Map6

Summary

Gene Symbol: Map6
Description: microtubule-associated protein 6
Alias: 2810411E12Rik, Map-6, Mtap6, STOP, microtubule-associated protein 6, stable tubule-only polypeptide
Species: mouse
Products:     Map6

Top Publications

  1. Fradley R, O Meara G, Newman R, Andrieux A, Job D, Reynolds D. STOP knockout and NMDA NR1 hypomorphic mice exhibit deficits in sensorimotor gating. Behav Brain Res. 2005;163:257-64 pubmed
    ..Both the stable tubule-only polypeptide (STOP) protein and the N-methyl-D-aspartate (NMDA) NR1 subunit are involved in neuronal development and physiology...
  2. Denarier E, Aguezzoul M, Jolly C, Vourc h C, Roure A, Andrieux A, et al. Genomic structure and chromosomal mapping of the mouse STOP gene (Mtap6). Biochem Biophys Res Commun. 1998;243:791-6 pubmed
    The microtubule associated protein STOP (Stable Tubule Only Polypeptide) is a calmodulin-regulated protein able to induce a high degree of microtubule stability...
  3. Aguezzoul M, Andrieux A, Denarier E. Overlap of promoter and coding sequences in the mouse STOP gene (Mtap6). Genomics. 2003;81:623-7 pubmed
    ..The STOP gene (Mtap6) is composed of 4 exons and presents different developmental and tissue specific alternative transcripts resulting ..
  4. Bosc C, Andrieux A, Job D. STOP proteins. Biochemistry. 2003;42:12125-32 pubmed
    ..b>STOP microtubule stabilizing activity has been ascribed to two classes of new bifunctional calmodulin- and microtubule-..
  5. Couegnas A, Schweitzer A, Andrieux A, Ghandour M, Boehm N. Expression pattern of STOP lacZ reporter gene in adult and developing mouse brain. J Neurosci Res. 2007;85:1515-27 pubmed
    Stable tubulin-only polypeptide (STOP) proteins are microtubule-associated proteins responsible for microtubule stabilization in neurons...
  6. Gory Fauré S, Windscheid V, Bosc C, Peris L, Proietto D, Franck R, et al. STOP-like protein 21 is a novel member of the STOP family, revealing a Golgi localization of STOP proteins. J Biol Chem. 2006;281:28387-96 pubmed
    Neuronal microtubules are stabilized by two calmodulin-regulated microtubule-associated proteins, E-STOP and N-STOP, which when suppressed in mice induce severe synaptic and behavioral deficits...
  7. Bouvrais Veret C, Weiss S, Hanoun N, Andrieux A, Schweitzer A, Job D, et al. Microtubule-associated STOP protein deletion triggers restricted changes in dopaminergic neurotransmission. J Neurochem. 2008;104:745-56 pubmed publisher
    The microtubule-associated stable tubule only polypeptide (STOP) protein plays a key-role in neuron architecture and synaptic plasticity...
  8. Powell K, Hori S, Leslie R, Andrieux A, Schellinck H, Thorne M, et al. Cognitive impairments in the STOP null mouse model of schizophrenia. Behav Neurosci. 2007;121:826-35 pubmed
    ..Adult mice that lack the stable tubule-only polypeptide (STOP) have neurochemical and behavioral abnormalities that model some features of schizophrenia...
  9. Bégou M, Brun P, Bertrand J, Job D, Schweitzer A, D Amato T, et al. Post-pubertal emergence of alterations in locomotor activity in stop null mice. Synapse. 2007;61:689-97 pubmed
    ..Here, we have looked for evidence of a prodromal phase in juvenile STOP null mice, which, during adulthood, imitate features of schizophrenia...

More Information

Publications31

  1. Bouvrais Veret C, Weiss S, Andrieux A, Schweitzer A, McIntosh J, Job D, et al. Sustained increase of alpha7 nicotinic receptors and choline-induced improvement of learning deficit in STOP knock-out mice. Neuropharmacology. 2007;52:1691-700 pubmed
    Mice deficient in the microtubule stabilizing protein STOP (stable tubule only polypeptide) show synaptic plasticity anomalies in hippocampus, dopamine hyper-reactivity in the limbic system and severe behavioral deficits...
  2. Eastwood S, Lyon L, George L, Andrieux A, Job D, Harrison P. Altered expression of synaptic protein mRNAs in STOP (MAP6) mutant mice. J Psychopharmacol. 2007;21:635-44 pubmed
    Stable tubule-only polypeptide (STOP) proteins are a family of microtubule associated proteins (MAPs) important in microtubule stabilization...
  3. Bégou M, Volle J, Bertrand J, Brun P, Job D, Schweitzer A, et al. The stop null mice model for schizophrenia displays [corrected] cognitive and social deficits partly alleviated by neuroleptics. Neuroscience. 2008;157:29-39 pubmed publisher
    ..Previous experiments have demonstrated that a STOP (stable tubule only peptide) gene deletion in mice leads to a phenotype mimicking some aspects of positive symptoms ..
  4. Baratier J, Peris L, Brocard J, Gory Fauré S, Dufour F, Bosc C, et al. Phosphorylation of microtubule-associated protein STOP by calmodulin kinase II. J Biol Chem. 2006;281:19561-9 pubmed
    b>STOP proteins are microtubule-associated, calmodulin-regulated proteins responsible for the high degree of stabilization displayed by neuronal microtubules...
  5. Galiano M, Bosc C, Schweitzer A, Andrieux A, Job D, Hallak M. Astrocytes and oligodendrocytes express different STOP protein isoforms. J Neurosci Res. 2004;78:329-37 pubmed
    ..This stabilization is due mainly to polymer association with STOP proteins...
  6. Fournet V, Jany M, Fabre V, Chali F, Orsal D, Schweitzer A, et al. The deletion of the microtubule-associated STOP protein affects the serotonergic mouse brain network. J Neurochem. 2010;115:1579-94 pubmed publisher
    The deletion of microtubule-associated protein stable tubule only polypeptide (STOP) leads to neuroanatomical, biochemical and severe behavioral alterations in mice, partly alleviated by antipsychotics...
  7. Andrieux A, Salin P, Vernet M, Kujala P, Baratier J, Gory Fauré S, et al. The suppression of brain cold-stable microtubules in mice induces synaptic defects associated with neuroleptic-sensitive behavioral disorders. Genes Dev. 2002;16:2350-64 pubmed
    ..Previous work has indicated an important role of the microtubule-associated protein STOP in the induction of microtubule cold stability. Here, we developed STOP null mice...
  8. Benardais K, Kasem B, Couegnas A, Samama B, Fernandez S, Schaeffer C, et al. Loss of STOP protein impairs peripheral olfactory neurogenesis. PLoS ONE. 2010;5:e12753 pubmed publisher
    b>STOP (Stable Tubulin-Only Polypeptide) null mice show behavioral deficits, impaired synaptic plasticity, decrease in synaptic vesicular pools and disturbances in dopaminergic transmission, and are considered a neurodevelopmental model of ..
  9. Denarier E, Fourest Lieuvin A, Bosc C, Pirollet F, Chapel A, Margolis R, et al. Nonneuronal isoforms of STOP protein are responsible for microtubule cold stability in mammalian fibroblasts. Proc Natl Acad Sci U S A. 1998;95:6055-60 pubmed
    ..We have previously described a neuronal protein, stable tubule-only polypeptide (STOP), that binds to microtubules and induces cold stability...
  10. Brun P, Bégou M, Andrieux A, Mouly Badina L, Clerget M, Schweitzer A, et al. Dopaminergic transmission in STOP null mice. J Neurochem. 2005;94:63-73 pubmed
    ..Here, we have examined the dopaminergic status of STOP (stable tubule only polypeptide) null mice, which lack a microtubule-stabilizing protein and which display neuroleptic-sensitive ..
  11. Bonnet C, Denarier E, Bosc C, Lazereg S, Denoulet P, Larcher J. Interaction of STOP with neuronal tubulin is independent of polyglutamylation. Biochem Biophys Res Commun. 2002;297:787-93 pubmed
    ..We have shown by blot overlay experiments that binding of STOP does not depend on the length of the polyglutamyl chains carried by tubulins...
  12. Volle J, Brocard J, Saoud M, Gory Fauré S, Brunelin J, Andrieux A, et al. Reduced expression of STOP/MAP6 in mice leads to cognitive deficits. Schizophr Bull. 2013;39:969-78 pubmed publisher
    STOP/MAP6 null (KO) mice recapitulate behavioral abnormalities related to positive and negative symptoms and cognitive deficits of schizophrenia...
  13. Hanaya R, Koning E, Ferrandon A, Schweitzer A, Andrieux A, Nehlig A. Deletion of the STOP gene, a microtubule stabilizing factor, leads only to discrete cerebral metabolic changes in mice. J Neurosci Res. 2008;86:813-20 pubmed
    In mice, deletion of the STOP protein leads to subtle anatomic changes and induces depleted synaptic vesicle pools, impaired synaptic plasticity, hyperdopaminergy, and major behavioral disorders alleviated by neuroleptics, hence leading ..
  14. Galiano M, Andrieux A, Deloulme J, Bosc C, Schweitzer A, Job D, et al. Myelin basic protein functions as a microtubule stabilizing protein in differentiated oligodendrocytes. J Neurosci Res. 2006;84:534-41 pubmed
    ..activity for MBP in cells has been difficult because oligodendrocytes contain variants of STOP (stable tubule only polypeptide) proteins, which are responsible for microtubule cold stability in different cell types...
  15. Guerrero K, Monge C, Bruckner A, Puurand U, Kadaja L, Kaambre T, et al. Study of possible interactions of tubulin, microtubular network, and STOP protein with mitochondria in muscle cells. Mol Cell Biochem. 2010;337:239-49 pubmed publisher
    We studied possible connections of tubulin, microtubular system, and microtubular network stabilizing STOP protein with mitochondria in rat and mouse cardiac and skeletal muscles by confocal microscopy and oxygraphy...
  16. Fournet V, Schweitzer A, Chevarin C, Deloulme J, Hamon M, Giros B, et al. The deletion of STOP/MAP6 protein in mice triggers highly altered mood and impaired cognitive performances. J Neurochem. 2012;121:99-114 pubmed publisher
    The microtubule-associated Stable Tubulie Only Polypeptide (STOP; also known as MAP6) protein plays a key role in neuron architecture and synaptic plasticity, the dysfunctions of which are thought to be implicated in the pathophysiology ..
  17. Profitt M, Deurveilher S, Robertson G, Rusak B, Semba K. Disruptions of Sleep/Wake Patterns in the Stable Tubule Only Polypeptide (STOP) Null Mouse Model of Schizophrenia. Schizophr Bull. 2016;42:1207-15 pubmed publisher
    ..Mice deficient in stable tubule only polypeptide (STOP) show cognitive, behavioral, and neurobiological deficits that resemble those seen in patients ..
  18. Tortosa E, Adolfs Y, Fukata M, Pasterkamp R, Kapitein L, Hoogenraad C. Dynamic Palmitoylation Targets MAP6 to the Axon to Promote Microtubule Stabilization during Neuronal Polarization. Neuron. 2017;94:809-825.e7 pubmed publisher
    ..Here, we show specific localization of microtubule-associated protein 6 (MAP6)/stable tubule-only polypeptide (STOP) throughout neuronal maturation and its role in axonal development...
  19. Kajitani K, Thorne M, Samson M, Robertson G. Nitric oxide synthase mediates the ability of darbepoetin alpha to improve the cognitive performance of STOP null mice. Neuropsychopharmacology. 2010;35:1718-28 pubmed publisher
    STOP (stable tubule only polypeptide) null mice display neurochemical and behavioral abnormalities that resemble several well-recognized features of schizophrenia...
  20. Charlet A, Muller A, Laux A, Kemmel V, Schweitzer A, Deloulme J, et al. Abnormal nociception and opiate sensitivity of STOP null mice exhibiting elevated levels of the endogenous alkaloid morphine. Mol Pain. 2010;6:96 pubmed publisher
    Mice deficient for the stable tubule only peptide (STOP) display altered dopaminergic neurotransmission associated with severe behavioural defects including disorganized locomotor activity...
  21. Delphin C, Bouvier D, Seggio M, Couriol E, Saoudi Y, Denarier E, et al. MAP6-F is a temperature sensor that directly binds to and protects microtubules from cold-induced depolymerization. J Biol Chem. 2012;287:35127-38 pubmed publisher
    ..In vivo, microtubules are protected from ice-cold induced depolymerization by the widely expressed MAP6/STOP family of proteins. However, the mechanism by which MAP6 stabilizes microtubules at 4 °C has not been identified...
  22. Deloulme J, Gory Fauré S, Mauconduit F, Chauvet S, Jonckheere J, Boulan B, et al. Microtubule-associated protein 6 mediates neuronal connectivity through Semaphorin 3E-dependent signalling for axonal growth. Nat Commun. 2015;6:7246 pubmed publisher
    ..Here we demonstrate a role for MAP6 in brain wiring that is independent of microtubule binding...