Genomes and Genes
Gene Symbol: Mag
Description: myelin-associated glycoprotein
Alias: Gma, siglec-4a, myelin-associated glycoprotein
- Williams G, Wood A, Williams E, Gao Y, Mercado M, Katz A, et al. Ganglioside inhibition of neurite outgrowth requires Nogo receptor function: identification of interaction sites and development of novel antagonists. J Biol Chem. 2008;283:16641-52 pubmed publisher..also antagonizes neurite outgrowth inhibition mediated by soluble forms of the myelin-associated glycoprotein (MAG)...
- Carenini S, Montag D, Cremer H, Schachner M, Martini R. Absence of the myelin-associated glycoprotein (MAG) and the neural cell adhesion molecule (N-CAM) interferes with the maintenance, but not with the formation of peripheral myelin. Cell Tissue Res. 1997;287:3-9 pubmedWe have previously shown that mice deficient in the gene for the myelin-associated glycoprotein (MAG) develop normal myelin in the peripheral nerves, but show axon and myelin degeneration at eight months of age, suggesting that MAG is ..
- Montag D, Giese K, Bartsch U, Martini R, Lang Y, Blüthmann H, et al. Mice deficient for the myelin-associated glycoprotein show subtle abnormalities in myelin. Neuron. 1994;13:229-46 pubmed..stem cells, we have generated mice with a null mutation in the gene encoding the myelin-associated glycoprotein (MAG), a recognition molecule implicated in myelin formation...
- Fujita Y, Endo S, Takai T, Yamashita T. Myelin suppresses axon regeneration by PIR-B/SHP-mediated inhibition of Trk activity. EMBO J. 2011;30:1389-401 pubmed publisher..mediates the regeneration-inhibiting effects of the myelin-derived protein Nogo, myelin-associated glycoprotein (MAG), and oligodendrocyte-myelin glycoprotein (OMgp)...
- Lee J, Geoffroy C, Chan A, Tolentino K, Crawford M, Leal M, et al. Assessing spinal axon regeneration and sprouting in Nogo-, MAG-, and OMgp-deficient mice. Neuron. 2010;66:663-70 pubmed publisher..We have conducted a comprehensive genetic analysis of the three major myelin inhibitors, Nogo, MAG, and OMgp, in injury-induced axonal growth, including compensatory sprouting of uninjured axons and regeneration of ..
- Bartsch U, Montag D, Bartsch S, Schachner M. Multiply myelinated axons in the optic nerve of mice deficient for the myelin-associated glycoprotein. Glia. 1995;14:115-22 pubmed
- Yin X, Crawford T, Griffin J, Tu P, Lee V, Li C, et al. Myelin-associated glycoprotein is a myelin signal that modulates the caliber of myelinated axons. J Neurosci. 1998;18:1953-62 pubmed..This study demonstrates that mice with a null mutation of the myelin-associated glycoprotein (MAG) gene have a chronic atrophy of myelinated PNS axons that results in paranodal myelin tomaculi and axonal ..
- Nguyen T, Mehta N, Conant K, Kim K, Jones M, Calabresi P, et al. Axonal protective effects of the myelin-associated glycoprotein. J Neurosci. 2009;29:630-7 pubmed publisher..One glial molecule, the myelin-associated glycoprotein (MAG), located in the adaxonal plasmalemma of myelin-producing cells, is known to signal to the axon and to modulate ..
- Winterstein C, Trotter J, Krämer Albers E. Distinct endocytic recycling of myelin proteins promotes oligodendroglial membrane remodeling. J Cell Sci. 2008;121:834-42 pubmed publisher..Interestingly, we found that PLP, myelin-associated glycoprotein (MAG) and myelin-oligodendrocyte glycoprotein (MOG), which localize to compact myelin, periaxonal loops and abaxonal ..
- Pomicter A, Deloyht J, Hackett A, Purdie N, Sato Bigbee C, Henderson S, et al. Nfasc155H and MAG are specifically susceptible to detergent extraction in the absence of the myelin sphingolipid sulfatide. Neurochem Res. 2013;38:2490-502 pubmed publisher..Furthermore, we use this in situ approach to show that stable association of myelin-associated glycoprotein (MAG) with the myelin membrane is sulfatide dependent while the membrane associations of myelin/oligodendrocyte ..
- Watzlawik J, Kahoud R, Ng S, Painter M, Papke L, Zoecklein L, et al. Polysialic acid as an antigen for monoclonal antibody HIgM12 to treat multiple sclerosis and other neurodegenerative disorders. J Neurochem. 2015;134:865-78 pubmed publisher..These findings indicate a new strategy for the treatment of neuro-motor disorders including multiple sclerosis. ..
- Fujita N, Sato S, Kurihara T, Inuzuka T, Takahashi Y, Miyatake T. Developmentally regulated alternative splicing of brain myelin-associated glycoprotein mRNA is lacking in the quaking mouse. FEBS Lett. 1988;232:323-7 pubmed..In quaking mouse, the mRNA without a 45-nucleotide exon portion was scarcely expressed throughout development. We conclude that the mechanism of splicing out the 45-nucleotide exon portion is lacking in quaking mouse...
- Loers G, Aboul Enein F, Bartsch U, Lassmann H, Schachner M. Comparison of myelin, axon, lipid, and immunopathology in the central nervous system of differentially myelin-compromised mutant mice: a morphological and biochemical study. Mol Cell Neurosci. 2004;27:175-89 pubmed..Mouse mutants deficient in the myelin-associated glycoprotein (MAG) and myelin basic protein (MBP) display subtle and severe myelin pathologies in the central nervous system (CNS), ..
- Uschkureit T, Sporkel O, Stracke J, Bussow H, Stoffel W. Early onset of axonal degeneration in double (plp-/-mag-/-) and hypomyelinosis in triple (plp-/-mbp-/-mag-/-) mutant mice. J Neurosci. 2000;20:5225-33 pubmedDouble (plp-/-mag-/-) and triple (plp-/-mbp-/-mag-/-) null-allelic mouse lines deficient in proteolipid protein (PLP), myelin-associated glycoprotein (MAG), and myelin basic protein (MBP) were generated and characterized genetically, ..
- Bribian A, Fontana X, Llorens F, Gavin R, Reina M, Garcia Verdugo J, et al. Role of the cellular prion protein in oligodendrocyte precursor cell proliferation and differentiation in the developing and adult mouse CNS. PLoS ONE. 2012;7:e33872 pubmed publisher..In addition, numerous NG2-positive cells were observed in cortical regions of adult PrP(c) knockout mice, although no significant changes in myelination can be seen, probably due to the death of surplus cells. ..
- Sheedlo H, Siegel G. Comparison of the distribution of Na+,K+-ATPase and myelin-associated glycoprotein (MAG) in the optic nerve, spinal cord and trigeminal ganglion of shiverer (shi/shi) and control (+/+) mice. Brain Res. 1987;415:105-14 pubmedNa+,K+ ATPase and myelin-associated glycoprotein (MAG) were studied by immunocytochemistry on paraffin sections of the spinal cord, optic nerve and trigeminal ganglion of adult control (+/+) and CNS myelin-deficient shiverer (shi/shi) ..
- Mantuano E, Lam M, Gonias S. LRP1 assembles unique co-receptor systems to initiate cell signaling in response to tissue-type plasminogen activator and myelin-associated glycoprotein. J Biol Chem. 2013;288:34009-18 pubmed publisher..Proteins that activate cell signaling by binding to LRP1 assemble different co-receptor systems. Ligand-specific co-receptor recruitment provides a mechanism by which one receptor, LRP1, may trigger different signaling responses. ..
- Lassmann H, Bartsch U, Montag D, Schachner M. Dying-back oligodendrogliopathy: a late sequel of myelin-associated glycoprotein deficiency. Glia. 1997;19:104-10 pubmed..These alterations are similar to those described before as "dying-back oligodendrogliopathy" in diseases of toxic or immune-mediated demyelination including multiple sclerosis. ..
- Barton D, Arquint M, Roder J, Dunn R, Francke U. The myelin-associated glycoprotein gene: mapping to human chromosome 19 and mouse chromosome 7 and expression in quivering mice. Genomics. 1987;1:107-12 pubmedMyelin-associated glycoprotein (MAG), a membrane glycoprotein of 100 kDa, is thought to be involved in the process of myelination. A cDNA encoding the amino-terminal half of rat MAG has recently been isolated and sequenced...
- Pernet V, Joly S, Christ F, Dimou L, Schwab M. Nogo-A and myelin-associated glycoprotein differently regulate oligodendrocyte maturation and myelin formation. J Neurosci. 2008;28:7435-44 pubmed publisher..The combined deletion of Nogo-A and MAG caused a more severe transient hypomyelination...
- Stubbs L, Carver E, Ashworth L, Lopez Molina L. Location of the DBP transcription factor gene in human and mouse. Mamm Genome. 1996;7:65-7 pubmed
- Fruttiger M, Montag D, Schachner M, Martini R. Crucial role for the myelin-associated glycoprotein in the maintenance of axon-myelin integrity. Eur J Neurosci. 1995;7:511-5 pubmed..Myelin-associated glycoprotein thus appears to play a crucial role in the long-term maintenance of the integrity of both myelin and axons. ..
- Mingorance A, Fontana X, Solé M, Burgaya F, Ureña J, Teng F, et al. Regulation of Nogo and Nogo receptor during the development of the entorhino-hippocampal pathway and after adult hippocampal lesions. Mol Cell Neurosci. 2004;26:34-49 pubmed..In conclusion, our results show that Nogo and its receptor might play key roles during development of hippocampal connections and that they are implicated in neuronal plasticity in the adult. ..
- Holz A, Schaeren Wiemers N, Schaefer C, Pott U, Colello R, Schwab M. Molecular and developmental characterization of novel cDNAs of the myelin-associated/oligodendrocytic basic protein. J Neurosci. 1996;16:467-77 pubmed..The late developmental expression of the MOBP gene suggests that the MOBP proteins act at the late steps of myelin formation, possibly in myelin compaction and in the maintenance of the myelin sheath. ..
- Kumar S, Yin X, Trapp B, Paulaitis M, Hoh J. Role of long-range repulsive forces in organizing axonal neurofilament distributions: evidence from mice deficient in myelin-associated glycoprotein. J Neurosci Res. 2002;68:681-90 pubmed..Among the models tested, a model in which the filaments interact through a long-range repulsive force is most consistent with the results of our analysis. ..
- Weiss M, Luciano C, Quarles R. Nerve conduction abnormalities in aging mice deficient for myelin-associated glycoprotein. Muscle Nerve. 2001;24:1380-7 pubmed..and electrophysiological analyses were done on 12-14-month-old mice deficient for myelin-associated glycoprotein (MAG) to further characterize the neuropathy that develops as they age...
- Bo L, Quarles R, Fujita N, Bartoszewicz Z, Sato S, Trapp B. Endocytic depletion of L-MAG from CNS myelin in quaking mice. J Cell Biol. 1995;131:1811-20 pubmed..The levels of the 67-kD isoform of the myelin-associated glycoprotein (S-MAG) relative to those of the 72-kD isoform (L-MAG) are increased in the quaking CNS, but not in other dysmyelinating ..
- Xie W, Uchida H, Nagai J, Ueda M, Chun J, Ueda H. Calpain-mediated down-regulation of myelin-associated glycoprotein in lysophosphatidic acid-induced neuropathic pain. J Neurochem. 2010;113:1002-11 pubmed publisher..intrathecal injection of LPA evoked a dose- and time-dependent down-regulation of myelin-associated glycoprotein (MAG) in the DR through LPA(1) receptor. A similar event was also observed in ex vivo DR cultures...
- Arquint M, Roder J, Chia L, Down J, Wilkinson D, Bayley H, et al. Molecular cloning and primary structure of myelin-associated glycoprotein. Proc Natl Acad Sci U S A. 1987;84:600-4 pubmedMyelin-associated glycoprotein (MAG) may play a role in the cellular interactions leading to myelination...
- Domino S, Hiraiwa N, Lowe J. Molecular cloning, chromosomal assignment and tissue-specific expression of a murine alpha(1,2)fucosyltransferase expressed in thymic and epididymal epithelial cells. Biochem J. 1997;327 ( Pt 1):105-15 pubmed
- Tang W, Zhang Y, Chang Q, Ahmad S, Dahlke I, Yi H, et al. Connexin29 is highly expressed in cochlear Schwann cells, and it is required for the normal development and function of the auditory nerve of mice. J Neurosci. 2006;26:1991-9 pubmed..developmental expression time course of Cx29 was similar to that of a myelin marker [myelin associate glycoprotein (MAG)]...
- Bartsch U, Bandtlow C, Schnell L, Bartsch S, Spillmann A, Rubin B, et al. Lack of evidence that myelin-associated glycoprotein is a major inhibitor of axonal regeneration in the CNS. Neuron. 1995;15:1375-81 pubmedThe MAG-deficient mouse was used to test whether MAG acts as a significant inhibitor of axonal regeneration in the adult mammalian CNS, as suggested by cell culture experiments...
- Gilman A. G proteins and dual control of adenylate cyclase. Cell. 1984;36:577-9 pubmed
- Kahn R, Der C, Bokoch G. The ras superfamily of GTP-binding proteins: guidelines on nomenclature. FASEB J. 1992;6:2512-3 pubmed
- Stolt C, Rehberg S, Ader M, Lommes P, Riethmacher D, Schachner M, et al. Terminal differentiation of myelin-forming oligodendrocytes depends on the transcription factor Sox10. Genes Dev. 2002;16:165-70 pubmed..Sox10 directly regulates myelin gene expression in oligodendrocytes, but does not control erbB3 expression as in peripheral glia. Sox10 thus functions in peripheral and central glia at different stages and through different mechanisms. ..
- Cho K, Yang L, Lu B, Feng Ma H, Huang X, Pekny M, et al. Re-establishing the regenerative potential of central nervous system axons in postnatal mice. J Cell Sci. 2005;118:863-72 pubmed..These results suggest that an early postnatal downregulation of Bcl-2 and post-traumatic reactive gliosis are two important elements of axon regenerative failure in the CNS. ..
- Chaudhry N, Bachelin C, Zujovic V, Hilaire M, Baldwin K, Follis R, et al. Myelin-Associated Glycoprotein Inhibits Schwann Cell Migration and Induces Their Death. J Neurosci. 2017;37:5885-5899 pubmed publisher..We now demonstrate that myelin-associated glycoprotein (MAG), a well known inhibitor of neurite outgrowth, inhibits rat SC migration and induces their death via ?-secretase-..
- Owens G, Bunge R. Schwann cells infected with a recombinant retrovirus expressing myelin-associated glycoprotein antisense RNA do not form myelin. Neuron. 1991;7:565-75 pubmedTo elucidate the role of myelin-associated glycoprotein (MAG) in the axon-Schwann cell interaction leading to myelination, neonatal rodent Schwann cells were infected in vitro with a recombinant retrovirus expressing MAG antisense RNA or ..
- Niemann S, Sidman R, Nave K. Evidence against altered forms of MAG in the dysmyelinated mouse mutant claw paw. Mamm Genome. 1998;9:903-4 pubmed
- Budel S, Padukkavidana T, Liu B, Feng Z, Hu F, Johnson S, et al. Genetic variants of Nogo-66 receptor with possible association to schizophrenia block myelin inhibition of axon growth. J Neurosci. 2008;28:13161-72 pubmed publisher..For a restricted subset of individuals diagnosed with schizophrenia, the expression of dysfunctional NGR variants may contribute to increased disease risk. ..
- McCallion A, Guenet J, Montague P, Griffiths I, Savioz A, Davies R. The mouse gene (Mobp) encoding myelin-associated oligodendrocytic basic protein maps to distal chromosome 9. Mamm Genome. 1996;7:847-9 pubmed
- Schachner M. Lessons from genetic knockout mice deficient in neural recognition molecules. Prog Brain Res. 1994;100:25-30 pubmed
- Lopez P, Ahmad A, Mehta N, Toner M, Rowland E, Zhang J, et al. Myelin-associated glycoprotein protects neurons from excitotoxicity. J Neurochem. 2011;116:900-8 pubmed publisher..One myelin molecule that protects and sustains axons is myelin-associated glycoprotein (MAG)...
- Ginkel C, Hartmann D, Vom Dorp K, Zlomuzica A, Farwanah H, Eckhardt M, et al. Ablation of neuronal ceramide synthase 1 in mice decreases ganglioside levels and expression of myelin-associated glycoprotein in oligodendrocytes. J Biol Chem. 2012;287:41888-902 pubmed publisher..Our results reveal an essential function of CerS1-derived ceramide in the regulation of cerebellar development and neurodevelopmentally regulated behavior. ..
- Pan B, Fromholt S, Hess E, Crawford T, Griffin J, Sheikh K, et al. Myelin-associated glycoprotein and complementary axonal ligands, gangliosides, mediate axon stability in the CNS and PNS: neuropathology and behavioral deficits in single- and double-null mice. Exp Neurol. 2005;195:208-17 pubmed..Myelin-associated glycoprotein (MAG), a minor constituent of central and peripheral nervous system myelin, is a member of the Siglec family of sialic ..
- Traka M, Goutebroze L, Denisenko N, Bessa M, Nifli A, Havaki S, et al. Association of TAG-1 with Caspr2 is essential for the molecular organization of juxtaparanodal regions of myelinated fibers. J Cell Biol. 2003;162:1161-72 pubmed..This complex is analogous to that described previously at paranodes, suggesting that similar molecules are crucial for different types of axo-glial interactions. ..
- Hillenbrand R, Molthagen M, Montag D, Schachner M. The close homologue of the neural adhesion molecule L1 (CHL1): patterns of expression and promotion of neurite outgrowth by heterophilic interactions. Eur J Neurosci. 1999;11:813-26 pubmed..The observation that CHL1 and L1 show overlapping, but also distinct patterns of synthesis in neurons and glia, suggests differential effects of L1-like molecules on neurite outgrowth. ..
- Vondran M, Clinton Luke P, Honeywell J, Dreyfus C. BDNF+/- mice exhibit deficits in oligodendrocyte lineage cells of the basal forebrain. Glia. 2010;58:848-56 pubmed publisher..BDNF+/- mice do not exhibit deficits in numbers of CC1+ OLGs. However, myelin basic protein, myelin associated glycoprotein, and proteolipid protein are reduced in BDNF+/- mice, suggesting that BDNF plays a role in ..
- Erb M, Flueck B, Kern F, Erne B, Steck A, Schaeren Wiemers N. Unraveling the differential expression of the two isoforms of myelin-associated glycoprotein in a mouse expressing GFP-tagged S-MAG specifically regulated and targeted into the different myelin compartments. Mol Cell Neurosci. 2006;31:613-27 pubmedThe two myelin-associated glycoprotein (MAG) isoforms are cell adhesion molecules that differ only in their cytoplasmic domains, but their specific roles are not well understood...
- Rowe P, Goulding J, Read A, Lehrach H, Francis F, Hanauer A, et al. Refining the genetic map for the region flanking the X-linked hypophosphataemic rickets locus (Xp22.1-22.2). Hum Genet. 1994;93:291-4 pubmed..Combining the genetic and physical data, we are able to propose the following gene marker order: Xptel-DXS43-DXS197-DXS999-DXS443-[(DXS3 65-AFM163yh2), HYP]-DXS274-DXS41-Xcen. ..
- Bartoszewicz Z, Lauter C, Quarles R. The myelin-associated glycoprotein of the peripheral nervous system in trembler mutants contains increased alpha 2-3 sialic acid and galactose. J Neurosci Res. 1996;43:587-93 pubmedThe myelin-associated glycoprotein (MAG) exhibits an abnormally high apparent molecular weight in sciatic nerve, but not in brain, of dysmyelinating trembler mutants (Inuzuka et al.: J Neurochem 44:793-797, 1985)...
- Gilman A. G proteins: transducers of receptor-generated signals. Annu Rev Biochem. 1987;56:615-49 pubmed
- Jaegle M, Mandemakers W, Broos L, Zwart R, Karis A, Visser P, et al. The POU factor Oct-6 and Schwann cell differentiation. Science. 1996;273:507-10 pubmed..Thus, Oct-6 appears to be required for the transition of promyelin cells to myelinating cells. Once these cells progress past this point, Oct-6 is no longer required, and myelination occurs normally. ..
- Bartoszewicz Z, Noronha A, Fujita N, Sato S, Bo L, Trapp B, et al. Abnormal expression and glycosylation of the large and small isoforms of myelin-associated glycoprotein in dysmyelinating quaking mutants. J Neurosci Res. 1995;41:27-38 pubmedThe relative expression of large (L) and small (S) isoforms of the myelin-associated glycoprotein (MAG) and their glycosylation were compared in developing spinal cord of quaking and control mice...
- Marcus J, Dupree J, Popko B. Myelin-associated glycoprotein and myelin galactolipids stabilize developing axo-glial interactions. J Cell Biol. 2002;156:567-77 pubmedWe have analyzed mice that lack both the myelin-associated glycoprotein (MAG) and the myelin galactolipids, two glial components implicated in mediating axo-glial interactions during the myelination process...
- Fry E, Ho C, David S. A role for Nogo receptor in macrophage clearance from injured peripheral nerve. Neuron. 2007;53:649-62 pubmed..These macrophages show reduced binding to myelin and MAG in vitro, which is reversed by NgR siRNA knockdown and by inhibiting Rho-associated kinase...
- Werner S, Mescher A, Neff A, King M, Chaturvedi S, Duffin K, et al. Neural MMP-28 expression precedes myelination during development and peripheral nerve repair. Dev Dyn. 2007;236:2852-64 pubmed..These results suggest that MMP-28 plays an evolutionarily conserved role in neural development and is likely to modulate the axonal-glial extracellular microenvironment. ..
- Fröb F, Bremer M, Finzsch M, Kichko T, Reeh P, Tamm E, et al. Establishment of myelinating Schwann cells and barrier integrity between central and peripheral nervous systems depend on Sox10. Glia. 2012;60:806-19 pubmed publisher..We infer that in addition to its many roles in Schwann cells, Sox10 is also important for the integrity of the boundary between central and peripheral nervous systems. ..
- Saunders A, Seldin M. The syntenic relationship of proximal mouse chromosome 7 and the myotonic dystrophy gene region on human chromosome 19q. Genomics. 1990;6:324-32 pubmed..Their order from the centromere was Prkcg, [Apoe, Atpa-2, Ckmm, D19S19h, Ercc-2], Cyp2b, Mag, Lhb. Two other murine loci, D7Rp2 and Ngfg, were also positioned within this interval...
- Inuzuka T, Quarles R, Heath J, Trapp B. Myelin-associated glycoprotein and other proteins in Trembler mice. J Neurochem. 1985;44:793-7 pubmedThe myelin-associated glycoprotein (MAG) and other myelin proteins were quantitated in homogenates of whole sciatic nerve from adult and 20-day-old Trember mice. In the nerves of adult mice, the concentration of MAG was increased from 1...
- D EUSTACHIO P, Colman D, Salzer J. Chromosomal location of the mouse gene that encodes the myelin-associated glycoproteins. J Neurochem. 1988;50:589-93 pubmedThe two myelin-associated glycoprotein (MAG) species, designated large MAG (L-MAG) and small MAG (S-MAG), are believed to be generated by differential splicing from a single RNA transcript...
- Cai Z, Sutton Smith P, Swift J, Cash K, Finnie J, Turnley A, et al. Tomacula in MAG-deficient mice. J Peripher Nerv Syst. 2002;7:181-9 pubmedThe pathogenesis of tomacula in mice with a null mutation of the myelin-associated glycoprotein (MAG) gene is not well understood...
- Simonen M, Pedersen V, Weinmann O, Schnell L, Buss A, Ledermann B, et al. Systemic deletion of the myelin-associated outgrowth inhibitor Nogo-A improves regenerative and plastic responses after spinal cord injury. Neuron. 2003;38:201-11 pubmed..CST fibers caudal to the lesion-regenerating and/or sprouting from spared intact fibers-were also found to be more frequent in Nogo-A-deficient animals. ..
- Chu C, Paul W. Fig1, an interleukin 4-induced mouse B cell gene isolated by cDNA representational difference analysis. Proc Natl Acad Sci U S A. 1997;94:2507-12 pubmed..The Fig1 cDNA sequence encodes a predicted 70-kDa flavoprotein with best homology to the monoamine oxidases, particularly in domains responsible for FAD binding. ..
- Carenini S, Montag D, Schachner M, Martini R. Subtle roles of neural cell adhesion molecule and myelin-associated glycoprotein during Schwann cell spiralling in P0-deficient mice. Glia. 1999;27:203-12 pubmed..of these up-regulated molecules, the neural cell adhesion molecule (N-CAM) and the myelin-associated glycoprotein (MAG)...
- Kleene R, Yang H, Kutsche M, Schachner M. The neural recognition molecule L1 is a sialic acid-binding lectin for CD24, which induces promotion and inhibition of neurite outgrowth. J Biol Chem. 2001;276:21656-63 pubmed..This glycoform is excluded together with L1 from raft microdomains, suggesting that molecular compartmentation in the surface membrane could play a role in signal transduction. ..
- Patzig J, Erwig M, Tenzer S, Kusch K, Dibaj P, Mobius W, et al. Septin/anillin filaments scaffold central nervous system myelin to accelerate nerve conduction. elife. 2016;5: pubmed publisher..We propose that pathological or aging-associated diminishment of the septin/anillin-scaffold causes myelin outfoldings that impair the normal nerve conduction velocity. ..
- Tong J, Potts J, Rochelle J, Seldin M, Agnew W. A single B1 subunit mapped to mouse chromosome 7 may be a common component of Na channel isoforms from brain, skeletal muscle and heart. Biochem Biophys Res Commun. 1993;195:679-85 pubmed..A mutation in a single beta 1 subunit forming functional complexes with multiple Na channel isoforms could underlie these deficits. ..
- Nagai J, Goshima Y, Ohshima T. CRMP4 mediates MAG-induced inhibition of axonal outgrowth and protection against Vincristine-induced axonal degeneration. Neurosci Lett. 2012;519:56-61 pubmed publisher..inhibitors (MAIs) have been shown to suppress axonal outgrowth, but a specific MAI, myelin-associated glycoprotein (MAG), has also been shown to protect neurons from axonal degeneration through activation of the small GTPase protein ..
- Fujikura K, Setsu T, Tanigaki K, Abe T, Kiyonari H, Terashima T, et al. Kif14 mutation causes severe brain malformation and hypomyelination. PLoS ONE. 2013;8:e53490 pubmed publisher..The discovery of mammalian models, laggard, has opened up horizons for researchers to add more knowledge regarding the etiology and pathology of brain malformation. ..
- Haney C, Sahenk Z, Li C, Lemmon V, Roder J, Trapp B. Heterophilic binding of L1 on unmyelinated sensory axons mediates Schwann cell adhesion and is required for axonal survival. J Cell Biol. 1999;146:1173-84 pubmed
- Yabe D, Nakamura T, Kanazawa N, Tashiro K, Honjo T. Calumenin, a Ca2+-binding protein retained in the endoplasmic reticulum with a novel carboxyl-terminal sequence, HDEF. J Biol Chem. 1997;272:18232-9 pubmed..Calumenin is expressed most strongly in heart of adult and 18.5-day embryos. The calumenin gene (Calu) was mapped at the proximal portion of mouse chromosome 7. ..
- Sugimori M, Nagao M, Parras C, Nakatani H, Lebel M, Guillemot F, et al. Ascl1 is required for oligodendrocyte development in the spinal cord. Development. 2008;135:1271-81 pubmed publisher..Thus, Ascl1 regulates multiple aspects of oligodendrocyte development in the spinal cord. ..
- Khazaei M, Halfter H, Karimzadeh F, Koo J, Margolis F, Young P. Bex1 is involved in the regeneration of axons after injury. J Neurochem. 2010;115:910-20 pubmed publisher..Wild-type mice could recover from sciatic nerve injury much faster than Bex1 knock-out mice. Our findings suggest that Bex1 could be considered as regeneration-associated gene. ..
- Liu B, Fournier A, GrandPre T, Strittmatter S. Myelin-associated glycoprotein as a functional ligand for the Nogo-66 receptor. Science. 2002;297:1190-3 pubmed..adult central nervous system (CNS) is limited by two proteins in myelin, Nogo and myelin-associated glycoprotein (MAG)...
- Schafer M, Fruttiger M, Montag D, Schachner M, Martini R. Disruption of the gene for the myelin-associated glycoprotein improves axonal regrowth along myelin in C57BL/Wlds mice. Neuron. 1996;16:1107-13 pubmedThe myelin-associated glycoprotein (MAG) has been shown to be inhibitory for certain neurons in vitro (Mukhopadhyay et al., 1994; McKerracher et al., 1994)...
- Kao S, Wu H, Xie J, Chang C, Ranish J, Graef I, et al. Calcineurin/NFAT signaling is required for neuregulin-regulated Schwann cell differentiation. Science. 2009;323:651-4 pubmed publisher..Our studies demonstrate that calcineurin and NFAT are essential for neuregulin and ErbB signaling, neural crest diversification, and differentiation of Schwann cells. ..
- Mikoshiba K, Okano H, Miyawaki A, Furuichi T, Ikenaka K. Molecular genetic analyses of myelin deficiency and cerebellar ataxia. Prog Brain Res. 1995;105:23-41 pubmed
- Keeney D. The novel skin-specific cytochrome P450 Cyp2b19 maps to proximal chromosome 7 in the mouse, near a cluster of Cyp2 family genes. Genomics. 1998;53:417-9 pubmed
- Fujita N, Kemper A, DuPree J, Nakayasu H, Bartsch U, Schachner M, et al. The cytoplasmic domain of the large myelin-associated glycoprotein isoform is needed for proper CNS but not peripheral nervous system myelination. J Neurosci. 1998;18:1970-8 pubmedThe myelin-associated glycoprotein (MAG) is a member of the immunoglobulin gene superfamily and is thought to play a critical role in the interaction of myelinating glial cells with the axon...
- Yin X, Kidd G, Nave K, Trapp B. P0 protein is required for and can induce formation of schmidt-lantermann incisures in myelin internodes. J Neurosci. 2008;28:7068-73 pubmed publisher..Membranes of these Schmidt-Lantermann (S-L) incisures contain the myelin-associated glycoprotein (MAG) but not P(0) or proteolipid protein (PLP), the structural proteins of compact PNS (P(0)) and CNS (PLP) myelin...
- Dutta D, Zameer A, Mariani J, Zhang J, Asp L, Huynh J, et al. Combinatorial actions of Tgf? and Activin ligands promote oligodendrocyte development and CNS myelination. Development. 2014;141:2414-28 pubmed publisher..Collectively, these findings suggest that, in mammalian spinal cord, Tgf? ligands and ActB together support oligodendrocyte development and myelin formation. ..