Mapk8ip3

Summary

Gene Symbol: Mapk8ip3
Description: mitogen-activated protein kinase 8 interacting protein 3
Alias: BB120594, D17Wsu15e, JIP-3, JSAP1, JSAP1a, JSAP1b, JSAP1c, JSAP1d, Jip3, Syd2, mKIAA1066, C-Jun-amino-terminal kinase-interacting protein 3, JNK MAP kinase scaffold protein 3, JNK-interacting protein 3, JNK/SAPK-associated protein 1, JNK/SAPK-associated protein 1c, JUN/SAPK-associated protein 1, c-Jun NH2-terminal kinase (JNK)/stress-activated protein kinase-associated protein 1, mitogen activated protein kinase 8 interacting protein 3, mitogen-activated protein kinase 8-interacting protein 3, sunday driver 2
Species: mouse

Top Publications

  1. pmc Cargo of kinesin identified as JIP scaffolding proteins and associated signaling molecules
    K J Verhey
    Howard Hughes Medical Institute, Harvard Medical School, Boston, Massachusetts 02115, USA
    J Cell Biol 152:959-70. 2001
  2. pmc Interaction of a mitogen-activated protein kinase signaling module with the neuronal protein JIP3
    N Kelkar
    Howard Hughes Medical Institute, Program in Molecular Medicine, Department of Biochemistry, University of Massachusetts Medical School, Worcester, Massachusetts 01605, USA
    Mol Cell Biol 20:1030-43. 2000
  3. pmc Sunday Driver links axonal transport to damage signaling
    Valeria Cavalli
    Department of Cellular and Molecular Medicine, Howard Hughes Medical Institute, University of California, San Diego, La Jolla, CA 92093, USA
    J Cell Biol 168:775-87. 2005
  4. pmc JSAP1, a novel jun N-terminal protein kinase (JNK)-binding protein that functions as a Scaffold factor in the JNK signaling pathway
    M Ito
    Department of Biosciences, School of Science, Kitasato University, Kanagawa 228, Japan
    Mol Cell Biol 19:7539-48. 1999
  5. ncbi In vitro development of mouse embryonic stem cells lacking JNK/stress-activated protein kinase-associated protein 1 (JSAP1) scaffold protein revealed its requirement during early embryonic neurogenesis
    Ping Xu
    Division of Neurofunctional Genomics, Department of Immunobiology and Neuroscience, Medical Institute of Bioregulation, Kyushu University and CREST, Japan Science and Technology Corp, Fukuoka 812 8582, Japan
    J Biol Chem 278:48422-33. 2003
  6. ncbi Kinesin-dependent axonal transport is mediated by the sunday driver (SYD) protein
    A B Bowman
    Howard Hughes Medical Institute, Department of Cellular and Molecular Medicine, University of California, San Diego, 9500 Gilman Drive La Jolla, CA 92093, USA
    Cell 103:583-94. 2000
  7. pmc c-Jun NH2-terminal kinase (JNK)-interacting protein-3 (JIP3) regulates neuronal axon elongation in a kinesin- and JNK-dependent manner
    Tao Sun
    Department of Neurobiology, Shandong Provincial Key Laboratory of Mental Disorders, School of Medicine, Shandong University, No 4 Wenhua Xi Road, Jinan, Shandong 250012, USA
    J Biol Chem 288:14531-43. 2013
  8. pmc Random monoallelic expression of three genes clustered within 60 kb of mouse t complex genomic DNA
    Y Sano
    Developmental Genomics and Aging Section, Laboratory of Genetics, National Institute on Aging, National Institutes of Health, Baltimore, MD 21224, USA
    Genome Res 11:1833-41. 2001
  9. ncbi Expression and distribution of JNK/SAPK-associated scaffold protein JSAP1 in developing and adult mouse brain
    Eriko Miura
    Department of Anatomy, Hokkaido University School of Medicine, Sapporo, Japan
    J Neurochem 97:1431-46. 2006
  10. ncbi FSCB, a novel protein kinase A-phosphorylated calcium-binding protein, is a CABYR-binding partner involved in late steps of fibrous sheath biogenesis
    Yan feng Li
    Center for Research in Contraceptive and Reproductive Health, Department of Cell Biology, University of Virginia, Charlottesville, VA 22908, USA
    J Biol Chem 282:34104-19. 2007

Scientific Experts

  • Tetsuya Matsuguchi
  • K J Verhey
  • Xinhua Yu
  • Tokiharu Sato
  • Katsuji Yoshioka
  • Hye Yeong Ha
  • Ik Hyun Cho
  • Valeria Cavalli
  • Masahide Asano
  • Nyaya Kelkar
  • Kang Woo Lee
  • Pyung Lim Han
  • Kazushi Sugihara
  • Asuka Iwanaga
  • M Ito
  • Tao Sun
  • Faneng Sun
  • Arundhati Sengupta Ghosh
  • Michihiko Ito
  • M Akechi
  • Atsushi Suzuki
  • Namiko Abe
  • Jin Wu
  • Lawrence S B Goldstein
  • Yan feng Li
  • Kyoung Shim Kim
  • Ja Kyeong Lee
  • Eriko Miura
  • N Takamatsu
  • Takahisa Takino
  • K Yoshioka
  • Roger J Davis
  • Jennifer Y Zhang
  • Shoko Akiyama
  • Koichi Obata
  • Yusaku Nakabeppu
  • Aarti R Uzgare
  • Jiuhong Yu
  • Ping Xu
  • Junji Kamogawa
  • Ying Shen
  • Zhe Yu Chen
  • Zhuo Huang
  • Na Li
  • Xing Yu Jiang
  • Nuo Yu
  • Liang Zhou
  • Lu Kai Zhai
  • Chao Zhang
  • Y Sano
  • Mark Chen
  • Bei Wang
  • T Shimada
  • Christine D Pozniak
  • Ryan J Watts
  • Ram Dixit
  • Joseph W Lewcock
  • H Nakashima
  • Chuanmei Zhu
  • M S Ko
  • Masatomo Watanabe
  • T Shiba
  • Yuji Kuwahara
  • Kouichi Itoh
  • Teruhiko Suzuki
  • N Kelkar
  • A B Bowman
  • G J Kargul
  • Chihiro Arikawa
  • Yasunori Kanaho
  • S Yamashita
  • Yuji Funakoshi
  • Hiroshi Watanabe
  • Hiroshi Hasegawa
  • Gary E Striker
  • Angels Almenar-Queralt
  • Steven P Briggs
  • Y Nakabeppu
  • Changlin Mei
  • Concepcion Lillo
  • David S Williams
  • Jean Lozach
  • Feng Zheng
  • Zhouxin Shen
  • Helen Vlassara
  • Takashi Torashima
  • Hirokazu Hirai
  • Hyo Jin Joo
  • Jung Bin Kim
  • Jang Hee Hong

Detail Information

Publications35

  1. pmc Cargo of kinesin identified as JIP scaffolding proteins and associated signaling molecules
    K J Verhey
    Howard Hughes Medical Institute, Harvard Medical School, Boston, Massachusetts 02115, USA
    J Cell Biol 152:959-70. 2001
    ....
  2. pmc Interaction of a mitogen-activated protein kinase signaling module with the neuronal protein JIP3
    N Kelkar
    Howard Hughes Medical Institute, Program in Molecular Medicine, Department of Biochemistry, University of Massachusetts Medical School, Worcester, Massachusetts 01605, USA
    Mol Cell Biol 20:1030-43. 2000
    ..Here we describe the molecular cloning of a putative molecular scaffold protein, JIP3, that binds the protein kinase components of a JNK signaling module and facilitates JNK activation in cultured ..
  3. pmc Sunday Driver links axonal transport to damage signaling
    Valeria Cavalli
    Department of Cellular and Molecular Medicine, Howard Hughes Medical Institute, University of California, San Diego, La Jolla, CA 92093, USA
    J Cell Biol 168:775-87. 2005
    ..Finally, we found that injury induces an enhanced interaction between syd and dynactin. Thus, a mobile axonal JNK-syd complex may generate a transport-dependent axonal damage surveillance system...
  4. pmc JSAP1, a novel jun N-terminal protein kinase (JNK)-binding protein that functions as a Scaffold factor in the JNK signaling pathway
    M Ito
    Department of Biosciences, School of Science, Kitasato University, Kanagawa 228, Japan
    Mol Cell Biol 19:7539-48. 1999
    ..mouse protein, termed Jun N-terminal protein kinase (JNK)/stress-activated protein kinase-associated protein 1 (JSAP1), by a yeast two-hybrid screen, using JNK3 MAPK as the bait...
  5. ncbi In vitro development of mouse embryonic stem cells lacking JNK/stress-activated protein kinase-associated protein 1 (JSAP1) scaffold protein revealed its requirement during early embryonic neurogenesis
    Ping Xu
    Division of Neurofunctional Genomics, Department of Immunobiology and Neuroscience, Medical Institute of Bioregulation, Kyushu University and CREST, Japan Science and Technology Corp, Fukuoka 812 8582, Japan
    J Biol Chem 278:48422-33. 2003
    The Jsap1 gene encodes a scaffold protein for c-Jun N-terminal kinase cascades...
  6. ncbi Kinesin-dependent axonal transport is mediated by the sunday driver (SYD) protein
    A B Bowman
    Howard Hughes Medical Institute, Department of Cellular and Molecular Medicine, University of California, San Diego, 9500 Gilman Drive La Jolla, CA 92093, USA
    Cell 103:583-94. 2000
    ..We propose that SYD mediates the axonal transport of at least one class of vesicles by interacting directly with KLC...
  7. pmc c-Jun NH2-terminal kinase (JNK)-interacting protein-3 (JIP3) regulates neuronal axon elongation in a kinesin- and JNK-dependent manner
    Tao Sun
    Department of Neurobiology, Shandong Provincial Key Laboratory of Mental Disorders, School of Medicine, Shandong University, No 4 Wenhua Xi Road, Jinan, Shandong 250012, USA
    J Biol Chem 288:14531-43. 2013
    ..Here, we report that c-Jun NH2-terminal kinase (JNK)-interacting protein-3 (JIP3) is highly expressed at axon tips during the critical period for axon development...
  8. pmc Random monoallelic expression of three genes clustered within 60 kb of mouse t complex genomic DNA
    Y Sano
    Developmental Genomics and Aging Section, Laboratory of Genetics, National Institute on Aging, National Institutes of Health, Baltimore, MD 21224, USA
    Genome Res 11:1833-41. 2001
    ..Here we report three additional genes, Nubp2, Igfals, and Jsap1, that show 50%-methylated CpG sites by Southern blot analyses and primarily monoallelic expression in single-cell ..
  9. ncbi Expression and distribution of JNK/SAPK-associated scaffold protein JSAP1 in developing and adult mouse brain
    Eriko Miura
    Department of Anatomy, Hokkaido University School of Medicine, Sapporo, Japan
    J Neurochem 97:1431-46. 2006
    ..JNK/SAPK-associated protein 1 (JSAP1 also referred to as JIP3) is a JNK-associated scaffold that controls the specificity and efficiency of JNK ..
  10. ncbi FSCB, a novel protein kinase A-phosphorylated calcium-binding protein, is a CABYR-binding partner involved in late steps of fibrous sheath biogenesis
    Yan feng Li
    Center for Research in Contraceptive and Reproductive Health, Department of Cell Biology, University of Virginia, Charlottesville, VA 22908, USA
    J Biol Chem 282:34104-19. 2007
    ..Due to its temporal appearance during spermiogenesis and location at the cortex of the fibrous sheath, FSCB is postulated to be involved in the later stages of fibrous sheath assembly...
  11. ncbi Neural-specific ablation of the scaffold protein JSAP1 in mice causes neonatal death
    Asuka Iwanaga
    Division of Molecular Cell Signaling, Department of Molecular and Cellular Biology, Cancer Research Institute, Kanazawa University, Ishikawa 920 0934, Japan
    Neurosci Lett 429:43-8. 2007
    We previously identified c-Jun NH(2)-terminal kinase (JNK)/stress-activated protein kinase-associated protein 1 (JSAP1, also known as JNK-interacting protein 3) as a scaffolding factor for JNK intracellular signaling pathways...
  12. doi Morphogenetic lung defects of JSAP1-deficient embryos proceeds via the disruptions of the normal expressions of cytoskeletal and chaperone proteins
    Hye Yeong Ha
    Division of Nano Sciences and Brain Disease Research Institute, Ewha Womans University, Seoul, Republic of Korea
    Proteomics 8:1071-80. 2008
    Recent studies have shown that JNK/stress-activated protein kinase-associated protein 1 (JSAP1)-deficient mice die from respiratory failure shortly after birth...
  13. doi The scaffold protein JSAP1 regulates proliferation and differentiation of cerebellar granule cell precursors by modulating JNK signaling
    Tokiharu Sato
    Division of Molecular Cell Signaling, Cancer Research Institute, Kanazawa University, 13 1 Takara machi, Kanazawa, Ishikawa 920 0934, Japan
    Mol Cell Neurosci 39:569-78. 2008
    ..Here we report that JSAP1, a scaffold protein for JNK signaling pathways, is expressed predominantly in the post-mitotic GCPs of the inner ..
  14. pmc Oxidative stress-induced JNK activation contributes to proinflammatory phenotype of aging diabetic mesangial cells
    Jin Wu
    Divison of Experimental Diabetes and Aging, Department of Geriatrics, Mount Sinai School of Medicine, New York, NY 10029, USA
    Am J Physiol Renal Physiol 297:F1622-31. 2009
    ..Proinflammatory phenotype of mesangial cells may contribute to chronic inflammatory lesions and disease progression of aging diabetic mice...
  15. pmc Sunday driver interacts with two distinct classes of axonal organelles
    Namiko Abe
    Department of Anatomy and Neurobiology, Washington University in St Louis, St Louis, Missouri 63110, USA
    J Biol Chem 284:34628-39. 2009
    ..We reported previously that the motor-binding protein Sunday Driver (syd), also known as JIP3 or JSAP1, links vesicular axonal transport to injury signaling...
  16. doi The scaffold protein JIP3 functions as a downstream effector of the small GTPase ARF6 to regulate neurite morphogenesis of cortical neurons
    Atsushi Suzuki
    Department of Physiological Chemistry, Graduate School of Comprehensive Human Sciences, University of Tsukuba, Tsukuba, Japan
    FEBS Lett 584:2801-6. 2010
    ..We identified the signaling scaffold protein JNK-interacting protein 3 (JIP3), which is exclusively expressed in neurons, as a downstream effector of ARF6...
  17. pmc JNK/stress-activated protein kinase associated protein 1 is required for early development of telencephalic commissures in embryonic brains
    Ik Hyun Cho
    Department of Anatomy, Kyung Hee University, Seoul 130 701, Korea
    Exp Mol Med 43:462-70. 2011
    We previously reported that mice lacking JSAP1 (jsap1-/-) were lethal and the brain of jsap1-/- at E18...
  18. pmc Sunday Driver/JIP3 binds kinesin heavy chain directly and enhances its motility
    Faneng Sun
    Department of Anatomy and Neurobiology, Washington University in St Louis, School of Medicine, St Louis, MO, USA
    EMBO J 30:3416-29. 2011
    ..We report that the adaptor protein Sunday Driver (syd, also known as JIP3 or JSAP1) interacts directly with KHC, in addition to and independently of its known interaction with KLC...
  19. pmc DLK induces developmental neuronal degeneration via selective regulation of proapoptotic JNK activity
    Arundhati Sengupta Ghosh
    Neurodegeneration Laboratories, Department of Neuroscience, Genentech, Inc, South San Francisco, CA 94080, USA
    J Cell Biol 194:751-64. 2011
    ..This specificity is dependent on interaction of DLK with the scaffolding protein JIP3 to form a specialized JNK signaling complex...
  20. ncbi Impairment of cardiomyogenesis in embryonic stem cells lacking scaffold protein JSAP1
    Tokiharu Sato
    Division of Cell Cycle Regulation, Cancer Research Institute, Kanazawa University, 13 1 Takara machi, Kanazawa, Ishikawa 920 0934, Japan
    Biochem Biophys Res Commun 338:1152-7. 2005
    We previously reported that c-Jun NH(2)-terminal kinase (JNK)/stress-activated protein kinase-associated protein 1 (JSAP1), a scaffold protein for JNK signaling, is important in embryonic stem (ES) cells during neurogenesis...
  21. ncbi JSAP1/JIP3 cooperates with focal adhesion kinase to regulate c-Jun N-terminal kinase and cell migration
    Takahisa Takino
    Department of Molecular Virology, Cancer Research Institute, Division of Neuroscience, Graduate School of Medical Science, Kanazawa University, Japan
    J Biol Chem 280:37772-81. 2005
    c-Jun N-terminal kinase (JNK)/stress-activated protein kinase-associated protein 1 (JSAP1) (also termed JNK-interacting protein 3; JIP3) is a member of a family of scaffold factors for the mitogen-activated protein kinase (MAPK) cascades,..
  22. pmc Role of the JIP4 scaffold protein in the regulation of mitogen-activated protein kinase signaling pathways
    Nyaya Kelkar
    Howard Hughes Medical Institute, Program in Molecular Medicine, University of Massachusetts Medical School, 373 Plantation St, Worcester, MA 01605, USA
    Mol Cell Biol 25:2733-43. 2005
    The c-Jun NH2-terminal kinase (JNK)-interacting protein (JIP) group of scaffold proteins (JIP1, JIP2, and JIP3) can interact with components of the JNK signaling pathway and potently activate JNK...
  23. ncbi Arthritis in MRL/lpr mice is under the control of multiple gene loci with an allelic combination derived from the original inbred strains
    Junji Kamogawa
    Ehime University School of Medicine, Shigenobu, Onsen gun, Ehime, Japan
    Arthritis Rheum 46:1067-74. 2002
    ..To clarify the mode of inheritance and the genome origins of arthritis in a lupus-prone strain of mice, MRL/MpJ, bearing a Fas deletion mutant gene, lpr (MRL/lpr)...
  24. ncbi Differential expression and/or activation of P38MAPK, erk1/2, and jnk during the initiation and progression of prostate cancer
    Aarti R Uzgare
    Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, Texas 77030, USA
    Prostate 55:128-39. 2003
    ....
  25. pmc Morphogenesis of the telencephalic commissure requires scaffold protein JNK-interacting protein 3 (JIP3)
    Nyaya Kelkar
    Howard Hughes Medical Institute and Program in Molecular Medicine, University of Massachusetts Medical School, 373 Plantation Street, Worcester, MA 01605, USA
    Proc Natl Acad Sci U S A 100:9843-8. 2003
    The murine JNK-interacting protein 3 (JIP3) protein (also known as JSAP1) is expressed exclusively in neurons and has been identified as a scaffold protein for the c-Jun NH2-terminal kinase (JNK) signaling pathway and as an adapter ..
  26. pmc JNK-interacting protein 3 associates with Toll-like receptor 4 and is involved in LPS-mediated JNK activation
    Tetsuya Matsuguchi
    Division of Host Defense, Center for Neural Disease and Cancer, Nagoya University Graduate School of Medicine, Nagoya, Japan
    EMBO J 22:4455-64. 2003
    ..with the cytoplasmic domain of mouse TLR4 by yeast two-hybrid screening and identified JNK-interacting protein 3 (JIP3), a scaffold protein for JNK, as a TLR4-associated protein...
  27. ncbi Expression of JNK cascade scaffold protein JSAP1 in the mouse nervous system
    M Akechi
    Molecular Biology, Department of Biosciences, School of Science, Kitasato University, 1 15 1 Kitasato, Sagamihara, Kanagawa 228 8555, Japan
    Neurosci Res 39:391-400. 2001
    ..We have earlier reported a scaffold protein JSAP1 (also known as JIP3) in the JNK MAPK cascade...
  28. ncbi Platelet-derived growth factor (PDGF) receptor-alpha-activated c-Jun NH2-terminal kinase-1 is critical for PDGF-induced p21WAF1/CIP1 promoter activity independent of p53
    Jiuhong Yu
    Department of Pathology, Barbara Ann Karmanos Cancer Institute, Wayne State University School of Medicine, Detroit, Michigan 48201, USA
    J Biol Chem 278:49582-8. 2003
    ..These results provide a molecular basis for differential regulation of the cell cycle and transformation by alpha- and beta-PDGFRs...
  29. pmc NF-kappaB RelA opposes epidermal proliferation driven by TNFR1 and JNK
    Jennifer Y Zhang
    VA Palo Alto Healthcare System, Palo Alto, California 94305, USA
    Genes Dev 18:17-22. 2004
    ..Thus, RelA antagonizes TNFR1-JNK proliferative signals in epidermis and plays a nonredundant role in restraining epidermal growth...
  30. ncbi Activation mechanism of c-Jun amino-terminal kinase in the course of neural differentiation of P19 embryonic carcinoma cells
    Shoko Akiyama
    Departments of Biochemistry and Clinical Oncology, Institute of Development, Aging and Cancer, Tohoku University, 4 1 Seiryo machi, Aoba ku, Sendai 980 8575, Japan
    J Biol Chem 279:36616-20. 2004
    ..These results suggest that two distinct TAK1-MKK4-JNK signaling pathways are independently activated at the different intracellular locations and may participate in the regulation of the neural differentiation of P19 cells...
  31. ncbi Role of mitogen-activated protein kinase activation in injured and intact primary afferent neurons for mechanical and heat hypersensitivity after spinal nerve ligation
    Koichi Obata
    Department of Anatomy and Neuroscience, Hyogo College of Medicine, Hyogo 663 8501, Japan
    J Neurosci 24:10211-22. 2004
    ....
  32. ncbi Isoforms of JSAP1 scaffold protein generated through alternative splicing
    M Ito
    Department of Biosciences, School of Science, Kitasato University, Sagamihara, 228 8555, Kanagawa, Japan
    Gene 255:229-34. 2000
    ..protein 1 (JSAP1), a scaffold protein that participates in JNK mitogen-activated protein kinase cascades, termed JSAP1a, JSAP1b, JSAP1c, and JSAP1d. The previously identified JSAP1 was renamed JSAP1a to avoid confusion...
  33. pmc Eleven densely clustered genes, six of them novel, in 176 kb of mouse t-complex DNA
    G J Kargul
    Laboratory of Genetics, National Institute on Aging, National Institutes of Health, Baltimore, MD 21224 6820 USA
    Genome Res 10:916-23. 2000
    ..embryonic collections, including Igfals (previously placed on chromosome 17), Nubp2 (a fully characterized gene), Jsap1 (a JNK-binding protein), Rsp29 (the mouse homologue of the rat gene), Ndk3 (a nucleoside diphosphate kinase), and ..
  34. ncbi The axon guidance defect of the telencephalic commissures of the JSAP1-deficient brain was partially rescued by the transgenic expression of JIP1
    Hye Yeong Ha
    Department of Neuroscience, Neuroscience Research Center and Medical Research Institute, Ewha Womans University School of Medicine, Seoul 110 783, Korea
    Dev Biol 277:184-99. 2005
    The JNK interacting protein, JSAP1, has been identified as a scaffold protein for mitogen-activated protein kinase (MAPK) signaling pathways and as a linker protein for the cargo transport along the axons...
  35. pmc Combining global genome and transcriptome approaches to identify the candidate genes of small-effect quantitative trait loci in collagen-induced arthritis
    Xinhua Yu
    Immunogenetics Group, University of Rostock, Schillingallee, 18055 Rostock, Germany
    Arthritis Res Ther 9:R3. 2007
    ..Of these 117 genes, 21 were located inside the support intervals of the 8 small-effect QTL and thus were considered as candidate genes...