Mapk7

Summary

Gene Symbol: Mapk7
Description: mitogen-activated protein kinase 7
Alias: BMK-1, BMK1, ERK-5, ERK5, Erk5-T, PRKM7, b2b2346Clo, mitogen-activated protein kinase 7, MAPK 7, big MAP kinase 1, extracellular signal-regulated kinase 5
Species: mouse
Products:     Mapk7

Top Publications

  1. García Hoz C, Sánchez Fernández G, García Escudero R, Fernandez Velasco M, Palacios García J, Ruiz Meana M, et al. Protein kinase C (PKC)ζ-mediated Gαq stimulation of ERK5 protein pathway in cardiomyocytes and cardiac fibroblasts. J Biol Chem. 2012;287:7792-802 pubmed publisher
    ..We have recently described that Gα(q) acts as an adaptor protein that facilitates PKCζ-mediated activation of ERK5 in epithelial cells...
  2. Zou J, Pan Y, Wang Z, Chang S, Wang W, Wang X, et al. Targeted deletion of ERK5 MAP kinase in the developing nervous system impairs development of GABAergic interneurons in the main olfactory bulb and behavioral discrimination between structurally similar odorants. J Neurosci. 2012;32:4118-32 pubmed publisher
    b>ERK5 MAP kinase is highly expressed in the developing nervous system and has been implicated in promoting the survival of immature neurons in culture...
  3. Pan Y, Chan G, Kuo C, Storm D, Xia Z. Inhibition of adult neurogenesis by inducible and targeted deletion of ERK5 mitogen-activated protein kinase specifically in adult neurogenic regions impairs contextual fear extinction and remote fear memory. J Neurosci. 2012;32:6444-55 pubmed publisher
    ..Here we report that ERK5 mitogen-activated protein kinase is specifically expressed in the neurogenic regions of the adult mouse brain...
  4. Seyfried J, Wang X, Kharebava G, Tournier C. A novel mitogen-activated protein kinase docking site in the N terminus of MEK5alpha organizes the components of the extracellular signal-regulated kinase 5 signaling pathway. Mol Cell Biol. 2005;25:9820-8 pubmed
    ..The formation of the MEK5/extracellular signal-regulated kinase 5 (ERK5) complex is critical for MEK5 to activate ERK5, to increase transcription via MEF2, and to enhance cellular ..
  5. Regan C, Li W, Boucher D, Spatz S, Su M, Kuida K. Erk5 null mice display multiple extraembryonic vascular and embryonic cardiovascular defects. Proc Natl Acad Sci U S A. 2002;99:9248-53 pubmed
    b>Erk5 is a mitogen-activated protein kinase, the biological role of which is largely undefined. Therefore, we deleted the erk5 gene in mice to assess its function in vivo...
  6. Pan Y, Kuo C, Storm D, Xia Z. Inducible and targeted deletion of the ERK5 MAP kinase in adult neurogenic regions impairs adult neurogenesis in the olfactory bulb and several forms of olfactory behavior. PLoS ONE. 2012;7:e49622 pubmed publisher
    ..Here we report that inducible and targeted deletion of erk5, a MAP kinase selectively expressed in the adult neurogenic regions of the adult brain, impairs adult neurogenesis ..
  7. Villa Moruzzi E. Targeting of FAK Ser910 by ERK5 and PP1delta in non-stimulated and phorbol ester-stimulated cells. Biochem J. 2007;408:7-18 pubmed
    ..protein kinase/ERK kinase) inhibitors UO126 and CI-1040 to inhibit ERK1/2 pointed to the involvement of ERK5. This hypothesis was confirmed by: (i) shRNA ERK5 gene silencing, which resulted in complete pSer910 loss in non-..
  8. Wang W, Pan Y, Wietecha T, Zou J, Abel G, Kuo C, et al. Extracellular signal-regulated kinase 5 (ERK5) mediates prolactin-stimulated adult neurogenesis in the subventricular zone and olfactory bulb. J Biol Chem. 2013;288:2623-31 pubmed publisher
    ..We report here for the first time that prolactin activates extracellular signal-regulated kinase 5 (ERK5), a MAP kinase that is specifically expressed in the neurogenic regions of the adult mouse brain...
  9. Wang X, Finegan K, Robinson A, Knowles L, Khosravi Far R, Hinchliffe K, et al. Activation of extracellular signal-regulated protein kinase 5 downregulates FasL upon osmotic stress. Cell Death Differ. 2006;13:2099-108 pubmed
    ..of this signaling cascade is underscored by the early embryonic death caused by the targeted deletion of the erk5 or the mek5 genes in mice...

More Information

Publications62

  1. Sunadome K, Yamamoto T, Ebisuya M, Kondoh K, Sehara Fujisawa A, Nishida E. ERK5 regulates muscle cell fusion through Klf transcription factors. Dev Cell. 2011;20:192-205 pubmed publisher
    ..Here, we show that ERK5 regulates muscle cell fusion through Klf transcription factors...
  2. Pan Y, Zou J, Wang W, Sakagami H, Garelick M, Abel G, et al. Inducible and conditional deletion of extracellular signal-regulated kinase 5 disrupts adult hippocampal neurogenesis. J Biol Chem. 2012;287:23306-17 pubmed publisher
    ..Here we report that extracellular signal-regulated kinase 5 (ERK5), a member of the mitogen-activated protein kinase family, is selectively expressed in the neurogenic regions of ..
  3. Sohn S, Li D, Lee L, Winoto A. Transcriptional regulation of tissue-specific genes by the ERK5 mitogen-activated protein kinase. Mol Cell Biol. 2005;25:8553-66 pubmed
    The ERK5 mitogen-activated protein kinase (MAPK) differs from other MAPKs in possessing a potent transcriptional activation domain...
  4. Barros J, Marshall C. Activation of either ERK1/2 or ERK5 MAP kinase pathways can lead to disruption of the actin cytoskeleton. J Cell Sci. 2005;118:1663-71 pubmed
    ..use of chemical inhibitors of MEK1/2 but it is now clear that these inhibitors also inactivate MEK5 in the MEK5-ERK5 MAP kinase pathway raising the possibility that this pathway may also be involved in oncogenic transformation...
  5. Sohn S, Sarvis B, Cado D, Winoto A. ERK5 MAPK regulates embryonic angiogenesis and acts as a hypoxia-sensitive repressor of vascular endothelial growth factor expression. J Biol Chem. 2002;277:43344-51 pubmed
    ..Here we report that embryos deficient for the ERK5 MAPK die between embryonic days 10.5 and 11.5 with angiogenic failure and cardiovascular defects...
  6. Schramp M, Ying O, Kim T, Martin G. ERK5 promotes Src-induced podosome formation by limiting Rho activation. J Cell Biol. 2008;181:1195-210 pubmed publisher
    ..Unlike extracellular signal-regulated kinase 1/2 (ERK1/2), ERK5 is constitutively activated in Src-transformed fibroblasts...
  7. Kamakura S, Moriguchi T, Nishida E. Activation of the protein kinase ERK5/BMK1 by receptor tyrosine kinases. Identification and characterization of a signaling pathway to the nucleus. J Biol Chem. 1999;274:26563-71 pubmed
    ERK5 (also known as BMK1), a member of the mitogen-activated protein kinase (MAPK) superfamily, was known to be activated strongly by oxidant and osmotic stresses...
  8. García Hoz C, Sánchez Fernández G, Diaz Meco M, Moscat J, Mayor F, Ribas C. G alpha(q) acts as an adaptor protein in protein kinase C zeta (PKCzeta)-mediated ERK5 activation by G protein-coupled receptors (GPCR). J Biol Chem. 2010;285:13480-9 pubmed publisher
    ..The ERK5 MAPK has been shown to be activated by G(q)-coupled GPCR via unknown mechanisms...
  9. Wang X, Merritt A, Seyfried J, Guo C, Papadakis E, Finegan K, et al. Targeted deletion of mek5 causes early embryonic death and defects in the extracellular signal-regulated kinase 5/myocyte enhancer factor 2 cell survival pathway. Mol Cell Biol. 2005;25:336-45 pubmed
    ..studies with mek5(-/-) MEFs indicate that MEK5 is required for mediating extracellular signal-regulated kinase 5 (ERK5) activation and for the regulation of the transcriptional activity of myocyte enhancer factor 2...
  10. Hayashi M, Kim S, Imanaka Yoshida K, Yoshida T, Abel E, Eliceiri B, et al. Targeted deletion of BMK1/ERK5 in adult mice perturbs vascular integrity and leads to endothelial failure. J Clin Invest. 2004;113:1138-48 pubmed
    Big mitogen-activated protein kinase 1 (BMK1), also known as ERK5, is a member of the MAPK family. Genetic ablation of BMK1 in mice leads to embryonic lethality, precluding the exploration of pathophysiological roles of BMK1 in adult mice...
  11. Yan L, Carr J, Ashby P, Murry Tait V, Thompson C, Arthur J. Knockout of ERK5 causes multiple defects in placental and embryonic development. BMC Dev Biol. 2003;3:11 pubmed
    b>ERK5 is a member of the mitogen activated protein kinase family activated by certain mitogenic or stressful stimuli in cells, but whose physiological role is largely unclear...
  12. Finegan K, Wang X, Lee E, Robinson A, Tournier C. Regulation of neuronal survival by the extracellular signal-regulated protein kinase 5. Cell Death Differ. 2009;16:674-83 pubmed publisher
    The extracellular signal-regulated protein kinase 5 (ERK5) is a mitogen-activated protein kinase that phosphorylates and regulates various transcription factors in response to growth factors and extracellular stresses...
  13. Yang M, Cooley B, Li W, Chen Y, Vasquez Vivar J, Scoggins N, et al. Platelet CD36 promotes thrombosis by activating redox sensor ERK5 in hyperlipidemic conditions. Blood. 2017;129:2917-2927 pubmed publisher
    ..mechanism for CD36 to promote thrombosis by increasing activation of MAPK extracellular signal-regulated kinase 5 (ERK5), a protein kinase known to be exquisitely sensitive to redox stress, through a signaling pathway requiring Src ..
  14. Li P, Ma Y, Sheng X, Dong H, Han H, Wang J, et al. Cyclic fluid shear stress promotes osteoblastic cells proliferation through ERK5 signaling pathway. Mol Cell Biochem. 2012;364:321-7 pubmed publisher
    ..Recently, ERK5 has been found to be involved in multiple cellular processes...
  15. Carter E, Cosgrove R, Gonzalez I, Eisemann J, Lovett F, Cobb L, et al. MEK5 and ERK5 are mediators of the pro-myogenic actions of IGF-2. J Cell Sci. 2009;122:3104-12 pubmed publisher
    ..The aim of this study was to investigate whether ERK5 and its upstream MKK activator, MEK5, were important in the pro-myogenic actions of IGF-2...
  16. Morimoto H, Kondoh K, Nishimoto S, Terasawa K, Nishida E. Activation of a C-terminal transcriptional activation domain of ERK5 by autophosphorylation. J Biol Chem. 2007;282:35449-56 pubmed
    b>ERK5 plays a crucial role in many biological processes by regulating transcription. ERK5 has a large C-terminal-half that contains a transcriptional activation domain...
  17. Wang W, Lu S, Li T, Pan Y, Zou J, Abel G, et al. Inducible activation of ERK5 MAP kinase enhances adult neurogenesis in the olfactory bulb and improves olfactory function. J Neurosci. 2015;35:7833-49 pubmed publisher
    ..We previously reported that ERK5, a MAP kinase selectively expressed in the neurogenic regions of the adult brain, plays a critical role in adult ..
  18. Maciejewska Z, Pascal A, Kubiak J, Ciemerych M. Phosphorylated ERK5/BMK1 transiently accumulates within division spindles in mouse oocytes and preimplantation embryos. Folia Histochem Cytobiol. 2011;49:528-34 pubmed
    ..The role of the signaling pathway involving ERK5 MAP kinase during meiotic and mitotic M-phase of the cell cycle is not well known...
  19. Fulford L, Milewski D, Ustiyan V, Ravishankar N, Cai Y, Le T, et al. The transcription factor FOXF1 promotes prostate cancer by stimulating the mitogen-activated protein kinase ERK5. Sci Signal. 2016;9:ra48 pubmed publisher
    ..Extracellular signal-regulated kinase 5 (ERK5) is associated with advanced-stage prostate adenocarcinoma (PCa) in patients...
  20. Zhu H, Guariglia S, Li W, Brancho D, Wang Z, Scherer P, et al. Role of extracellular signal-regulated kinase 5 in adipocyte signaling. J Biol Chem. 2014;289:6311-22 pubmed publisher
    ..Here, we uncover a role of extracellular signal-regulated kinase 5 (ERK5) in adipocyte signaling...
  21. Grewal P, Holzfeind P, Bittner R, Hewitt J. Mutant glycosyltransferase and altered glycosylation of alpha-dystroglycan in the myodystrophy mouse. Nat Genet. 2001;28:151-4 pubmed
    ..We speculate that abnormal post-translational modification of alpha-dystroglycan may contribute to the myd phenotype. ..
  22. Chu U, Duellman T, Weaver S, Tao Y, Yang J. Endothelial protective genes induced by statin are mimicked by ERK5 activation as triggered by a drug combination of FTI-277 and GGTI-298. Biochim Biophys Acta. 2015;1850:1415-25 pubmed publisher
    ..Here, we explored the mechanism of statin-mediated activation of ERK5 in the human endothelium with the goal of identifying compounds that confer endothelial protection but are nontoxic ..
  23. Li T, Pan Y, Wang W, Abel G, Zou J, Xu L, et al. Targeted deletion of the ERK5 MAP kinase impairs neuronal differentiation, migration, and survival during adult neurogenesis in the olfactory bulb. PLoS ONE. 2013;8:e61948 pubmed publisher
    ..This pattern of expression suggests a role for ERK5 in the regulation of adult OB neurogenesis...
  24. Wang Y, Su B, Xia Z. Brain-derived neurotrophic factor activates ERK5 in cortical neurons via a Rap1-MEKK2 signaling cascade. J Biol Chem. 2006;281:35965-74 pubmed
    The extracellular signal-regulated kinase 5 (ERK5) is activated in neurons of the central nervous system by neurotrophins including brain-derived neurotrophic factor (BDNF)...
  25. Marchetti A, Colletti M, Cozzolino A, Steindler C, Lunadei M, Mancone C, et al. ERK5/MAPK is activated by TGFbeta in hepatocytes and required for the GSK-3beta-mediated Snail protein stabilization. Cell Signal. 2008;20:2113-8 pubmed publisher
    Extracellular signal-regulated protein kinase 5 (ERK5) is a mitogen-activated protein kinase, specifically activated by MEK5, and involved in the regulation of many cellular functions including proliferation, survival, differentiation and ..
  26. Weinreich M, Jameson S, Hogquist K. Postselection thymocyte maturation and emigration are independent of IL-7 and ERK5. J Immunol. 2011;186:1343-7 pubmed publisher
    ..In endothelial cells KLF2 expression has been shown to be dependent on the mitogen-activated protein kinase ERK5. Furthermore, it has been reported that IL-7 signaling leads to the phosphorylation of ERK5...
  27. Gilley R, March H, Cook S. ERK1/2, but not ERK5, is necessary and sufficient for phosphorylation and activation of c-Fos. Cell Signal. 2009;21:969-77 pubmed publisher
    ..However, recent reports have also suggested a prominent role for the closely related ERK5 pathway in regulating the expression, transcriptional activation and nuclear localization of c-Fos...
  28. Sohn S, Lewis G, Winoto A. Non-redundant function of the MEK5-ERK5 pathway in thymocyte apoptosis. EMBO J. 2008;27:1896-906 pubmed publisher
    ..Recently, these inhibitors were also shown to affect MEK5, an upstream activator of ERK5, another class of MAPK with homology to ERK1/2...
  29. Shishido T, Woo C, Ding B, McClain C, Molina C, Yan C, et al. Effects of MEK5/ERK5 association on small ubiquitin-related modification of ERK5: implications for diabetic ventricular dysfunction after myocardial infarction. Circ Res. 2008;102:1416-25 pubmed publisher
    ..Activation of ERK5, an atypical mitogen activated protein kinase with transcriptional activity, inhibits apoptosis and LV dysfunction ..
  30. Woo C, Shishido T, McClain C, Lim J, Li J, Yang J, et al. Extracellular signal-regulated kinase 5 SUMOylation antagonizes shear stress-induced antiinflammatory response and endothelial nitric oxide synthase expression in endothelial cells. Circ Res. 2008;102:538-45 pubmed publisher
    ..H(2)O(2) and AGE (advanced glycation end products), 2 well-known mediators of diabetes, negatively regulated ERK5 transcriptional activity and laminar flow-induced endothelial nitric oxide synthase expression through ERK5 ..
  31. McGary K, Park T, Woods J, Cha H, Wallingford J, Marcotte E. Systematic discovery of nonobvious human disease models through orthologous phenotypes. Proc Natl Acad Sci U S A. 2010;107:6544-9 pubmed publisher
    ..Phenologs reveal functionally coherent, evolutionarily conserved gene networks-many predating the plant-animal divergence-capable of identifying candidate disease genes. ..
  32. Garaude J, Kaminski S, Cherni S, Hipskind R, Villalba M. The role of ERK5 in T-cell signalling. Scand J Immunol. 2005;62:515-20 pubmed
    The mitogen-activated protein kinase (MAPK) ERK5 plays an important role in mammary epithelial proliferation, endothelial cell survival and normal embryonic development...
  33. Rovira Clavé X, Angulo Ibáñez M, Tournier C, Reina M, Espel E. Dual role of ERK5 in the regulation of T cell receptor expression at the T cell surface. J Leukoc Biol. 2016;99:143-52 pubmed publisher
    ..We provide evidence that the MAPK ERK5 regulates the surface expression of the TCR/CD3 complex by controlling the degradation of the CD3ζ chain and the ..
  34. Pan Y, Storm D, Xia Z. The maintenance of established remote contextual fear memory requires ERK5 MAP kinase and ongoing adult neurogenesis in the hippocampus. PLoS ONE. 2012;7:e50455 pubmed publisher
    ..Here we used an inducible gene-specific approach for conditional deletion of erk5 in the adult neurogenic regions of the mouse brain to specifically impair adult neurogenesis...
  35. Heo K, Chang E, Le N, Cushman H, Yeh E, Fujiwara K, et al. De-SUMOylation enzyme of sentrin/SUMO-specific protease 2 regulates disturbed flow-induced SUMOylation of ERK5 and p53 that leads to endothelial dysfunction and atherosclerosis. Circ Res. 2013;112:911-23 pubmed publisher
    ..Although a possible link between SUMOylation of p53 and ERK5 detected during endothelial apoptosis and inflammation has been suggested, the mechanistic insights, especially ..
  36. Christie G, Williams D, MacIsaac F, Dickinson R, Rosewell I, Keyse S. The dual-specificity protein phosphatase DUSP9/MKP-4 is essential for placental function but is not required for normal embryonic development. Mol Cell Biol. 2005;25:8323-33 pubmed
  37. Dalmay T, Horsefield R, Braunstein T, Baulcombe D. SDE3 encodes an RNA helicase required for post-transcriptional gene silencing in Arabidopsis. EMBO J. 2001;20:2069-78 pubmed
    ..These proteins are similar to, but clearly distinct from Upf1p and SMG-2, which are required for nonsense-mediated mRNA decay in yeast and Caenorhabditis elegans and, in the case of SMG-2, for PTGS. ..
  38. Geng X, Liu S, Chen Y. [Involvement of ERK5 and JNK in the BMP9-induced differentiation of C3H10T1/2 cells into cardiomyocyte-like cells]. Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi. 2014;30:829-32, 840 pubmed
    To investigate the roles of extracellular signal-regulated kinase 5 (ERK5) and c-Jun N-terminal kinase (JNK) in the differentiation of C3H10T1/2 cells into cardiomyocyte-like cells induced by bone morphogenetic protein 9 (BMP9)...
  39. Liu W, Ruiz Velasco A, Wang S, Khan S, Zi M, Jungmann A, et al. Metabolic stress-induced cardiomyopathy is caused by mitochondrial dysfunction due to attenuated Erk5 signaling. Nat Commun. 2017;8:494 pubmed publisher
    ..Here, we show that extracellular signal-regulated protein kinase 5 (Erk5) is lost in the hearts of obese/diabetic animal models and that cardiac-specific deletion of Erk5 in mice (Erk5-CKO)..
  40. Lin E, Amantea C, Nomanbhoy T, Weissig H, Ishiyama J, Hu Y, et al. ERK5 kinase activity is dispensable for cellular immune response and proliferation. Proc Natl Acad Sci U S A. 2016;113:11865-11870 pubmed
    Unlike other members of the MAPK family, ERK5 contains a large C-terminal domain with transcriptional activation capability in addition to an N-terminal canonical kinase domain...
  41. Le N, Takei Y, Izawa Ishizawa Y, Heo K, Lee H, Smrcka A, et al. Identification of activators of ERK5 transcriptional activity by high-throughput screening and the role of endothelial ERK5 in vasoprotective effects induced by statins and antimalarial agents. J Immunol. 2014;193:3803-15 pubmed publisher
    Because ERK5 inhibits endothelial inflammation and dysfunction, activating ERK5 might be a novel approach to protecting vascular endothelial cells (ECs) against various pathological conditions of the blood vessel...
  42. Heo K, Cushman H, Akaike M, Woo C, Wang X, Qiu X, et al. ERK5 activation in macrophages promotes efferocytosis and inhibits atherosclerosis. Circulation. 2014;130:180-91 pubmed publisher
    ..treated with pitavastatin in vitro, efferocytosis-related signaling and phagocytic capacity were upregulated in an ERK5 activity-dependent manner...
  43. Charni S, Aguilo J, Garaude J, de Bettignies G, Jacquet C, Hipskind R, et al. ERK5 knockdown generates mouse leukemia cells with low MHC class I levels that activate NK cells and block tumorigenesis. J Immunol. 2009;182:3398-405 pubmed publisher
    ..We show herein that stable expression of a small hairpin RNA for ERK5 (shERK5) decreases ERK5 levels in human and mouse leukemic cells and leads to their elimination by NK cells in vivo...
  44. Yan C, Luo H, Lee J, Abe J, Berk B. Molecular cloning of mouse ERK5/BMK1 splice variants and characterization of ERK5 functional domains. J Biol Chem. 2001;276:10870-8 pubmed
    ..Human MAPK 5 (ERK5) or Big MAP kinase 1 (BMK1) is a recently cloned member of the MAPK family...
  45. Sánchez Fernández G, Cabezudo S, García Hoz C, Tobin A, Mayor F, Ribas C. ERK5 activation by Gq-coupled muscarinic receptors is independent of receptor internalization and ?-arrestin recruitment. PLoS ONE. 2013;8:e84174 pubmed publisher
    ..Recently, the activation of ERK5 MAPK by Gq-coupled receptors has been described to involve a direct interaction between G?q and two novel effectors,..
  46. Han J, Hwang A, Nam D, Kim S, Choi H, Lim J, et al. ERK5 regulates basic fibroblast growth factor-induced type 1 plasminogen activator inhibitor expression and cell proliferation in lung fibroblasts. Life Sci. 2015;135:1-8 pubmed publisher
    bFGF is a potent mitogen of cells associated with fibrosis. Although ERK5 has been reported to play roles in the development of fibrosis, its roles in regulating bFGF-induced fibrotic responses are not understood, especially in lung ..
  47. Bin G, Bo Z, Jing W, Jin J, Xiaoyi T, Cong C, et al. Fluid shear stress suppresses TNF-?-induced apoptosis in MC3T3-E1 cells: Involvement of ERK5-AKT-FoxO3a-Bim/FasL signaling pathways. Exp Cell Res. 2016;343:208-217 pubmed publisher
    ..Extracellular signal-regulated kinase 5 (ERK5) is a member of the mitogen-activated protein kinase (MAPK) family that has been implicated in cell survival...
  48. Kondoh K, Terasawa K, Morimoto H, Nishida E. Regulation of nuclear translocation of extracellular signal-regulated kinase 5 by active nuclear import and export mechanisms. Mol Cell Biol. 2006;26:1679-90 pubmed
    Extracellular signal-regulated kinase 5 (ERK5), a member of the mitogen-activated protein kinase family, plays an important role in growth factor signaling to the nucleus...
  49. McCaw B, Chow S, Wong E, Tan K, Guo H, Guy G. Identification and characterization of mErk5-T, a novel Erk5/Bmk1 splice variant. Gene. 2005;345:183-90 pubmed
    Extracellular regulated kinase 5 (ERK5) is an unusually large member of the MAP kinase family of signaling molecules that plays an important role in cellular proliferation, differentiation and survival...
  50. Xia G, Li X, Zhu X, Yin X, Ding H, Qiao Y. Mangiferin protects osteoblast against oxidative damage by modulation of ERK5/Nrf2 signaling. Biochem Biophys Res Commun. 2017;491:807-813 pubmed publisher
    ..cell proliferation of MC3T3-E1 cells in a time- and dose-dependent manner and stimulate the phosphorylation of ERK5. Cells were divided as five groups: control, H2O2 (100 ?M, control), H2O2
  51. Finegan K, Perez Madrigal D, Hitchin J, Davies C, Jordan A, Tournier C. ERK5 is a critical mediator of inflammation-driven cancer. Cancer Res. 2015;75:742-53 pubmed publisher
    ..Here, we report that the protein kinase ERK5 controls the expression of a specific subset of inflammatory mediators in the mouse epidermis, which triggers the ..
  52. Li P, Ma Y, Shen H, Han H, Wang J, Cheng H, et al. Cytoskeletal reorganization mediates fluid shear stress-induced ERK5 activation in osteoblastic cells. Cell Biol Int. 2012;36:229-36 pubmed publisher
    ..Here, we investigated the potential involvement of a novel MAPK (mitogen-activated protein kinase) member, ERK5 (extracellular-signal-regulated kinase 5), in the response of osteoblastic cells to FSS (fluid shear stress)...
  53. Pearson G, Cobb M. Cell condition-dependent regulation of ERK5 by cAMP. J Biol Chem. 2002;277:48094-8 pubmed
    b>ERK5 activity is increased by agents known to activate receptor tyrosine kinases, G-protein coupled receptors, and stress response pathways. We now find a role for cAMP in the regulation of ERK5...