Map3k7

Summary

Gene Symbol: Map3k7
Description: mitogen-activated protein kinase kinase kinase 7
Alias: B430101B05, C87327, Tak1, mitogen-activated protein kinase kinase kinase 7, TGF-beta-activated kinase 1, transforming growth factor-beta-activated kinase 1
Species: mouse
Products:     Map3k7

Top Publications

  1. Takaesu G, Kishida S, Hiyama A, Yamaguchi K, Shibuya H, Irie K, et al. TAB2, a novel adaptor protein, mediates activation of TAK1 MAPKKK by linking TAK1 to TRAF6 in the IL-1 signal transduction pathway. Mol Cell. 2000;5:649-58 pubmed
    The TAK1 MAPKKK mediates activation of JNK and NF-KB in the IL-1-activated signaling pathway. Here we report the identification of TAB2, a novel intermediate in the IL-1 pathway that functionally links TAK1 to TRAF6...
  2. Nikopoulos G, Martins J, Adams T, Karaczyn A, Adams D, Vary C, et al. NRAGE: a potential rheostat during branching morphogenesis. Mech Dev. 2009;126:337-49 pubmed publisher
    ..Our results suggested that in early kidney development NRAGE might have multiple roles during renal branching morphogenesis through association with both the BMP and GDNF signaling pathways. ..
  3. Besse A, Lamothe B, Campos A, Webster W, Maddineni U, Lin S, et al. TAK1-dependent signaling requires functional interaction with TAB2/TAB3. J Biol Chem. 2007;282:3918-28 pubmed
    Transforming growth factor beta-activated kinase 1 (TAK1), a member of the MAPKKK family, was initially described to play an essential role in the transforming growth factor beta-signaling pathway, but recent evidence has emerged ..
  4. Sayama K, Hanakawa Y, Nagai H, Shirakata Y, Dai X, Hirakawa S, et al. Transforming growth factor-beta-activated kinase 1 is essential for differentiation and the prevention of apoptosis in epidermis. J Biol Chem. 2006;281:22013-20 pubmed
    ..To test this, we generated keratinocyte-specific TAK1-deficient mice from Map3k7(flox/flox) mice and K5-Cre mice...
  5. Takaesu G, Inagaki M, Takubo K, Mishina Y, Hess P, Dean G, et al. TAK1 (MAP3K7) signaling regulates hematopoietic stem cells through TNF-dependent and -independent mechanisms. PLoS ONE. 2012;7:e51073 pubmed publisher
    A cytokine/stress signaling kinase Tak1 (Map3k7) deficiency is known to impair hematopoietic progenitor cells. However, the role of TAK1 signaling in the stem cell function of the hematopoietic system is not yet well defined...
  6. Hoffmann A, Preobrazhenska O, Wodarczyk C, Medler Y, Winkel A, Shahab S, et al. Transforming growth factor-beta-activated kinase-1 (TAK1), a MAP3K, interacts with Smad proteins and interferes with osteogenesis in murine mesenchymal progenitors. J Biol Chem. 2005;280:27271-83 pubmed
    b>TAK1 (transforming growth factor-beta-activated kinase-1), a MAP3K with considerable sequence similarity to Raf-1 and MEKK-1, has been identified as a transforming growth factor-beta/bone morphogenetic protein (BMP)-activated cytosolic ..
  7. Xiao Y, Li H, Zhang J, Volk A, Zhang S, Wei W, et al. TNF-?/Fas-RIP-1-induced cell death signaling separates murine hematopoietic stem cells/progenitors into 2 distinct populations. Blood. 2011;118:6057-67 pubmed publisher
    ..progenitor cells (HSPCs) by examining their contributions to the development of bone marrow failure syndromes in Tak1-knockout mice (Tak1(-/-))...
  8. Liu H, Xie M, Schneider M, Chen Z. Essential role of TAK1 in thymocyte development and activation. Proc Natl Acad Sci U S A. 2006;103:11677-82 pubmed
    The protein kinase TAK1 mediates the activation of NF-kappaB in response to stimulation by proinflammatory cytokines and microbial pathogens in the innate immunity pathways...
  9. Broglie P, Matsumoto K, Akira S, Brautigan D, Ninomiya Tsuji J. Transforming growth factor beta-activated kinase 1 (TAK1) kinase adaptor, TAK1-binding protein 2, plays dual roles in TAK1 signaling by recruiting both an activator and an inhibitor of TAK1 kinase in tumor necrosis factor signaling pathway. J Biol Chem. 2010;285:2333-9 pubmed publisher
    Transforming growth factor beta-activated kinase 1 (TAK1) kinase is an indispensable signaling intermediate in tumor necrosis factor (TNF), interleukin 1, and Toll-like receptor signaling pathways...

More Information

Publications74

  1. Di Y, Li S, Wang L, Zhang Y, Dorf M. Homeostatic interactions between MEKK3 and TAK1 involved in NF-kappaB signaling. Cell Signal. 2008;20:705-13 pubmed publisher
    ..of the mitogen-activated protein kinase kinase kinase (MAP3K) family including MEKK3 and TGFbeta-activating kinase (TAK1) play nonredundant roles in activation of the NF-kappaB transcription factor...
  2. Scholz R, Sidler C, Thali R, Winssinger N, Cheung P, Neumann D. Autoactivation of transforming growth factor beta-activated kinase 1 is a sequential bimolecular process. J Biol Chem. 2010;285:25753-66 pubmed publisher
    Transforming growth factor-beta-activated kinase 1 (TAK1), an MAP3K, is a key player in processing a multitude of inflammatory stimuli. TAK1 autoactivation involves the interplay with TAK1-binding proteins (TAB), e.g...
  3. Dai L, Aye Thu C, Liu X, Xi J, Cheung P. TAK1, more than just innate immunity. IUBMB Life. 2012;64:825-34 pubmed publisher
    Transforming growth factor ?-activated kinase 1 (TAK1) is a key regulator of the innate immunity and the proinflammatory signaling pathway...
  4. Omori E, Matsumoto K, Sanjo H, Sato S, Akira S, Smart R, et al. TAK1 is a master regulator of epidermal homeostasis involving skin inflammation and apoptosis. J Biol Chem. 2006;281:19610-7 pubmed
    Transforming growth factor beta-activated kinase 1 (TAK1) functions downstream of inflammatory cytokines to activate c-Jun N-terminal kinase (JNK) as well as NF-kappaB in several cell types...
  5. Thiefes A, Wolter S, Mushinski J, Hoffmann E, Dittrich Breiholz O, Graue N, et al. Simultaneous blockade of NFkappaB, JNK, and p38 MAPK by a kinase-inactive mutant of the protein kinase TAK1 sensitizes cells to apoptosis and affects a distinct spectrum of tumor necrosis factor [corrected] target genes. J Biol Chem. 2005;280:27728-41 pubmed
    ..fibroblasts were infected with retroviruses encoding TAK1K63W, an inactive mutant of the protein kinase TAK1. Expression of this protein inhibited tumor necrosis factor (TNF)-induced activation of NFkappaB, JNK, and p38 MAPK ..
  6. Shi wen X, Parapuram S, Pala D, Chen Y, Carter D, Eastwood M, et al. Requirement of transforming growth factor beta-activated kinase 1 for transforming growth factor beta-induced alpha-smooth muscle actin expression and extracellular matrix contraction in fibroblasts. Arthritis Rheum. 2009;60:234-41 pubmed publisher
    ..The present study was undertaken to assess whether TGFbeta-activated kinase 1 (TAK1) acts downstream of FAK/Src to mediate fibrogenic responses in fibroblasts...
  7. Omori E, Inagaki M, Mishina Y, Matsumoto K, Ninomiya Tsuji J. Epithelial transforming growth factor ?-activated kinase 1 (TAK1) is activated through two independent mechanisms and regulates reactive oxygen species. Proc Natl Acad Sci U S A. 2012;109:3365-70 pubmed publisher
    ..Transforming growth factor ?-activated kinase 1 (TAK1) is a signaling intermediate of innate immune signaling pathways and is critically involved in the redox regulation ..
  8. Fan Y, Yu Y, Shi Y, Sun W, Xie M, Ge N, et al. Lysine 63-linked polyubiquitination of TAK1 at lysine 158 is required for tumor necrosis factor alpha- and interleukin-1beta-induced IKK/NF-kappaB and JNK/AP-1 activation. J Biol Chem. 2010;285:5347-60 pubmed publisher
    Transforming growth factor-beta-activated kinase 1 (TAK1) plays an essential role in the tumor necrosis factor alpha (TNFalpha)- and interleukin-1beta (IL-1beta)-induced IkappaB kinase (IKK)/nuclear factor-kappaB (NF-kappaB) and c-Jun N-..
  9. Inagaki M, Omori E, Kim J, Komatsu Y, Scott G, Ray M, et al. TAK1-binding protein 1, TAB1, mediates osmotic stress-induced TAK1 activation but is dispensable for TAK1-mediated cytokine signaling. J Biol Chem. 2008;283:33080-6 pubmed publisher
    b>TAK1 kinase is an indispensable intermediate in several cytokine signaling pathways including tumor necrosis factor, interleukin-1, and transforming growth factor-beta signaling pathways...
  10. Gao L, Sheu T, Dong Y, Hoak D, Zuscik M, Schwarz E, et al. TAK1 regulates SOX9 expression in chondrocytes and is essential for postnatal development of the growth plate and articular cartilages. J Cell Sci. 2013;126:5704-13 pubmed publisher
    b>TAK1 is a MAP3K that mediates non-canonical TGF-? and BMP signaling...
  11. Hong S, Lim S, Li A, Lee C, Lee Y, Lee E, et al. Smad7 binds to the adaptors TAB2 and TAB3 to block recruitment of the kinase TAK1 to the adaptor TRAF2. Nat Immunol. 2007;8:504-13 pubmed
    ..that the TGF-beta-induced signaling protein Smad7 bound to TAB2 and TAB3, which are adaptors that link the kinase TAK1 to 'upstream' regulators in the proinflammatory tumor necrosis factor (TNF) signaling pathway...
  12. Komatsu Y, Shibuya H, Takeda N, Ninomiya Tsuji J, Yasui T, Miyado K, et al. Targeted disruption of the Tab1 gene causes embryonic lethality and defects in cardiovascular and lung morphogenesis. Mech Dev. 2002;119:239-49 pubmed
    ..kinase-1 binding protein-1 (TAB1) was identified as a molecule that activates TGF-beta activated kinase-1 (TAK1)...
  13. Iwata J, Hacia J, Suzuki A, Sanchez Lara P, Urata M, Chai Y. Modulation of noncanonical TGF-? signaling prevents cleft palate in Tgfbr2 mutant mice. J Clin Invest. 2012;122:873-85 pubmed publisher
    ..of TGF-?2 and TGF-? receptor type III (T?RIII); activation of a T?RI/T?RIII-mediated, SMAD-independent, TRAF6/TAK1/p38 signaling pathway; and defective cell proliferation in the palatal mesenchyme...
  14. Yamaguchi K, Shirakabe K, Shibuya H, Irie K, Oishi I, Ueno N, et al. Identification of a member of the MAPKKK family as a potential mediator of TGF-beta signal transduction. Science. 1995;270:2008-11 pubmed
    ..A genetic selection based on a MAPK pathway in yeast was used to identify a mouse protein kinase (TAK1) distinct from other members of the MAPKKK family...
  15. Hasegawa M, Fujimoto Y, Lucas P, Nakano H, Fukase K, Nunez G, et al. A critical role of RICK/RIP2 polyubiquitination in Nod-induced NF-kappaB activation. EMBO J. 2008;27:373-83 pubmed
    ..Instead, polyubiquitination of RICK was found to mediate the recruitment of TAK1, a kinase that was found to be essential for Nod1-induced signaling...
  16. Tseng P, Matsuzawa A, Zhang W, Mino T, Vignali D, Karin M. Different modes of ubiquitination of the adaptor TRAF3 selectively activate the expression of type I interferons and proinflammatory cytokines. Nat Immunol. 2010;11:70-5 pubmed publisher
    ..Inhibition of degradative ubiquitination of TRAF3 prevented the expression of all proinflammatory cytokines without affecting the interferon response. ..
  17. Yang Y, Xia F, Hermance N, Mabb A, Simonson S, Morrissey S, et al. A cytosolic ATM/NEMO/RIP1 complex recruits TAK1 to mediate the NF-kappaB and p38 mitogen-activated protein kinase (MAPK)/MAPK-activated protein 2 responses to DNA damage. Mol Cell Biol. 2011;31:2774-86 pubmed publisher
    ..we show that DNA damage stimulates the formation of a cytosolic complex containing ATM, NEMO (IKK?), RIP1, and TAK1. We find that RIP1 is modified by SUMO-1 and ubiquitin in response to DNA damage and demonstrate that modified RIP1 ..
  18. Omori E, Morioka S, Matsumoto K, Ninomiya Tsuji J. TAK1 regulates reactive oxygen species and cell death in keratinocytes, which is essential for skin integrity. J Biol Chem. 2008;283:26161-8 pubmed publisher
    Mice with a keratinocyte-specific deletion of Tak1 exhibit severe skin inflammation due to hypersensitivity to tumor necrosis factor (TNF) killing. Here we have examined the mechanisms underlying this hypersensitivity...
  19. Kajino Sakamoto R, Inagaki M, Lippert E, Akira S, Robine S, Matsumoto K, et al. Enterocyte-derived TAK1 signaling prevents epithelium apoptosis and the development of ileitis and colitis. J Immunol. 2008;181:1143-52 pubmed
    Recent studies have revealed that TAK1 kinase is an essential intermediate in several innate immune signaling pathways...
  20. Tang M, Wei X, Guo Y, Breslin P, Zhang S, Zhang S, et al. TAK1 is required for the survival of hematopoietic cells and hepatocytes in mice. J Exp Med. 2008;205:1611-9 pubmed publisher
    Transforming growth factor beta-activated kinase 1 (TAK1), a member of the MAPKKK family, is a key mediator of proinflammatory and stress signals...
  21. Morioka S, Inagaki M, Komatsu Y, Mishina Y, Matsumoto K, Ninomiya Tsuji J. TAK1 kinase signaling regulates embryonic angiogenesis by modulating endothelial cell survival and migration. Blood. 2012;120:3846-57 pubmed publisher
    TGF-? activated kinase 1 (TAK1) is a mediator of various cytokine signaling pathways. Germline deficiency of Tak1 causes multiple abnormalities, including dilated blood vessels at midgestation...
  22. Greenblatt M, Shim J, Zou W, Sitara D, Schweitzer M, Hu D, et al. The p38 MAPK pathway is essential for skeletogenesis and bone homeostasis in mice. J Clin Invest. 2010;120:2457-73 pubmed publisher
    ..Among the MAPK kinase kinase (MAP3K) family, we identified TGF-beta-activated kinase 1 (TAK1; also known as MAP3K7) as the critical activator upstream of p38 in osteoblasts...
  23. Ajibade A, Wang Q, Cui J, Zou J, Xia X, Wang M, et al. TAK1 negatively regulates NF-?B and p38 MAP kinase activation in Gr-1+CD11b+ neutrophils. Immunity. 2012;36:43-54 pubmed publisher
    ..Specific deletion of TAK1 (Map3k7(?M/?M)) led to development of splenomegaly and lymphomegaly associated with neutrophilia...
  24. Vanlangenakker N, Vanden Berghe T, Bogaert P, Laukens B, Zobel K, Deshayes K, et al. cIAP1 and TAK1 protect cells from TNF-induced necrosis by preventing RIP1/RIP3-dependent reactive oxygen species production. Cell Death Differ. 2011;18:656-65 pubmed publisher
    ..of RIP1 allows it to bind to the pro-survival kinase transforming growth factor-?-activated kinase 1 (TAK1) which prevents it from activating caspase-8-dependent death, a process reverted by the de-ubiquitinase CYLD...
  25. Sato S, Sanjo H, Takeda K, Ninomiya Tsuji J, Yamamoto M, Kawai T, et al. Essential function for the kinase TAK1 in innate and adaptive immune responses. Nat Immunol. 2005;6:1087-95 pubmed
    ..Here we generated mouse strains with conditional expression of a Map3k7 allele encoding part of TAK1...
  26. Omori E, Matsumoto K, Zhu S, Smart R, Ninomiya Tsuji J. Ablation of TAK1 upregulates reactive oxygen species and selectively kills tumor cells. Cancer Res. 2010;70:8417-25 pubmed publisher
    b>TAK1 kinase activates multiple transcription factors and regulates the level of reactive oxygen species (ROS). We have previously reported that ablation of TAK1 in keratinocytes causes hypersensitivity to ROS-induced cell apoptosis...
  27. Arsura M, Panta G, Bilyeu J, Cavin L, Sovak M, Oliver A, et al. Transient activation of NF-kappaB through a TAK1/IKK kinase pathway by TGF-beta1 inhibits AP-1/SMAD signaling and apoptosis: implications in liver tumor formation. Oncogene. 2003;22:412-25 pubmed
    ..In turn, the activation of IKK following TGF-beta1 treatment is mediated by the TAK1 kinase...
  28. Uemura N, Kajino T, Sanjo H, Sato S, Akira S, Matsumoto K, et al. TAK1 is a component of the Epstein-Barr virus LMP1 complex and is essential for activation of JNK but not of NF-kappaB. J Biol Chem. 2006;281:7863-72 pubmed
    ..Here we demonstrate that TAK1 mitogen-activated protein kinase kinase kinase and TAK1-binding protein 2 (TAB2), together with TRAF6, are ..
  29. Sato S, Sanjo H, Tsujimura T, Ninomiya Tsuji J, Yamamoto M, Kawai T, et al. TAK1 is indispensable for development of T cells and prevention of colitis by the generation of regulatory T cells. Int Immunol. 2006;18:1405-11 pubmed
    Transforming growth factor (TGF)-beta-activating kinase 1 (TAK1) is critical for Toll-like receptor- and tumor necrosis factor-mediated cellular responses...
  30. Yamazaki K, Gohda J, Kanayama A, Miyamoto Y, Sakurai H, Yamamoto M, et al. Two mechanistically and temporally distinct NF-kappaB activation pathways in IL-1 signaling. Sci Signal. 2009;2:ra66 pubmed publisher
    ..Although transforming growth factor-beta-activated kinase 1 (TAK1) and mitogen-activated protein kinase (MAPK) kinase kinase 3 (MEKK3) are both crucial for IL-1-dependent activation ..
  31. Kim J, Kajino Sakamoto R, Omori E, Jobin C, Ninomiya Tsuji J. Intestinal epithelial-derived TAK1 signaling is essential for cytoprotection against chemical-induced colitis. PLoS ONE. 2009;4:e4561 pubmed publisher
    We have previously reported that intestinal epithelium-specific TAK1 deleted mice exhibit severe inflammation and mortality at postnatal day 1 due to TNF-induced epithelial cell death...
  32. Herrero Martin G, Høyer Hansen M, García García C, Fumarola C, Farkas T, Lopez Rivas A, et al. TAK1 activates AMPK-dependent cytoprotective autophagy in TRAIL-treated epithelial cells. EMBO J. 2009;28:677-85 pubmed publisher
    ..Ca(2+)/calmodulin-dependent kinase kinase-beta, but depends on transforming growth factor-beta-activating kinase 1 (TAK1) and TAK1-binding subunit 2...
  33. Ahmed N, Zeng M, Sinha I, Polin L, Wei W, Rathinam C, et al. The E3 ligase Itch and deubiquitinase Cyld act together to regulate Tak1 and inflammation. Nat Immunol. 2011;12:1176-83 pubmed publisher
    ..complex sequentially cleaved Lys63-linked ubiquitin chains and catalyzed Lys48-linked ubiquitination on the kinase Tak1 to terminate inflammatory signaling via tumor necrosis factor...
  34. Vucur M, Reisinger F, Gautheron J, Janssen J, Roderburg C, Cardenas D, et al. RIP3 inhibits inflammatory hepatocarcinogenesis but promotes cholestasis by controlling caspase-8- and JNK-dependent compensatory cell proliferation. Cell Rep. 2013;4:776-90 pubmed publisher
    ..These findings demonstrate a function of RIP3 in regulating carcinogenesis and cholestasis. Controlling RIP3 or Caspase-8 might represent a chemopreventive or therapeutic strategy against hepatocellular carcinoma and biliary disease. ..
  35. Lluis J, Nachbur U, Cook W, Gentle I, Moujalled D, Moulin M, et al. TAK1 is required for survival of mouse fibroblasts treated with TRAIL, and does so by NF-kappaB dependent induction of cFLIPL. PLoS ONE. 2010;5:e8620 pubmed publisher
    ..To determine the role of TGF-beta-Activated Kinase-1 (TAK1) in TRAIL signalling, we analyzed the effects of adding TRAIL to mouse embryonic fibroblasts (MEFs) derived from ..
  36. Long M, Park S, Strickland I, Hayden M, Ghosh S. Nuclear factor-kappaB modulates regulatory T cell development by directly regulating expression of Foxp3 transcription factor. Immunity. 2009;31:921-31 pubmed publisher
    ..Hence, NF-kappaB signaling pathway is a key regulator of Foxp3 expression during natural Treg cell development. ..
  37. Kajino T, Omori E, Ishii S, Matsumoto K, Ninomiya Tsuji J. TAK1 MAPK kinase kinase mediates transforming growth factor-beta signaling by targeting SnoN oncoprotein for degradation. J Biol Chem. 2007;282:9475-81 pubmed
    ..Here, we report the role of TAK1 as a SnoN protein kinase...
  38. Rajasekaran K, Chu H, Kumar P, Xiao Y, Tinguely M, Samarakoon A, et al. Transforming growth factor-beta-activated kinase 1 regulates natural killer cell-mediated cytotoxicity and cytokine production. J Biol Chem. 2011;286:31213-24 pubmed publisher
    ..Here we show that transforming growth factor-? (TGF-?)-activated kinase 1 (TAK1) is abundantly present in NK cells, and activation via NKG2D results in its phosphorylation...
  39. Cheung P, Campbell D, Nebreda A, Cohen P. Feedback control of the protein kinase TAK1 by SAPK2a/p38alpha. EMBO J. 2003;22:5793-805 pubmed
    TAB1, a subunit of the kinase TAK1, was phosphorylated by SAPK2a/p38alpha at Ser423, Thr431 and Ser438 in vitro...
  40. Lamothe B, Lai Y, Xie M, Schneider M, Darnay B. TAK1 is essential for osteoclast differentiation and is an important modulator of cell death by apoptosis and necroptosis. Mol Cell Biol. 2013;33:582-95 pubmed publisher
    Transforming growth factor ? (TGF-?)-activated kinase 1 (TAK1), a mitogen-activated protein 3 (MAP3) kinase, plays an essential role in inflammation by activating the I?B kinase (IKK)/nuclear factor ?B (NF-?B) and stress kinase (p38 and c-..
  41. Hamidi A, von Bulow V, Hamidi R, Winssinger N, Barluenga S, Heldin C, et al. Polyubiquitination of transforming growth factor ? (TGF?)-associated kinase 1 mediates nuclear factor-?B activation in response to different inflammatory stimuli. J Biol Chem. 2012;287:123-33 pubmed publisher
    ..The TGF?-associated kinase 1 (TAK1) is an upstream regulator of NF-?B signaling...
  42. Eftychi C, Karagianni N, Alexiou M, Apostolaki M, Kollias G. Myeloid TAKI [corrected] acts as a negative regulator of the LPS response and mediates resistance to endotoxemia. PLoS ONE. 2012;7:e31550 pubmed publisher
    TGF?-activated kinase 1 (TAK1), a member of the mitogen-activated protein kinase kinase kinase (MAP3K) family, is considered a key intermediate in a multitude of innate immune signaling pathways...
  43. Shim J, Greenblatt M, Xie M, Schneider M, Zou W, Zhai B, et al. TAK1 is an essential regulator of BMP signalling in cartilage. EMBO J. 2009;28:2028-41 pubmed publisher
    TGFbeta activated kinase 1 (TAK1), a member of the MAPKKK family, controls diverse functions ranging from innate and adaptive immune system activation to vascular development and apoptosis...
  44. Xie M, Zhang D, Dyck J, Li Y, Zhang H, Morishima M, et al. A pivotal role for endogenous TGF-beta-activated kinase-1 in the LKB1/AMP-activated protein kinase energy-sensor pathway. Proc Natl Acad Sci U S A. 2006;103:17378-83 pubmed
    TGF-beta-activated kinase-1 (TAK1), also known as MAPKK kinase-7 (MAP3K7), is a candidate effector of multiple circuits in cardiac biology and disease...
  45. Morioka S, Omori E, Kajino T, Kajino Sakamoto R, Matsumoto K, Ninomiya Tsuji J. TAK1 kinase determines TRAIL sensitivity by modulating reactive oxygen species and cIAP. Oncogene. 2009;28:2257-65 pubmed publisher
    ..The mechanism that determines sensitivity to TRAIL-killing is still elusive. Here we report that deletion of TAK1 kinase greatly increased activation of caspase-3 and cell death after TRAIL stimulation in keratinocytes, ..
  46. Kim J, Omori E, Matsumoto K, Nunez G, Ninomiya Tsuji J. TAK1 is a central mediator of NOD2 signaling in epidermal cells. J Biol Chem. 2008;283:137-44 pubmed
    ..Here we show that transforming growth factor beta-activated kinase 1 (TAK1) is an essential intermediate of NOD2 signaling...
  47. Mendoza H, Campbell D, Burness K, Hastie J, Ronkina N, Shim J, et al. Roles for TAB1 in regulating the IL-1-dependent phosphorylation of the TAB3 regulatory subunit and activity of the TAK1 complex. Biochem J. 2008;409:711-22 pubmed
    The protein kinase TAK1 (transforming growth factor-beta-activated kinase 1), which has been implicated in the activation of MAPK (mitogen-activated protein kinase) cascades and the production of inflammatory mediators by LPS (..
  48. Xia Z, Sun L, Chen X, Pineda G, Jiang X, Adhikari A, et al. Direct activation of protein kinases by unanchored polyubiquitin chains. Nature. 2009;461:114-9 pubmed publisher
    ..as UBE2N) and UEV1A (UBE2V1) to catalyse Lys 63-linked polyubiquitination, which activates the TAK1 (also known as MAP3K7) kinase complex...
  49. Srivastava R, Burbach B, Shimizu Y. NF-kappaB activation in T cells requires discrete control of IkappaB kinase alpha/beta (IKKalpha/beta) phosphorylation and IKKgamma ubiquitination by the ADAP adapter protein. J Biol Chem. 2010;285:11100-5 pubmed publisher
    ..In this study, we identify a novel site in ADAP that is critical for association with the TAK1 kinase. ADAP is critical for recruitment of TAK1 and the CBM complex, but not IKK, to protein kinase C-theta...
  50. Kajino Sakamoto R, Omori E, Nighot P, Blikslager A, Matsumoto K, Ninomiya Tsuji J. TGF-beta-activated kinase 1 signaling maintains intestinal integrity by preventing accumulation of reactive oxygen species in the intestinal epithelium. J Immunol. 2010;185:4729-37 pubmed publisher
    ..In this article, we report that TGF-?-activated kinase 1 (TAK1) is a key regulator of ROS in the intestinal epithelium...
  51. Arslan S, Scheidereit C. The prevalence of TNF?-induced necrosis over apoptosis is determined by TAK1-RIP1 interplay. PLoS ONE. 2011;6:e26069 pubmed publisher
    ..Here, we show that in cells lacking TGF?-activated Kinase-1 (TAK1) expression, catalytically active Receptor Interacting Protein 1 (RIP1)-dependent programmed necrosis overrides ..
  52. Jadrich J, O Connor M, Coucouvanis E. The TGF beta activated kinase TAK1 regulates vascular development in vivo. Development. 2006;133:1529-41 pubmed
    TGFbeta activated kinase 1 (TAK1) is a MAPKKK that in cell culture systems has been shown to act downstream of a variety of signaling molecules, including TGFbeta...
  53. Wan Y, Chi H, Xie M, Schneider M, Flavell R. The kinase TAK1 integrates antigen and cytokine receptor signaling for T cell development, survival and function. Nat Immunol. 2006;7:851-8 pubmed
    The kinase TAK1 is critical for innate and B cell immunity. The function of TAK1 in T cells is unclear, however...
  54. Gunnell L, Jonason J, Loiselle A, Kohn A, Schwarz E, Hilton M, et al. TAK1 regulates cartilage and joint development via the MAPK and BMP signaling pathways. J Bone Miner Res. 2010;25:1784-97 pubmed publisher
    ..TGF-beta activated kinase 1 (TAK1) is a MAP3K activated by TGF-beta, BMP, and other mitogen-activated protein kinase (MAPK) signaling components...
  55. Sayama K, Kajiya K, Sugawara K, Sato S, Hirakawa S, Shirakata Y, et al. Inflammatory mediator TAK1 regulates hair follicle morphogenesis and anagen induction shown by using keratinocyte-specific TAK1-deficient mice. PLoS ONE. 2010;5:e11275 pubmed publisher
    ..By comparing keratinocyte-specific TAK1-deficient mice (Map3k7(fl/fl)K5-Cre) with control mice, we found that the number of hair germs (hair follicles precursors) in Map3k7(fl/..
  56. Kumar M, Makonchuk D, Li H, Mittal A, Kumar A. TNF-like weak inducer of apoptosis (TWEAK) activates proinflammatory signaling pathways and gene expression through the activation of TGF-beta-activated kinase 1. J Immunol. 2009;182:2439-48 pubmed publisher
    ..In this study, we tested the hypothesis that TAK1 (TGF-beta-activated kinase 1) is involved in TWEAK-induced activation of NF-kappaB and MAPK and expression of ..
  57. Shim J, Xiao C, Paschal A, Bailey S, Rao P, Hayden M, et al. TAK1, but not TAB1 or TAB2, plays an essential role in multiple signaling pathways in vivo. Genes Dev. 2005;19:2668-81 pubmed
    TGF-beta-activated kinase 1 (TAK1), a member of the MAPKKK family, is thought to be a key modulator of the inducible transcription factors NF-kappaB and AP-1 and, therefore, plays a crucial role in regulating the genes that mediate ..
  58. Wu M, Shi L, Cimic A, Romero L, Sui G, Lees C, et al. Suppression of Tak1 promotes prostate tumorigenesis. Cancer Res. 2012;72:2833-43 pubmed publisher
    ..1. The MAP3K7 gene, which encodes TGF-? activated kinase-1 (Tak1), is a putative prostate tumor suppressor gene within this ..
  59. Bettermann K, Vucur M, Haybaeck J, Koppe C, Janssen J, Heymann F, et al. TAK1 suppresses a NEMO-dependent but NF-kappaB-independent pathway to liver cancer. Cancer Cell. 2010;17:481-96 pubmed publisher
    The MAP3-kinase TGF-beta-activated kinase 1 (TAK1) critically modulates innate and adaptive immune responses and connects cytokine stimulation with activation of inflammatory signaling pathways...
  60. Morioka S, Broglie P, Omori E, Ikeda Y, Takaesu G, Matsumoto K, et al. TAK1 kinase switches cell fate from apoptosis to necrosis following TNF stimulation. J Cell Biol. 2014;204:607-23 pubmed publisher
    ..Here we report the biological event switching to activate necrosis over apoptosis. TAK1 kinase is normally transiently activated upon TNF stimulation...
  61. Liu Q, Busby J, Molkentin J. Interaction between TAK1-TAB1-TAB2 and RCAN1-calcineurin defines a signalling nodal control point. Nat Cell Biol. 2009;11:154-61 pubmed publisher
    ..Here we performed a yeast two-hybrid screen with RCAN1 as bait, identifying TAK1 binding protein 2 (TAB2) as an interacting partner...
  62. Zippel N, Malik R, Frömel T, Popp R, Bess E, Strilic B, et al. Transforming growth factor-?-activated kinase 1 regulates angiogenesis via AMP-activated protein kinase-?1 and redox balance in endothelial cells. Arterioscler Thromb Vasc Biol. 2013;33:2792-9 pubmed publisher
    Transforming growth factor-?-activated kinase 1 (TAK1) is a mitogen-activated protein 3-kinase and an AMP-activated protein kinase (AMPK) kinase in some cell types...
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