor dysfunction. Transgene expression in Mecp2 mutant mice, however, rescued the RTT phenotype...
  6. ncbi Formation of tau inclusions in knock-in mice with familial Alzheimer disease (FAD) mutation of presenilin 1 (PS1)
    Kentaro Tanemura
    Laboratory for Alzheimer Disease and Neural Architecture, Brain Science Institute, RIKEN, Wako, Saitama 351 0198, Japan
    J Biol Chem 281:5037-41. 2006
    ..with various phosphodependent tau antibodies and with Alz50, which recognizes the conformational change of PHF tau. Some neurons exhibited Congo red birefringence and Thioflavin T reactivity, both of which are histological ..
  7. doi Performance of aβ1-40, aβ1-42, total tau, and phosphorylated tau as predictors of dementia in a cohort of patients with mild cognitive impairment
    Lucilla Parnetti
    Clinica Neurologica, Universita degli Studi di Perugia, Perugia, Italy
    J Alzheimers Dis 29:229-38. 2012
    ..Cerebrospinal fluid (CSF) classical biomarkers, i.e., amyloid-β 1-42 (Aβ1-42), total tau (t-tau), and phosphorylated tau (p-tau) reflect the neuropathological changes taking place in AD brains, thus ..
  8. ncbi Increased tau phosphorylation in apolipoprotein E4 transgenic mice is associated with activation of extracellular signal-regulated kinase: modulation by zinc
    Faith M Harris
    Gladstone Institute of Neurological Disease, University of California, San Francisco, California 94141 9100, USA
    J Biol Chem 279:44795-801. 2004
    ..Neuronal expression of apoE4 or apoE4 fragments in transgenic mice increases tau phosphorylation...
  9. doi Developmental expression of prion protein and its ligands stress-inducible protein 1 and vitronectin
    Glaucia N M Hajj
    Ludwig Institute for Cancer Research, São Paulo 01323 903, Brazil
    J Comp Neurol 517:371-84. 2009
    ..Finally, although STI1 and Vn are PrP(C) ligands, their expression was not altered in PrP(C)-null mice...
  10. ncbi BAG-1 associates with Hsc70.Tau complex and regulates the proteasomal degradation of Tau protein
    Evan Elliott
    Department of Neurobiology, Weizmann Insitute of Science, Rehovot, Israel 76100
    J Biol Chem 282:37276-84. 2007
    Intraneuronal accumulation of phosphorylated Tau protein is a molecular pathology found in many forms of dementia, including Alzheimer disease...
  11. doi Microglial activation in brain lesions with tau deposits: comparison of human tauopathies and tau transgenic mice TgTauP301L
    Atsushi Sasaki
    Department of Human Pathology, Gunma University Graduate School of Medicine, Gunma, Japan
    Brain Res 1214:159-68. 2008
    The aim of this study is to clarify the relationship of microglia to phosphorylated tau accumulation and the characteristics of microglial activation in brain lesions of human tauopathies in comparison to mutant tau transgenic (TG) mice...
  12. pmc Hyperphosphorylated Tau in an α-synuclein-overexpressing transgenic model of Parkinson's disease
    Thomas Haggerty
    Laboratory of Molecular Neurochemistry, Department of Biochemistry and Molecular and Cell Biology, Georgetown University Medical Center, The New Research Building, Room W222, Washington, DC 20007, USA
    Eur J Neurosci 33:1598-610. 2011
    ..PD with dementia, we have recently described elevated levels of tauopathy, indexed as increased hyperphosphorylated Tau (p-Tau)...
  13. pmc Early growth response 1 (Egr-1) regulates phosphorylation of microtubule-associated protein tau in mammalian brain
    Yifan Lu
    The Bloomfield Center for Research in Aging, Lady Davis Institute for Medical Research, Jewish General Hospital, Montreal, Quebec H3T 1E2, Canada
    J Biol Chem 286:20569-81. 2011
    In the normal brain, tau protein is phosphorylated at a number of proline- and non-proline directed sites, which reduce tau microtubule binding and thus regulate microtubule dynamics...
  14. ncbi Deletion of the ubiquitin ligase CHIP leads to the accumulation, but not the aggregation, of both endogenous phospho- and caspase-3-cleaved tau species
    Chad A Dickey
    Mayo Clinic College of Medicine, Jacksonville, Florida 32224, USA
    J Neurosci 26:6985-96. 2006
    ..Hereditary mutations in the MAPT gene were shown to promote the formation of structurally distinct tau aggregates in patients that had a ..
  15. ncbi Axonopathy and amyotrophy in mice transgenic for human four-repeat tau protein
    A Probst
    Abteilung Neuropathologie, Institut fur Pathologie, Universitat Basel, Switzerland
    Acta Neuropathol 99:469-81. 2000
    Coding region and intronic mutations in the tau gene cause frontotemporal dementia and parkinsonism linked to chromosome 17. Some of these mutations lead to an overproduction of tau isoforms with four microtubule-binding repeats...
  16. ncbi Altered microtubule organization in small-calibre axons of mice lacking tau protein
    A Harada
    Department of Anatomy and Cell Biology, School of Medicine, University of Tokyo, Japan
    Nature 369:488-91. 1994
    The tau gene encodes a protein (Tau) that is a major neuronal microtubule-associated protein localized mostly in axons...
  17. ncbi Assembly of paired helical filaments from mouse tau: implications for the neurofibrillary pathology in transgenic mouse models for Alzheimer's disease
    T Kampers
    Max Planck Unit for Structural Molecular Biology, Hamburg, Germany
    FEBS Lett 451:39-44. 1999
    In Alzheimer's disease and related dementias, human tau protein aggregates into paired helical filaments and neurofibrillary tangles. However, such tau aggregates have not yet been demonstrated in transgenic mouse models of the disease...
  18. ncbi Role of Pax6 in development of the cerebellar system
    D Engelkamp
    MRC Human Genetics Unit, Western General Hospital, Crewe Road, Edinburgh, EH4 2XU, Scotland
    Development 126:3585-96. 1999
    ..Our results suggest that Pax6 plays a strong role during hindbrain migration processes and at least part of its activity is mediated through regulation of the netrin receptor Unc5h3...
  19. pmc Prominent axonopathy in the brain and spinal cord of transgenic mice overexpressing four-repeat human tau protein
    K Spittaels
    Experimental Genetics Group, Center for Human Genetics, Flemish Institute for Biotechnology, Katholieke Universiteit Leuven, Belgium
    Am J Pathol 155:2153-65. 1999
    Mutations in the human tau gene cause frontotemporal dementia and parkinsonism linked to chromosome 17...
  20. ncbi Muscle weakness, hyperactivity, and impairment in fear conditioning in tau-deficient mice
    S Ikegami
    Mitsubishi Kasei Institute of Life Sciences, Tokyo, Japan
    Neurosci Lett 279:129-32. 2000
    b>Tau, one of the major neuronal microtubule-associated proteins (MAPs), is important for neuronal cell morphogenesis and axonal maintenance...
  21. pmc Defects in axonal elongation and neuronal migration in mice with disrupted tau and map1b genes
    Y Takei
    Department of Cell Biology and Anatomy, Graduate School of Medicine, University of Tokyo, Hongo, Bunkyo ku, Tokyo 113 0033, Japan
    J Cell Biol 150:989-1000. 2000
    b>Tau and MAP1B are the main members of neuronal microtubule-associated proteins (MAPs), the functions of which have remained obscure because of a putative functional redundancy (Harada, A., K. Oguchi, S. Okabe, J. Kuno, S. Terada, T...
  22. ncbi Glycogen synthase kinase-3beta phosphorylates protein tau and rescues the axonopathy in the central nervous system of human four-repeat tau transgenic mice
    K Spittaels
    Experimental Genetics Group, Center for Human Genetics, Flemish Institute for Biotechnology, Katholieke Universiteit Leuven, Gasthuisberg O and N 06, B 3000 Leuven, Belgium
    J Biol Chem 275:41340-9. 2000
    Protein tau filaments in brain of patients suffering from Alzheimer's disease, frontotemporal dementia, and other tauopathies consist of protein tau that is hyperphosphorylated...
  23. ncbi Tau filament formation in transgenic mice expressing P301L tau
    J Gotz
    Division of Psychiatry Research, University of Zurich, 8008 Zurich, Switzerland
    J Biol Chem 276:529-34. 2001
    Mutations in the microtubule-associated protein tau, including P301L, are genetically coupled to hereditary frontotemporal dementia with parkinsonism linked to chromosome 17...
  24. ncbi Neurotrophins are required for nerve growth during development
    K L Tucker
    Department of Neurobiochemistry, Max Planck Institute of Neurobiology, Am Klopferspitz 18a, 82152 Martinsried, Germany
    Nat Neurosci 4:29-37. 2001
    ....
  25. ncbi The rate of Tau synthesis is differentially regulated during postnatal development in mouse cerebellum
    G J Vilá-Ortiz
    Instituto de Investigaciones Bioquímicas Fundación Campomar IIB UBA, IIBBA CONICET, Buenos Aires, Argentina
    Cell Mol Neurobiol 21:535-43. 2001
    1. Tau, which is a microtubule-associated protein, with mRNA targeted to the axon and growth cone, is involved in axonal elongation...
  26. pmc Tau is essential to beta -amyloid-induced neurotoxicity
    Mark Rapoport
    Institute for Neuroscience, Northwestern University, Chicago, IL 60611, USA
    Proc Natl Acad Sci U S A 99:6364-9. 2002
    ..peptide (Abeta); neurofibrillary tangles represent intracellular bundles of self-assembled hyperphosphorylated tau proteins...
  27. ncbi Isoforms changes of tau protein during development in various species
    Hiroshi Takuma
    Department of Neuroscience, Osaka City University Medical School, 1 4 3 Asahimachi, Abenoku, 545 8585, Osaka, Japan
    Brain Res Dev Brain Res 142:121-7. 2003
    b>Tau protein is one of the major microtubule-associated proteins of the vertebrate nervous system. Some kinds of isoforms, for example, six isoforms in humans, are generated from a single gene by alternative mRNA splicing...
  28. ncbi Hyperphosphorylation and aggregation of tau in mice expressing normal human tau isoforms
    Cathy Andorfer
    Departments of Neuroscience and Pathology, Albert Einstein College of Medicine, Bronx, New York, USA
    J Neurochem 86:582-90. 2003
    Neurofibrillary tangles are composed of insoluble aggregates of the microtubule-associated protein tau. In Alzheimer's disease the accumulation of neurofibrillary tangles occurs in the absence of tau mutations...
  29. ncbi CHIP and Hsp70 regulate tau ubiquitination, degradation and aggregation
    Leonard Petrucelli
    Mayo Clinic, Jacksonville, FL 32224, USA
    Hum Mol Genet 13:703-14. 2004
    ..g. tau and alpha-synuclein respectively)...
  30. ncbi Changed conformation of mutant Tau-P301L underlies the moribund tauopathy, absent in progressive, nonlethal axonopathy of Tau-4R/2N transgenic mice
    Dick Terwel
    Experimental Genetics Group, Department of Human Genetics, KU Leuven, B 3000 Leuven, Belgium
    J Biol Chem 280:3963-73. 2005
    Protein tau-3R/4R isoform ratio and phosphorylation regulates binding to microtubules and, when disturbed by aging or mutations, results in diverse tauopathies and in neurodegeneration...
  31. ncbi Proteomic and functional analyses reveal a mitochondrial dysfunction in P301L tau transgenic mice
    Della C David
    Division of Psychiatry Research, University of Zurich, 8008 Zurich, Switzerland
    J Biol Chem 280:23802-14. 2005
    Transgenic mice overexpressing the P301L mutant human tau protein exhibit an accumulation of hyperphosphorylated tau and develop neurofibrillary tangles...
  32. pmc A developmental switch in the response of DRG neurons to ETS transcription factor signaling
    Simon Hippenmeyer
    Biozentrum, Department of Cell Biology, University of Basel, Switzerland
    PLoS Biol 3:e159. 2005
    ..Together, our findings indicate that DRG sensory neurons exhibit a temporal developmental switch that can be revealed by distinct responses to ETS transcription factor signaling at sequential steps of neuronal maturation...
  33. ncbi Cell-cycle reentry and cell death in transgenic mice expressing nonmutant human tau isoforms
    Cathy Andorfer
    Department of Neuroscience, Albert Einstein College of Medicine, Bronx, New York 10461, USA
    J Neurosci 25:5446-54. 2005
    Mutations in the microtubule-associated protein tau gene have been linked to neurofibrillary tangle (NFT) formation in several neurodegenerative diseases known as tauopathies; however, no tau mutations occur in Alzheimer's disease, ..
  34. ncbi The effect of insulin deficiency on tau and neurofilament in the insulin knockout mouse
    Ruben Schechter
    William K Warren Medical Research Institute, University of Oklahoma Medical Health Science Center, Tulsa, OK 74107, USA
    Biochem Biophys Res Commun 334:979-86. 2005
    ..The I-/- exhibited hyperphosphorylation of tau, at threonine 231, and neurofilament...
  35. ncbi Altered depression-related behavior and neurochemical changes in serotonergic neurons in mutant R406W human tau transgenic mice
    Nobuaki Egashira
    Department of Neuropharmacology, Faculty of Pharmaceutical Sciences, Fukuoka University, 8 19 1 Nanakuma, Fukuoka 814 0180, Japan
    Brain Res 1059:7-12. 2005
    Mutant R406W human tau was originally identified in frontotemporal dementia and parkinsonism linked to chromosome 17 (FTDP-17) and causes a hereditary tauopathy that clinically resembles Alzheimer's disease (AD)...
  36. ncbi Transgenic mice expressing mutant (N279K) human tau show mutation dependent cognitive deficits without neurofibrillary tangle formation
    Taizo Taniguchi
    Laboratory of Molecular Pharmacology, Biosignal Research Center, Kobe University, Nada Ku, Japan
    FEBS Lett 579:5704-12. 2005
    Mutations in the tau gene, which is located on chromosome 17, were found causative for autosomal dominantly inherited frontotemporal dementia and parkinsonism linked to chromosome 17 (FTDP-17)...
  37. ncbi Tau and GSK3beta dephosphorylations are required for regulating Pin1 phosphorylation
    Sae H Min
    Division of Laboratory Animal Resources, National Institute of Toxicological Research, Korea FDA, 122 704, Seoul, Korea
    Neurochem Res 30:955-61. 2005
    Pin1 binds mitotically phosphorylated Thr231-Pro232 and Thr212-Pro213 sites on tau, and a Pin1 deficiency in mice leads to tau hyperphosphorylation...
  38. ncbi Temporal profile of amyloid-beta (Abeta) oligomerization in an in vivo model of Alzheimer disease. A link between Abeta and tau pathology
    Salvatore Oddo
    Department of Neurobiology and Behavior, University of California, Irvine, California 92697 4545, USA
    J Biol Chem 281:1599-604. 2006
    Accumulation of amyloid-beta (Abeta) is one of the earliest molecular events in Alzheimer disease (AD), whereas tau pathology is thought to be a later downstream event...
  39. ncbi Peripheral hyperinsulinemia promotes tau phosphorylation in vivo
    Susanna Freude
    Department of Internal Medicine II, LFI 4 061, University of Cologne, Kerpener Str 62, D 50937 Cologne, Germany
    Diabetes 54:3343-8. 2005
    ..Formation of neurofibrillary tangles, which contain hyperphosphorylated tau, represents a key step in the pathogenesis of neurodegenerative diseases...
  40. ncbi Improved long-term potentiation and memory in young tau-P301L transgenic mice before onset of hyperphosphorylation and tauopathy
    Karin Boekhoorn
    Swammerdam Institute for Life Sciences, Center for Neuroscience, University of Amsterdam, 1098 SM Amsterdam, The Netherlands
    J Neurosci 26:3514-23. 2006
    The microtubule binding protein tau is implicated in neurodegenerative tauopathies, including frontotemporal dementia (FTD) with Parkinsonism caused by diverse mutations in the tau gene...
  41. pmc Tau is hyperphosphorylated at multiple sites in mouse brain in vivo after streptozotocin-induced insulin deficiency
    Buffie J Clodfelder-Miller
    Department of Psychiatry and Behavioral Neurobiology, 1720 Seventh Ave South, Sparks Center 1057, University of Alabama, Birmingham, AL 35294 0017, USA
    Diabetes 55:3320-5. 2006
    ..characteristics of Alzheimer's disease is the presence of neurofibrillary tangles containing hyperphosphorylated tau, a microtubule-associated protein...
  42. pmc The high-affinity HSP90-CHIP complex recognizes and selectively degrades phosphorylated tau client proteins
    Chad A Dickey
    Department of Neuroscience, Mayo Clinic College of Medicine, Jacksonville, Florida, USA
    J Clin Invest 117:648-58. 2007
    ..component of Alzheimer's disease (AD) is the formation of neurofibrillary tangles composed of hyperphosphorylated tau (p-tau). Expediting the removal of these p-tau species may be a relevant therapeutic strategy...
  43. ncbi Reducing endogenous tau ameliorates amyloid beta-induced deficits in an Alzheimer's disease mouse model
    Erik D Roberson
    Gladstone Institute of Neurological Disease, San Francisco, CA 94158, USA
    Science 316:750-4. 2007
    ..The microtubule-associated protein tau is also involved in the disease, but it is unclear whether treatments aimed at tau could block Abeta-induced ..
  44. pmc Interaction of tau protein with the dynactin complex
    Enrico Magnani
    Department of Clinical Neurosciences, Brain Repair Centre, University of Cambridge, Cambridge, UK
    EMBO J 26:4546-54. 2007
    b>Tau is an axonal microtubule-associated protein involved in microtubule assembly and stabilization...
  45. ncbi Hippocampus of Ames dwarf mice is resistant to beta-amyloid-induced tau hyperphosphorylation and changes in apoptosis-regulatory protein levels
    Matthew Schrag
    Department of Pharmacology, Physiology and Therapeutics, School of Medicine and Health Sciences, University of North Dakota, Grand Forks, North Dakota 58202, USA
    Hippocampus 18:239-44. 2008
    ..not their normal phenotype counterparts (wild type), are resistant to Abeta25-35-induced hyperphosphorylation of tau protein, reduction in levels of the antiapoptotic protein Bcl-2, increase in levels of the pro-apoptotic protein ..
  46. pmc Axonal transport rates in vivo are unaffected by tau deletion or overexpression in mice
    Aidong Yuan
    Center for Dementia Research, Nathan Kline Institute, Orangeburg, New York 10962, USA
    J Neurosci 28:1682-7. 2008
    Elevated tau expression has been proposed as a possible basis for impaired axonal transport in Alzheimer's disease...
  47. pmc Pin1 has opposite effects on wild-type and P301L tau stability and tauopathy
    Jormay Lim
    Cancer Biology Program, Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts 02115, USA
    J Clin Invest 118:1877-89. 2008
    b>Tau pathology is a hallmark of many neurodegenerative diseases including Alzheimer disease (AD) and frontotemporal dementia with Parkinsonism linked to chromosome 17 (FTDP-17)...
  48. doi Divergent phosphorylation pattern of tau in P301L tau transgenic mice
    Natasha Deters
    Alzheimer s and Parkinson s Disease Laboratory, Brain and Mind Research Institute, University of Sydney, 100 Mallett St, Camperdown, NSW 2050, Australia
    Eur J Neurosci 28:137-47. 2008
    Aggregates of hyperphosphorylated tau are prominent in brains of patients with Alzheimer's disease or frontotemporal dementia (FTD)...
  49. doi A putative role for cell cycle-related proteins in microtubule-based neuroplasticity
    Stefanie Schmetsdorf
    Paul Flechsig Institute for Brain Research, Department for Molecular and Cellular Mechanisms of Neurodegeneration, University of Leipzig, Leipzig, Germany
    Eur J Neurosci 29:1096-107. 2009
    ..D, E, A and B as well as Cdks 1, 2 and 4 were also found to be associated with the microtubule-associated protein tau. Cyclin/Cdk complexes, in addition, exhibit kinase activity towards tau...
  50. doi Tau--an inhibitor of deacetylase HDAC6 function
    Mar Perez
    Centro de Biologia Molecular Severo Ochoa CSIC UAM, Universidad Autonoma de Madrid, Madrid, Spain
    J Neurochem 109:1756-66. 2009
    ..acetylation of the alpha tubulin subunit, mainly in those microtubules from neurons containing neurofibrillary tau pathology...
  51. pmc Tau fragmentation, aggregation and clearance: the dual role of lysosomal processing
    Yipeng Wang
    Max Planck Unit for Structural Molecular Biology, Notkestrasse 85, 22607 Hamburg, Germany
    Hum Mol Genet 18:4153-70. 2009
    Aggregation and cleavage are two hallmarks of Tau pathology in Alzheimer disease (AD), and abnormal fragmentation of Tau is thought to contribute to the nucleation of Tau paired helical filaments...
  52. pmc Age-dependent impairment of cognitive and synaptic function in the htau mouse model of tau pathology
    Manuela Polydoro
    Dominick P Purpura Department of Neuroscience, Albert Einstein College of Medicine, Bronx, New York 10461, USA
    J Neurosci 29:10741-9. 2009
    ..tangles (NFTs), which are intracellular aggregates of conformationally abnormal and hyperphosphorylated tau. The presence of NFTs in the forebrain is associated with impairments of cognitive function, supporting a central ..
  53. pmc AAV-tau mediates pyramidal neurodegeneration by cell-cycle re-entry without neurofibrillary tangle formation in wild-type mice
    Tomasz Jaworski
    Experimental Genetics Group, Department of Human Genetics, KULeuven Campus, Leuven, Belgium
    PLoS ONE 4:e7280. 2009
    ..Transgenic mouse models do not resolve this problem conclusively, i.e. the relative hierarchy of amyloid and tau pathology depends on the actual model and the genes expressed or inactivated...
  54. pmc Stringent specificity in the construction of a GABAergic presynaptic inhibitory circuit
    J Nicholas Betley
    Howard Hughes Medical Institute, Kavli Institute of Brain Science, Departments of Neuroscience, Biochemistry and Molecular Biophysics, Columbia University, New York, NY 10032, USA
    Cell 139:161-74. 2009
    ..The organization of a GABAergic circuit that mediates presynaptic inhibition in the mammalian CNS is therefore controlled by a stringent program of sensory recognition and signaling...
  55. pmc Increased tau phosphorylation and cleavage in mouse models of type 1 and type 2 diabetes
    Bhumsoo Kim
    Department of Neurology, University of Michigan, Ann Arbor, Michigan 48109 2200, USA
    Endocrinology 150:5294-301. 2009
    ..Abnormally phosphorylated tau is a major building block of neurofibrillary tangles, a classic neuropathological characteristic of AD...
  56. pmc Loss of tau elicits axonal degeneration in a mouse model of Alzheimer's disease
    H N Dawson
    Division of Neurology, Duke University, Durham, NC 27710, USA
    Neuroscience 169:516-31. 2010
    A central issue in the pathogenesis of tauopathy is the question of how tau protein dysfunction leads to neurodegeneration...
  57. doi Dendritic function of tau mediates amyloid-beta toxicity in Alzheimer's disease mouse models
    Lars M Ittner
    Alzheimer s and Parkinson s Disease Laboratory, Brain and Mind Research Institute, University of Sydney, Sydney NSW 2050, Australia
    Cell 142:387-97. 2010
    Alzheimer's disease (AD) is characterized by amyloid-beta (Abeta) and tau deposition in brain. It has emerged that Abeta toxicity is tau dependent, although mechanistically this link remains unclear...
  58. doi Amyloid β accelerates phosphorylation of tau and neurofibrillary tangle formation in an amyloid precursor protein and tau double-transgenic mouse model
    Yusuke Seino
    Department of General Medicine, Mutsu General Hospital, Mutsu, Japan
    J Neurosci Res 88:3547-54. 2010
    ..difference in theprogression of Aβ accumulation among 2×TgTau(+/-) APP(+/-) and 1×TgTau(-/-) APP(+/-) , and tau accumulation among 2×TgTau(+/-) APP(+/-) and 1×Tg Tau(+/-) APP(-/-) ...
  59. pmc Differential subcellular recruitment of monoacylglycerol lipase generates spatial specificity of 2-arachidonoyl glycerol signaling during axonal pathfinding
    Erik Keimpema
    European Neuroscience Institute at Aberdeen and Division of Applied Medicine, Aberdeen AB25 2ZD, United Kingdom
    J Neurosci 30:13992-4007. 2010
    ....
  60. pmc Requirement of cannabinoid CB(1) receptors in cortical pyramidal neurons for appropriate development of corticothalamic and thalamocortical projections
    Chia Shan Wu
    Department of Pediatrics, Baylor College of Medicine, Houston, TX, USA
    Eur J Neurosci 32:693-706. 2010
    ..These findings are important in understanding the long-term consequences of alterations in CB(1)R activity during development, a potential etiology for the mental health disorders linked to prenatal cannabis use...
  61. pmc Nuclear tau, a key player in neuronal DNA protection
    Audrey Sultan
    Inserm UMR837, Alzheimer and Tauopathies, 1 rue Michel Polonovski, 59045 Lille, France
    J Biol Chem 286:4566-75. 2011
    b>Tau, a neuronal protein involved in neurodegenerative disorders such as Alzheimer disease, which is primarily described as a microtubule-associated protein, has also been observed in the nuclei of neuronal and non-neuronal cells...
  62. pmc Immunotherapy targeting pathological tau prevents cognitive decline in a new tangle mouse model
    Allal Boutajangout
    Department of Physiology and Neuroscience, New York University School of Medicine, New York, New York 10016, USA
    J Neurosci 30:16559-66. 2010
    ..Limited emphasis has been put into clearing tau/tangle pathology, another major hallmark of the disease...
  63. pmc E46K human alpha-synuclein transgenic mice develop Lewy-like and tau pathology associated with age-dependent, detrimental motor impairment
    Kristel L Emmer
    Department of Pharmacology, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    J Biol Chem 286:35104-18. 2011
    ..E46K human α-syn mice also develop abundant neuronal tau inclusions that resemble neurofibrillary tangles...
  64. pmc In vivo microdialysis reveals age-dependent decrease of brain interstitial fluid tau levels in P301S human tau transgenic mice
    Kaoru Yamada
    Department of Neurology, Hope Center for Neurological Disorders, Washington University, St Louis, Missouri 63110, USA
    J Neurosci 31:13110-7. 2011
    Although tau is a cytoplasmic protein, it is also found in brain extracellular fluids, e.g., CSF...
  65. doi Tau's role in the developing brain: implications for intellectual disability
    Tamar Sapir
    Department of Molecular Genetics, Weizmann Institute of Science, 76100 Rehovot, Israel
    Hum Mol Genet 21:1681-92. 2012
    Microdeletions encompassing the MAPT (Tau) locus resulting in intellectual disability raised the hypothesis that Tau may regulate early functions in the developing brain...
  66. pmc Tau reduction does not prevent motor deficits in two mouse models of Parkinson's disease
    Meaghan Morris
    Gladstone Institute of Neurological Disease, San Francisco, California, United States of America
    PLoS ONE 6:e29257. 2011
    ..The tau protein has been implicated in the pathogenesis of diverse neurodegenerative disorders, including Alzheimer's ..
  67. doi Tau deficiency induces parkinsonism with dementia by impairing APP-mediated iron export
    Peng Lei
    Mental Health Research Institute, The University of Melbourne, Victoria, Australia
    Nat Med 18:291-5. 2012
    The microtubule-associated protein tau has risk alleles for both Alzheimer's disease and Parkinson's disease and mutations that cause brain degenerative diseases termed tauopathies...
  68. pmc Loss of HDAC6, a novel CHIP substrate, alleviates abnormal tau accumulation
    Casey Cook
    Mayo Clinic, 4500 San Pablo Road, Jacksonville, FL 32224, USA
    Hum Mol Genet 21:2936-45. 2012
    The abnormal accumulation of the microtubule-binding protein tau is associated with a number of neurodegenerative conditions, and correlates with cognitive decline in Alzheimer's disease...
  69. pmc Cognitive defects are reversible in inducible mice expressing pro-aggregant full-length human Tau
    Ann Van der Jeugd
    Laboratory of Biological Psychology, Department of Psychology, K U Leuven, Tiensestraat 102, 3000 Leuven, Belgium
    Acta Neuropathol 123:787-805. 2012
    Neurofibrillary lesions of abnormal Tau are hallmarks of Alzheimer disease and frontotemporal dementias...
  70. doi Lack of tau proteins rescues neuronal cell death and decreases amyloidogenic processing of APP in APP/PS1 mice
    Karelle Leroy
    Laboratory of Histology, Neuroanatomy, and Neuropathology, Universite Libre de Bruxelles, 808 Route de Lennik, Brussels, Belgium
    Am J Pathol 181:1928-40. 2012
    Lack of tau expression has been reported to protect against excitotoxicity and to prevent memory deficits in mice expressing mutant amyloid precursor protein (APP) identified in familial Alzheimer disease...
  71. pmc Age-appropriate cognition and subtle dopamine-independent motor deficits in aged tau knockout mice
    Meaghan Morris
    Gladstone Institute of Neurological Disease, San Francisco, CA 94158, USA
    Neurobiol Aging 34:1523-9. 2013
    The microtubule-associated protein tau is expressed throughout the nervous system, most highly in neurons but also in glial cells. Its functions in adult and aging mammals remain to be defined...
  72. pmc HDAC6 mutations rescue human tau-induced microtubule defects in Drosophila
    Ying Xiong
    Key Laboratory of Molecular and Developmental Biology, Institute of Genetics and Developmental Biology, Chinese Academy of Sciences, Beijing 100101, China
    Proc Natl Acad Sci U S A 110:4604-9. 2013
    ..disease (AD) and related tauopathy patients contain neurofibrillary tangles composed of hyperphosphorylated tau protein...
  73. pmc An unbiased approach to identifying tau kinases that phosphorylate tau at sites associated with Alzheimer disease
    Annalisa Cavallini
    Eli Lilly and Company Limited, Erl Wood Manor, Sunninghill Road, Windlesham, Surrey GU20 6PH, United Kingdom
    J Biol Chem 288:23331-47. 2013
    ..the hallmarks of Alzheimer disease (AD), are composed of paired helical filaments of abnormally hyperphosphorylated tau. The accumulation of these proteinaceous aggregates in AD correlates with synaptic loss and severity of dementia...
  74. pmc Microtubule-associated protein tau is essential for long-term depression in the hippocampus
    Tetsuya Kimura
    Department of Aging Neurobiology, Center for Development of Advanced Medicine for Dementia, National Center for Geriatrics and Gerontology, 35 Gengo, Morioka, Obu, Aichi 474 8522, Japan
    Philos Trans R Soc Lond B Biol Sci 369:20130144. 2014
    The microtubule-associated protein tau is a principal component of neurofibrillary tangles, and has been identified as a key molecule in Alzheimer's disease and other tauopathies...
  75. pmc Loss of MAP function leads to hippocampal synapse loss and deficits in the Morris Water Maze with aging
    Qiu Lan Ma
    Department of Neurology, University of California, Los Angeles, California 90095, Geriatric Research, Education and Clinical Center, Greater Los Angeles Veterans Affairs Healthcare System, Los Angeles, California 90073
    J Neurosci 34:7124-36. 2014
    Hyperphosphorylation and accumulation of tau aggregates are prominent features in tauopathies, including Alzheimer's disease, but the impact of loss of tau function on synaptic and cognitive deficits remains poorly understood...
  76. ncbi Oligodendroglial tau filament formation in transgenic mice expressing G272V tau
    J Gotz
    Division of Psychiatry Research, University of Zurich, August Forel Str 1, 8008 Zurich, Switzerland
    Eur J Neurosci 13:2131-40. 2001
    Genetic evidence indicates that several mutations in tau, including G272V, are linked to frontotemporal dementia with parkinsonism...
  77. ncbi Hyperphosphorylated tau and paired helical filament-like structures in the brains of mice carrying mutant amyloid precursor protein and mutant presenilin-1 transgenes
    M A Kurt
    St George s Hospital Medical School, London, UK
    Neurobiol Dis 14:89-97. 2003
    ..composed mainly of beta-amyloid (Abeta) and neurofibrillary tangles principally composed of hyperphosphorylated tau are the major pathological features of Alzheimer's disease (AD)...
  78. pmc Role of MAP1B in axonal retrograde transport of mitochondria
    Eva Maria Jimenez-Mateos
    Centro de Biologia Molecular Severo Ochoa, Campus de Cantoblanco, Universidad Autonoma de Madrid, 28049 Madrid, Spain
    Biochem J 397:53-9. 2006
    The MAPs (microtubule-associated proteins) MAP1B and tau are well known for binding to microtubules and stabilizing these structures...
  79. ncbi Overexpression of the mouse dishevelled-1 protein inhibits GSK-3beta-mediated phosphorylation of tau in transfected mammalian cells
    U Wagner
    Department of Neuroscience, The Institute of Psychiatry, London, UK
    FEBS Lett 411:369-72. 1997
    b>Tau is a neuronal microtubule-associated protein whose function is modulated by phosphorylation. GSK-3beta is a tau kinase...
  80. doi The γ-secretase modulator CHF5074 reduces the accumulation of native hyperphosphorylated tau in a transgenic mouse model of Alzheimer's disease
    Annamaria Lanzillotta
    Division of Pharmacology and Experimental Therapeutics, Department of Biomedical Sciences and Biotechnologies, School of Medicine, University of Brescia and Istituto Nazionale di Neuroscienze Brescia, Italy
    J Mol Neurosci 45:22-31. 2011
    The relationship between β-amyloid (Aβ) and tau is not fully understood, though it is proposed that in the pathogenesis of Alzheimer's disease (AD) Aβ accumulation precedes and promotes tau hyperphosphorylation via activation of ..
  81. pmc Tau protein is required for amyloid {beta}-induced impairment of hippocampal long-term potentiation
    Olivia A Shipton
    Department of Physiology, Anatomy, and Genetics, University of Oxford, Oxford OX1 3PT, United Kingdom
    J Neurosci 31:1688-92. 2011
    Amyloid β (Aβ) and tau protein are both implicated in memory impairment, mild cognitive impairment (MCI), and early Alzheimer's disease (AD), but whether and how they interact is unknown...
  82. pmc Loss of fused in sarcoma (FUS) promotes pathological Tau splicing
    Denise Orozco
    German Center for Neurodegenerative Diseases DZNE, Munich, Germany
    EMBO Rep 13:759-64. 2012
    ..Here we identify Tau mRNA as a physiological splicing target of FUS...
  83. pmc Neurotransmitter release at the thalamocortical synapse instructs barrel formation but not axon patterning in the somatosensory cortex
    Nicolas Narboux-Nême
    Institut National de la Sante et de la Recherche Medicale, UMR S 839, 75005 France
    J Neurosci 32:6183-96. 2012
    ..Thus, efficient synaptic release is required at thalamocortical but not at corticocortical synapses for building the whisker to barrel map and for efficient sensory function...
  84. ncbi Participation of structural microtubule-associated proteins (MAPs) in the development of neuronal polarity
    C Gonzalez-Billault
    Centro de Biologia Molecular Severo Ochoa, CSIC, Universidad Autonoma de Madrid, Campus Cantoblanco, Madrid, Spain
    J Neurosci Res 67:713-9. 2002
    ..In this report we have characterized the effect of the combined suppression of MAP1B and tau, and MAP1B and MAP2 on neuronal polarization in cultured hippocampal cells grown on a laminin-containing substrate...
  85. ncbi Abeta-degrading endopeptidase, neprilysin, in mouse brain: synaptic and axonal localization inversely correlating with Abeta pathology
    Shinjiro Fukami
    Laboratory for Proteolytic Neuroscience, RIKEN Brain Science Institute, Wako Shi, Saitama, Japan
    Neurosci Res 43:39-56. 2002
    ....
  86. ncbi Inactivation of integrin-linked kinase induces aberrant tau phosphorylation via sustained activation of glycogen synthase kinase 3beta in N1E-115 neuroblastoma cells
    Toshiaki Ishii
    Department of Pathobiological Science, Obihiro University of Agriculture and Veterinary Medicine, Obihiro Hokkaido 080 8555, Japan
    J Biol Chem 278:26970-5. 2003
    ..Satoh, E., and Nishimura, M. (2001) J. Biol. Chem. 276, 42994-43003). Here we report that ILK controls tau phosphorylation via regulation of glycogen synthase kinase-3beta (GSK-3beta) activity in N1E-115 cells...
  87. ncbi Glycogen synthase kinase-3 plays a crucial role in tau exon 10 splicing and intranuclear distribution of SC35. Implications for Alzheimer's disease
    Felix Hernandez
    Centro de Biología Molecular Severo Ochoa Consejo Superior de Investigaciones Científicas CSIC Universidad Autónoma, Fac Ciencias Universidad Autónoma de Madrid, Cantoblanco, 28049 Madrid, Spain
    J Biol Chem 279:3801-6. 2004
    Tauopathies, including Alzheimer's disease, are neurodegenerative disorders in which tau protein accumulates as a consequence of alterations in its metabolism...
  88. ncbi A digenic cause of cleft lip in A-strain mice and definition of candidate genes for the two loci
    Diana M Juriloff
    Department of Medical Genetics, University of British Columbia, Vancouver, British ColumbiaV6T 1Z3, Canada
    Birth Defects Res A Clin Mol Teratol 70:509-18. 2004
    ..Our previous studies mapped two loci: clf1 on Chr11 and clf2 on Chr13--with a strong genetic maternal effect on the level of risk. Here we test the hypothesis that CL(P) is digenic and identify candidate genes for clf1 and clf2...
  89. ncbi Cre recombinase specificity defined by the tau locus
    Ella Korets-Smith
    Samuel Lunenfeld Research Institute, 600 University Ave, Toronto, Ontario, M5G 1X5, Canada
    Genesis 40:131-8. 2004
    We generated a transgenic mouse line (tau::Cre) by targeting the Cre to the tau locus (Mapt)...
  90. ncbi Disease-related modifications in tau affect the interaction between Fyn and Tau
    Kiran Bhaskar
    Department of Internal Medicine, Roy J and Lucille A Carver College of Medicine, University of Iowa, Iowa City, Iowa 52242, USA
    J Biol Chem 280:35119-25. 2005
    Microtubule-associated protein tau is the major component of the neurofibrillary tangles of Alzheimer disease (AD) and is genetically linked to frontotemporal dementias (FTDP-17)...
  91. ncbi Genetic interactions between doublecortin and doublecortin-like kinase in neuronal migration and axon outgrowth
    Thomas A S Deuel
    Howard Hughes Medical Institute, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts 02115, USA
    Neuron 49:41-53. 2006
    ..Dcx and Dclk may directly or indirectly regulate microtubule-based vesicle transport, a process critical to both neuronal migration and axon outgrowth...
  92. pmc Cell-cycle markers in a transgenic mouse model of human tauopathy: increased levels of cyclin-dependent kinase inhibitors p21Cip1 and p27Kip1
    Patrice Delobel
    Medical Research Council Laboratory of Molecular Biology, Hills Road, Cambridge CB2 2QH, UK
    Am J Pathol 168:878-87. 2006
    ..an abnormal reactivation of the cell cycle may precede and cause the hyperphosphorylation and filament formation of tau protein in Alzheimer's disease and other tauopathies...
  93. ncbi Tau isoforms expression in transgenic mouse model of amyotrophic lateral sclerosis
    Ewa Usarek
    Department of Biochemistry, Medical University of Warsaw, Banacha 1, 02 097 Warsaw, Poland
    Neurochem Res 31:597-602. 2006
    b>Tau is a protein involved in regulation of microtubule stability, axonal differentiation and transport. Alteration of retrograde transport may lead to motor neuron degeneration...
  94. ncbi The roles of cyclin-dependent kinase 5 and glycogen synthase kinase 3 in tau hyperphosphorylation
    Florian Plattner
    Wolfson Institute for Biomedical Research, University College London, London WC1E 6BT, United Kingdom
    J Biol Chem 281:25457-65. 2006
    Hyperphosphorylation of the microtubule-associated protein tau is a characteristic feature of neurodegenerative tauopathies including Alzheimer disease...
  95. ncbi Reduction of soluble Abeta and tau, but not soluble Abeta alone, ameliorates cognitive decline in transgenic mice with plaques and tangles
    Salvatore Oddo
    Departments of Neurobiology and Behavior and Neurology, and Institute for Brain Aging and Dementia, University of California, Irvine, California 92697, USA
    J Biol Chem 281:39413-23. 2006
    ..Here we report the novel finding that soluble tau also plays a role in the cognitive decline in the presence of concomitant Abeta pathology...
  96. ncbi LKB1 and SAD kinases define a pathway required for the polarization of cortical neurons
    Anthony P Barnes
    Neuroscience Center, Department of Pharmacology, University of North Carolina, Chapel Hill, NC 27599, USA
    Cell 129:549-63. 2007
    ..Thus, we provide evidence in vivo and in vitro for a multikinase pathway that links extracellular signals to the intracellular machinery required for axon specification...
  97. pmc Mitochondrial oxidative stress causes hyperphosphorylation of tau
    Simon Melov
    Buck Institute for Age Research, Novato, California, United States of America
    PLoS ONE 2:e536. 2007
    ..oxidative stress could modulate or regulate two of the key neurochemical hallmarks of Alzheimer's disease (AD): tau phosphorylation, and beta-amyloid deposition...
  98. ncbi Coupling of mammalian target of rapamycin with phosphoinositide 3-kinase signaling pathway regulates protein phosphatase 2A- and glycogen synthase kinase-3 -dependent phosphorylation of Tau
    Volker Meske
    Center of Anatomy, Institute of Integrative Neuroanatomy, Department of Clinical Cell and Neurobiology, Charite, Charite Platz 1, 10098 Berlin, Germany
    J Biol Chem 283:100-9. 2008
    b>Tau is an important microtubule-stabilizing protein in neurons. In its hyperphosphorylated form, Tau protein loses its ability to bind to microtubules and then accumulates and is part of pathological lesions characterizing tauopathies, e...
  99. ncbi Cdc42 regulates cofilin during the establishment of neuronal polarity
    Boyan K Garvalov
    Axonal Growth and Regeneration Group, Max Planck Institute of Neurobiology, 82152 Martinsried, Germany
    J Neurosci 27:13117-29. 2007
    ..We conclude that Cdc42 is a key regulator of axon specification, and that cofilin is a physiological downstream effector of Cdc42 in this process...
  100. doi Biosynthesis and processing of endogenous BDNF: CNS neurons store and secrete BDNF, not pro-BDNF
    Tomoya Matsumoto
    Biozentrum, University of Basel, Klingelbergstrasse 50 70, CH 4056 Basel, Switzerland
    Nat Neurosci 11:131-3. 2008
    ..Here we examined the biochemistry of endogenous BDNF in mouse neurons using sensitive reagents and found that pro-BDNF is rapidly converted intracellularly to mature BDNF, the latter being stored and released by excitatory input...
  101. doi Memory and exploratory impairment in mice that lack the Park-2 gene and that over-express the human FTDP-17 mutant Tau
    Paloma Navarro
    Fundacion Jimenez Diaz Capio Clinica Ntra Sra Concepcion, Universidad Autonoma de Madrid, Madrid, Spain
    Behav Brain Res 189:350-6. 2008
    ..Conversely, in some forms of parkinsonism, mutations in the tau gene have also been observed...

Research Grants10

  1. MAP KINASE REGULATION OF MICROGLIAL ACTIVATION
    Narayan Bhat; Fiscal Year: 2004
    ..The suppressive effects of the kinase inhibitors on activation-associated microglial functions; i.e., targeting of oligodendrocytes and myelin phagocytosis will be tested using in vitro models. ..
  2. MAP KINASES IN OLIGODENDROCYTE CELL SIGNALING
    Narayan Bhat; Fiscal Year: 2005
    ..Putative MAPK-responsive elements and relevant binding activities will be determined by deletion and gel shift analyses ..
  3. Neuroinflammation in Cholesterol-Induced AD Pathogenesis
    Narayan Bhat; Fiscal Year: 2009
    ..The outcome of these studies should have implications for developing novel and effective anti- inflammatory treatments for AD. ..
  4. Proteome analysis in mice expressing P301L tau
    Irving Vega; Fiscal Year: 2005
    ..We intend to employ this high throughput technology in the analysis of tau and other proteins during the development of tauopathy in the FTDP-17 mouse model JNPL3, which expresses the human ..
  5. BIOLOGY OF ALZHEIMER PAIRED HELICAL FILAMENTS
    Virginia Lee; Fiscal Year: 2001
    ..blocks of Alzheimer's disease (AD) neurofibrillary tangles (NFTs) are formed from hyperphosphorylated brain tau known as PHFtau...
  6. ALZHEIMER PATHOPHYSIOLOGY IN HUMAN CATARACT FORMATION
    PETER FREDERIKSE; Fiscal Year: 2002
    ..abstract_text> ..
  7. MITOCHONDRIAL OXIDATIVE STRESS AND NEURODEGENERATION
    Simon Melov; Fiscal Year: 2004
    ....
  8. Mechanisms of Tau-Based Neurodegeneration
    Mark Forman; Fiscal Year: 2005
    Filamentous tau inclusions in neurons, astrocytes and oligodendrocytes are the neuropathological hallmark of both sporadic and familial tauopathies...
  9. Comparative Functional Genomics of Longevity Assurance
    Simon Melov; Fiscal Year: 2006
    ..In years four and five we will apply the functional genomic approach defined above, as well as statistical methods refined during the first three years, to the analysis of mouse RI lines with differential lifespans. ..
  10. Alzheimer disease biomarkers in lens
    Peter H Frederikse; Fiscal Year: 2010
    ..These studies build on our earlier studies to understand the role of AbetaPP and Abeta in the lens which are already providing a new and specific conceptual basis for understanding cataract and its links with the brain. ..