Mapk14

Summary

Gene Symbol: Mapk14
Description: mitogen-activated protein kinase 14
Alias: CSBP2, Crk1, Csbp1, Mxi2, PRKM14, PRKM15, p38, p38-alpha, p38MAPK, p38a, p38alpha, mitogen-activated protein kinase 14, MAP kinase 14, MAP kinase p38 alpha, MAPK 14, mitogen-activated protein kinase p38 alpha, p38 MAP kinase alpha, p38 MAPK
Species: mouse
Products:     Mapk14

Top Publications

  1. McGuire V, Gray A, Monk C, Santos S, Lee K, Aubareda A, et al. Cross talk between the Akt and p38? pathways in macrophages downstream of Toll-like receptor signaling. Mol Cell Biol. 2013;33:4152-65 pubmed publisher
    ..Both phosphatidylinositol 3-kinase (PI3K)-Akt and p38 mitogen-activated protein kinase (MAPK) signaling pathways are activated rapidly in response to TLR activation and ..
  2. Al Huseini L, Aw Yeang H, Sethu S, Alhumeed N, Hamdam J, Tingle Y, et al. Nuclear factor-erythroid 2 (NF-E2) p45-related factor-2 (Nrf2) modulates dendritic cell immune function through regulation of p38 MAPK-cAMP-responsive element binding protein/activating transcription factor 1 signaling. J Biol Chem. 2013;288:22281-8 pubmed publisher
    ..CD86) and antigen-specific T cell activation capacity observed in Nrf2(-/-) iDCs was reversed by inhibition of p38 MAPK but not JNK...
  3. Hsieh C, Kuro O M, Rosenblatt K, Brobey R, Papaconstantinou J. The ASK1-Signalosome regulates p38 MAPK activity in response to levels of endogenous oxidative stress in the Klotho mouse models of aging. Aging (Albany NY). 2010;2:597-611 pubmed
    Reactive oxygen species (ROS) and elevated levels of p38 MAPK activity accelerate physiological aging...
  4. Kim S, Lee K, Park S, Jeon M, Lee Y. Inhibition of p38 MAPK reduces expression of vascular endothelial growth factor in allergic airway disease. J Clin Immunol. 2012;32:574-86 pubmed publisher
    ..However, there are little data on the relationship between p38 MAPK signaling and VEGF expression in allergic airway disease...
  5. Ortuño M, Ruiz Gaspa S, Rodríguez Carballo E, Susperregui A, Bartrons R, Rosa J, et al. p38 regulates expression of osteoblast-specific genes by phosphorylation of osterix. J Biol Chem. 2010;285:31985-94 pubmed publisher
    ..Furthermore, we show that Osterix is a novel substrate for p38 MAPK in vitro and in vivo and that Ser-73 and Ser-77 are the regulatory sites phosphorylated by p38...
  6. Ritprajak P, Hayakawa M, Sano Y, Otsu K, Park J. Cell type-specific targeting dissociates the therapeutic from the adverse effects of protein kinase inhibition in allergic skin disease. Proc Natl Acad Sci U S A. 2012;109:9089-94 pubmed publisher
    The kinase p38?, originally identified because of its endotoxin- and cytokine-inducible activity and affinity for antiinflammatory compounds, has been posited as a promising therapeutic target for various immune-mediated disorders...
  7. Kang Y, Otsuka M, van den Berg A, Hong L, Huang Z, Wu X, et al. Epithelial p38alpha controls immune cell recruitment in the colonic mucosa. PLoS Pathog. 2010;6:e1000934 pubmed publisher
    ..Here we show that p38alpha in IECs is critical for chemokine expression, subsequent immune cell recruitment into the intestinal mucosa, and ..
  8. Brien P, Pugazhendhi D, Woodhouse S, Oxley D, Pell J. p38? MAPK regulates adult muscle stem cell fate by restricting progenitor proliferation during postnatal growth and repair. Stem Cells. 2013;31:1597-610 pubmed publisher
    ..The mitogen-activated protein kinase p38? has been implicated in the regulation of these processes but its influence in adult muscle remains unknown...
  9. Wu Z, Xiong Y, Gajanayake T, Ming X, Yang Z. p38 Mitogen-activated protein kinase is required for glucosamine-induced endothelial nitric oxide synthase uncoupling and plasminogen-activator inhibitor expression. Circ J. 2012;76:2015-22 pubmed
    ..p38 mitogen-activated protein kinase (p38mapk) has been shown to be involved in HBP-mediated biological processes...

More Information

Publications86

  1. Ewen K, Jackson A, Wilhelm D, Koopman P. A male-specific role for p38 mitogen-activated protein kinase in germ cell sex differentiation in mice. Biol Reprod. 2010;83:1005-14 pubmed publisher
    ..We report that p38 MAPK is phosphorylated and therefore activated only in XY germ cells around the time of sex differentiation...
  2. Bachstetter A, Xing B, de Almeida L, Dimayuga E, Watterson D, Van Eldik L. Microglial p38? MAPK is a key regulator of proinflammatory cytokine up-regulation induced by toll-like receptor (TLR) ligands or beta-amyloid (A?). J Neuroinflammation. 2011;8:79 pubmed publisher
    ..The serine/threonine protein kinase p38? MAPK is a key enzyme in the parallel and convergent intracellular signaling pathways involved in stressor-induced ..
  3. Staples C, Owens D, Maier J, Cato A, Keyse S. Cross-talk between the p38alpha and JNK MAPK pathways mediated by MAP kinase phosphatase-1 determines cellular sensitivity to UV radiation. J Biol Chem. 2010;285:25928-40 pubmed publisher
    ..The induction of DUSP1/MKP-1 mRNA and protein in response to UV radiation is mediated by activation of the p38alpha but not the JNK1 or JNK2 MAPK pathways...
  4. Li F, Zhang M, Hussain F, Triantaphyllopoulos K, Clark A, Bhavsar P, et al. Inhibition of p38 MAPK-dependent bronchial contraction after ozone by corticosteroids. Eur Respir J. 2011;37:933-42 pubmed publisher
    ..contractile responses of bronchial rings to acetylcholine (ACh) were measured using a myograph in the presence of p38 MAPK inhibitor, SB239063 (10⁻⁶ M) or dexamethasone (10⁻⁶ M)...
  5. Thouverey C, Caverzasio J. The p38? MAPK positively regulates osteoblast function and postnatal bone acquisition. Cell Mol Life Sci. 2012;69:3115-25 pubmed publisher
    ..Abnormalities in either osteoclast or osteoblast functions lead to bone disorders. The p38 MAPK pathway has been shown to be essential in controlling osteoblast differentiation and skeletogenesis...
  6. Jang J, Kim H, Kim Y, Choi Y, Kim B, Shin H, et al. Aqueous fraction from Cuscuta japonica seed suppresses melanin synthesis through inhibition of the p38 mitogen-activated protein kinase signaling pathway in B16F10 cells. J Ethnopharmacol. 2012;141:338-44 pubmed publisher
    ..The present study aimed to investigate the inhibitory effect of Cuscuta japonica Choisy seeds on alpha-melanocyte-stimulating hormone (?-MSH)-induced melanogenesis...
  7. Bachstetter A, Rowe R, Kaneko M, Goulding D, Lifshitz J, Van Eldik L. The p38? MAPK regulates microglial responsiveness to diffuse traumatic brain injury. J Neurosci. 2013;33:6143-53 pubmed publisher
    ..We recently demonstrated, using in vitro models, that p38? MAPK signaling in microglia is a key event in promoting cytokine production in response to diverse disease-..
  8. Warr N, Bogani D, Siggers P, Brixey R, Tateossian H, Dopplapudi A, et al. Minor abnormalities of testis development in mice lacking the gene encoding the MAPK signalling component, MAP3K1. PLoS ONE. 2011;6:e19572 pubmed publisher
    ..Based on these observations, we conclude that MAP3K1 is not required for mouse testis determination. We discuss the significance of these data for the functional interpretation of sex-reversing MAP3K1 mutations in humans. ..
  9. Huang G, Wang Y, Vogel P, Kanneganti T, Otsu K, Chi H. Signaling via the kinase p38? programs dendritic cells to drive TH17 differentiation and autoimmune inflammation. Nat Immunol. 2012;13:152-61 pubmed publisher
    ..We report here that the mitogen-activated protein kinase p38? programmed DCs to drive the differentiation of the T(H)17 subset of helper T cells...
  10. Xing B, Bachstetter A, Van Eldik L. Microglial p38? MAPK is critical for LPS-induced neuron degeneration, through a mechanism involving TNF?. Mol Neurodegener. 2011;6:84 pubmed publisher
    The p38? MAPK isoform is a well-established therapeutic target in peripheral inflammatory diseases, but the importance of this kinase in pathological microglial activation and detrimental inflammation in CNS disorders is less well ..
  11. Bordicchia M, Liu D, Amri E, Ailhaud G, Dessì Fulgheri P, Zhang C, et al. Cardiac natriuretic peptides act via p38 MAPK to induce the brown fat thermogenic program in mouse and human adipocytes. J Clin Invest. 2012;122:1022-36 pubmed publisher
    ..concentrations, ANP and ?-AR agonists additively enhanced expression of brown fat and mitochondrial markers in a p38 MAPK-dependent manner...
  12. Namiki K, Matsunaga H, Yoshioka K, Tanaka K, Murata K, Ishida J, et al. Mechanism for p38?-mediated experimental autoimmune encephalomyelitis. J Biol Chem. 2012;287:24228-38 pubmed publisher
    One of the mitogen-activated protein kinases, p38, has been found to play a crucial role in various inflammatory responses...
  13. Warr N, Carré G, Siggers P, Faleato J, Brixey R, Pope M, et al. Gadd45? and Map3k4 interactions regulate mouse testis determination via p38 MAPK-mediated control of Sry expression. Dev Cell. 2012;23:1020-31 pubmed publisher
    ..Sex reversal in both mutants is associated with reduced phosphorylation of p38 MAPK and GATA4. In addition, embryos lacking both p38? and p38? also exhibit XY gonadal sex reversal...
  14. Ferreiro I, Barragan M, Gubern A, Ballestar E, Joaquin M, Posas F. The p38 SAPK is recruited to chromatin via its interaction with transcription factors. J Biol Chem. 2010;285:31819-28 pubmed publisher
    In mammals, the stress-activated protein kinase (SAPK) p38 coordinates a rapid and complex transcriptional program to adapt to sudden changes in the extracellular environment...
  15. Barry A, Boucherit N, Mottola G, Vadovic P, Trouplin V, Soubeyran P, et al. Impaired stimulation of p38?-MAPK/Vps41-HOPS by LPS from pathogenic Coxiella burnetii prevents trafficking to microbicidal phagolysosomes. Cell Host Microbe. 2012;12:751-63 pubmed publisher
    ..We find that while avirulent C. burnetii LPS (avLPS) stimulates host p38?-MAPK signaling required for proper trafficking of bacteria containing compartments to lysosomes for destruction, ..
  16. Jirmanova L, Giardino Torchia M, Sarma N, Mittelstadt P, Ashwell J. Lack of the T cell-specific alternative p38 activation pathway reduces autoimmunity and inflammation. Blood. 2011;118:3280-9 pubmed publisher
    Stimulation via the T-cell receptor (TCR) activates p38? and p38? by phosphorylation of p38 Tyr-323 (p38(Y323)). Here we characterize knockin mice in which p38? and/or ? Tyr-323 has been replaced with Phe...
  17. Gutierrez Uzquiza A, Arechederra M, Bragado P, Aguirre Ghiso J, Porras A. p38? mediates cell survival in response to oxidative stress via induction of antioxidant genes: effect on the p70S6K pathway. J Biol Chem. 2012;287:2632-42 pubmed publisher
    We reveal a novel pro-survival role for mammalian p38? in response to H(2)O(2), which involves an up-regulation of antioxidant defenses...
  18. Jones N, Tyner K, Nibarger L, Stanley H, Cornelison D, Fedorov Y, et al. The p38alpha/beta MAPK functions as a molecular switch to activate the quiescent satellite cell. J Cell Biol. 2005;169:105-16 pubmed
    ..Here, we report that the p38alpha/beta family of mitogen-activated protein kinases (MAPKs) reversibly regulates the quiescent state of the skeletal ..
  19. Ota A, Zhang J, Ping P, Han J, Wang Y. Specific regulation of noncanonical p38alpha activation by Hsp90-Cdc37 chaperone complex in cardiomyocyte. Circ Res. 2010;106:1404-12 pubmed publisher
    ..proteomic and biochemical tools, we established that heat shock protein (Hsp)90-Cdc37 chaperones are part of the p38alpha signaling complex in mammalian cells both in vitro and in vivo...
  20. Park J, Greten F, Li Z, Karin M. Macrophage apoptosis by anthrax lethal factor through p38 MAP kinase inhibition. Science. 2002;297:2048-51 pubmed
    ..This dismantling of the p38 MAPK module represents a strategy used by B. anthracis to paralyze host innate immunity.
  21. Lee N, Wong C, Chan P, Lun S, Lui G, Wong B, et al. Hypercytokinemia and hyperactivation of phospho-p38 mitogen-activated protein kinase in severe human influenza A virus infection. Clin Infect Dis. 2007;45:723-31 pubmed
    ..Intracellular signaling molecules regulating lymphocyte activation, phospho-p38 mitogen-activated protein kinase and phospho-extracellular signal-regulated protein kinase in CD4+ and CD8+ T ..
  22. Zuluaga S, Alvarez Barrientos A, Gutierrez Uzquiza A, Benito M, Nebreda A, Porras A. Negative regulation of Akt activity by p38alpha MAP kinase in cardiomyocytes involves membrane localization of PP2A through interaction with caveolin-1. Cell Signal. 2007;19:62-74 pubmed
    Cardiomyocyte-derived cell lines deficient in p38alpha are more resistant to apoptosis owing to lower expression of the pro-apoptotic proteins Bax and Fas and upregulation of the ERK survival pathway...
  23. Wang Z, Harkins P, Ulevitch R, Han J, Cobb M, Goldsmith E. The structure of mitogen-activated protein kinase p38 at 2.1-A resolution. Proc Natl Acad Sci U S A. 1997;94:2327-32 pubmed
    The structure of mitogen-activated protein (MAP) kinase p38 has been solved at 2.1-A to an R factor of 21.0%, making p38 the second low activity MAP kinase solved to date...
  24. Mudgett J, Ding J, Guh Siesel L, Chartrain N, Yang L, Gopal S, et al. Essential role for p38alpha mitogen-activated protein kinase in placental angiogenesis. Proc Natl Acad Sci U S A. 2000;97:10454-9 pubmed
    ..mediates signaling in response to environmental stresses and inflammatory cytokines, but the requirements for the p38 MAPK pathway in normal mammalian development have not been elucidated...
  25. Allen M, Svensson L, Roach M, Hambor J, McNeish J, Gabel C. Deficiency of the stress kinase p38alpha results in embryonic lethality: characterization of the kinase dependence of stress responses of enzyme-deficient embryonic stem cells. J Exp Med. 2000;191:859-70 pubmed
    ..A genetic approach was employed to inactivate the gene encoding one p38 isoform, p38alpha. Mice null for the p38alpha allele die during embryonic development...
  26. Hu Y, Chan E, Wang S, Li B. Activation of p38 mitogen-activated protein kinase is required for osteoblast differentiation. Endocrinology. 2003;144:2068-74 pubmed
    b>p38 MAPK is a conserved subfamily of MAPKs involved in inflammatory response, stress response, cell growth and survival, as well as differentiation of a variety of cell types...
  27. Ulsamer A, Ortuño M, Ruiz S, Susperregui A, Osses N, Rosa J, et al. BMP-2 induces Osterix expression through up-regulation of Dlx5 and its phosphorylation by p38. J Biol Chem. 2008;283:3816-26 pubmed
    ..Furthermore, we show that Dlx5 is a novel substrate for p38 MAPK in vitro and in vivo and that Ser-34 and Ser-217 are the sites phosphorylated by p38...
  28. Hui L, Bakiri L, Mairhorfer A, Schweifer N, Haslinger C, Kenner L, et al. p38alpha suppresses normal and cancer cell proliferation by antagonizing the JNK-c-Jun pathway. Nat Genet. 2007;39:741-9 pubmed
    The mitogen-activated protein kinase (MAPK) p38alpha controls inflammatory responses and cell proliferation...
  29. Fong B, Watson P, Watson A. Mouse preimplantation embryo responses to culture medium osmolarity include increased expression of CCM2 and p38 MAPK activation. BMC Dev Biol. 2007;7:2 pubmed
    ..Recently, a novel scaffolding protein called Osmosensing Scaffold for MEKK3 (OSM) was linked to p38 MAPK activation in response to sorbitol-induced hypertonicity...
  30. Kang Y, Chen J, Otsuka M, Mols J, Ren S, Wang Y, et al. Macrophage deletion of p38alpha partially impairs lipopolysaccharide-induced cellular activation. J Immunol. 2008;180:5075-82 pubmed
    The activation of p38alpha, a MAPK family member, is associated with macrophage activation by microbial pattern molecules, such as LPS...
  31. Nakagawa H, Maeda S, Hikiba Y, Ohmae T, Shibata W, Yanai A, et al. Deletion of apoptosis signal-regulating kinase 1 attenuates acetaminophen-induced liver injury by inhibiting c-Jun N-terminal kinase activation. Gastroenterology. 2008;135:1311-21 pubmed publisher
    ..Although the prolonged activation of p38 also was attenuated in ASK1(-/-) mice, the p38 signaling pathway was not likely to be involved in APAP-induced ..
  32. Böhm C, Hayer S, Kilian A, Zaiss M, Finger S, Hess A, et al. The alpha-isoform of p38 MAPK specifically regulates arthritic bone loss. J Immunol. 2009;183:5938-47 pubmed publisher
    Pharmacological inhibitors have provided evidence for the key role of p38 MAPK in osteoclast differentiation and in inflammation-induced bone loss...
  33. Hu J, Chen T, Zhuang Z, Kong L, Yu M, Liu Y, et al. Feedback control of MKP-1 expression by p38. Cell Signal. 2007;19:393-400 pubmed
    ..Thus, p38 MAPK plays a critical role in mediating expression of MKP-1 at a post-transcriptional level...
  34. Hsieh C, Papaconstantinou J. The effect of aging on p38 signaling pathway activity in the mouse liver and in response to ROS generated by 3-nitropropionic acid. Mech Ageing Dev. 2002;123:1423-35 pubmed
    ..aging affects the response of the p38 alpha signaling pathway to 3-NPA...
  35. Kim C, Sano Y, Todorova K, Carlson B, Arpa L, Celada A, et al. The kinase p38 alpha serves cell type-specific inflammatory functions in skin injury and coordinates pro- and anti-inflammatory gene expression. Nat Immunol. 2008;9:1019-27 pubmed publisher
    ..Among the many p38 isoforms, p38 alpha is the most widely expressed in adult tissues and can be targeted by various pharmacological inhibitors...
  36. Kelkar N, Standen C, Davis R. Role of the JIP4 scaffold protein in the regulation of mitogen-activated protein kinase signaling pathways. Mol Cell Biol. 2005;25:2733-43 pubmed
    ..Specifically, JIP4 does not activate JNK signaling. In contrast, JIP4 serves as an activator of the p38 mitogen-activated protein (MAP) kinase pathway by a mechanism that requires the MAP kinase kinases MKK3 and MKK6...
  37. Thiefes A, Wolter S, Mushinski J, Hoffmann E, Dittrich Breiholz O, Graue N, et al. Simultaneous blockade of NFkappaB, JNK, and p38 MAPK by a kinase-inactive mutant of the protein kinase TAK1 sensitizes cells to apoptosis and affects a distinct spectrum of tumor necrosis factor [corrected] target genes. J Biol Chem. 2005;280:27728-41 pubmed
    ..Expression of this protein inhibited tumor necrosis factor (TNF)-induced activation of NFkappaB, JNK, and p38 MAPK and sensitized the cells to TNF-induced apoptosis...
  38. O Keefe S, Mudgett J, Cupo S, Parsons J, Chartrain N, Fitzgerald C, et al. Chemical genetics define the roles of p38alpha and p38beta in acute and chronic inflammation. J Biol Chem. 2007;282:34663-71 pubmed
    ..Defining the roles of the various p38 family members, specifically p38alpha and p38beta, in these processes has been difficult...
  39. Lluis F, Ballestar E, Suelves M, Esteller M, Munoz Canoves P. E47 phosphorylation by p38 MAPK promotes MyoD/E47 association and muscle-specific gene transcription. EMBO J. 2005;24:974-84 pubmed
    ..Here we show that p38 MAPK, whose activity is essential for myogenesis, regulates MyoD/E47 heterodimerization...
  40. Karunakaran S, Saeed U, Mishra M, Valli R, Joshi S, Meka D, et al. Selective activation of p38 mitogen-activated protein kinase in dopaminergic neurons of substantia nigra leads to nuclear translocation of p53 in 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-treated mice. J Neurosci. 2008;28:12500-9 pubmed publisher
    ..We now demonstrate the selective phosphorylation of p38 MAP kinase within the dopaminergic neurons, whereas JNK activation occurs predominantly in the microglia...
  41. Matsuyama M, Mizusaki H, Shimono A, Mukai T, Okumura K, Abe K, et al. A novel isoform of Vinexin, Vinexin gamma, regulates Sox9 gene expression through activation of MAPK cascade in mouse fetal gonad. Genes Cells. 2005;10:421-34 pubmed
    ..Thus, Vinexin gamma seems to be implicated in regulation of Sox9 gene expression by modulating MAPK cascade in mouse fetal gonads. ..
  42. Salvador J, Mittelstadt P, Guszczynski T, Copeland T, Yamaguchi H, Appella E, et al. Alternative p38 activation pathway mediated by T cell receptor-proximal tyrosine kinases. Nat Immunol. 2005;6:390-5 pubmed
    ..Here we show that T cells stimulated through the T cell receptor (TCR) used an alternative mechanism in which p38 was phosphorylated on Tyr323 and subsequently autophosphorylated residues Thr180 and Tyr182...
  43. De Angelis L, Zhao J, Andreucci J, Olson E, Cossu G, McDermott J. Regulation of vertebrate myotome development by the p38 MAP kinase-MEF2 signaling pathway. Dev Biol. 2005;283:171-9 pubmed
    ..Here, we report a critical interaction between the p38 mitogen-activated protein kinase (p38 MAPK) and MEF2 in the developing somite myotome...
  44. White A, Pargellis C, Studts J, Werneburg B, Farmer B. Molecular basis of MAPK-activated protein kinase 2:p38 assembly. Proc Natl Acad Sci U S A. 2007;104:6353-8 pubmed
    b>p38 MAPK and MAPK-activated protein kinase 2 (MK2) are key components of signaling pathways leading to many cellular responses, notably the proinflammatory cytokine production...
  45. Derijard B, Raingeaud J, Barrett T, Wu I, Han J, Ulevitch R, et al. Independent human MAP-kinase signal transduction pathways defined by MEK and MKK isoforms. Science. 1995;267:682-5 pubmed
    ..MAP) kinases include extracellular signal-regulated protein kinase (ERK), c-Jun amino-terminal kinase (JNK), and p38 subgroups. These MAP kinase isoforms are activated by dual phosphorylation on threonine and tyrosine...
  46. Berenson L, Yang J, Sleckman B, Murphy T, Murphy K. Selective requirement of p38alpha MAPK in cytokine-dependent, but not antigen receptor-dependent, Th1 responses. J Immunol. 2006;176:4616-21 pubmed
    The role of the p38 MAPK pathway in Th1 development has been controversial, because indirect manipulations of either upstream p38 activators or modifiers of p38 activity have had variable effects on IFN-gamma production in CD4+ T cells...
  47. Bulavin D, Phillips C, Nannenga B, Timofeev O, Donehower L, Anderson C, et al. Inactivation of the Wip1 phosphatase inhibits mammary tumorigenesis through p38 MAPK-mediated activation of the p16(Ink4a)-p19(Arf) pathway. Nat Genet. 2004;36:343-50 pubmed
    ..encoding Wip1 phosphatase activated the p53 and p16 (also called Ink4a)-p19 (also called ARF) pathways through p38 MAPK signaling and suppressed in vitro transformation of mouse embryo fibroblasts (MEFs) by oncogenes...
  48. Natale D, Paliga A, Beier F, D Souza S, Watson A. p38 MAPK signaling during murine preimplantation development. Dev Biol. 2004;268:76-88 pubmed
    ..b>p38 MAPK, p38-regulated or -activated kinase (PRAK; MK5), map kinase-activated protein kinase 2 (MK2), and heat shock ..
  49. Schmeck B, Zahlten J, Moog K, van Laak V, Huber S, Hocke A, et al. Streptococcus pneumoniae-induced p38 MAPK-dependent phosphorylation of RelA at the interleukin-8 promotor. J Biol Chem. 2004;279:53241-7 pubmed
    ..Inhibition of p38 MAPK by chemical inhibitors or by RNA interference targeting p38alpha reduces pneumococci-induced NF-kappaB-dependent gene transcription...
  50. Obata K, Yamanaka H, Kobayashi K, Dai Y, Mizushima T, Katsura H, et al. Role of mitogen-activated protein kinase activation in injured and intact primary afferent neurons for mechanical and heat hypersensitivity after spinal nerve ligation. J Neurosci. 2004;24:10211-22 pubmed
    ..partial nerve injury, we examined the phosphorylation of extracellular signal-regulated protein kinase (ERK), p38 MAPK, and c-Jun N-terminal kinase (JNK) in the L4 and L5 dorsal root ganglion (DRG) in the L5 spinal nerve ligation (..
  51. Zhang X, Mernaugh G, Yang D, Gewin L, Srichai M, Harris R, et al. beta1 integrin is necessary for ureteric bud branching morphogenesis and maintenance of collecting duct structural integrity. Development. 2009;136:3357-66 pubmed publisher
    ..Thus beta1 integrins can regulate organ branching morphogenesis during development by mediating growth-factor-dependent signaling in addition to their well-defined role as adhesion receptors. ..
  52. Blanco Aparicio C, Torres J, Pulido R. A novel regulatory mechanism of MAP kinases activation and nuclear translocation mediated by PKA and the PTP-SL tyrosine phosphatase. J Cell Biol. 1999;147:1129-36 pubmed
    ..binding and tyrosine dephosphorylation of the MAP kinases extracellular signal-regulated kinase (ERK)1/2 and p38alpha were impaired...
  53. Hu M, Wang Y, Mikhail A, Qiu W, Tan T. Murine p38-delta mitogen-activated protein kinase, a developmentally regulated protein kinase that is activated by stress and proinflammatory cytokines. J Biol Chem. 1999;274:7095-102 pubmed
    The p38 mitogen-activated protein kinases (MAPK) play a crucial role in stress and inflammatory responses and are also involved in activation of the human immunodeficiency virus gene expression...
  54. Otsu K, Yamashita N, Nishida K, Hirotani S, Yamaguchi O, Watanabe T, et al. Disruption of a single copy of the p38alpha MAP kinase gene leads to cardioprotection against ischemia-reperfusion. Biochem Biophys Res Commun. 2003;302:56-60 pubmed
    ..We examined the role of p38alpha in ischemia-reperfusion injury by studying p38alpha(+/-) mice...
  55. Zakkar M, Chaudhury H, Sandvik G, Enesa K, Luong L, Cuhlmann S, et al. Increased endothelial mitogen-activated protein kinase phosphatase-1 expression suppresses proinflammatory activation at sites that are resistant to atherosclerosis. Circ Res. 2008;103:726-32 pubmed publisher
    ..induce adhesion molecules (eg, vascular cell adhesion molecule [VCAM]-1) in endothelial cells (ECs) by activating p38 and c-Jun N-terminal kinase (JNK) mitogen-activated protein (MAP) kinases by phosphorylation...
  56. Heinrichsdorff J, Luedde T, Perdiguero E, Nebreda A, Pasparakis M. p38 alpha MAPK inhibits JNK activation and collaborates with IkappaB kinase 2 to prevent endotoxin-induced liver failure. EMBO Rep. 2008;9:1048-54 pubmed publisher
    ..Here, we show that hepatocyte-specific ablation of p38alpha in mice results in excessive activation of JNK in the liver after in vivo challenge with bacterial ..
  57. Wu H, Wang X, Liu S, Wu Y, Zhao T, Chen X, et al. Sema4C participates in myogenic differentiation in vivo and in vitro through the p38 MAPK pathway. Eur J Cell Biol. 2007;86:331-44 pubmed
    ..Taken together, these observations reveal novel functional potentialities of Sema4C which suggest that Sema4C promotes terminal myogenic differentiation in a p38 MAPK-dependent manner.
  58. Xu M, Bruchas M, Ippolito D, Gendron L, Chavkin C. Sciatic nerve ligation-induced proliferation of spinal cord astrocytes is mediated by kappa opioid activation of p38 mitogen-activated protein kinase. J Neurosci. 2007;27:2570-81 pubmed
    ..by mitogen-activated protein kinase (MAPK) activation by KOR because (1) U50,488 treatment increased phospho-p38 MAPK-immunoreactivity 247 +/- 44% over untreated cells, (2) the increase in phospho-p38 induced by U50,488 was blocked ..
  59. Kaiser R, Bueno O, Lips D, Doevendans P, Jones F, Kimball T, et al. Targeted inhibition of p38 mitogen-activated protein kinase antagonizes cardiac injury and cell death following ischemia-reperfusion in vivo. J Biol Chem. 2004;279:15524-30 pubmed
    ..p38 vectors reduced apoptosis induced by 2-deoxyglucose treatment, whereas overexpression of wild-type p38alpha or an activated mitogen-activated protein kinase kinase (MKK)6 mutant each enhanced cell death...
  60. O RIORDAN M, Yi C, Gonzales R, Lee K, Portnoy D. Innate recognition of bacteria by a macrophage cytosolic surveillance pathway. Proc Natl Acad Sci U S A. 2002;99:13861-6 pubmed
    ..signaling is associated with translocation of NF-kappaB into the nucleus and phosphorylation of the p38 mitogen-activated protein (MAP) kinase...
  61. Cuadrado A, Corrado N, Perdiguero E, Lafarga V, Munoz Canoves P, Nebreda A. Essential role of p18Hamlet/SRCAP-mediated histone H2A.Z chromatin incorporation in muscle differentiation. EMBO J. 2010;29:2014-25 pubmed publisher
    ..We show that the SRCAP subunit named ZNHIT1 or p18(Hamlet), which is a substrate of p38 MAPK, is recruited to the myogenin promoter at the onset of muscle differentiation, in a p38 MAPK-dependent manner...
  62. Zohn I, Li Y, Skolnik E, Anderson K, Han J, Niswander L. p38 and a p38-interacting protein are critical for downregulation of E-cadherin during mouse gastrulation. Cell. 2006;125:957-69 pubmed
    ..We demonstrate that p38 MAP kinase and a p38-interacting protein (p38IP) are critically required for downregulation of E-cadherin during ..
  63. Kang Y, Seit Nebi A, Davis R, Han J. Multiple activation mechanisms of p38alpha mitogen-activated protein kinase. J Biol Chem. 2006;281:26225-34 pubmed
    The p38alpha MAPK participates in a variety of biological processes...
  64. Akimoto T, Pohnert S, Li P, Zhang M, Gumbs C, Rosenberg P, et al. Exercise stimulates Pgc-1alpha transcription in skeletal muscle through activation of the p38 MAPK pathway. J Biol Chem. 2005;280:19587-93 pubmed
    ..transient increase of Pgc-1alpha mRNA expression in mouse plantaris muscle, concurrent with an activation of the p38 MAPK pathway...
  65. Maekawa M, Yamamoto T, Tanoue T, Yuasa Y, Chisaka O, Nishida E. Requirement of the MAP kinase signaling pathways for mouse preimplantation development. Development. 2005;132:1773-83 pubmed
    ..Our results show that inhibition of the JNK pathway or of the p38 MAP kinase pathway, but not of the ERK pathway, results in inhibition of cavity formation, and that JNK and p38 are ..
  66. Tseng Y, Kriauciunas K, Kokkotou E, Kahn C. Differential roles of insulin receptor substrates in brown adipocyte differentiation. Mol Cell Biol. 2004;24:1918-29 pubmed
    ..Although IRS-4 is not essential for the process, overexpression of IRS-4 can compensate for the deficiency in differentiation in IRS-1 KO cells. ..
  67. Lee C, Onesime D, Reddy C, Dhanasekaran N, Reddy E. JLP: A scaffolding protein that tethers JNK/p38MAPK signaling modules and transcription factors. Proc Natl Acad Sci U S A. 2002;99:14189-94 pubmed
    ..acts as a scaffolding protein to bring together Max and c-Myc along with JNK (c-Jun NH2-terminal kinase) and p38MAPK, as well as their upstream kinases MKK4 (MAPK kinase 4) and MEKK3 (MAPK kinase kinase 3)...
  68. Avni D, Ernst O, Philosoph A, Zor T. Role of CREB in modulation of TNFalpha and IL-10 expression in LPS-stimulated RAW264.7 macrophages. Mol Immunol. 2010;47:1396-403 pubmed publisher
    ..Furthermore, inhibitors of p38 and MSK1, but not PKA, completely blocked the production of IL-10 and TNFalpha in LPS-stimulated macrophages...
  69. Wong E, Le Guezennec X, Demidov O, Marshall N, Wang S, Krishnamurthy J, et al. p38MAPK controls expression of multiple cell cycle inhibitors and islet proliferation with advancing age. Dev Cell. 2009;17:142-9 pubmed publisher
    ..Little is known, however, about the upstream signals that induce their expression. Here, we explore the role of p38MAPK by generating a dominant-negative allele (p38(AF)) in which activating phosphorylation sites Thr180 and Tyr182 ..
  70. Li Y, Chen Y, John J, Moylan J, Jin B, Mann D, et al. TNF-alpha acts via p38 MAPK to stimulate expression of the ubiquitin ligase atrogin1/MAFbx in skeletal muscle. FASEB J. 2005;19:362-70 pubmed
    ..to either TNF-alpha or H2O2 also produced general activation of the mitogen-activated protein kinases (MAPKs): p38, ERK1/2, and JNK...
  71. Zhang Y, Mei Z, Wu J, Wang Z. Enzymatic activity and substrate specificity of mitogen-activated protein kinase p38alpha in different phosphorylation states. J Biol Chem. 2008;283:26591-601 pubmed publisher
    ..In this study, we have prepared MAP kinase p38alpha, a member of the MAP kinase family, in all phosphorylated forms and characterized their biochemical properties...
  72. Jacquet S, Nishino Y, Kumphune S, Sicard P, Clark J, Kobayashi K, et al. The role of RIP2 in p38 MAPK activation in the stressed heart. J Biol Chem. 2008;283:11964-71 pubmed publisher
    The activation of p38 MAPK by dual phosphorylation aggravates myocardial ischemic injury and depresses cardiac contractile function...
  73. Wada T, Stepniak E, Hui L, Leibbrandt A, Katada T, Nishina H, et al. Antagonistic control of cell fates by JNK and p38-MAPK signaling. Cell Death Differ. 2008;15:89-93 pubmed
    ..Two independent stress kinase signaling pathways, p38-MAPK, and JNKs, have evolved that relay developmental and environmental cues to determine cell responses...
  74. Wang X, Goh C, Li B. p38 mitogen-activated protein kinase regulates osteoblast differentiation through osterix. Endocrinology. 2007;148:1629-37 pubmed
    b>p38 MAPK has been shown to regulate osteoblast differentiation. Inhibition of this kinase with inhibitors or dominant-negative mutant impedes osteoblast differentiation...
  75. Briata P, Forcales S, Ponassi M, Corte G, Chen C, Karin M, et al. p38-dependent phosphorylation of the mRNA decay-promoting factor KSRP controls the stability of select myogenic transcripts. Mol Cell. 2005;20:891-903 pubmed
    ..Here, we demonstrate that p38 alpha and beta isoforms also control muscle-gene expression posttranscriptionally, by stabilizing critical myogenic ..
  76. Nick J, Young S, Arndt P, Lieber J, Suratt B, Poch K, et al. Selective suppression of neutrophil accumulation in ongoing pulmonary inflammation by systemic inhibition of p38 mitogen-activated protein kinase. J Immunol. 2002;169:5260-9 pubmed
    ..Inhibition of p38 MAPK before exposing a cell to stress stimuli has profound anti-inflammatory effects, but little is known about the ..
  77. Bikkavilli R, Feigin M, Malbon C. p38 mitogen-activated protein kinase regulates canonical Wnt-beta-catenin signaling by inactivation of GSK3beta. J Cell Sci. 2008;121:3598-607 pubmed publisher
    ..with the canonical Wnt-beta-catenin signaling pathway in response to Wnt3a, we observed a strong activation of p38 MAPK in mouse F9 teratocarcinoma cells...