Gene Symbol: Mapk4
Description: mitogen-activated protein kinase 4
Alias: A330097D03Rik, Erk3, Prkm4, p63Mapk, mitogen-activated protein kinase 4, ERK-4, Erk3-related, MAP kinase 4, MAPK 4, extracellular signal-regulated kinase 4
Rousseau J, Klinger S, Rachalski A, Turgeon B, Déléris P, Vigneault E, et al
. Targeted inactivation of Mapk4 in mice reveals specific nonredundant functions of Erk3/Erk4 subfamily mitogen-activated protein kinases. Mol Cell Biol. 2010;30:5752-63 pubmed publisher
..To investigate the specific functions of Erk4, we have generated mice with a targeted disruption of the Mapk4 gene...
Turgeon B, Lang B, Meloche S. The protein kinase ERK3 is encoded by a single functional gene: genomic analysis of the ERK3 gene family. Genomics. 2002;80:673-80 pubmed
..the structure of MAPK6 is closely related to that of the gene encoding the homologous protein kinase p63(MAPK) (MAPK4), suggesting that the two genes arose by duplication...
Klinger S, Turgeon B, Lévesque K, Wood G, Aagaard Tillery K, Meloche S. Loss of Erk3 function in mice leads to intrauterine growth restriction, pulmonary immaturity, and neonatal lethality. Proc Natl Acad Sci U S A. 2009;106:16710-5 pubmed publisher
Extracellular signal-regulated kinase 3 (Erk3) is an atypical member of the mitogen-activated protein (MAP) kinase family. No function has yet been ascribed to this MAP kinase...
Kant S, Schumacher S, Singh M, Kispert A, Kotlyarov A, Gaestel M. Characterization of the atypical MAPK ERK4 and its activation of the MAPK-activated protein kinase MK5. J Biol Chem. 2006;281:35511-9 pubmed
The extracellular-regulated kinase (ERK) 4 (MAPK4) and ERK3 (MAPK6) are structurally related atypical MAPKs displaying major differences only in the C-terminal extension...
Garcia J, Zalba G, Detera Wadleigh S, de Miguel C. Isolation of a cDNA encoding the rat MAP-kinase homolog of human p63mapk. Mamm Genome. 1996;7:810-4 pubmed
..5% identity. rMNK2 showed 77% homology with rat ERK3 and its human homolog p97(mapk), and 43% homology with both rat genes rMNK1(ERK1) and ERK2, within the kinase ..
Xu H, Dembski M, Yang Q, Yang D, Moriarty A, Tayber O, et al
. Dual specificity mitogen-activated protein (MAP) kinase phosphatase-4 plays a potential role in insulin resistance. J Biol Chem. 2003;278:30187-92 pubmed
..Our data suggest that MKP-4 negatively regulates insulin signaling and, consequently, may contribute to the pathogenesis of insulin resistance. ..
Marquis M, Daudelin J, Boulet S, Sirois J, Crain K, Mathien S, et al
. The catalytic activity of the mitogen-activated protein kinase extracellular signal-regulated kinase 3 is required to sustain CD4+ CD8+ thymocyte survival. Mol Cell Biol. 2014;34:3374-87 pubmed publisher
Extracellular signal-regulated kinase 3 (ERK3) is an atypical member of the mitogen-activated protein kinase (MAPK) family whose function is largely unknown...
Li S, Ou X, Wang Z, Xiong B, Tong J, Wei L, et al
. ERK3 is required for metaphase-anaphase transition in mouse oocyte meiosis. PLoS ONE. 2010;5: pubmed publisher
b>ERK3 (extracellular signal-regulated kinase 3) is an atypical member of the mitogen-activated protein (MAP) kinase family of serine/threonine kinases...
Marquis M, Boulet S, Mathien S, Rousseau J, Thebault P, Daudelin J, et al
. The non-classical MAP kinase ERK3 controls T cell activation. PLoS ONE. 2014;9:e86681 pubmed publisher
..b>ERK3 is an atypical member of the MAPK family with highest homology to ERK1/2...