Lynx1

Summary

Gene Symbol: Lynx1
Description: Ly6/neurotoxin 1
Alias: AI838844, SLURP-2, ly-6/neurotoxin-like protein 1, GC26, secreted Ly-6/uPAR domain-containing protein 2, secreted Ly-6/uPAR-related protein 2
Species: mouse
Products:     Lynx1

Top Publications

  1. Dessaud E, Salaün D, Gayet O, Chabbert M, Delapeyrière O. Identification of lynx2, a novel member of the ly-6/neurotoxin superfamily, expressed in neuronal subpopulations during mouse development. Mol Cell Neurosci. 2006;31:232-42 pubmed
    ..As it is preferentially expressed in the nervous system, we called this gene lynx2, by analogy with lynx1, a nAChR modulator...
  2. Ibanez Tallon I, Miwa J, Wang H, Adams N, Crabtree G, Sine S, et al. Novel modulation of neuronal nicotinic acetylcholine receptors by association with the endogenous prototoxin lynx1. Neuron. 2002;33:893-903 pubmed
    We previously identified lynx1 as a neuronal membrane molecule related to snake alpha-neurotoxins able to modulate nAChRs. Here, we show that lynx1 colocalizes with nAChRs on CNS neurons and physically associates with nAChRs...
  3. Miwa J, Stevens T, King S, Caldarone B, Ibanez Tallon I, Xiao C, et al. The prototoxin lynx1 acts on nicotinic acetylcholine receptors to balance neuronal activity and survival in vivo. Neuron. 2006;51:587-600 pubmed
    ..b>lynx1, the founding member of a family of mammalian prototoxins, modulates nAChR function in vitro by altering agonist ..
  4. Tekinay A, Nong Y, Miwa J, Lieberam I, Ibanez Tallon I, Greengard P, et al. A role for LYNX2 in anxiety-related behavior. Proc Natl Acad Sci U S A. 2009;106:4477-82 pubmed publisher
  5. Morishita H, Miwa J, Heintz N, Hensch T. Lynx1, a cholinergic brake, limits plasticity in adult visual cortex. Science. 2010;330:1238-40 pubmed publisher
    ..Here, we identified an increase in expression of Lynx1 protein in mice that prevented plasticity in the primary visual cortex late in life...
  6. Miwa J, Ibanez Tallon I, Crabtree G, Sanchez R, Sali A, Role L, et al. lynx1, an endogenous toxin-like modulator of nicotinic acetylcholine receptors in the mammalian CNS. Neuron. 1999;23:105-14 pubmed
    ..A novel murine gene, lynx1, is highly expressed in the brain and contains the cysteine-rich motif characteristic of this class of neurotoxins...
  7. Bukhari N, Burman P, Hussein A, Demars M, Sadahiro M, Brady D, et al. Unmasking Proteolytic Activity for Adult Visual Cortex Plasticity by the Removal of Lynx1. J Neurosci. 2015;35:12693-702 pubmed publisher
    ..of monocular deprivation when the mice older than 2 months are raised in standard cages by the genetic removal of Lynx1, a negative regulator of adult plasticity...
  8. Thomsen M, Arvaniti M, Jensen M, Shulepko M, Dolgikh D, Pinborg L, et al. Lynx1 and Aβ1-42 bind competitively to multiple nicotinic acetylcholine receptor subtypes. Neurobiol Aging. 2016;46:13-21 pubmed publisher
    b>Lynx1 regulates synaptic plasticity in the brain by regulating nicotinic acetylcholine receptors (nAChRs)...
  9. Parker R, O Neill H, Henley B, Wageman C, Drenan R, Marks M, et al. Deletion of lynx1 reduces the function of ?6* nicotinic receptors. PLoS ONE. 2017;12:e0188715 pubmed publisher
    ..b>Lynx1 modulates several nAChR subtypes; lynx1-nAChR interaction sites could possibly provide drug targets...

More Information

Publications16

  1. Miwa J, Walz A. Enhancement in motor learning through genetic manipulation of the Lynx1 gene. PLoS ONE. 2012;7:e43302 pubmed publisher
    ..Previous studies indicate lynx1 inhibits nicotinic receptor function and limits neuronal plasticity...
  2. Eom T, Zhang C, Wang H, Lay K, Fak J, Noebels J, et al. NOVA-dependent regulation of cryptic NMD exons controls synaptic protein levels after seizure. elife. 2013;2:e00178 pubmed publisher
    ..The data reveal a hidden means of dynamic RNA regulation linking electrical activity to splicing and protein output, and of mediating homeostatic excitation/inhibition balance in neurons.DOI:http://dx.doi.org/10.7554/eLife.00178.001. ..
  3. Kobayashi A, Parker R, Wright A, Brahem H, Ku P, Oliver K, et al. Lynx1 supports neuronal health in the mouse dorsal striatum during aging: an ultrastructural investigation. J Mol Neurosci. 2014;53:525-36 pubmed publisher
    ..Although lynx1 null mutant mice exhibit augmented learning and plasticity, they also exhibit macroscopic vacuolation in the ..
  4. Nichols W, Henderson B, Yu C, Parker R, RICHARDS C, Lester H, et al. Lynx1 shifts α4β2 nicotinic receptor subunit stoichiometry by affecting assembly in the endoplasmic reticulum. J Biol Chem. 2014;289:31423-32 pubmed publisher
    ..Here, we demonstrate that lynx1 also exerts effects on α4β2 nAChRs within the endoplasmic reticulum...
  5. Sajo M, Ellis Davies G, Morishita H. Lynx1 Limits Dendritic Spine Turnover in the Adult Visual Cortex. J Neurosci. 2016;36:9472-8 pubmed publisher
    ..b>Lynx1, an endogenous inhibitor of nicotinic acetylcholine receptors, was previously shown to increase its expression in ..
  6. Smith M, Burman P, Sadahiro M, Kidd B, Dudley J, Morishita H. Integrative Analysis of Disease Signatures Shows Inflammation Disrupts Juvenile Experience-Dependent Cortical Plasticity. Eneuro. 2016;3: pubmed publisher
    ..These findings suggest that inflammation may have unrecognized adverse consequences on the postnatal developmental trajectory and indicate that treating inflammation may reduce the burden of neurodevelopmental disorders. ..
  7. Takesian A, Bogart L, Lichtman J, Hensch T. Inhibitory circuit gating of auditory critical-period plasticity. Nat Neurosci. 2018;21:218-227 pubmed publisher
    ..Developmental transitions in nicotinic acetylcholine receptor (nAChR) sensitivity in these cells caused by Lynx1 protein can be overridden to extend critical-period closure...