Mapt

Summary

Gene Symbol: Mapt
Description: microtubule-associated protein tau
Alias: AI413597, AW045860, Mtapt, Tau, microtubule-associated protein tau, PHF-tau, neurofibrillary tangle protein, paired helical filament-tau
Species: mouse
Products:     Mapt

Top Publications

  1. Morris M, Hamto P, Adame A, Devidze N, Masliah E, Mucke L. Age-appropriate cognition and subtle dopamine-independent motor deficits in aged tau knockout mice. Neurobiol Aging. 2013;34:1523-9 pubmed publisher
    The microtubule-associated protein tau is expressed throughout the nervous system, most highly in neurons but also in glial cells. Its functions in adult and aging mammals remain to be defined...
  2. Sultan A, Nesslany F, Violet M, Bégard S, Loyens A, Talahari S, et al. Nuclear tau, a key player in neuronal DNA protection. J Biol Chem. 2011;286:4566-75 pubmed publisher
    b>Tau, a neuronal protein involved in neurodegenerative disorders such as Alzheimer disease, which is primarily described as a microtubule-associated protein, has also been observed in the nuclei of neuronal and non-neuronal cells...
  3. Kimura T, Whitcomb D, Jo J, Regan P, Piers T, Heo S, et al. Microtubule-associated protein tau is essential for long-term depression in the hippocampus. Philos Trans R Soc Lond B Biol Sci. 2014;369:20130144 pubmed publisher
    The microtubule-associated protein tau is a principal component of neurofibrillary tangles, and has been identified as a key molecule in Alzheimer's disease and other tauopathies...
  4. Polydoro M, Acker C, Duff K, Castillo P, Davies P. Age-dependent impairment of cognitive and synaptic function in the htau mouse model of tau pathology. J Neurosci. 2009;29:10741-9 pubmed publisher
    ..tangles (NFTs), which are intracellular aggregates of conformationally abnormal and hyperphosphorylated tau. The presence of NFTs in the forebrain is associated with impairments of cognitive function, supporting a central ..
  5. Roberson E, Halabisky B, Yoo J, Yao J, Chin J, Yan F, et al. Amyloid-?/Fyn-induced synaptic, network, and cognitive impairments depend on tau levels in multiple mouse models of Alzheimer's disease. J Neurosci. 2011;31:700-11 pubmed publisher
    ..Recent evidence suggests that microtubule-associated protein tau may mediate amyloid-? peptide (A?) toxicity by modulating the tyrosine kinase Fyn...
  6. Kim B, Backus C, Oh S, Hayes J, Feldman E. Increased tau phosphorylation and cleavage in mouse models of type 1 and type 2 diabetes. Endocrinology. 2009;150:5294-301 pubmed publisher
    ..Abnormally phosphorylated tau is a major building block of neurofibrillary tangles, a classic neuropathological characteristic of AD...
  7. Morris M, Koyama A, Masliah E, Mucke L. Tau reduction does not prevent motor deficits in two mouse models of Parkinson's disease. PLoS ONE. 2011;6:e29257 pubmed publisher
    ..The tau protein has been implicated in the pathogenesis of diverse neurodegenerative disorders, including Alzheimer's ..
  8. Min S, Cho J, Oh J, Shim S, Hwang D, Lee S, et al. Tau and GSK3beta dephosphorylations are required for regulating Pin1 phosphorylation. Neurochem Res. 2005;30:955-61 pubmed
    Pin1 binds mitotically phosphorylated Thr231-Pro232 and Thr212-Pro213 sites on tau, and a Pin1 deficiency in mice leads to tau hyperphosphorylation...
  9. Holth J, Bomben V, Reed J, Inoue T, Younkin L, Younkin S, et al. Tau loss attenuates neuronal network hyperexcitability in mouse and Drosophila genetic models of epilepsy. J Neurosci. 2013;33:1651-9 pubmed publisher
    ..Genetic removal of Mapt, the gene encoding tau, in AD models overexpressing amyloid-? (A?) decreases hyperexcitability and normalizes the ..
  10. Wu C, Zhu J, Wager Miller J, Wang S, O LEARY D, Monory K, et al. Requirement of cannabinoid CB(1) receptors in cortical pyramidal neurons for appropriate development of corticothalamic and thalamocortical projections. Eur J Neurosci. 2010;32:693-706 pubmed publisher
    ..These findings are important in understanding the long-term consequences of alterations in CB(1)R activity during development, a potential etiology for the mental health disorders linked to prenatal cannabis use. ..

Detail Information

Publications77

  1. Morris M, Hamto P, Adame A, Devidze N, Masliah E, Mucke L. Age-appropriate cognition and subtle dopamine-independent motor deficits in aged tau knockout mice. Neurobiol Aging. 2013;34:1523-9 pubmed publisher
    The microtubule-associated protein tau is expressed throughout the nervous system, most highly in neurons but also in glial cells. Its functions in adult and aging mammals remain to be defined...
  2. Sultan A, Nesslany F, Violet M, Bégard S, Loyens A, Talahari S, et al. Nuclear tau, a key player in neuronal DNA protection. J Biol Chem. 2011;286:4566-75 pubmed publisher
    b>Tau, a neuronal protein involved in neurodegenerative disorders such as Alzheimer disease, which is primarily described as a microtubule-associated protein, has also been observed in the nuclei of neuronal and non-neuronal cells...
  3. Kimura T, Whitcomb D, Jo J, Regan P, Piers T, Heo S, et al. Microtubule-associated protein tau is essential for long-term depression in the hippocampus. Philos Trans R Soc Lond B Biol Sci. 2014;369:20130144 pubmed publisher
    The microtubule-associated protein tau is a principal component of neurofibrillary tangles, and has been identified as a key molecule in Alzheimer's disease and other tauopathies...
  4. Polydoro M, Acker C, Duff K, Castillo P, Davies P. Age-dependent impairment of cognitive and synaptic function in the htau mouse model of tau pathology. J Neurosci. 2009;29:10741-9 pubmed publisher
    ..tangles (NFTs), which are intracellular aggregates of conformationally abnormal and hyperphosphorylated tau. The presence of NFTs in the forebrain is associated with impairments of cognitive function, supporting a central ..
  5. Roberson E, Halabisky B, Yoo J, Yao J, Chin J, Yan F, et al. Amyloid-?/Fyn-induced synaptic, network, and cognitive impairments depend on tau levels in multiple mouse models of Alzheimer's disease. J Neurosci. 2011;31:700-11 pubmed publisher
    ..Recent evidence suggests that microtubule-associated protein tau may mediate amyloid-? peptide (A?) toxicity by modulating the tyrosine kinase Fyn...
  6. Kim B, Backus C, Oh S, Hayes J, Feldman E. Increased tau phosphorylation and cleavage in mouse models of type 1 and type 2 diabetes. Endocrinology. 2009;150:5294-301 pubmed publisher
    ..Abnormally phosphorylated tau is a major building block of neurofibrillary tangles, a classic neuropathological characteristic of AD...
  7. Morris M, Koyama A, Masliah E, Mucke L. Tau reduction does not prevent motor deficits in two mouse models of Parkinson's disease. PLoS ONE. 2011;6:e29257 pubmed publisher
    ..The tau protein has been implicated in the pathogenesis of diverse neurodegenerative disorders, including Alzheimer's ..
  8. Min S, Cho J, Oh J, Shim S, Hwang D, Lee S, et al. Tau and GSK3beta dephosphorylations are required for regulating Pin1 phosphorylation. Neurochem Res. 2005;30:955-61 pubmed
    Pin1 binds mitotically phosphorylated Thr231-Pro232 and Thr212-Pro213 sites on tau, and a Pin1 deficiency in mice leads to tau hyperphosphorylation...
  9. Holth J, Bomben V, Reed J, Inoue T, Younkin L, Younkin S, et al. Tau loss attenuates neuronal network hyperexcitability in mouse and Drosophila genetic models of epilepsy. J Neurosci. 2013;33:1651-9 pubmed publisher
    ..Genetic removal of Mapt, the gene encoding tau, in AD models overexpressing amyloid-? (A?) decreases hyperexcitability and normalizes the ..
  10. Wu C, Zhu J, Wager Miller J, Wang S, O LEARY D, Monory K, et al. Requirement of cannabinoid CB(1) receptors in cortical pyramidal neurons for appropriate development of corticothalamic and thalamocortical projections. Eur J Neurosci. 2010;32:693-706 pubmed publisher
    ..These findings are important in understanding the long-term consequences of alterations in CB(1)R activity during development, a potential etiology for the mental health disorders linked to prenatal cannabis use. ..
  11. Lim J, Balastik M, Lee T, Nakamura K, Liou Y, Sun A, et al. Pin1 has opposite effects on wild-type and P301L tau stability and tauopathy. J Clin Invest. 2008;118:1877-89 pubmed publisher
    b>Tau pathology is a hallmark of many neurodegenerative diseases including Alzheimer disease (AD) and frontotemporal dementia with Parkinsonism linked to chromosome 17 (FTDP-17)...
  12. Cook C, Gendron T, Scheffel K, Carlomagno Y, Dunmore J, Deture M, et al. Loss of HDAC6, a novel CHIP substrate, alleviates abnormal tau accumulation. Hum Mol Genet. 2012;21:2936-45 pubmed publisher
    The abnormal accumulation of the microtubule-binding protein tau is associated with a number of neurodegenerative conditions, and correlates with cognitive decline in Alzheimer's disease...
  13. Wang Y, Martinez Vicente M, Krüger U, Kaushik S, Wong E, Mandelkow E, et al. Tau fragmentation, aggregation and clearance: the dual role of lysosomal processing. Hum Mol Genet. 2009;18:4153-70 pubmed publisher
    Aggregation and cleavage are two hallmarks of Tau pathology in Alzheimer disease (AD), and abnormal fragmentation of Tau is thought to contribute to the nucleation of Tau paired helical filaments...
  14. Schrag M, Sharma S, Brown Borg H, Ghribi O. Hippocampus of Ames dwarf mice is resistant to beta-amyloid-induced tau hyperphosphorylation and changes in apoptosis-regulatory protein levels. Hippocampus. 2008;18:239-44 pubmed
    ..not their normal phenotype counterparts (wild type), are resistant to Abeta25-35-induced hyperphosphorylation of tau protein, reduction in levels of the antiapoptotic protein Bcl-2, increase in levels of the pro-apoptotic protein ..
  15. Seino Y, Kawarabayashi T, Wakasaya Y, Watanabe M, Takamura A, Yamamoto Watanabe Y, et al. Amyloid ? accelerates phosphorylation of tau and neurofibrillary tangle formation in an amyloid precursor protein and tau double-transgenic mouse model. J Neurosci Res. 2010;88:3547-54 pubmed publisher
    ..difference in theprogression of A? accumulation among 2×TgTau(+/-) APP(+/-) and 1×TgTau(-/-) APP(+/-) , and tau accumulation among 2×TgTau(+/-) APP(+/-) and 1×Tg Tau(+/-) APP(-/-) ...
  16. Delobel P, Lavenir I, Fraser G, Ingram E, Holzer M, Ghetti B, et al. Analysis of tau phosphorylation and truncation in a mouse model of human tauopathy. Am J Pathol. 2008;172:123-31 pubmed
    Recent evidence has suggested that truncation of tau protein at the caspase cleavage site D421 precedes hyperphosphorylation and may be necessary for the assembly of tau into filaments in Alzheimer's disease and other tauopathies...
  17. Ishii T, Furuoka H, Muroi Y, Nishimura M. Inactivation of integrin-linked kinase induces aberrant tau phosphorylation via sustained activation of glycogen synthase kinase 3beta in N1E-115 neuroblastoma cells. J Biol Chem. 2003;278:26970-5 pubmed
    ..Satoh, E., and Nishimura, M. (2001) J. Biol. Chem. 276, 42994-43003). Here we report that ILK controls tau phosphorylation via regulation of glycogen synthase kinase-3beta (GSK-3beta) activity in N1E-115 cells...
  18. Keimpema E, Barabas K, Morozov Y, Tortoriello G, Torii M, Cameron G, et al. Differential subcellular recruitment of monoacylglycerol lipase generates spatial specificity of 2-arachidonoyl glycerol signaling during axonal pathfinding. J Neurosci. 2010;30:13992-4007 pubmed publisher
  19. Bhaskar K, Yen S, Lee G. Disease-related modifications in tau affect the interaction between Fyn and Tau. J Biol Chem. 2005;280:35119-25 pubmed
    Microtubule-associated protein tau is the major component of the neurofibrillary tangles of Alzheimer disease (AD) and is genetically linked to frontotemporal dementias (FTDP-17)...
  20. Yuan A, Kumar A, Peterhoff C, Duff K, Nixon R. Axonal transport rates in vivo are unaffected by tau deletion or overexpression in mice. J Neurosci. 2008;28:1682-7 pubmed publisher
    Elevated tau expression has been proposed as a possible basis for impaired axonal transport in Alzheimer's disease...
  21. Sasaki A, Kawarabayashi T, Murakami T, Matsubara E, Ikeda M, Hagiwara H, et al. Microglial activation in brain lesions with tau deposits: comparison of human tauopathies and tau transgenic mice TgTauP301L. Brain Res. 2008;1214:159-68 pubmed publisher
    The aim of this study is to clarify the relationship of microglia to phosphorylated tau accumulation and the characteristics of microglial activation in brain lesions of human tauopathies in comparison to mutant tau transgenic (TG) mice...
  22. Nagae S, Tanoue T, Takeichi M. Temporal and spatial expression profiles of the Fat3 protein, a giant cadherin molecule, during mouse development. Dev Dyn. 2007;236:534-43 pubmed
    ..Based on these observations, we suggest that Fat3 plays a role in the interactions between neurites derived from specific subsets of neurons during development. ..
  23. David D, Hauptmann S, Scherping I, Schuessel K, Keil U, Rizzu P, et al. Proteomic and functional analyses reveal a mitochondrial dysfunction in P301L tau transgenic mice. J Biol Chem. 2005;280:23802-14 pubmed
    Transgenic mice overexpressing the P301L mutant human tau protein exhibit an accumulation of hyperphosphorylated tau and develop neurofibrillary tangles...
  24. Lei P, Ayton S, Finkelstein D, Spoerri L, Ciccotosto G, Wright D, et al. Tau deficiency induces parkinsonism with dementia by impairing APP-mediated iron export. Nat Med. 2012;18:291-5 pubmed publisher
    The microtubule-associated protein tau has risk alleles for both Alzheimer's disease and Parkinson's disease and mutations that cause brain degenerative diseases termed tauopathies...
  25. Boutajangout A, Quartermain D, Sigurdsson E. Immunotherapy targeting pathological tau prevents cognitive decline in a new tangle mouse model. J Neurosci. 2010;30:16559-66 pubmed publisher
    ..Limited emphasis has been put into clearing tau/tangle pathology, another major hallmark of the disease...
  26. Egashira N, Iwasaki K, Takashima A, Watanabe T, Kawabe H, Matsuda T, et al. Altered depression-related behavior and neurochemical changes in serotonergic neurons in mutant R406W human tau transgenic mice. Brain Res. 2005;1059:7-12 pubmed
    Mutant R406W human tau was originally identified in frontotemporal dementia and parkinsonism linked to chromosome 17 (FTDP-17) and causes a hereditary tauopathy that clinically resembles Alzheimer's disease (AD)...
  27. Sapir T, Frotscher M, Levy T, Mandelkow E, Reiner O. Tau's role in the developing brain: implications for intellectual disability. Hum Mol Genet. 2012;21:1681-92 pubmed publisher
    Microdeletions encompassing the MAPT (Tau) locus resulting in intellectual disability raised the hypothesis that Tau may regulate early functions in the developing brain...
  28. Ke Y, Delerue F, Gladbach A, Götz J, Ittner L. Experimental diabetes mellitus exacerbates tau pathology in a transgenic mouse model of Alzheimer's disease. PLoS ONE. 2009;4:e7917 pubmed publisher
    ..also plays a role in Alzheimer's disease (AD) as it is involved in the metabolism of beta-amyloid (Abeta) and tau, two proteins that form Abeta plaques and neurofibrillary tangles (NFTs), respectively, the hallmark lesions in AD...
  29. Dolan P, Johnson G. A caspase cleaved form of tau is preferentially degraded through the autophagy pathway. J Biol Chem. 2010;285:21978-87 pubmed publisher
    The microtubule-associated protein tau plays a central role in the pathogenesis of Alzheimer disease (AD) and abnormally accumulates as neurofibrillary tangles; therefore, the pathways by which tau is degraded have been examined ..
  30. Andrews Zwilling Y, Bien Ly N, Xu Q, Li G, Bernardo A, Yoon S, et al. Apolipoprotein E4 causes age- and Tau-dependent impairment of GABAergic interneurons, leading to learning and memory deficits in mice. J Neurosci. 2010;30:13707-17 pubmed publisher
    ..and tauopathy occurred earliest in hilar interneurons in apoE4 fragment transgenic mice; eliminating endogenous Tau prevented hilar GABAergic interneuron loss and the learning and memory deficits...
  31. Betley J, Wright C, Kawaguchi Y, Erdelyi F, Szabo G, Jessell T, et al. Stringent specificity in the construction of a GABAergic presynaptic inhibitory circuit. Cell. 2009;139:161-74 pubmed publisher
    ..The organization of a GABAergic circuit that mediates presynaptic inhibition in the mammalian CNS is therefore controlled by a stringent program of sensory recognition and signaling. ..
  32. Haggerty T, Credle J, Rodriguez O, Wills J, Oaks A, Masliah E, et al. Hyperphosphorylated Tau in an ?-synuclein-overexpressing transgenic model of Parkinson's disease. Eur J Neurosci. 2011;33:1598-610 pubmed publisher
    ..PD with dementia, we have recently described elevated levels of tauopathy, indexed as increased hyperphosphorylated Tau (p-Tau)...
  33. Ma Q, Zuo X, Yang F, Ubeda O, Gant D, Alaverdyan M, et al. Loss of MAP function leads to hippocampal synapse loss and deficits in the Morris Water Maze with aging. J Neurosci. 2014;34:7124-36 pubmed publisher
    Hyperphosphorylation and accumulation of tau aggregates are prominent features in tauopathies, including Alzheimer's disease, but the impact of loss of tau function on synaptic and cognitive deficits remains poorly understood...
  34. Deters N, Ittner L, Götz J. Divergent phosphorylation pattern of tau in P301L tau transgenic mice. Eur J Neurosci. 2008;28:137-47 pubmed publisher
    Aggregates of hyperphosphorylated tau are prominent in brains of patients with Alzheimer's disease or frontotemporal dementia (FTD)...
  35. Jiménez Mateos E, Gonzalez Billault C, Dawson H, Vitek M, Avila J. Role of MAP1B in axonal retrograde transport of mitochondria. Biochem J. 2006;397:53-9 pubmed
    The MAPs (microtubule-associated proteins) MAP1B and tau are well known for binding to microtubules and stabilizing these structures...
  36. Oddo S, Vasilevko V, Caccamo A, Kitazawa M, Cribbs D, LaFerla F. Reduction of soluble Abeta and tau, but not soluble Abeta alone, ameliorates cognitive decline in transgenic mice with plaques and tangles. J Biol Chem. 2006;281:39413-23 pubmed
    ..Here we report the novel finding that soluble tau also plays a role in the cognitive decline in the presence of concomitant Abeta pathology...
  37. Dixit R, Ross J, Goldman Y, Holzbaur E. Differential regulation of dynein and kinesin motor proteins by tau. Science. 2008;319:1086-9 pubmed publisher
    ..In neurons, microtubules are abundantly decorated with microtubule-associated proteins (MAPs) such as tau. Motor proteins thus encounter MAPs frequently along their path...
  38. Dickey C, Kamal A, Lundgren K, Klosak N, Bailey R, Dunmore J, et al. The high-affinity HSP90-CHIP complex recognizes and selectively degrades phosphorylated tau client proteins. J Clin Invest. 2007;117:648-58 pubmed
    ..component of Alzheimer's disease (AD) is the formation of neurofibrillary tangles composed of hyperphosphorylated tau (p-tau). Expediting the removal of these p-tau species may be a relevant therapeutic strategy...
  39. Luikenhuis S, Giacometti E, Beard C, Jaenisch R. Expression of MeCP2 in postmitotic neurons rescues Rett syndrome in mice. Proc Natl Acad Sci U S A. 2004;101:6033-8 pubmed
    ..Expression of the Mecp2 transgene in postmitotic neurons resulted in symptoms of severe motor dysfunction. Transgene expression in Mecp2 mutant mice, however, rescued the RTT phenotype. ..
  40. Vossel K, Zhang K, Brodbeck J, Daub A, Sharma P, Finkbeiner S, et al. Tau reduction prevents Abeta-induced defects in axonal transport. Science. 2010;330:198 pubmed publisher
    Amyloid-? (A?) peptides, derived from the amyloid precursor protein, and the microtubule-associated protein tau are key pathogenic factors in Alzheimer's disease (AD). How exactly they impair cognitive functions is unknown...
  41. Yamada K, Cirrito J, Stewart F, Jiang H, Finn M, Holmes B, et al. In vivo microdialysis reveals age-dependent decrease of brain interstitial fluid tau levels in P301S human tau transgenic mice. J Neurosci. 2011;31:13110-7 pubmed publisher
    Although tau is a cytoplasmic protein, it is also found in brain extracellular fluids, e.g., CSF...
  42. Ando K, Leroy K, Héraud C, Yilmaz Z, Authelet M, Suain V, et al. Accelerated human mutant tau aggregation by knocking out murine tau in a transgenic mouse model. Am J Pathol. 2011;178:803-16 pubmed publisher
    Many models of human tauopathies have been generated in mice by expression of a human mutant tau with maintained expression of mouse endogenous tau...
  43. Oddo S, Caccamo A, Tran L, Lambert M, Glabe C, Klein W, et al. Temporal profile of amyloid-beta (Abeta) oligomerization in an in vivo model of Alzheimer disease. A link between Abeta and tau pathology. J Biol Chem. 2006;281:1599-604 pubmed
    Accumulation of amyloid-beta (Abeta) is one of the earliest molecular events in Alzheimer disease (AD), whereas tau pathology is thought to be a later downstream event...
  44. Clodfelder Miller B, Zmijewska A, Johnson G, Jope R. Tau is hyperphosphorylated at multiple sites in mouse brain in vivo after streptozotocin-induced insulin deficiency. Diabetes. 2006;55:3320-5 pubmed
    ..characteristics of Alzheimer's disease is the presence of neurofibrillary tangles containing hyperphosphorylated tau, a microtubule-associated protein...
  45. Van der Jeugd A, Hochgräfe K, Ahmed T, Decker J, Sydow A, Hofmann A, et al. Cognitive defects are reversible in inducible mice expressing pro-aggregant full-length human Tau. Acta Neuropathol. 2012;123:787-805 pubmed publisher
    Neurofibrillary lesions of abnormal Tau are hallmarks of Alzheimer disease and frontotemporal dementias...
  46. Petrucelli L, Dickson D, Kehoe K, Taylor J, Snyder H, Grover A, et al. CHIP and Hsp70 regulate tau ubiquitination, degradation and aggregation. Hum Mol Genet. 2004;13:703-14 pubmed
    ..g. tau and alpha-synuclein respectively)...
  47. Xiong Y, Zhao K, Wu J, Xu Z, Jin S, Zhang Y. HDAC6 mutations rescue human tau-induced microtubule defects in Drosophila. Proc Natl Acad Sci U S A. 2013;110:4604-9 pubmed publisher
    ..disease (AD) and related tauopathy patients contain neurofibrillary tangles composed of hyperphosphorylated tau protein...
  48. Rodriguez Martin T, Cuchillo Ibanez I, Noble W, Nyenya F, Anderton B, Hanger D. Tau phosphorylation affects its axonal transport and degradation. Neurobiol Aging. 2013;34:2146-57 pubmed publisher
    Phosphorylated forms of microtubule-associated protein tau accumulate in neurofibrillary tangles in Alzheimer's disease...
  49. Rapoport M, Dawson H, Binder L, Vitek M, Ferreira A. Tau is essential to beta -amyloid-induced neurotoxicity. Proc Natl Acad Sci U S A. 2002;99:6364-9 pubmed
    ..peptide (Abeta); neurofibrillary tangles represent intracellular bundles of self-assembled hyperphosphorylated tau proteins...
  50. Shipton O, Leitz J, Dworzak J, Acton C, Tunbridge E, Denk F, et al. Tau protein is required for amyloid {beta}-induced impairment of hippocampal long-term potentiation. J Neurosci. 2011;31:1688-92 pubmed publisher
    Amyloid ? (A?) and tau protein are both implicated in memory impairment, mild cognitive impairment (MCI), and early Alzheimer's disease (AD), but whether and how they interact is unknown...
  51. Harris F, Brecht W, Xu Q, Mahley R, Huang Y. Increased tau phosphorylation in apolipoprotein E4 transgenic mice is associated with activation of extracellular signal-regulated kinase: modulation by zinc. J Biol Chem. 2004;279:44795-801 pubmed
    ..Neuronal expression of apoE4 or apoE4 fragments in transgenic mice increases tau phosphorylation...
  52. Congdon E, Gu J, Sait H, Sigurdsson E. Antibody uptake into neurons occurs primarily via clathrin-dependent Fc? receptor endocytosis and is a prerequisite for acute tau protein clearance. J Biol Chem. 2013;288:35452-65 pubmed publisher
    b>Tau immunotherapy is effective in transgenic mice, but the mechanisms of Tau clearance are not well known. To this end, Tau antibody uptake was analyzed in brain slice cultures and primary neurons...
  53. Terwel D, Lasrado R, Snauwaert J, Vandeweert E, Van Haesendonck C, Borghgraef P, et al. Changed conformation of mutant Tau-P301L underlies the moribund tauopathy, absent in progressive, nonlethal axonopathy of Tau-4R/2N transgenic mice. J Biol Chem. 2005;280:3963-73 pubmed
    Protein tau-3R/4R isoform ratio and phosphorylation regulates binding to microtubules and, when disturbed by aging or mutations, results in diverse tauopathies and in neurodegeneration...
  54. Takuma H, Arawaka S, Mori H. Isoforms changes of tau protein during development in various species. Brain Res Dev Brain Res. 2003;142:121-7 pubmed
    b>Tau protein is one of the major microtubule-associated proteins of the vertebrate nervous system. Some kinds of isoforms, for example, six isoforms in humans, are generated from a single gene by alternative mRNA splicing...
  55. Hippenmeyer S, Vrieseling E, Sigrist M, Portmann T, Laengle C, Ladle D, et al. A developmental switch in the response of DRG neurons to ETS transcription factor signaling. PLoS Biol. 2005;3:e159 pubmed
    ..Together, our findings indicate that DRG sensory neurons exhibit a temporal developmental switch that can be revealed by distinct responses to ETS transcription factor signaling at sequential steps of neuronal maturation. ..
  56. Schmetsdorf S, Arnold E, Holzer M, Arendt T, Gärtner U. A putative role for cell cycle-related proteins in microtubule-based neuroplasticity. Eur J Neurosci. 2009;29:1096-107 pubmed publisher
    ..D, E, A and B as well as Cdks 1, 2 and 4 were also found to be associated with the microtubule-associated protein tau. Cyclin/Cdk complexes, in addition, exhibit kinase activity towards tau...
  57. Dickey C, Yue M, Lin W, Dickson D, Dunmore J, Lee W, et al. Deletion of the ubiquitin ligase CHIP leads to the accumulation, but not the aggregation, of both endogenous phospho- and caspase-3-cleaved tau species. J Neurosci. 2006;26:6985-96 pubmed
    ..Hereditary mutations in the MAPT gene were shown to promote the formation of structurally distinct tau aggregates in patients that had a ..
  58. Morgan D, Munireddy S, Alamed J, Deleon J, Diamond D, Bickford P, et al. Apparent behavioral benefits of tau overexpression in P301L tau transgenic mice. J Alzheimers Dis. 2008;15:605-14 pubmed
    Transgenic mice expressing human tau containing the P301L tau mutation (JNPL3; tau mice) develop motor neuron loss, paralysis and death between 7 and 12 months...
  59. Dawson H, Cantillana V, Jansen M, Wang H, Vitek M, Wilcock D, et al. Loss of tau elicits axonal degeneration in a mouse model of Alzheimer's disease. Neuroscience. 2010;169:516-31 pubmed publisher
    A central issue in the pathogenesis of tauopathy is the question of how tau protein dysfunction leads to neurodegeneration...
  60. Jaworski T, Dewachter I, Lechat B, Croes S, Termont A, Demedts D, et al. AAV-tau mediates pyramidal neurodegeneration by cell-cycle re-entry without neurofibrillary tangle formation in wild-type mice. PLoS ONE. 2009;4:e7280 pubmed publisher
    ..Transgenic mouse models do not resolve this problem conclusively, i.e. the relative hierarchy of amyloid and tau pathology depends on the actual model and the genes expressed or inactivated...
  61. Vega I, Traverso E, Ferrer Acosta Y, Matos E, Colon M, Gonzalez J, et al. A novel calcium-binding protein is associated with tau proteins in tauopathy. J Neurochem. 2008;106:96-106 pubmed publisher
    ..group of neurological disorders characterized by the presence of intraneuronal hyperphosphorylated and filamentous tau. Mutations in the tau gene have been found in kindred with tauopathy...
  62. Andorfer C, Acker C, Kress Y, Hof P, Duff K, Davies P. Cell-cycle reentry and cell death in transgenic mice expressing nonmutant human tau isoforms. J Neurosci. 2005;25:5446-54 pubmed
    Mutations in the microtubule-associated protein tau gene have been linked to neurofibrillary tangle (NFT) formation in several neurodegenerative diseases known as tauopathies; however, no tau mutations occur in Alzheimer's disease, ..
  63. Leroy K, Ando K, Laporte V, Dedecker R, Suain V, Authelet M, et al. Lack of tau proteins rescues neuronal cell death and decreases amyloidogenic processing of APP in APP/PS1 mice. Am J Pathol. 2012;181:1928-40 pubmed publisher
    Lack of tau expression has been reported to protect against excitotoxicity and to prevent memory deficits in mice expressing mutant amyloid precursor protein (APP) identified in familial Alzheimer disease...
  64. Liu Y, Lv K, Li Z, Yu A, Chen J, Teng J. PACSIN1, a Tau-interacting protein, regulates axonal elongation and branching by facilitating microtubule instability. J Biol Chem. 2012;287:39911-24 pubmed publisher
    b>Tau is a major member of the neuronal microtubule-associated proteins. It promotes tubulin assembly and stabilizes axonal microtubules...
  65. Holmes B, DeVos S, Kfoury N, Li M, Jacks R, Yanamandra K, et al. Heparan sulfate proteoglycans mediate internalization and propagation of specific proteopathic seeds. Proc Natl Acad Sci U S A. 2013;110:E3138-47 pubmed publisher
    ..The mechanism by which aggregated extracellular proteins such as tau and ?-synuclein bind and enter cells to trigger intracellular fibril formation is unknown...
  66. Cavallini A, Brewerton S, Bell A, Sargent S, Glover S, Hardy C, et al. An unbiased approach to identifying tau kinases that phosphorylate tau at sites associated with Alzheimer disease. J Biol Chem. 2013;288:23331-47 pubmed publisher
    ..the hallmarks of Alzheimer disease (AD), are composed of paired helical filaments of abnormally hyperphosphorylated tau. The accumulation of these proteinaceous aggregates in AD correlates with synaptic loss and severity of dementia...
  67. Muramatsu K, Hashimoto Y, Uemura T, Kunii M, Harada R, Sato T, et al. Neuron-specific recombination by Cre recombinase inserted into the murine tau locus. Biochem Biophys Res Commun. 2008;370:419-23 pubmed publisher
    ..b>Tau, a microtubule-associated protein, is expressed abundantly in neurons but scarcely in glias and other tissues...
  68. Perez M, Santa Maria I, Gomez de Barreda E, Zhu X, Cuadros R, Cabrero J, et al. Tau--an inhibitor of deacetylase HDAC6 function. J Neurochem. 2009;109:1756-66 pubmed publisher
    ..acetylation of the alpha tubulin subunit, mainly in those microtubules from neurons containing neurofibrillary tau pathology...
  69. Emmer K, Waxman E, Covy J, Giasson B. E46K human alpha-synuclein transgenic mice develop Lewy-like and tau pathology associated with age-dependent, detrimental motor impairment. J Biol Chem. 2011;286:35104-18 pubmed publisher
    ..E46K human ?-syn mice also develop abundant neuronal tau inclusions that resemble neurofibrillary tangles...
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