Gene Symbol: Mafb
Description: v-maf musculoaponeurotic fibrosarcoma oncogene family, protein B (avian)
Alias: Kreisler, Krml, Krml1, transcription factor MafB, Kreisler (maf-related) leucine zipper protein, V-maf musculoaponeurotic fibrosarcoma oncogene homolog B, maf-B, segmentation protein Kr, transcription factor Maf-1
Species: mouse
Products:     Mafb

Top Publications

  1. Artner I, Blanchi B, Raum J, Guo M, Kaneko T, Cordes S, et al. MafB is required for islet beta cell maturation. Proc Natl Acad Sci U S A. 2007;104:3853-8 pubmed
    ..Islet cell development was examined in mice lacking MafB, a transcription factor expressed in immature alpha (glucagon(+)) and beta (insulin(+)) cells and capable of ..
  2. Appler J, Lu C, Druckenbrod N, Yu W, Koundakjian E, Goodrich L. Gata3 is a critical regulator of cochlear wiring. J Neurosci. 2013;33:3679-91 pubmed publisher
    ..As the first auditory-specific regulator of SGN development, Gata3 provides a useful molecular entry point for efforts to engineer SGNs for the restoration of hearing. ..
  3. Artner I, Hang Y, Guo M, Gu G, Stein R. MafA is a dedicated activator of the insulin gene in vivo. J Endocrinol. 2008;198:271-9 pubmed publisher
    ..The closely related MafA and MafB transcription factors are both key mammalian beta-cell regulators...
  4. Rossel M, Capecchi M. Mice mutant for both Hoxa1 and Hoxb1 show extensive remodeling of the hindbrain and defects in craniofacial development. Development. 1999;126:5027-40 pubmed
  5. Artner I, Le Lay J, Hang Y, Elghazi L, Schisler J, Henderson E, et al. MafB: an activator of the glucagon gene expressed in developing islet alpha- and beta-cells. Diabetes. 2006;55:297-304 pubmed
    ..Here, we demonstrate that within the adult pancreas, MafB is only expressed in islet alpha-cells and contributes to cell type-specific expression of the glucagon gene ..
  6. Choo D, Ward J, Reece A, Dou H, Lin Z, Greinwald J. Molecular mechanisms underlying inner ear patterning defects in kreisler mutants. Dev Biol. 2006;289:308-17 pubmed
    Prior studies have shown that kreisler mutants display early inner ear defects that are related to abnormal hindbrain development and signaling. These defects in kreisler mice have been linked to mutation of the kr/mafB gene...
  7. Theil T, Ariza McNaughton L, Manzanares M, Brodie J, Krumlauf R, Wilkinson D. Requirement for downregulation of kreisler during late patterning of the hindbrain. Development. 2002;129:1477-85 pubmed
    ..A cascade of transcriptional activators, including the bZIP transcription factor encoded by the kreisler gene controls this segmentation process...
  8. McKay I, Muchamore I, Krumlauf R, Maden M, Lumsden A, Lewis J. The kreisler mouse: a hindbrain segmentation mutant that lacks two rhombomeres. Development. 1994;120:2199-211 pubmed
    b>kreisler is a recessive mutation resulting in gross malformation of the inner ear of homozygous mice. The defects in the inner ear are related to abnormalities in the hindbrain of the embryo, adjacent to the ear rudiments. At E9...
  9. Saul S, Brzezinski J, Altschuler R, Shore S, Rudolph D, Kabara L, et al. Math5 expression and function in the central auditory system. Mol Cell Neurosci. 2008;37:153-69 pubmed
    ..These cells co-express MafB and are post-mitotic...

More Information


  1. Wang S, Zhang J, Zhao A, Hipkens S, Magnuson M, Gu G. Loss of Myt1 function partially compromises endocrine islet cell differentiation and pancreatic physiological function in the mouse. Mech Dev. 2007;124:898-910 pubmed
    ..The consequences of Myt1 inactivation in the developing pancreas could be masked by activation of its paralogs, Myt1l and Myt3. These findings suggest Myt1 is involved in proper endocrine differentiation and function. ..
  2. Tillmanns S, Otto C, Jaffray E, Du Roure C, Bakri Y, Vanhille L, et al. SUMO modification regulates MafB-driven macrophage differentiation by enabling Myb-dependent transcriptional repression. Mol Cell Biol. 2007;27:5554-64 pubmed
    ..Thus, the myeloid transcription factor MafB promotes macrophage differentiation of myeloid progenitors, but a constitutively active Myb ..
  3. Aziz A, Vanhille L, Mohideen P, Kelly L, Otto C, Bakri Y, et al. Development of macrophages with altered actin organization in the absence of MafB. Mol Cell Biol. 2006;26:6808-18 pubmed
    In the hematopoietic system the bZip transcription factor MafB is selectively expressed at high levels in monocytes and macrophages and promotes macrophage differentiation in myeloid progenitors, whereas a dominant-negative allele can ..
  4. Nishimura W, Kondo T, Salameh T, El Khattabi I, Dodge R, Bonner Weir S, et al. A switch from MafB to MafA expression accompanies differentiation to pancreatic beta-cells. Dev Biol. 2006;293:526-39 pubmed
    ..Ectopically expressed large-Maf factors, MafA, MafB, or cMaf, induced expression from insulin and glucagon reporter constructs, demonstrating a redundancy in their ..
  5. Blanchi B, Kelly L, Viemari J, Lafon I, Burnet H, Bevengut M, et al. MafB deficiency causes defective respiratory rhythmogenesis and fatal central apnea at birth. Nat Neurosci. 2003;6:1091-100 pubmed
    ..Here we show that mice deficient for the transcription factor MafB die from central apnea at birth and are defective for respiratory rhythmogenesis in vitro...
  6. Sadl V, Sing A, Mar L, Jin F, Cordes S. Analysis of hindbrain patterning defects caused by the kreisler(enu) mutation reveals multiple roles of Kreisler in hindbrain segmentation. Dev Dyn. 2003;227:134-42 pubmed
    The embryonic hindbrain is subdivided into eight subunits, termed rhombomeres (r1-r8). The Kreisler (Krml1/MafB/val) transcription factor is expressed in and essential for patterning rhombomeres 5 and 6...
  7. Cordes S, Barsh G. The mouse segmentation gene kr encodes a novel basic domain-leucine zipper transcription factor. Cell. 1994;79:1025-34 pubmed
    The mouse kreisler (kr) mutation causes segmentation abnormalities in the caudal hindbrain and defective inner ear development...
  8. Huang K, Serria M, Nakabayashi H, Nishi S, Sakai M. Molecular cloning and functional characterization of the mouse mafB gene. Gene. 2000;242:419-26 pubmed
    ..To clarify the molecular mechanisms controlling mafB expression, a genomic clone of the mouse mafB gene was isolated and analyzed...
  9. Wang S, Jensen J, Seymour P, Hsu W, Dor Y, Sander M, et al. Sustained Neurog3 expression in hormone-expressing islet cells is required for endocrine maturation and function. Proc Natl Acad Sci U S A. 2009;106:9715-20 pubmed publisher
    ..These findings demonstrate that Neurog3 is required not only for initiating endocrine cell differentiation, but also for promoting islet cell maturation and maintaining islet function. ..
  10. Manzanares M, Trainor P, Nonchev S, Ariza McNaughton L, Brodie J, Gould A, et al. The role of kreisler in segmentation during hindbrain development. Dev Biol. 1999;211:220-37 pubmed
    The mouse kreisler gene is expressed in rhombomeres (r) 5 and 6 during neural development and kreisler mutants have patterning defects in the hindbrain that are not fully understood...
  11. Kim K, Kim J, Lee J, Jin H, Kook H, Kim K, et al. MafB negatively regulates RANKL-mediated osteoclast differentiation. Blood. 2007;109:3253-9 pubmed
    ..Here, we show that MafB negatively regulates RANKL-induced osteoclast differentiation...
  12. Frohman M, Martin G, Cordes S, Halamek L, Barsh G. Altered rhombomere-specific gene expression and hyoid bone differentiation in the mouse segmentation mutant, kreisler (kr). Development. 1993;117:925-36 pubmed in situ hybridization, the expression of five rhombomere-specific genes in mouse embryos homozygous for the kreisler (kr) mutation, in which rhombomeres 4-7 are replaced by a smooth morphologically unsegmented neural tube...
  13. Nishimura W, Rowan S, Salameh T, Maas R, Bonner Weir S, Sell S, et al. Preferential reduction of beta cells derived from Pax6-MafB pathway in MafB deficient mice. Dev Biol. 2008;314:443-56 pubmed publisher
    During pancreatic development insulin(+) cells co-express the transcription factors MafB and Pax6, and transition from a MafA(-) to MafA(+) state...
  14. Wang S, Hecksher Sorensen J, Xu Y, Zhao A, Dor Y, Rosenberg L, et al. Myt1 and Ngn3 form a feed-forward expression loop to promote endocrine islet cell differentiation. Dev Biol. 2008;317:531-40 pubmed publisher
  15. Matsuoka T, Zhao L, Artner I, Jarrett H, Friedman D, Means A, et al. Members of the large Maf transcription family regulate insulin gene transcription in islet beta cells. Mol Cell Biol. 2003;23:6049-62 pubmed
    ..that mouse islets express not only MafA but also other members of the large Maf family, specifically c-Maf and MafB. Furthermore, immunohistochemical studies revealed that at least MafA and MafB were present within the nuclei of ..
  16. DeFalco T, Takahashi S, Capel B. Two distinct origins for Leydig cell progenitors in the fetal testis. Dev Biol. 2011;352:14-26 pubmed publisher
    ..molecular heterogeneity in the interstitium and have characterized new markers of distinct cell types in the gonad: MAFB, C-MAF, and VCAM1...
  17. Vitobello A, Ferretti E, Lampe X, Vilain N, Ducret S, Ori M, et al. Hox and Pbx factors control retinoic acid synthesis during hindbrain segmentation. Dev Cell. 2011;20:469-82 pubmed publisher
    ..These findings reveal a feed-forward mechanism linking Hox-Pbx-dependent RA synthesis during early axial patterning with the establishment of spatially restricted Hox-Pbx activity in the developing hindbrain. ..
  18. Giudicelli F, Gilardi Hebenstreit P, Mechta Grigoriou F, Poquet C, Charnay P. Novel activities of Mafb underlie its dual role in hindbrain segmentation and regional specification. Dev Biol. 2003;253:150-62 pubmed
    The bZip transcription factor Mafb is expressed in two segments of the developing vertebrate hindbrain: the rhombomeres 5 and 6...
  19. Sarrazin S, Mossadegh Keller N, Fukao T, Aziz A, Mourcin F, Vanhille L, et al. MafB restricts M-CSF-dependent myeloid commitment divisions of hematopoietic stem cells. Cell. 2009;138:300-13 pubmed publisher
    ..Here, we report that the monocytic transcription factor MafB specifically restricts the ability of M-CSF to instruct myeloid commitment divisions in HSCs...
  20. Seymour P, Freude K, Tran M, Mayes E, Jensen J, Kist R, et al. SOX9 is required for maintenance of the pancreatic progenitor cell pool. Proc Natl Acad Sci U S A. 2007;104:1865-70 pubmed
    ..These findings will be of major significance for the development of in vitro protocols for cell replacement therapies. ..
  21. Sadl V, Jin F, Yu J, Cui S, Holmyard D, Quaggin S, et al. The mouse Kreisler (Krml1/MafB) segmentation gene is required for differentiation of glomerular visceral epithelial cells. Dev Biol. 2002;249:16-29 pubmed
    ..bZip) transcription factors of the Maf subfamily have been implicated in cellular differentiation processes, Kreisler (Krml1/MafB), the gene affected in the mouse kreisler (kr) mutation, is known for its role in hindbrain ..
  22. Machiya J, Shibata Y, Yamauchi K, Hirama N, Wada T, Inoue S, et al. Enhanced expression of MafB inhibits macrophage apoptosis induced by cigarette smoke exposure. Am J Respir Cell Mol Biol. 2007;36:418-26 pubmed
    ..Among the transcriptional factors investigated, only MafB was upregulated in AMs from CS-exposed mice...
  23. Moriguchi T, Hamada M, Morito N, Terunuma T, Hasegawa K, Zhang C, et al. MafB is essential for renal development and F4/80 expression in macrophages. Mol Cell Biol. 2006;26:5715-27 pubmed
    b>MafB is a member of the large Maf family of transcription factors that share similar basic region/leucine zipper DNA binding motifs and N-terminal activation domains...
  24. Voiculescu O, Taillebourg E, Pujades C, Kress C, Buart S, Charnay P, et al. Hindbrain patterning: Krox20 couples segmentation and specification of regional identity. Development. 2001;128:4967-78 pubmed
  25. Zhao Y, Flandin P, Vogt D, Blood A, Hermesz E, Westphal H, et al. Ldb1 is essential for development of Nkx2.1 lineage derived GABAergic and cholinergic neurons in the telencephalon. Dev Biol. 2014;385:94-106 pubmed publisher
    ..These results provide evidence that Ldb1 plays an essential role as a transcription co-regulator of Lhx6 and Lhx8 in the control of mammalian telencephalon development. ..
  26. Vicente Dueñas C, González Herrero I, García Cenador M, García Criado F, Sanchez Garcia I. Loss of p53 exacerbates multiple myeloma phenotype by facilitating the reprogramming of hematopoietic stem/progenitor cells to malignant plasma cells by MafB. Cell Cycle. 2012;11:3896-900 pubmed publisher
    ..Chromosomal translocations affecting MAFB are present in a significant percentage of multiple myeloma patients...
  27. Fekete D. Development of the vertebrate ear: insights from knockouts and mutants. Trends Neurosci. 1999;22:263-9 pubmed
    ..Genes that are regionally expressed in the inner ear can, when absent or mutated, yield selective ablation of specific inner-ear structures or cell types. ..
  28. Churchill A, Gutiérrez G, Singer R, Lorberbaum D, Fischer K, Sussel L. Genetic evidence that Nkx2.2 acts primarily downstream of Neurog3 in pancreatic endocrine lineage development. elife. 2017;6: pubmed publisher
    ..Consistently, we demonstrate Nkx2.2 functions as an integral component of a modular regulatory program to correctly specify pancreatic islet cell fates. ..
  29. Manzanares M, Cordes S, Ariza McNaughton L, Sadl V, Maruthainar K, Barsh G, et al. Conserved and distinct roles of kreisler in regulation of the paralogous Hoxa3 and Hoxb3 genes. Development. 1999;126:759-69 pubmed
    ..that was found to contain a single high-affinity binding site for the Maf bZIP protein Krml1, encoded by the kreisler gene...
  30. McKay I, Lewis J, Lumsden A. The role of FGF-3 in early inner ear development: an analysis in normal and kreisler mutant mice. Dev Biol. 1996;174:370-8 pubmed
    ..In kreisler mutant embryos, however, there is no heightened expression in r5 and r6, but the early patch of expression in the ..
  31. Plank J, Mundell N, Frist A, Legrone A, Kim T, Musser M, et al. Influence and timing of arrival of murine neural crest on pancreatic beta cell development and maturation. Dev Biol. 2011;349:321-30 pubmed publisher
    ..Together, these data demonstrate that the neural crest is a critical regulator of beta cell development on two levels: by negatively regulating beta cell proliferation and by promoting beta cell maturation. ..
  32. Park J, Tischfield M, Nugent A, Cheng L, Di Gioia S, Chan W, et al. Loss of MAFB Function in Humans and Mice Causes Duane Syndrome, Aberrant Extraocular Muscle Innervation, and Inner-Ear Defects. Am J Hum Genet. 2016;98:1220-1227 pubmed publisher
    ..Here, we report on three heterozygous loss-of-function MAFB mutations causing DRS and a dominant-negative MAFB mutation causing DRS and deafness...
  33. Mar L, Rivkin E, Kim D, Yu J, Cordes S. A genetic screen for mutations that affect cranial nerve development in the mouse. J Neurosci. 2005;25:11787-95 pubmed
  34. McKay I, Lewis J, Lumsden A. Organization and development of facial motor neurons in the kreisler mutant mouse. Eur J Neurosci. 1997;9:1499-506 pubmed
    ..The motor neurons of the facial nerve are known to originate within rhombomeres 4 and 5. In the kreisler mouse mutant there is a specific disruption of the hindbrain rhombomeres 5 and 6 appear to be absent...
  35. Spaeth J, Hunter C, Bonatakis L, Guo M, French C, Slack I, et al. The FOXP1, FOXP2 and FOXP4 transcription factors are required for islet alpha cell proliferation and function in mice. Diabetologia. 2015;58:1836-44 pubmed publisher
    ..Collectively, these findings reveal an important role for the FOXP1, 2, and 4 proteins in governing postnatal alpha cell expansion and function. ..
  36. Dieterich L, Klein S, Mathelier A, Sliwa Primorac A, Ma Q, Hong Y, et al. DeepCAGE Transcriptomics Reveal an Important Role of the Transcription Factor MAFB in the Lymphatic Endothelium. Cell Rep. 2015;13:1493-1504 pubmed publisher
    ..We found that MAFB, a TF involved in differentiation of various cell types, is rapidly induced and activated by VEGF-C...
  37. Zelarayan L, Vendrell V, Alvarez Y, Dominguez Frutos E, Theil T, Alonso M, et al. Differential requirements for FGF3, FGF8 and FGF10 during inner ear development. Dev Biol. 2007;308:379-91 pubmed
    ..Together these results provide important insights into how the spatial and temporal expression of various FGFs controls different steps of inner ear formation during vertebrate development. ..
  38. Textor L, Wilmanns M, Holton S. Expression, purification, crystallization and preliminary crystallographic analysis of the mouse transcription factor MafB in complex with its DNA-recognition motif Cmare. Acta Crystallogr Sect F Struct Biol Cryst Commun. 2007;63:657-61 pubmed
    The MafB transcription factor (residues 211-305) has been overexpressed in and purified from Escherichia coli...
  39. Cheng G, Salerno J, Cao Z, Pagano P, Lambeth J. Identification and characterization of VPO1, a new animal heme-containing peroxidase. Free Radic Biol Med. 2008;45:1682-94 pubmed publisher
    ..5 mM. When co-expressed in cells, VPO1 can use H(2)O(2) produced by NADPH oxidase enzymes. VPO1 is likely to carry out peroxidative reactions previously attributed exclusively to myeloperoxidase in the vascular system. ..
  40. Li F, Su Y, Cheng Y, Jiang X, Peng Y, Li Y, et al. Conditional deletion of Men1 in the pancreatic β-cell leads to glucagon-expressing tumor development. Endocrinology. 2015;156:48-57 pubmed publisher
    ..homeobox POU domain protein 4 (Brn4) and v-maf musculoaponeurotic fibrosarcoma oncogene family, protein B (MafB). Moreover, the inactivation of β-cell-specific transcription factors was observed in mutant β-cells...
  41. Mechta Grigoriou F, Giudicelli F, Pujades C, Charnay P, Yaniv M. c-jun regulation and function in the developing hindbrain. Dev Biol. 2003;258:419-31 pubmed
    Hindbrain development is a well-characterised segmentation process in vertebrates. The bZip transcription factor MafB/kreisler is specifically expressed in rhombomeres (r) 5 and 6 of the developing vertebrate hindbrain and is required ..
  42. Sturgeon K, Kaneko T, Biemann M, Gauthier A, Chawengsaksophak K, Cordes S. Cdx1 refines positional identity of the vertebrate hindbrain by directly repressing Mafb expression. Development. 2011;138:65-74 pubmed publisher
    ..Mafb (Kreisler, Krml1, valentino), a basic domain leucine zipper transcription factor, is required for development of r5 and r6 ..
  43. Remacle S, Abbas L, De Backer O, Pacico N, Gavalas A, Gofflot F, et al. Loss of function but no gain of function caused by amino acid substitutions in the hexapeptide of Hoxa1 in vivo. Mol Cell Biol. 2004;24:8567-75 pubmed
  44. Hamada M, Nakamura M, Tran M, Moriguchi T, Hong C, Ohsumi T, et al. MafB promotes atherosclerosis by inhibiting foam-cell apoptosis. Nat Commun. 2014;5:3147 pubmed publisher
    b>MafB is a transcription factor that induces myelomonocytic differentiation. However, the precise role of MafB in the pathogenic function of macrophages has never been clarified...
  45. Koshida R, Oishi H, Hamada M, Takei Y, Takahashi S. MafB is required for development of the hindbrain choroid plexus. Biochem Biophys Res Commun. 2017;483:288-293 pubmed publisher
    ..However, molecular mechanisms underlying ChP development are poorly understood compared to neural development. MafB is a bZip transcription factor that is known to be expressed in the roof plate...
  46. Anderson K, White P, Kaestner K, Sussel L. Identification of known and novel pancreas genes expressed downstream of Nkx2.2 during development. BMC Dev Biol. 2009;9:65 pubmed publisher
    ..2 in maintaining appropriate exocrine gene expression. Most importantly, Nkx2.2 appears to function within a complex regulatory loop with Ngn3 at a key endocrine differentiation step. ..
  47. Wang S, Yan J, Anderson D, Xu Y, Kanal M, Cao Z, et al. Neurog3 gene dosage regulates allocation of endocrine and exocrine cell fates in the developing mouse pancreas. Dev Biol. 2010;339:26-37 pubmed publisher
    ..The control of Neurog3+ cell number and the Neurog3 threshold-dependent endocrine differentiation mechanism combine to select a specific proportion of pancreatic progenitor cells to adopt the islet cell fate. ..
  48. Fujiyama T, Yamada M, Terao M, Terashima T, Hioki H, Inoue Y, et al. Inhibitory and excitatory subtypes of cochlear nucleus neurons are defined by distinct bHLH transcription factors, Ptf1a and Atoh1. Development. 2009;136:2049-58 pubmed publisher
  49. Alvarez Y, Alonso M, Vendrell V, Zelarayan L, Chamero P, Theil T, et al. Requirements for FGF3 and FGF10 during inner ear formation. Development. 2003;130:6329-38 pubmed
    ..We thus created double mutant mice for FGF3 and FGF10, which form severely reduced otic vesicles, suggesting redundant roles of these FGFs, acting in combination as neural signals for otic vesicle formation. ..
  50. Kase S, Imaki J, Harada T, Harada C, Ohgami K, Shiratori K, et al. Expression of maf-B mRNA in the epithelium around the eyelid closure of the mouse eye at embryonic day 18. Anat Embryol (Berl). 2004;209:153-6 pubmed
    ..In contrast, basal cells in the eyelid closure and in the epidermis, as well as keratinizing cells, did not express maf-B. These data indicate that maf-B mRNA is expressed during development of the eyelid closure. ..
  51. Morito N, Yoh K, Ojima M, Okamura M, Nakamura M, Hamada M, et al. Overexpression of Mafb in podocytes protects against diabetic nephropathy. J Am Soc Nephrol. 2014;25:2546-57 pubmed publisher
    We previously showed that the transcription factor Mafb is essential for podocyte differentiation and foot process formation. Podocytes are susceptible to injury in diabetes, and this injury leads to progression of diabetic nephropathy...
  52. Kim S, Lee J, Merrins M, Gavrilova O, Bisteau X, Kaldis P, et al. Loss of Cyclin-dependent Kinase 2 in the Pancreas Links Primary ?-Cell Dysfunction to Progressive Depletion of ?-Cell Mass and Diabetes. J Biol Chem. 2017;292:3841-3853 pubmed publisher
    ..Thus, CDK2 serves as an important nexus linking primary ?-cell dysfunction to progressive ?-cell mass deterioration in diabetes. ..
  53. Talchai C, Xuan S, Kitamura T, Depinho R, Accili D. Generation of functional insulin-producing cells in the gut by Foxo1 ablation. Nat Genet. 2012;44:406-12, S1 pubmed publisher
    ..The data indicate that Neurog3(+) enteroendocrine progenitors require active Foxo1 to prevent differentiation into Ins(+) cells. Foxo1 ablation in gut epithelium may provide an approach to restore insulin production in type 1 diabetes. ..
  54. Raum J, Soleimanpour S, Groff D, Coré N, Fasano L, Garratt A, et al. Tshz1 Regulates Pancreatic β-Cell Maturation. Diabetes. 2015;64:2905-14 pubmed publisher
    ..1) and α-cell (MafB and Arx) formation and function are downregulated...
  55. Pouilhe M, Gilardi Hebenstreit P, Desmarquet Trin Dinh C, Charnay P. Direct regulation of vHnf1 by retinoic acid signaling and MAF-related factors in the neural tube. Dev Biol. 2007;309:344-57 pubmed
    ..Our data suggest that MAFB, which is itself regulated by vHNF1, acts as a positive modulator of vHnf1 in r5 and r6, whereas another MAF-..
  56. Lu J, Herrera P, Carreira C, Bonnavion R, Seigne C, Calender A, et al. Alpha cell-specific Men1 ablation triggers the transdifferentiation of glucagon-expressing cells and insulinoma development. Gastroenterology. 2010;138:1954-65 pubmed publisher
    ..The purpose of the current study was to address this issue in relation to islet tumor histogenesis...
  57. Aziz A, Soucie E, Sarrazin S, Sieweke M. MafB/c-Maf deficiency enables self-renewal of differentiated functional macrophages. Science. 2009;326:867-71 pubmed publisher
    ..Here, we report that combined deficiency for the transcription factors MafB and c-Maf enables extended expansion of mature monocytes and macrophages in culture without loss of differentiated ..
  58. Nishimura W, Takahashi S, Yasuda K. MafA is critical for maintenance of the mature beta cell phenotype in mice. Diabetologia. 2015;58:566-74 pubmed publisher
    ..cells in db/db and multiple low-dose streptozotocin mice underwent similar dedifferentiation with expression of Mafb, which is expressed in immature beta cells...
  59. Conrad E, Dai C, Spaeth J, Guo M, Cyphert H, Scoville D, et al. The MAFB transcription factor impacts islet α-cell function in rodents and represents a unique signature of primate islet β-cells. Am J Physiol Endocrinol Metab. 2016;310:E91-E102 pubmed publisher
    Analysis of MafB(-/-) mice has suggested that the MAFB transcription factor was essential to islet α- and β-cell formation during development, although the postnatal physiological impact could not be studied here because these ..
  60. Johnson N, Posluszny J, He L, Szilagyi A, Gamelli R, Shankar R, et al. Perturbed MafB/GATA1 axis after burn trauma bares the potential mechanism for immune suppression and anemia of critical illness. J Leukoc Biol. 2016;100:725-736 pubmed
  61. Shichita T, Ito M, Morita R, Komai K, Noguchi Y, Ooboshi H, et al. MAFB prevents excess inflammation after ischemic stroke by accelerating clearance of damage signals through MSR1. Nat Med. 2017;23:723-732 pubmed publisher
    ..of MSR1 levels in infiltrating myeloid cells observed 3 d after experimental stroke was dependent on the transcription factor Mafb. Combined deficiency for Msr1 and Marco, or for Mafb alone, in infiltrating myeloid cells caused ..
  62. Sato Nishiwaki M, Aida Y, Abe S, Shibata Y, Kimura T, Yamauchi K, et al. Reduced number and morphofunctional change of alveolar macrophages in MafB gene-targeted mice. PLoS ONE. 2013;8:e73963 pubmed publisher
    ..We previously demonstrated that the transcription factor, MafB, increased in the AMs of mice exposed to cigarette smoke, and in those of human patients with COPD...
  63. Medina Martinez O, Shah R, Jamrich M. Pitx3 controls multiple aspects of lens development. Dev Dyn. 2009;238:2193-201 pubmed publisher
    ..In general, our study shows that the abnormal phenotype of the ak lenses is not due to just one molecular pathway, rather in the absence of Pitx3 expression multiple aspects of lens development are disrupted. ..
  64. Dupé V, Ghyselinck N, Wendling O, Chambon P, Mark M. Key roles of retinoic acid receptors alpha and beta in the patterning of the caudal hindbrain, pharyngeal arches and otocyst in the mouse. Development. 1999;126:5051-9 pubmed
    ..In the mutant hindbrain, the expression domain of kreisler is twice its normal size and the caudal stripe of Krox-20 extends into the presumptive rhombomeres 6 and 7 region...
  65. Kim F, Sing l A, Kaneko T, Bieman M, Stallwood N, Sadl V, et al. The vHNF1 homeodomain protein establishes early rhombomere identity by direct regulation of Kreisler expression. Mech Dev. 2005;122:1300-9 pubmed
    ..The Kreisler (MafB, Krml1, Val) gene is earliest gene expressed in an r5/r6-restricted manner and is essential for r5 and r6 ..
  66. Lin Z, Cantos R, Patente M, Wu D. Gbx2 is required for the morphogenesis of the mouse inner ear: a downstream candidate of hindbrain signaling. Development. 2005;132:2309-18 pubmed
    ..These inner ear phenotypes are remarkably similar to those reported in kreisler mice, which have inner ear defects attributed to defects in the hindbrain...
  67. Li J, Lao Z, Joyner A. New regulatory interactions and cellular responses in the isthmic organizer region revealed by altering Gbx2 expression. Development. 2005;132:1971-81 pubmed
    ..Our studies provide new insights into the regulatory interactions that maintain isthmic organizer gene expression and the consequences of altered levels of organizer gene expression on cell survival. ..
  68. Ladher R, Wright T, Moon A, Mansour S, Schoenwolf G. FGF8 initiates inner ear induction in chick and mouse. Genes Dev. 2005;19:603-13 pubmed
    ..Thus, Fgf8 plays a critical upstream role in an FGF signaling cascade required for otic induction in chick and mouse. ..
  69. Kajihara M, Sone H, Amemiya M, Katoh Y, Isogai M, Shimano H, et al. Mouse MafA, homologue of zebrafish somite Maf 1, contributes to the specific transcriptional activity through the insulin promoter. Biochem Biophys Res Commun. 2003;312:831-42 pubmed
    ..These results indicate that MafA is the homologue of zebrafish SMaf1 and acts as a transcriptional activator of the insulin gene promoter through the RIPE3b element. ..
  70. Deol M. THE ABNORMALITIES OF THE INNER EAR IN KREISLER MICE. J Embryol Exp Morphol. 1964;12:475-90 pubmed
  71. Chatonnet F, del Toro E, Voiculescu O, Charnay P, Champagnat J. Different respiratory control systems are affected in homozygous and heterozygous kreisler mutant mice. Eur J Neurosci. 2002;15:684-92 pubmed
    During embryonic development, restricted expression of the regulatory genes Krox20 and kreisler are involved in segmentation and antero-posterior patterning of the hindbrain neural tube...
  72. Ruben R. Development and cell kinetics of the kreisler (kr-kr) mouse. Laryngoscope. 1973;83:1440-68 pubmed
  73. Kierdorf K, Erny D, Goldmann T, Sander V, Schulz C, Perdiguero E, et al. Microglia emerge from erythromyeloid precursors via Pu.1- and Irf8-dependent pathways. Nat Neurosci. 2013;16:273-80 pubmed publisher
    ..Our data provide cellular and molecular insights into the origin and development of microglia. ..
  74. Millonig J, Millen K, Hatten M. The mouse Dreher gene Lmx1a controls formation of the roof plate in the vertebrate CNS. Nature. 2000;403:764-9 pubmed
    ..Lmx1a is expressed in the roof plate along the neuraxis during development of the CNS. Thus, Lmx1a is required for development of the roof plate and, in turn, for specification of dorsal cell fates in the CNS and developing vertebrae. ..
  75. Niederreither K, Vermot J, Le Roux I, Schuhbaur B, Chambon P, Dolle P. The regional pattern of retinoic acid synthesis by RALDH2 is essential for the development of posterior pharyngeal arches and the enteric nervous system. Development. 2003;130:2525-34 pubmed
    ..Thus, RALDH2 plays a crucial role in producing RA required for pharyngeal development, and RA is one of the diffusible mesodermal signals that pattern the pharyngeal endoderm. ..
  76. Tomotsune D, Shirai M, Takihara Y, Shimada K. Regulation of Hoxb3 expression in the hindbrain and pharyngeal arches by rae28, a member of the mammalian Polycomb group of genes. Mech Dev. 2000;98:165-9 pubmed
    ..5 to E12.5. Expression of kreisler and Krox20, which function as positive regulators of Hoxb3 expression, was not affected in rae28-deficient ..