Mapk8

Summary

Gene Symbol: Mapk8
Description: mitogen-activated protein kinase 8
Alias: AI849689, JNK, JNK1, Prkm8, SAPK1, mitogen-activated protein kinase 8, JNK1 beta1 protein kinase, MAP kinase 8, MAPK 8, c-Jun N-terminal kinase 1, protein kinase mitogen-activated 8, stress-activated protein kinase JNK1
Species: mouse

Top Publications

  1. ncbi The Jnk1 and Jnk2 protein kinases are required for regional specific apoptosis during early brain development
    C Y Kuan
    Section of Neurobiology, Yale University School of Medicine, New Haven, Connecticut 06510, USA
    Neuron 22:667-76. 1999
  2. ncbi JNK1 in hematopoietically derived cells contributes to diet-induced inflammation and insulin resistance without affecting obesity
    Giovanni Solinas
    Department of Medicine, University of Fribourg, Chemin du Musee 5, CH 1700 Fribourg, Switzerland
    Cell Metab 6:386-97. 2007
  3. ncbi JNK1 is required for maintenance of neuronal microtubules and controls phosphorylation of microtubule-associated proteins
    Lufen Chang
    Laboratory of Gene Regulation and Signal Transduction, University of California, San Diego, School of Medicine, La Jolla, CA 92037, USA
    Dev Cell 4:521-33. 2003
  4. pmc DCX, a new mediator of the JNK pathway
    Amos Gdalyahu
    Department of Molecular Genetics, The Weizmann Institute of Science, Rehovot, Israel
    EMBO J 23:823-32. 2004
  5. pmc Retinol-binding protein 4 inhibits insulin signaling in adipocytes by inducing proinflammatory cytokines in macrophages through a c-Jun N-terminal kinase- and toll-like receptor 4-dependent and retinol-independent mechanism
    Julie Norseen
    Division of Endocrinology, Diabetes, and Metabolism, Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts, USA
    Mol Cell Biol 32:2010-9. 2012
  6. doi G alpha o mediates WNT-JNK signaling through dishevelled 1 and 3, RhoA family members, and MEKK 1 and 4 in mammalian cells
    Rama Kamesh Bikkavilli
    Department of Pharmacology, Health Sciences Center, State University of New York at Stony Brook, Stony Brook, NY 11794 8651, USA
    J Cell Sci 121:234-45. 2008
  7. pmc Multisite phosphorylation regulates Bim stability and apoptotic activity
    Anette Hübner
    Howard Hughes Medical Institute, University of Massachusetts Medical School, Worcester, MA 01605, USA
    Mol Cell 30:415-25. 2008
  8. ncbi A subpopulation of macrophages infiltrates hypertrophic adipose tissue and is activated by free fatty acids via Toll-like receptors 2 and 4 and JNK-dependent pathways
    M T Audrey Nguyen
    Division of Endocrinology Metabolism, University of California, San Diego, La Jolla, California 92093, USA
    J Biol Chem 282:35279-92. 2007
  9. pmc Loss of mitogen-activated protein kinase kinase kinase 4 (MAP3K4) reveals a requirement for MAPK signalling in mouse sex determination
    Debora Bogani
    Mammalian Genetics Unit, Medical Research Council MRC Harwell, Oxfordshire, United Kingdom
    PLoS Biol 7:e1000196. 2009
  10. pmc c-Jun NH(2)-terminal kinase (JNK)1 and JNK2 have distinct roles in CD8(+) T cell activation
    Dietrich Conze
    Section of Immunobiology, Department of Medicine, University of Vermont, Burlington, VT 05405, USA
    J Exp Med 195:811-23. 2002

Research Grants

  1. 'Death' and 'MAPK' pathways with myocardial ischemia
    Junichi Sadoshima; Fiscal Year: 2001
  2. Chemical Genetics Analysis Targeted to the Mouse Prostate Epithelium
    Roger Davis; Fiscal Year: 2007
  3. SIGNAL TRANSDUCTION BY THE EGF RECEPTOR
    Roger Davis; Fiscal Year: 2001
  4. STRUCTURAL ORGANIZATION OF SIGNALING PATHWAYS
    Roger Davis; Fiscal Year: 2004
  5. Prevention of cardiac cell death by Mst1 inhibitor
    Junichi Sadoshima; Fiscal Year: 2005
  6. Functional Analysis of the Beta-Cell
    Roger Davis; Fiscal Year: 2006
  7. Anti-aging and Stress Resistance by Sir2
    Junichi Sadoshima; Fiscal Year: 2006
  8. Prevention of neointimal thickening by Mst1
    Junichi Sadoshima; Fiscal Year: 2006
  9. Mechanisms of Action of Pro-inflammatory Cytokines
    Roger J Davis; Fiscal Year: 2010
  10. Mechanisms of Neurodegeneration
    Roger J Davis; Fiscal Year: 2010

Detail Information

Publications146 found, 100 shown here

  1. ncbi The Jnk1 and Jnk2 protein kinases are required for regional specific apoptosis during early brain development
    C Y Kuan
    Section of Neurobiology, Yale University School of Medicine, New Haven, Connecticut 06510, USA
    Neuron 22:667-76. 1999
    ..Here, we address this issue using mutant mice lacking different members of the family (Jnk1, Jnk2, and Jnk3)...
  2. ncbi JNK1 in hematopoietically derived cells contributes to diet-induced inflammation and insulin resistance without affecting obesity
    Giovanni Solinas
    Department of Medicine, University of Fribourg, Chemin du Musee 5, CH 1700 Fribourg, Switzerland
    Cell Metab 6:386-97. 2007
    ..Activation of JNKs (mainly JNK1) in insulin target cells results in phosphorylation of insulin receptor substrates (IRSs) at serine and threonine ..
  3. ncbi JNK1 is required for maintenance of neuronal microtubules and controls phosphorylation of microtubule-associated proteins
    Lufen Chang
    Laboratory of Gene Regulation and Signal Transduction, University of California, San Diego, School of Medicine, La Jolla, CA 92037, USA
    Dev Cell 4:521-33. 2003
    ..We found that a member of the c-Jun NH(2)-terminal protein kinase (JNK) subgroup of MAP kinases, JNK1, is involved in regulation of MT dynamics in neuronal cells...
  4. pmc DCX, a new mediator of the JNK pathway
    Amos Gdalyahu
    Department of Molecular Genetics, The Weizmann Institute of Science, Rehovot, Israel
    EMBO J 23:823-32. 2004
    ..Here we demonstrate that DCX is a substrate of JNK and interacts with both c-Jun N-terminal kinase (JNK) and JNK interacting protein (JIP)...
  5. pmc Retinol-binding protein 4 inhibits insulin signaling in adipocytes by inducing proinflammatory cytokines in macrophages through a c-Jun N-terminal kinase- and toll-like receptor 4-dependent and retinol-independent mechanism
    Julie Norseen
    Division of Endocrinology, Diabetes, and Metabolism, Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts, USA
    Mol Cell Biol 32:2010-9. 2012
    ..RBP4 effects are markedly attenuated in JNK1-/- JNK2-/- macrophages and TLR4-/- macrophages...
  6. doi G alpha o mediates WNT-JNK signaling through dishevelled 1 and 3, RhoA family members, and MEKK 1 and 4 in mammalian cells
    Rama Kamesh Bikkavilli
    Department of Pharmacology, Health Sciences Center, State University of New York at Stony Brook, Stony Brook, NY 11794 8651, USA
    J Cell Sci 121:234-45. 2008
    In Drosophila, activation of Jun N-terminal Kinase (JNK) mediated by Frizzled and Dishevelled leads to signaling linked to planar cell polarity...
  7. pmc Multisite phosphorylation regulates Bim stability and apoptotic activity
    Anette Hübner
    Howard Hughes Medical Institute, University of Massachusetts Medical School, Worcester, MA 01605, USA
    Mol Cell 30:415-25. 2008
    ..Together, these data indicate that phosphorylation can regulate Bim by multiple mechanisms and that the phosphorylation of Bim on different sites can contribute to the sensitivity of cellular apoptotic responses...
  8. ncbi A subpopulation of macrophages infiltrates hypertrophic adipose tissue and is activated by free fatty acids via Toll-like receptors 2 and 4 and JNK-dependent pathways
    M T Audrey Nguyen
    Division of Endocrinology Metabolism, University of California, San Diego, La Jolla, California 92093, USA
    J Biol Chem 282:35279-92. 2007
    ..Here, we show that FFAs can cause activation of RAW264.7 cells primarily via the JNK signaling cascade and that TLR2 and TLR4 are upstream of JNK and help transduce FFA proinflammatory signals...
  9. pmc Loss of mitogen-activated protein kinase kinase kinase 4 (MAP3K4) reveals a requirement for MAPK signalling in mouse sex determination
    Debora Bogani
    Mammalian Genetics Unit, Medical Research Council MRC Harwell, Oxfordshire, United Kingdom
    PLoS Biol 7:e1000196. 2009
    ....
  10. pmc c-Jun NH(2)-terminal kinase (JNK)1 and JNK2 have distinct roles in CD8(+) T cell activation
    Dietrich Conze
    Section of Immunobiology, Department of Medicine, University of Vermont, Burlington, VT 05405, USA
    J Exp Med 195:811-23. 2002
    ..Here we examined the role of JNK1 and JNK2 in CD8(+) T cells...
  11. pmc Response to 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) differs in mouse strains and reveals a divergence in JNK signaling and COX-2 induction prior to loss of neurons in the substantia nigra pars compacta
    Justin D Boyd
    Department of Developmental Neurobiology, St Jude Children s Research Hospital, 332 N Lauderdale, Memphis, Tennessee 38105, USA
    Brain Res 1175:107-16. 2007
    ..Recent studies have described the activation of a stress-induced signal cascade, c-Jun N-terminal kinase (JNK)-mediated activation of c-Jun, and an increase in the expression of a downstream effector, cyclooxygenase 2 (COX-2),..
  12. pmc Jun N-terminal kinase 1 regulates epithelial-to-mesenchymal transition induced by TGF-beta1
    John F Alcorn
    Department of Pathology, University of Vermont, Burlington, VT 05405, USA
    J Cell Sci 121:1036-45. 2008
    ..Primary cultures of mouse tracheal epithelial cells (MTEC) from wild-type, JNK1-/- or JNK2-/- mice were comparatively evaluated for their ability to undergo EMT in response to TGF-beta1...
  13. pmc Prevention of steatosis by hepatic JNK1
    Guadalupe Sabio
    Howard Hughes Medical Institute, University of Massachusetts Medical School, Worcester, MA 01605, USA
    Cell Metab 10:491-8. 2009
    ..The cJun NH(2)-terminal kinase 1 (JNK1) signaling pathway is implicated in the pathogenesis of hepatic steatosis and drugs that target JNK1 may be useful ..
  14. ncbi Role of interleukin-4 in resistance to Cryptococcus neoformans infection
    Rebecca Blackstock
    Department of Microbiology and Immunology, University of Oklahoma Health Sciences Center, P O Box 26901, Oklahoma City, OK 73190, USA
    Am J Respir Cell Mol Biol 30:109-17. 2004
    ..Enhanced immunity in the primed IL-4KO mice was reflected in a more moderate increase in IL-5 and IL-10 with maintenance of interferon-gamma levels...
  15. pmc JNK-1 deficiency limits macrophage-mediated antigen-induced arthritis
    Monica Guma
    Department of Medicine, University of California at San Diego, La Jolla, California 92093 0663, USA
    Arthritis Rheum 63:1603-12. 2011
    To elucidate the nonredundant roles of JNK-1 and JNK-2 in antigen-induced arthritis (AIA).
  16. ncbi JNK is required for effector T-cell function but not for T-cell activation
    C Dong
    Howard Hughes Medical Institute, Section of Immunobiology, Yale University School of Medicine, New Haven, Connecticut 06520, USA
    Nature 405:91-4. 2000
    ..Previously, we found that T cells from mice deficient in the Jnk1 or Jnk2 gene can be activated and produce IL-2 normally, but are deficient in functional differentiation into Th1 ..
  17. pmc The dual-specificity protein phosphatase DUSP9/MKP-4 is essential for placental function but is not required for normal embryonic development
    Graham R Christie
    Cancer Research UK Molecular Pharmacology Unit, Biomedical Research Centre, Level 5, Ninewells Hospital and Medical School, Dundee DD1 9SY, Scotland, United Kingdom
    Mol Cell Biol 25:8323-33. 2005
    ....
  18. pmc Gadd45beta promotes hepatocyte survival during liver regeneration in mice by modulating JNK signaling
    Salvatore Papa
    Ben May Department for Cancer Research and Department of Pathology, University of Chicago, Chicago, Illinois 60637, USA
    J Clin Invest 118:1911-23. 2008
    In the liver, the JNK cascade is induced downstream of TNF receptors (TNFRs) in response to inflammatory, microbial, and toxic challenges...
  19. ncbi The E3 ubiquitin ligase itch couples JNK activation to TNFalpha-induced cell death by inducing c-FLIP(L) turnover
    Lufen Chang
    Division of Cancer Immunotherapeutics and Tumor Immunology, Beckman Research Institute at City of Hope, City of Hope National Medical Center, 1500 E Duarte Road, KCRB 3009, Duarte, CA 91010, USA
    Cell 124:601-13. 2006
    ..b>JNK1 or Itch deficiency or treatment with a JNK inhibitor renders mice resistant in three distinct models of TNFalpha-..
  20. doi Transcription activation of myostatin by trichostatin A in differentiated C2C12 myocytes via ASK1-MKK3/4/6-JNK and p38 mitogen-activated protein kinase pathways
    Der Sheng Han
    Department of Physical Medicine and Rehabilitation, National Taiwan University Hospital BeiHu Branch, Taipei, Taiwan
    J Cell Biochem 111:564-73. 2010
    ..Pretreatment with p38 MAPK (SB203580) and JNK (SP600125) inhibitors, but not ERK (PD98059) inhibitor, blocked TSA-induced myostatin expression, respectively, by ..
  21. pmc Convergent extension, planar-cell-polarity signalling and initiation of mouse neural tube closure
    Patricia Ybot-Gonzalez
    Neural Development Unit, Institute of Child Health, University College London, 30 Guilford Street, London WC1N 1EH, UK
    Development 134:789-99. 2007
    ..These findings identify a cell-autonomous defect of convergent extension, requiring PCP signalling via RhoA-Rho kinase, during the development of severe neural tube defects in the mouse...
  22. ncbi Suppression of inflammatory cytokine production by carbon monoxide involves the JNK pathway and AP-1
    Danielle Morse
    Division of Pulmonary, Allergy, and Critical Care Medicine, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15213, USA
    J Biol Chem 278:36993-8. 2003
    ..IL-1beta in response to LPS compared with control mice, and no effect of CO on these cytokine levels was seen in Jnk1 or Jnk2 genedeleted mice...
  23. pmc Suppression of p53-dependent senescence by the JNK signal transduction pathway
    Madhumita Das
    Program in Molecular Medicine, Department of Cancer Cell Biology, and Howard Hughes Medical Institute, University of Massachusetts Medical School, Worcester, MA 01605, USA
    Proc Natl Acad Sci U S A 104:15759-64. 2007
    ..using conditional and chemical genetic alleles of the ubiquitously expressed murine genes that encode the isoforms JNK1 and JNK2. Our analysis demonstrates that JNK is not essential for proliferation...
  24. ncbi The receptor tyrosine kinase Ror2 is involved in non-canonical Wnt5a/JNK signalling pathway
    Isao Oishi
    Department of Genome Sciences, Faculty of Medical Sciences, Graduate School of Medicine, Kobe University, Chuo Ku, Kobe 650 0017, Japan
    Genes Cells 8:645-54. 2003
    ..Since Ror2 possesses an extracellular cysteine-rich domain (CRD) that resembles the Wnt-binding sites of the Frizzled (Fz) proteins, it is conceivable that Ror2 interacts with members of the Wnt family...
  25. ncbi JNK2 is a positive regulator of the cJun transcription factor
    Anja Jaeschke
    Howard Hughes Medical Institute and Program in Molecular Medicine, University of Massachusetts Medical School, Worcester, Massachusetts 01605, USA
    Mol Cell 23:899-911. 2006
    ..Studies of Jnk1(-/-) and Jnk2(-/-) mice suggest that the JNK1 and JNK2 isoforms have opposite effects on cJun expression and ..
  26. ncbi c-Jun N-terminal kinase mediates hydrogen peroxide-induced cell death via sustained poly(ADP-ribose) polymerase-1 activation
    S Zhang
    Department of Community, Occupational and Family Medicine, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Republic of Singapore
    Cell Death Differ 14:1001-10. 2007
    ..Our previous study has illustrated that c-Jun-N-terminal kinase 1 (JNK1) is the main executor in hydrogen peroxide (H(2)O(2))-induced nonapoptotic cell death...
  27. ncbi JNK1 is required for T cell-mediated immunity against Leishmania major infection
    S L Constant
    Section of Immunobiology, Yale University School of Medicine, and Howard Hughes Medical Institute New Haven, CT 06520, USA
    J Immunol 165:2671-6. 2000
    ..In the current study, we used Jnk1-deficient mice to examine the function of JNK during an in vivo pathogenic infection, leishmaniasis, which is ..
  28. pmc c-Jun N-terminal kinase is required for metalloproteinase expression and joint destruction in inflammatory arthritis
    Z Han
    Division of Rheumatology, Allergy and Immunology, University of California, San Diego, School of Medicine, La Jolla, California 92093, USA
    J Clin Invest 108:73-81. 2001
    ..The essential role of JNK was confirmed in cultured synoviocytes from JNK1 knockout mice and JNK2 knockout mice, each of which had a partial defect in IL-1--induced AP-1 activation and ..
  29. pmc Suppression of Ras-stimulated transformation by the JNK signal transduction pathway
    Norman J Kennedy
    Howard Hughes Medical Institute, University of Massachusetts Medical School, Worcester, Massachusetts 01605, USA
    Genes Dev 17:629-37. 2003
    The c-Jun NH(2)-terminal kinase (JNK) phosphorylates and activates members of the activator protein-1 (AP-1) group of transcription factors and is implicated in oncogenic transformation...
  30. ncbi Chemical genetic analysis of the time course of signal transduction by JNK
    Juan Jose Ventura
    Howard Hughes Medical Institute and Program in Molecular Medicine, University of Massachusetts Medical School, Worcester, 01605, USA
    Mol Cell 21:701-10. 2006
    ..embryonic fibroblasts to tumor necrosis factor (TNF) causes biphasic activation of the c-Jun NH(2)-terminal kinase (JNK) signaling pathway...
  31. pmc Loss of hepatic NF-kappa B activity enhances chemical hepatocarcinogenesis through sustained c-Jun N-terminal kinase 1 activation
    Toshiharu Sakurai
    Laboratory of Gene Regulation and Signal Transduction, School of Medicine, University of California at San Diego, 9500 Gilman Drive MC 0723, La Jolla, CA 92093 0723, USA
    Proc Natl Acad Sci U S A 103:10544-51. 2006
    ..Hepatocytes express both JNK1 and JNK2, but previous studies indicate that JNK1 is more important for hepatocyte proliferation...
  32. doi JNK3 is abundant in insulin-secreting cells and protects against cytokine-induced apoptosis
    S Abdelli
    Service of Medical Genetics, CHUV Hospital, Chemin des Falaises 1, 1011, Lausanne, Switzerland
    Diabetologia 52:1871-80. 2009
    In insulin-secreting cells, activation of the c-Jun NH(2)-terminal kinase (JNK) pathway triggers apoptosis. Whereas JNK1 and JNK2 are ubiquitously produced, JNK3 has been described exclusively in neurons...
  33. pmc JNK1 controls mast cell degranulation and IL-1{beta} production in inflammatory arthritis
    Monica Guma
    Laboratory of Gene Regulation and Signal Transduction, Department of Pharmacology and Pathology, Division of Rheumatology, School of Medicine, University of California at San Diego, La Jolla, CA 92093, USA
    Proc Natl Acad Sci U S A 107:22122-7. 2010
    ..The proinflammatory function of JNK1 requires bone marrow-derived cells, particularly mast cells...
  34. pmc Targeted disruption of the MKK4 gene causes embryonic death, inhibition of c-Jun NH2-terminal kinase activation, and defects in AP-1 transcriptional activity
    D Yang
    Howard Hughes Medical Institute, University of Massachusetts Medical School, Worcester 01605, USA
    Proc Natl Acad Sci U S A 94:3004-9. 1997
    ..kinase group of dual specificity protein kinases that functions as an activator of the c-Jun NH2-terminal kinase (JNK) in vitro...
  35. pmc Mitogen-activated protein kinase kinase 7 is an activator of the c-Jun NH2-terminal kinase
    C Tournier
    Program in Molecular Medicine, Department of Biochemistry and Molecular Biology, University of Massachusetts Medical School, Worcester, MA 01605, USA
    Proc Natl Acad Sci U S A 94:7337-42. 1997
    The c-Jun NH2-terminal kinase (JNK) group of mitogen-activated protein (MAP) kinases is activated by phosphorylation on Thr and Tyr...
  36. pmc JNK targets p53 ubiquitination and degradation in nonstressed cells
    S Y Fuchs
    The Ruttenberg Cancer Center, Mount Sinai School of Medicine, New York, New York 10029, USA
    Genes Dev 12:2658-63. 1998
    In this study we elucidated the role of nonactive JNK in regulating p53 stability. The amount of p53-JNK complex was inversely correlated with p53 level...
  37. ncbi Defective T cell differentiation in the absence of Jnk1
    C Dong
    Section of Immunobiology, Howard Hughes Medical Institute, Yale University School of Medicine, New Haven, CT 06520, USA
    Science 282:2092-5. 1998
    ..JNK activity observed in wild-type activated TH cells was severely reduced in TH cells from Jnk1-/- mice...
  38. ncbi Defective neural tube morphogenesis and altered apoptosis in the absence of both JNK1 and JNK2
    K Sabapathy
    Research Institute of Molecular Pathology, Dr Bohr Gasse 7, A 1030, Vienna, Austria
    Mech Dev 89:115-24. 1999
    Mice lacking both c-Jun-NH(2)-terminal kinases (JNK1 and JNK2) were generated to define their roles in development...
  39. ncbi Requirement of JNK for stress-induced activation of the cytochrome c-mediated death pathway
    C Tournier
    Howard Hughes Medical Institute, Program in Molecular Medicine, Department of Biochemistry and Molecular Biology, University of Massachusetts Medical School, Worcester, MA 01605, USA
    Science 288:870-4. 2000
    The c-Jun NH2-terminal kinase (JNK) is activated when cells are exposed to ultraviolet (UV) radiation. However, the functional consequence of JNK activation in UV-irradiated cells has not been established...
  40. pmc c-Jun NH2-terminal kinase (JNK)1 and JNK2 have similar and stage-dependent roles in regulating T cell apoptosis and proliferation
    K Sabapathy
    Research Institute of Molecular Pathology, Vienna A 1030, Austria
    J Exp Med 193:317-28. 2001
    Apoptotic and mitogenic stimuli activate c-Jun NH2-terminal kinases (JNKs) in T cells. Although T cells express both JNK1 and JNK2 isozymes, the absence of JNK2 alone can result in resistance to anti-CD3-induced thymocyte apoptosis and ..
  41. ncbi Deficiency of c-Jun-NH(2)-terminal kinase-1 in mice enhances skin tumor development by 12-O-tetradecanoylphorbol-13-acetate
    Qing Bai She
    The Hormel Institute, University of Minnesota, Austin, Minnesota 55912, USA
    Cancer Res 62:1343-8. 2002
    ..Here, we show that JNK1-deficient (Jnk1(-/-)) mice are more susceptible to TPA-induced skin tumor development than wild-type mice...
  42. pmc c-Jun NH(2)-terminal kinase (JNK)1 and JNK2 signaling pathways have divergent roles in CD8(+) T cell-mediated antiviral immunity
    Nathalie Arbour
    Division of Virology, Department of Neuropharmacology, The Scripps Research Institute, La Jolla, CA 92037, USA
    J Exp Med 195:801-10. 2002
    ..To determine whether JNKs are involved in antiviral T cell immunity, and whether JNK1 and JNK2 bear biological differences, we investigated the immune responses of JNK1-deficient and JNK2-deficient ..
  43. ncbi Survival signaling mediated by c-Jun NH(2)-terminal kinase in transformed B lymphoblasts
    Patricia Hess
    Howard Hughes Medical Institute and Program in Molecular Medicine, University of Massachusetts Medical School, 373 Plantation Street, Worcester, Massachusetts 01605, USA
    Nat Genet 32:201-5. 2002
    ..We find that disruption of the JNK ortholog Mapk8 (also known as Jnk1) in mice causes defective transformation of pre-B cells by BCR-ABL in vitro and in vivo...
  44. ncbi MAPK-upstream protein kinase (MUK) regulates the radial migration of immature neurons in telencephalon of mouse embryo
    Syu ichi Hirai
    Department of Molecular Biology, Yokohama City University School of Medicine, 3 9 Fukuura, Kanazawa Ku, Yokohama 236 0004, Japan
    Development 129:4483-95. 2002
    ..We show that the protein levels of a JNK activator kinase, MUK/DLK/ZPK, and JNK activity increase potently and temporally in newly generated neurons in ..
  45. ncbi JNK1 modulates osteoclastogenesis through both c-Jun phosphorylation-dependent and -independent mechanisms
    Jean Pierre David
    Research Institute of Molecular Pathology, Dr Bohr Gasse 7, A 1030 Vienna, Austria
    J Cell Sci 115:4317-25. 2002
    ..Using mice lacking JNK1 or JNK2, we demonstrate that JNK1, but not JNK2, is specifically activated by the osteoclast-differentiating factor ..
  46. ncbi A central role for JNK in obesity and insulin resistance
    Jiro Hirosumi
    Division of Biological Sciences and Department of Nutrition, Harvard School of Public Health, 665 Huntington Avenue, Boston, Massachusetts 02115, USA
    Nature 420:333-6. 2002
    ..Here we show that JNK activity is abnormally elevated in obesity. Furthermore, an absence of JNK1 results in decreased adiposity, significantly improved insulin sensitivity and enhanced insulin receptor signalling ..
  47. ncbi Deficiency in the c-Jun NH2-terminal kinase signaling pathway confers susceptibility to hyperoxic lung injury in mice
    Danielle Morse
    Division of Pulmonary, Allergy and Critical Care Medicine, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA
    Am J Physiol Lung Cell Mol Physiol 285:L250-7. 2003
    ..We examined the effect of Jnk1 gene deletion on in vivo responses to hyperoxia in mice...
  48. pmc c-Jun NH(2)-terminal kinase is essential for the regulation of AP-1 by tumor necrosis factor
    Juan Jose Ventura
    Howard Hughes Medical Institute and Program in Molecular Medicine, University of Massachusetts Medical School, Worcester, Massachusetts 01605, USA
    Mol Cell Biol 23:2871-82. 2003
    ..To examine the role of the JNK signaling pathway, we compared the effects of TNF on wild-type and Jnk1(-/-) Jnk2(-/-) murine embryo fibroblasts. We show that JNK is required for the normal regulation of AP-1 by TNF...
  49. pmc A critical role of neural-specific JNK3 for ischemic apoptosis
    Chia Yi Kuan
    Department of Pediatrics, Division of Developmental Biology, Children s Hospital Medical Center, Cincinnati, OH 45229, USA
    Proc Natl Acad Sci U S A 100:15184-9. 2003
    ..signaling is an important contributor to stress-induced apoptosis, but it is unclear whether JNK and its isoforms (JNK1, JNK2, and JNK3) have distinct roles in cerebral ischemia...
  50. pmc JNK-mediated induction of cyclooxygenase 2 is required for neurodegeneration in a mouse model of Parkinson's disease
    Stephane Hunot
    Section of Immunobiology, Yale University School of Medicine, New Haven, CT 06520, USA
    Proc Natl Acad Sci U S A 101:665-70. 2004
    ..Examination of various JNK-deficient mice shows that both JNK2 and JNK3, but not JNK1, are required for MPTP-induced c-Jun activation and dopaminergic cell demise...
  51. ncbi Overexpression or ablation of JNK in skeletal muscle has no effect on glycogen synthase activity
    Nobuharu Fujii
    Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02215, USA
    Am J Physiol Cell Physiol 287:C200-8. 2004
    ..with these findings, basal and contraction-induced glycogen synthase activity was normal in muscles of both JNK1- and JNK2-deficient mice...
  52. ncbi Distinct roles for JNK1 and JNK2 in regulating JNK activity and c-Jun-dependent cell proliferation
    Kanaga Sabapathy
    Research Institute of Molecular Pathology, Dr Bohrgasse 7, A 1030 Vienna, Austria
    Mol Cell 15:713-25. 2004
    ..Although JNK1 and JNK2 were shown to differentially regulate fibroblast proliferation, the underlying mechanistic basis remains ..
  53. ncbi Requirement of JNK2 for scavenger receptor A-mediated foam cell formation in atherogenesis
    Romeo Ricci
    Cardiovascular Research, Institute of Physiology, and Division of Cardiology, University Hospital Zurich, CH 8057 Zurich, Switzerland
    Science 306:1558-61. 2004
    ..We show that atherosclerosis-prone ApoE-/- mice simultaneously lacking JNK2 (ApoE-/- JNK2-/- mice), but not ApoE-/- JNK1-/- mice, developed less atherosclerosis than do ApoE-/- mice...
  54. ncbi A novel isoform of Vinexin, Vinexin gamma, regulates Sox9 gene expression through activation of MAPK cascade in mouse fetal gonad
    Makoto Matsuyama
    Division of Sex Differentiation, National Institute for Basic Biology, Okazaki 444 8787, Japan
    Genes Cells 10:421-34. 2005
    ..Thus, Vinexin gamma seems to be implicated in regulation of Sox9 gene expression by modulating MAPK cascade in mouse fetal gonads...
  55. ncbi Simultaneous blockade of NFkappaB, JNK, and p38 MAPK by a kinase-inactive mutant of the protein kinase TAK1 sensitizes cells to apoptosis and affects a distinct spectrum of tumor necrosis factor [corrected] target genes
    Axel Thiefes
    Institute of Pharmacology, Medical School Hannover, Carl Neuberg Strasse 1, D 30625 Hannover, Germany
    J Biol Chem 280:27728-41. 2005
    ..interleukin-1 was also suppressed in cells that expressed TAK1 antisense RNA or that were genetically deficient in JNK1/2 or p65 NFkappaB...
  56. ncbi Genetic inhibition or activation of JNK1/2 protects the myocardium from ischemia-reperfusion-induced cell death in vivo
    Robert A Kaiser
    Department of Pediatrics, University of Cincinnati, Children s Hospital Medical Center, Division of Molecular Cardiovascular Biology, Cincinnati, Ohio 45229 3039, USA
    J Biol Chem 280:32602-8. 2005
    ..b>jnk1-/-, jnk2-/-, and transgenic mice expressing dominant negative JNK1/2 within the heart were each shown to have less ..
  57. ncbi JNK1 is essential for CD8+ T cell-mediated tumor immune surveillance
    Yunfei Gao
    Section of Rheumatology, Department of Medicine, Yale University School of Medicine, New Haven, CT 06520, USA
    J Immunol 175:5783-9. 2005
    b>JNK1 has divergent roles in regulating the effector functions of CD4+ and CD8+ T cells. However, the function of JNK1 in tumor immune surveillance is unknown...
  58. pmc Phosphoinositide-3 kinase-Rac1-c-Jun NH2-terminal kinase signaling mediates collagen I-induced cell scattering and up-regulation of N-cadherin expression in mouse mammary epithelial cells
    Yasushi Shintani
    Department of Oral Biology, Eppley Institute for Research in Cancer and Allied Diseases, and Eppley Cancer Center, University of Nebraska Medical Center, Omaha, NE 68198 7696, USA
    Mol Biol Cell 17:2963-75. 2006
    ..Rac1 and c-Jun NH2-terminal kinase (JNK) were activated when cells were plated on collagen I, and dominant inhibitory Rac1 (RacN17) or inhibition of JNK ..
  59. pmc Functional in vivo interactions between JNK1 and JNK2 isoforms in obesity and insulin resistance
    Gurol Tuncman
    Department of Genetics and Complex Diseases, Harvard School of Public Health, 665 Huntington Avenue, Boston, MA 02115, USA
    Proc Natl Acad Sci U S A 103:10741-6. 2006
    ..Obesity increases total JNK activity, and JNK1, but not JNK2, deficiency results in reduced adiposity and improved insulin sensitivity...
  60. pmc JNK1 deficiency does not enhance muscle glucose metabolism in lean mice
    C A Witczak
    Research Division, Joslin Diabetes Center, Department of Medicine, Brigham and Women s Hospital, and Harvard Medical School, Boston, MA 02215, USA
    Biochem Biophys Res Commun 350:1063-8. 2006
    Mice deficient in c-jun-NH(2)-terminal kinase 1 (JNK1) exhibit decreased fasting blood glucose and insulin levels, and protection against obesity-induced insulin resistance, suggesting increased glucose disposal into skeletal muscle...
  61. pmc Saturated fatty acids inhibit induction of insulin gene transcription by JNK-mediated phosphorylation of insulin-receptor substrates
    Giovanni Solinas
    Laboratory of Gene Regulation and Signal Transduction, School of Medicine, University of California at San Diego, 9500 Gilman Drive, MC 0723, La Jolla, CA 92093 0723, USA
    Proc Natl Acad Sci U S A 103:16454-9. 2006
    JNKs are attractive targets for treatment of obesity and type-2 diabetes. A sustained increase in JNK activity was observed in dietary and genetic models of obesity in mice, whereas JNK deficiency prevented obesity-induced insulin ..
  62. ncbi JNK1 Is required for the induction of Mkp1 expression in macrophages during proliferation and lipopolysaccharide-dependent activation
    Ester Sánchez-Tilló
    Institute for Research in Biomedicine and University of Barcelona, Barcelona Science Park, Josep Samitier 1 5, E 08028 Barcelona, Spain
    J Biol Chem 282:12566-73. 2007
    ..The lack of Mkp1 induction caused by JNK inhibition prolonged ERK-1/2 and p38 phosphorylation. The two JNK genes, jnk1 and jnk2, are constitutively expressed in macrophages...
  63. ncbi Liver-specific knockdown of JNK1 up-regulates proliferator-activated receptor gamma coactivator 1 beta and increases plasma triglyceride despite reduced glucose and insulin levels in diet-induced obese mice
    Ruojing Yang
    Department of Metabolic Disease Research, Abbott Laboratories, Abbott Park, Illinois 60064, USA
    J Biol Chem 282:22765-74. 2007
    ..Genetic disruption of JNK1, but not JNK2, improves insulin sensitivity in diet-induced obese (DIO) mice...
  64. pmc c-Jun N-terminal kinase (JNK) cooperates with Gsk3beta to regulate Dishevelled-mediated microtubule stability
    Lorenza Ciani
    Department of Anatomy and Developmental Biology, University College London, London, UK
    BMC Cell Biol 8:27. 2007
    ..A divergent Wnt-Dvl canonical pathway which bifurcates downstream of Gsk3beta regulates MT dynamics...
  65. ncbi Differential transmission of MEKK1 morphogenetic signals by JNK1 and JNK2
    Atsushi Takatori
    Department of Environmental Health and Center of Environmental Genetics, University of Cincinnati Medical Center, Cincinnati, OH 45267 0056, USA
    Development 135:23-32. 2008
    b>JNK1 and JNK2 are two ubiquitously expressed isoforms that exert redundant roles in many physiological processes, but the extent of their relative contributions to these processes has not been well characterized...
  66. pmc Mitogen-activated protein kinase phosphatase-1 represses c-Jun NH2-terminal kinase-mediated apoptosis via NF-kappaB regulation
    Zhaoqing Wang
    Division of Molecular Radiobiology, Purdue University School of Health Sciences, 550 Stadium Mall Drive, West Lafayette, IN 47907, USA
    J Biol Chem 283:21011-23. 2008
    ..that MKP-1 was negatively bridging between NF-kappaB-mediated prosurvival pathway and c-Jun N-terminal kinase (JNK)-mediated proapoptotic response...
  67. pmc A predominant role for parenchymal c-Jun amino terminal kinase (JNK) in the regulation of systemic insulin sensitivity
    SARA N VALLERIE
    Department of Genetics and Complex Diseases, Harvard School of Public Health, Boston, Massachusetts, United States of America
    PLoS ONE 3:e3151. 2008
    It has been established that c-Jun N-terminal kinase 1 (JNK1) is essential to the pathogenesis of insulin resistance and type 2 diabetes...
  68. pmc c-Jun N-terminal kinase 1 is required for the development of pulmonary fibrosis
    John F Alcorn
    Department of Pathology, University of Vermont, Burlington, VT 05405, USA
    Am J Respir Cell Mol Biol 40:422-32. 2009
    ..The stress-activated protein kinase, c-Jun N-terminal kinase 1 (JNK1), is activated by a large variety of cellular stresses and environmental insults...
  69. doi c-Jun N-terminal kinase 1 is deleterious to the function and survival of murine pancreatic islets
    J L Varona-Santos
    Diabetes Research Institute, University of Miami Miller School of Medicine, 1450 NW 10th Avenue, Miami, FL 33136, USA
    Diabetologia 51:2271-80. 2008
    Inhibition of c-jun N-terminal kinase (JNK) favours pancreatic islet function and survival. Since two JNK isoforms are present in the pancreas (JNK1 and JNK2), we addressed their specific roles in experimental islet transplantation.
  70. pmc Proliferation of human HCC cells and chemically induced mouse liver cancers requires JNK1-dependent p21 downregulation
    Lijian Hui
    Research Institute of Molecular Pathology, Vienna, Austria
    J Clin Invest 118:3943-53. 2008
    ..Here, we show that activation of JNK1 but not JNK2 was increased in human primary hepatocellular carcinomas (HCCs)...
  71. pmc A stress signaling pathway in adipose tissue regulates hepatic insulin resistance
    Guadalupe Sabio
    Howard Hughes Medical Institute, University of Massachusetts Medical School, Worcester, MA 01605, USA
    Science 322:1539-43. 2008
    A high-fat diet causes activation of the regulatory protein c-Jun NH2-terminal kinase 1 (JNK1) and triggers development of insulin resistance. JNK1 is therefore a potential target for therapeutic treatment of metabolic syndrome...
  72. pmc Induction of hepatitis by JNK-mediated expression of TNF-alpha
    Madhumita Das
    Program in Molecular Medicine, University of Massachusetts Medical School, Worcester, MA 01605, USA
    Cell 136:249-60. 2009
    ..To test this hypothesis, we examined the phenotype of mice with compound disruption of the Jnk1 and Jnk2 genes...
  73. pmc GCK is essential to systemic inflammation and pattern recognition receptor signaling to JNK and p38
    Jian Zhong
    The Molecular Cardiology Research Institute, and Department of Medicine, Tufts University School of Medicine, Boston, MA 02111, USA
    Proc Natl Acad Sci U S A 106:4372-7. 2009
    ..Disruption of gck substantially reduces PAMP activation of macrophage Jun-N-terminal kinase (JNK) and p38 mitogen-activated protein kinases (MAPKs) via reduced activation of the MAPK-kinase-kinases (MAP3Ks) mixed ..
  74. pmc Mcl-1 integrates the opposing actions of signaling pathways that mediate survival and apoptosis
    Caroline Morel
    Howard Hughes Medical Institute and Program in Molecular Medicine, University of Massachusetts Medical School, Worcester, MA 01605, USA
    Mol Cell Biol 29:3845-52. 2009
    ..Here we demonstrate that prior phosphorylation of Mcl-1 by the c-Jun N-terminal protein kinase (JNK) is essential for Mcl-1 phosphorylation by GSK3...
  75. pmc The JNKs differentially regulate RNA polymerase III transcription by coordinately modulating the expression of all TFIIIB subunits
    Shuping Zhong
    Department of Biochemistry and Molecular Biology, Keck School of Medicine, University of Southern California, Norris Comprehensive Cancer Center, 2011 Zonal Avenue, Los Angeles, CA 90033, USA
    Proc Natl Acad Sci U S A 106:12682-7. 2009
    ..In both mouse and human cells, loss or reduction in JNK1 expression represses RNA pol III transcription...
  76. pmc Role of muscle c-Jun NH2-terminal kinase 1 in obesity-induced insulin resistance
    Guadalupe Sabio
    Howard Hughes Medical Institute, University of Massachusetts Medical School, 373 Plantation Street, Worcester, MA 01605, USA
    Mol Cell Biol 30:106-15. 2010
    ..by feeding of a high-fat diet (HFD) is associated with an increased activation of c-Jun NH(2)-terminal kinase 1 (JNK1)...
  77. pmc Gadd45beta deficiency in rheumatoid arthritis: enhanced synovitis through JNK signaling
    Camilla I Svensson
    University of California San Diego School of Medicine, La Jolla, CA 92093, USA
    Arthritis Rheum 60:3229-40. 2009
    b>JNK-mediated cell signaling plays a critical role in matrix metalloproteinase (MMP) expression and joint destruction in rheumatoid arthritis (RA)...
  78. pmc Functional role of c-Jun-N-terminal kinase in feeding regulation
    Elizabeth K Unger
    UCSF Diabetes Center, Department of Anatomy, University of California, San Francisco, California 94143, USA
    Endocrinology 151:671-82. 2010
    ..b>JNK1-deficient mice feed more upon central administration of glucocorticoids, and glucocorticoid receptor nuclear ..
  79. doi c-Jun N-terminal kinase primes endothelial cells at atheroprone sites for apoptosis
    Hera Chaudhury
    BHF Cardiovascular Sciences Unit, National Heart and Lung Institute, Imperial College London, Hammersmith Campus, Du Cane Road, London W12 ONN, UK
    Arterioscler Thromb Vasc Biol 30:546-53. 2010
    ..The c-Jun N-terminal kinase (JNK) is activated constitutively in EC at atherosusceptible sites but is inactivated at atheroprotected sites by ..
  80. pmc Role of the hypothalamic-pituitary-thyroid axis in metabolic regulation by JNK1
    Guadalupe Sabio
    Howard Hughes Medical Institute, University of Massachusetts Medical School, Worcester, Massachusetts 01605, USA
    Genes Dev 24:256-64. 2010
    The cJun N-terminal kinase 1 (JNK1) is implicated in diet-induced obesity. Indeed, germline ablation of the murine Jnk1 gene prevents diet-induced obesity...
  81. pmc Hypothalamic and pituitary c-Jun N-terminal kinase 1 signaling coordinately regulates glucose metabolism
    Bengt F Belgardt
    Department of Mouse Genetics and Metabolism, Institute for Genetics, Cologne Excellence Cluster on Cellular Stress Responses in Aging Associated Diseases and Center of Molecular Medicine Cologne, University of Cologne, D 50674 Cologne, Germany
    Proc Natl Acad Sci U S A 107:6028-33. 2010
    ..To resolve the importance of JNK1 signaling in the hypothalamic/pituitary circuitry, we have generated mice with a conditional inactivation of JNK1 ..
  82. pmc c-Jun N-terminal kinase 1 promotes transforming growth factor-β1-induced epithelial-to-mesenchymal transition via control of linker phosphorylation and transcriptional activity of Smad3
    Jos L J van der Velden
    Department of Pathology, Health Sciences Research Facility, University of Vermont, Burlington, VT 05405, USA
    Am J Respir Cell Mol Biol 44:571-81. 2011
    ..Because TGF-β1 signals via Smad complexes, the goal of the present study was to determine the impact of JNK1 on phosphorylation of Smad3 and Smad3-dependent transcriptional responses in lung epithelial cells...
  83. pmc Role of JNK in a Trp53-dependent mouse model of breast cancer
    Cristina Cellurale
    Howard Hughes Medical Institute, Program in Molecular Medicine, University of Massachusetts Medical School, Worcester, Massachusetts, United States of America
    PLoS ONE 5:e12469. 2010
    ..To test the role of JNK, we examined the effect of ablation of the Jnk1 and Jnk2 genes in a Trp53-dependent model of breast cancer using BALB/c mice...
  84. doi Peptidoglycan induces interleukin-6 expression through the TLR2 receptor, JNK, c-Jun, and AP-1 pathways in microglia
    Hsiao Yun Lin
    Institute of Medical Science, China Medical University, Taichung, Taiwan
    J Cell Physiol 226:1573-82. 2011
    ..In contrast, PGN-induced IL-6 mRNA and protein up-regulation were attenuated by the SAPK/JNK (c-Jun N-terminal kinases) inhibitor SP600125...
  85. pmc Mitochondrial c-Jun N-terminal kinase (JNK) signaling initiates physiological changes resulting in amplification of reactive oxygen species generation
    Jeremy W Chambers
    Department of Molecular Therapeutics, The Scripps Research Institute, Scripps Florida, Jupiter, Florida 33458, USA
    J Biol Chem 286:16052-62. 2011
    The JNK signaling cascade is critical for cellular responses to a variety of environmental and cellular stimuli...
  86. pmc JNK1, but not JNK2, is required in two mechanistically distinct models of inflammatory arthritis
    Katja Denninger
    Department of Pharmacology and Pharmacotherapy, Institute of Molecular Biology, University of Copenhagen, Copenhagen, Denmark
    Am J Pathol 179:1884-93. 2011
    ..N-terminal kinases (JNKs) in inflammatory arthritis have been investigated; however, the roles of each isotype (ie, JNK1 and JNK2) in rheumatoid arthritis and conclusions about whether inhibition of one or both is necessary for ..
  87. pmc c-Jun N-terminal kinase (JNK)-dependent acute liver injury from acetaminophen or tumor necrosis factor (TNF) requires mitochondrial Sab protein expression in mice
    Sanda Win
    Division of Gastrointestinal and Liver Diseases, University of Southern California Research Center for Liver Diseases, University of Southern California, Los Angeles, California 90089 9121, USA
    J Biol Chem 286:35071-8. 2011
    Sustained JNK activation plays a critical role in hepatotoxicity by acetaminophen or GalN/TNF-α...
  88. pmc Role of JNK in mammary gland development and breast cancer
    Cristina Cellurale
    Howard Hughes Medical Institute and Program in Molecular Medicine, University of Massachusetts Medical School, Worcester, Massachusetts 01605, USA
    Cancer Res 72:472-81. 2012
    ..In this study, we employed a compound deletion of the murine Jnk1 and Jnk2 genes in the mammary gland to evaluate the requirement for these ubiquitously expressed genes in breast ..
  89. pmc Loss of mitogen-activated protein kinase kinase kinase 4 (MEKK4) results in enhanced apoptosis and defective neural tube development
    Hongbo Chi
    Section of Immunobiology, Department of Neurobiology and Kavli Institute of Neuroscience, and Howard Hughes Medical Institute, Yale University School of Medicine, New Haven, CT 06520, USA
    Proc Natl Acad Sci U S A 102:3846-51. 2005
    ..Mitogen-activated protein kinases (MAPKs), such as c-Jun N-terminal kinase (JNK), are implicated in facilitating neural tube closure, yet upstream regulators remain to be identified...
  90. ncbi Cloning and characterization of a small-size peptide Zfra that regulates the cytotoxic function of tumor necrosis factor by interacting with JNK1
    Li Jin Hsu
    Guthrie Research Institute, Laboratory of Molecular Immunology, 1 Guthrie Square, Sayre, PA 18840, USA
    Biochem Biophys Res Commun 327:415-23. 2005
    ..assay and co-immunoprecipitation, TNF and UV light were shown to induce Zfra to rapidly self-associate and bind JNK1. While JNK1 is a downstream effector of the TNF signaling, Zfra regulation of the TNF cytotoxic function is likely ..
  91. pmc JNK1 is not essential for TNF-mediated joint disease
    Marcus Koller
    Department of Internal Medicine III, Division of Rheumatology, Medical University of Vienna, Austria
    Arthritis Res Ther 7:R166-73. 2005
    ..Human TNF transgenic (hTNFtg) mice, which develop inflammatory arthritis, were intercrossed with JNK1-deficient (JNK1-/-) mice...
  92. ncbi c-Jun N-terminal kinase regulates CTP:phosphocholine cytidylyltransferase
    Alan J Ryan
    Department of Internal Medicine, Roy J and Lucille A Carver College of Medicine, University of Iowa, Iowa City, IA 52242, USA
    Arch Biochem Biophys 447:23-33. 2006
    ..We report high-level expression of two major isoforms of the c-Jun N-terminal kinase family (JNK1 and JNK2) in murine lung epithelia...
  93. ncbi Neuron-specific phosphorylation of c-Jun N-terminal kinase increased in the brain of hypoxic preconditioned mice
    Nan Zhang
    Institute for Biomedical Science of Pain, Beijing Key Laboratory for Neural Regeneration and Repairing, Department of Neurobiology, Capital Medical University, 10 You An Men Wai Xi Tou Tiao, Beijing 100069, China
    Neurosci Lett 423:219-24. 2007
    ..In the current study, we investigated the involvement of c-Jun N-terminal kinase (JNK) in the brain of HPC mice...
  94. pmc Identification of ROCK1 as an upstream activator of the JIP-3 to JNK signaling axis in response to UVB damage
    Pat P Ongusaha
    Cutaneous Biology Research Center, Massachusetts General Hospital and Harvard Medical School, Charlestown, MA 02129, USA
    Sci Signal 1:ra14. 2008
    Although apoptosis triggered by ultraviolet B (UVB)-mediated activation of the c-Jun N-terminal kinase (JNK) pathway is mediated by both intrinsic and extrinsic pathways, the mechanism of initiation of JNK activation remains obscure...
  95. pmc c-Jun N-terminal kinase-1 from hematopoietic cells mediates progression from hepatic steatosis to steatohepatitis and fibrosis in mice
    Yuzo Kodama
    Department of Medicine, University of California, San Diego, La Jolla, California 92093, USA
    Gastroenterology 137:1467-1477.e5. 2009
    c-Jun N-terminal kinase (JNK) plays a pivotal role in the development of the metabolic syndrome including nonalcoholic fatty liver disease...
  96. doi Disturbed blood flow induces RelA expression via c-Jun N-terminal kinase 1: a novel mode of NF-κB regulation that promotes arterial inflammation
    Simon Cuhlmann
    British Heart Foundation Cardiovascular Sciences Unit, National Heart and Lung Institute, Imperial College London, United Kingdom
    Circ Res 108:950-9. 2011
    ..Although the signaling pathways that regulate transcriptional activation of NF-κB are defined, the mechanisms that regulate the expression levels of NF-κB transcription factors are uncertain...
  97. pmc c-Jun N-terminal kinase phosphorylates DCP1a to control formation of P bodies
    Katharina Rzeczkowski
    Rudolf Buchheim Institute of Pharmacology, Justus Liebig University Giessen, 35392 Giessen, Germany
    J Cell Biol 194:581-96. 2011
    Cytokines and stress-inducing stimuli signal through c-Jun N-terminal kinase (JNK) using a diverse and only partially defined set of downstream effectors...
  98. ncbi alpha-Synuclein protects against oxidative stress via inactivation of the c-Jun N-terminal kinase stress-signaling pathway in neuronal cells
    Makoto Hashimoto
    Department of Neurosciences, University of California San Diego, School of Medicine, La Jolla, California 92093 0624, USA
    J Biol Chem 277:11465-72. 2002
    ..Because c-Jun N-terminal kinase (JNK), a member of the mitogen-activated protein kinase family, plays an important role in stress response, the main ..
  99. ncbi Modulation of CREB activity by the Rho GTPase regulates cell and organism size during mouse embryonic development
    Raffaella Sordella
    MGH Cancer Center and Harvard Medical School, Charlestown, MA 02129, USA
    Dev Cell 2:553-65. 2002
    ..Together, these results suggest that activity of the Rho GTPase modulates a signal from insulin/IGFs to CREB that determines cell size and animal size during embryogenesis...
  100. pmc The MEKK1-JNK pathway plays a protective role in pressure overload but does not mediate cardiac hypertrophy
    Junichi Sadoshima
    Cardiovascular Research Institute, Department of Cell Biology and Molecular Medicine, University of Medicine and Dentistry of New Jersey, New Jersey Medical School, Newark 07103, USA
    J Clin Invest 110:271-9. 2002
    Mitogen-activated protein kinase kinase kinase (MEKK1) mediates activation of c-Jun NH(2)-terminal kinase (JNK)...
  101. ncbi Differential expression and/or activation of P38MAPK, erk1/2, and jnk during the initiation and progression of prostate cancer
    Aarti R Uzgare
    Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, Texas 77030, USA
    Prostate 55:128-39. 2003
    ....

Research Grants12

  1. 'Death' and 'MAPK' pathways with myocardial ischemia
    Junichi Sadoshima; Fiscal Year: 2001
    ..Our study will contribute to the understanding of the mechanism of cardiac myocyte apoptosis by hR and may provide clues to prevent myocyte loss and reduced cardiac function after myocardial I/R. ..
  2. Chemical Genetics Analysis Targeted to the Mouse Prostate Epithelium
    Roger Davis; Fiscal Year: 2007
    ..It is anticipated that the development of this specific model for JNK will provide information that will guide the application of the same method to other protein kinases The Specific ..
  3. SIGNAL TRANSDUCTION BY THE EGF RECEPTOR
    Roger Davis; Fiscal Year: 2001
    ..In the second aim, the investigator will attempt to identify target molecules that interact with ZPR1. In the third specific aim, the investigator will determine ZPR1 function using genetic analysis in yeast. ..
  4. STRUCTURAL ORGANIZATION OF SIGNALING PATHWAYS
    Roger Davis; Fiscal Year: 2004
    ..A focus of this study is the c-fun NH2-terminal kinase (JNK) group of MAP kinases...
  5. Prevention of cardiac cell death by Mst1 inhibitor
    Junichi Sadoshima; Fiscal Year: 2005
    ..abstract_text> ..
  6. Functional Analysis of the Beta-Cell
    Roger Davis; Fiscal Year: 2006
    The overall goal of this research program is to understand the role of the c-Jun N-terminal kinase (JNK) group of mitogen-activated protein (MAP) kinases...
  7. Anti-aging and Stress Resistance by Sir2
    Junichi Sadoshima; Fiscal Year: 2006
    ..unreadable] [unreadable] [unreadable]..
  8. Prevention of neointimal thickening by Mst1
    Junichi Sadoshima; Fiscal Year: 2006
    ..unreadable] [unreadable] [unreadable]..
  9. Mechanisms of Action of Pro-inflammatory Cytokines
    Roger J Davis; Fiscal Year: 2010
    ..A focus of this study is the c-Jun NH2-terminal kinase (JNK) group of MAP kinases...
  10. Mechanisms of Neurodegeneration
    Roger J Davis; Fiscal Year: 2010
    ..A focus of this study is the c-Jun NH2-terminal kinase (JNK) group of MAP kinases...
  11. Sertoli Cell Mediated Engulfment of Apoptotic Germ Cells
    Kodi S Ravichandran; Fiscal Year: 2010
    ..abstract_text> ..