Gene Symbol: Mab21l2
Description: mab-21-like 2 (C. elegans)
Alias: protein mab-21-like 2
Species: mouse
Products:     Mab21l2

Top Publications

  1. Mariani M, Baldessari D, Francisconi S, Viggiano L, Rocchi M, Zappavigna V, et al. Two murine and human homologs of mab-21, a cell fate determination gene involved in Caenorhabditis elegans neural development. Hum Mol Genet. 1999;8:2397-406 pubmed
  2. Wong R, Chow K. Depletion of Mab21l1 and Mab21l2 messages in mouse embryo arrests axial turning, and impairs notochord and neural tube differentiation. Teratology. 2002;65:70-7 pubmed
    ..In this report, we characterized in detail two Mab21 orthologs in mouse, Mab21l1 and Mab21l2. We examined the genomic organizations of Mab21 genes and used northern blot and in situ hybridizations to assay ..
  3. Yamada R, Mizutani Koseki Y, Koseki H, Takahashi N. Requirement for Mab21l2 during development of murine retina and ventral body wall. Dev Biol. 2004;274:295-307 pubmed
    ..a family of genes that are highly conserved from vertebrates to invertebrates, and two homologues Mab21l1 and Mab21l2 have been identified in many species...
  4. Wong R, Chan K, Chow K. Developmental expression of Mab21l2 during mouse embryogenesis. Mech Dev. 1999;87:185-8 pubmed al., 1998. Mech. Dev. 79, 131-135. We report here the expression profile of a second murine mab-21 homolog, Mab21l2 [Wong, R.L.Y., Wong, H.T., Chow, K.L., 1999. Cyto. Cell Genet., [in press]...
  5. Wong R, Wong H, Chow K. Genomic cloning and chromosomal localization of the mouse Mab21l2 locus. Cytogenet Cell Genet. 1999;86:21-4 pubmed
    A second mouse gene related to the nematode mab-21 gene has been isolated. This gene, Mab21l2, encodes a transcript with an open reading frame discretely organized in a single exon. It shares 93.3% and 55...
  6. Yamada R, Mizutani Koseki Y, Hasegawa T, Osumi N, Koseki H, Takahashi N. Cell-autonomous involvement of Mab21l1 is essential for lens placode development. Development. 2003;130:1759-70 pubmed
    ..a family of genes that are highly conserved from vertebrates to invertebrates, and two homologs, Mab21l1 and Mab21l2, have been identified in many species...
  7. Tsang W, Shek K, Lee T, Chow K. An evolutionarily conserved nested gene pair - Mab21 and Lrba/Nbea in metazoan. Genomics. 2009;94:177-87 pubmed publisher
    ..paralogous genomic sequence comparison strategy was used in this study to align these paralogous nested pairs, Mab21l2-Lrba and Mab21l1-Nbea, to identify the associated paralogous non-coding elements (pNEs) they shared...
  8. Matsumaru D, Haraguchi R, Moon A, Satoh Y, Nakagata N, Yamamura K, et al. Genetic analysis of the role of Alx4 in the coordination of lower body and external genitalia formation. Eur J Hum Genet. 2014;22:350-7 pubmed publisher
    ..Moreover, Hh gain-of-function mutants phenocopied some of these phenotypes. These observations reveal novel information regarding the pathogenic mechanisms of syndromic lower ventral body malformations, which are largely unknown. ..
  9. Rainger J, Pehlivan D, Johansson S, Bengani H, Sanchez Pulido L, Williamson K, et al. Monoallelic and biallelic mutations in MAB21L2 cause a spectrum of major eye malformations. Am J Hum Genet. 2014;94:915-23 pubmed publisher
    We identified four different missense mutations in the single-exon gene MAB21L2 in eight individuals with bilateral eye malformations from five unrelated families via three independent exome sequencing projects...

More Information


  1. Dai M, Wang Y, Fang L, Irwin D, Zhu T, Zhang J, et al. Differential expression of Meis2, Mab21l2 and Tbx3 during limb development associated with diversification of limb morphology in mammals. PLoS ONE. 2014;9:e106100 pubmed publisher
    ..In this study, we focused on two additional genes, Meis2 and Mab21l2, identified from the mRNA-Seq data...