Gene Symbol: Ltbr
Description: lymphotoxin B receptor
Alias: AI256028, LTbetaR, Ltar, TNF-R-III, TNFCR, TNFR-RP, TNFR2-RP, TNFRrp, Tnfbr, Tnfrsf3, tumor necrosis factor receptor superfamily member 3, LT-beta receptor, TNF receptor-related protein, lymphotoxin-beta receptor
Species: mouse
Products:     Ltbr

Top Publications

  1. Abe K, Yarovinsky F, Murakami T, Shakhov A, Tumanov A, Ito D, et al. Distinct contributions of TNF and LT cytokines to the development of dendritic cells in vitro and their recruitment in vivo. Blood. 2003;101:1477-83 pubmed
    ..significantly reduced in TNF(-/-) and TNF receptor (TNFR) p55(-/-) mice, but normal in LTalpha(-/-), LTbeta(-/-), LTbetaR(-/-) mice...
  2. Stopfer P, Männel D, Hehlgans T. Lymphotoxin-beta receptor activation by activated T cells induces cytokine release from mouse bone marrow-derived mast cells. J Immunol. 2004;172:7459-65 pubmed
    Lymphotoxin-beta receptor (LTbetaR) signaling is known to play a key role in embryonic lymphoid organ formation as well as maintenance of lymphoid architecture...
  3. Grabner R, Lotzer K, Döpping S, Hildner M, Radke D, Beer M, et al. Lymphotoxin beta receptor signaling promotes tertiary lymphoid organogenesis in the aorta adventitia of aged ApoE-/- mice. J Exp Med. 2009;206:233-48 pubmed publisher
    ..medial smooth muscle cells (SMCs) beneath intimal plaques in abdominal aortae become activated through lymphotoxin beta receptor (LTbetaR) to express the lymphorganogenic chemokines CXCL13 and CCL21...
  4. Force W, Walter B, Hession C, Tizard R, Kozak C, Browning J, et al. Mouse lymphotoxin-beta receptor. Molecular genetics, ligand binding, and expression. J Immunol. 1995;155:5280-8 pubmed
    ..heterotrimer is a membrane-anchored ligand expressed by activated T cells which binds specifically to the LT beta receptor (LT beta R), a member of the TNFR family...
  5. Müller J, Siebenlist U. Lymphotoxin beta receptor induces sequential activation of distinct NF-kappa B factors via separate signaling pathways. J Biol Chem. 2003;278:12006-12 pubmed
    b>Lymphotoxin beta receptor (LTbetaR)-induced activation of NF-kappaB in mouse embryo fibroblasts was mediated by the classical pathway and by an alternative or second pathway...
  6. McDonald K, McDonough J, Dieckgraefe B, Newberry R. Dendritic cells produce CXCL13 and participate in the development of murine small intestine lymphoid tissues. Am J Pathol. 2010;176:2367-77 pubmed publisher
    ..Cluster formation was dependent on lymphotoxin and the lymphotoxin beta receptor and independent of lymphocytes...
  7. Tumanov A, Koroleva E, Guo X, Wang Y, Kruglov A, Nedospasov S, et al. Lymphotoxin controls the IL-22 protection pathway in gut innate lymphoid cells during mucosal pathogen challenge. Cell Host Microbe. 2011;10:44-53 pubmed publisher
    ..Taken together, our data show that LT?R signaling in gut lymphoid follicles regulates IL-22 production by ILCs in response to mucosal pathogen challenge...
  8. Krautler N, Kana V, Kranich J, Tian Y, Perera D, Lemm D, et al. Follicular dendritic cells emerge from ubiquitous perivascular precursors. Cell. 2012;150:194-206 pubmed publisher
    ..The ubiquity of preFDC and their strategic location at blood vessels may explain the de novo generation of organized lymphoid tissue at sites of lymphocytic inflammation...
  9. Fütterer A, Mink K, Luz A, Kosco Vilbois M, Pfeffer K. The lymphotoxin beta receptor controls organogenesis and affinity maturation in peripheral lymphoid tissues. Immunity. 1998;9:59-70 pubmed
    b>Lymphotoxin beta receptor (LTbetaR)-/- mice were created by gene targeting. LTbetaR-/- mice lacked Peyer's patches, colon-associated lymphoid tissues, and all lymph nodes...

More Information


  1. Scheu S, Alferink J, Pötzel T, Barchet W, Kalinke U, Pfeffer K. Targeted disruption of LIGHT causes defects in costimulatory T cell activation and reveals cooperation with lymphotoxin beta in mesenteric lymph node genesis. J Exp Med. 2002;195:1613-24 pubmed
    ..This suggests the existance of an additional undiscovered ligand for the LTbeta receptor (LTbetaR) or a weak LTalpha(3)-LTbetaR interaction in vivo involved in the formation of secondary lymphoid organs...
  2. Anders R, Subudhi S, Wang J, Pfeffer K, Fu Y. Contribution of the lymphotoxin beta receptor to liver regeneration. J Immunol. 2005;175:1295-300 pubmed
    ..glycoprotein D for herpesvirus entry mediator on T cells (LIGHT), signaling through the lymphotoxin receptor (LTbetaR) expressed on mature hepatocytes induces massive hepatomegaly...
  3. Bénézech C, White A, Mader E, Serre K, Parnell S, Pfeffer K, et al. Ontogeny of stromal organizer cells during lymph node development. J Immunol. 2010;184:4521-30 pubmed publisher
    ..precursor cells become ICAM-1(int)VCAM-1(int) cells, in a process independent of LTi cells and lymphotoxin beta receptor (LTbetaR) signaling...
  4. Endres R, Alimzhanov M, Plitz T, Fütterer A, Kosco Vilbois M, Nedospasov S, et al. Mature follicular dendritic cell networks depend on expression of lymphotoxin beta receptor by radioresistant stromal cells and of lymphotoxin beta and tumor necrosis factor by B cells. J Exp Med. 1999;189:159-68 pubmed
    ..factor (TNF), lymphotoxin (LT) alpha, and LTbeta, as well as their receptors TNF receptor p55 (TNFRp55) and LTbetaR play essential roles in the development of GCs...
  5. Zindl C, Kim T, Zeng M, Archambault A, Grayson M, Choi K, et al. The lymphotoxin LTalpha(1)beta(2) controls postnatal and adult spleen marginal sinus vascular structure and function. Immunity. 2009;30:408-20 pubmed publisher
  6. Banks T, Rickert S, Benedict C, Ma L, Ko M, Meier J, et al. A lymphotoxin-IFN-beta axis essential for lymphocyte survival revealed during cytomegalovirus infection. J Immunol. 2005;174:7217-25 pubmed
    The importance of lymphotoxin (LT) betaR (LTbetaR) as a regulator of lymphoid organogenesis is well established, but its role in host defense has yet to be fully defined...
  7. Lo J, Wang Y, Tumanov A, Bamji M, Yao Z, Reardon C, et al. Lymphotoxin beta receptor-dependent control of lipid homeostasis. Science. 2007;316:285-8 pubmed
    ..the ability to control lipid levels in the blood, inhibition of LT and LIGHT signaling with a soluble lymphotoxin beta receptor decoy protein attenuated the dyslipidemia...
  8. Furtado G, Marinkovic T, Martin A, Garin A, Hoch B, Hubner W, et al. Lymphotoxin beta receptor signaling is required for inflammatory lymphangiogenesis in the thyroid. Proc Natl Acad Sci U S A. 2007;104:5026-31 pubmed
    ..Genetic deletion of lymphotoxin beta receptor or lymphotoxin alpha abrogated development of lymphatic vessels in the inflamed areas in the thyroid but ..
  9. Kabashima K, Banks T, Ansel K, Lu T, Ware C, Cyster J. Intrinsic lymphotoxin-beta receptor requirement for homeostasis of lymphoid tissue dendritic cells. Immunity. 2005;22:439-50 pubmed
    ..We conclude that LT alpha 1 bet a2 acts on DCs or DC precursors to promote DC homeostasis, and we suggest that DC proliferation is an important pathway for locally maintaining these cells in the steady state. ..
  10. Lo J, Basak S, James E, Quiambo R, Kinsella M, Alegre M, et al. Coordination between NF-kappaB family members p50 and p52 is essential for mediating LTbetaR signals in the development and organization of secondary lymphoid tissues. Blood. 2006;107:1048-55 pubmed
    Recent studies revealed that the lymphotoxin/lymphotoxin beta receptor (LT)/LTbetaR system activates the noncanonical nuclear factor-kappaB (NF-kappaB) signaling pathway involving I kappa B kinase 1/I kappa B kinase alpha (IKK1/IKKalpha) ..
  11. Venanzi E, Gray D, Benoist C, Mathis D. Lymphotoxin pathway and Aire influences on thymic medullary epithelial cells are unconnected. J Immunol. 2007;179:5693-700 pubmed
    ..The expression and function of Aire were unaffected in medullary epithelial cells of mice lacking either lymphotoxin beta receptor or the lymphotoxin alpha-chain, and there was minimal overlap between the sets of genes controlled by ..
  12. Wimmer N, Huber B, Barabas N, Röhrl J, Pfeffer K, Hehlgans T. Lymphotoxin ? receptor activation on macrophages induces cross-tolerance to TLR4 and TLR9 ligands. J Immunol. 2012;188:3426-33 pubmed publisher
  13. Lorenz R, Chaplin D, McDonald K, McDonough J, Newberry R. Isolated lymphoid follicle formation is inducible and dependent upon lymphotoxin-sufficient B lymphocytes, lymphotoxin beta receptor, and TNF receptor I function. J Immunol. 2003;170:5475-82 pubmed
    ..Here we demonstrate that that similar to PP formation, ILF formation requires lymphotoxin (LT)- and LT beta receptor-dependent events...
  14. Lo J, Chin R, Lee Y, Kang H, Wang Y, Weinstock J, et al. Differential regulation of CCL21 in lymphoid/nonlymphoid tissues for effectively attracting T cells to peripheral tissues. J Clin Invest. 2003;112:1495-505 pubmed
  15. De Trez C, Schneider K, Potter K, Droin N, Fulton J, Norris P, et al. The inhibitory HVEM-BTLA pathway counter regulates lymphotoxin receptor signaling to achieve homeostasis of dendritic cells. J Immunol. 2008;180:238-48 pubmed
    ..Mice deficient in LTalpha, LTbeta, LTbetaR, and the NFkappaB inducing kinase show a specific loss of CD8- DC subsets...
  16. Browning J, French L. Visualization of lymphotoxin-beta and lymphotoxin-beta receptor expression in mouse embryos. J Immunol. 2002;168:5079-87 pubmed
    The heteromeric lymphotoxin alphabeta ligand (LT) binds to the LTbeta receptor (LTbetaR) and provides an essential trigger for lymph node (LN) development...
  17. Tamada K, Tamura H, Flies D, Fu Y, Celis E, Pease L, et al. Blockade of LIGHT/LTbeta and CD40 signaling induces allospecific T cell anergy, preventing graft-versus-host disease. J Clin Invest. 2002;109:549-57 pubmed
    ..that blockade of LIGHT, a T cell costimulatory molecule belonging to the TNF superfamily, by soluble lymphotoxin beta receptor-Ig (LTbetaR-Ig) inhibits the cytotoxic T lymphocyte (CTL) response to host antigenic disparities and ..
  18. Phan T, Green J, Gray E, Xu Y, Cyster J. Immune complex relay by subcapsular sinus macrophages and noncognate B cells drives antibody affinity maturation. Nat Immunol. 2009;10:786-93 pubmed publisher
    ..Thus, we characterize SCS macrophages as specialized antigen-presenting cells functioning at the apex of an antigen transport chain that promotes humoral immunity. ..
  19. Crowe P, VanArsdale T, Walter B, Ware C, Hession C, Ehrenfels B, et al. A lymphotoxin-beta-specific receptor. Science. 1994;264:707-10 pubmed
    ..A receptor specific for human LT-beta was identified, which suggests that cell surface LT may have functions that are distinct from those of secreted LT-alpha. ..
  20. Summers DeLuca L, McCarthy D, Cosovic B, Ward L, Lo C, Scheu S, et al. Expression of lymphotoxin-alphabeta on antigen-specific T cells is required for DC function. J Exp Med. 2007;204:1071-81 pubmed
    ..member lymphotoxin-alphabeta (LTalphabeta) in this process because signaling through the LTbeta-receptor (LTbetaR) controls multiple aspects of lymphoid tissue organization...
  21. Browning J, Allaire N, Ngam Ek A, Notidis E, Hunt J, Perrin S, et al. Lymphotoxin-beta receptor signaling is required for the homeostatic control of HEV differentiation and function. Immunity. 2005;23:539-50 pubmed
    ..Thus, the homeostatic maintenance of functional HEV status in adult mice relies largely on LTbeta R signaling. ..
  22. Honda K, Nakano H, Yoshida H, Nishikawa S, Rennert P, Ikuta K, et al. Molecular basis for hematopoietic/mesenchymal interaction during initiation of Peyer's patch organogenesis. J Exp Med. 2001;193:621-30 pubmed
    Mice deficient in lymphotoxin beta receptor (LTbetaR) or interleukin 7 receptor alpha (IL-7Ralpha) lack Peyer's patches (PPs). Deficiency in CXC chemokine receptor 5 (CXCR5) also severely affects the development of PPs...
  23. Matsumoto M, Iwamasa K, Rennert P, Yamada T, Suzuki R, Matsushima A, et al. Involvement of distinct cellular compartments in the abnormal lymphoid organogenesis in lymphotoxin-alpha-deficient mice and alymphoplasia (aly) mice defined by the chimeric analysis. J Immunol. 1999;163:1584-91 pubmed
    ..Supporting this hypothesis, up-regulation of VCAM-1 on aly mouse embryonic fibroblasts by signals through LTbetaR, which is exclusively expressed by nonlymphoid cells, was disturbed...
  24. Wu Q, Wang Y, Wang J, Hedgeman E, Browning J, Fu Y. The requirement of membrane lymphotoxin for the presence of dendritic cells in lymphoid tissues. J Exp Med. 1999;190:629-38 pubmed
    ..However, LTbetaR(-/-) mice show reduced numbers of DCs, similar to the mice lacking membrane LT alpha/beta...
  25. Yilmaz Z, Weih D, Sivakumar V, Weih F. RelB is required for Peyer's patch development: differential regulation of p52-RelB by lymphotoxin and TNF. EMBO J. 2003;22:121-30 pubmed
    ..LTbeta receptor (LTbetaR)-deficient mice also lack PPs, and we demonstrate that LTbetaR signaling induces p52-RelB and classical p50-RelA ..
  26. Dejardin E, Droin N, Delhase M, Haas E, Cao Y, Makris C, et al. The lymphotoxin-beta receptor induces different patterns of gene expression via two NF-kappaB pathways. Immunity. 2002;17:525-35 pubmed
    The lymphotoxin-beta receptor (LTbetaR) plays critical roles in inflammation and lymphoid organogenesis through activation of NF-kappaB...
  27. Rennert P, James D, Mackay F, Browning J, Hochman P. Lymph node genesis is induced by signaling through the lymphotoxin beta receptor. Immunity. 1998;9:71-9 pubmed
    ..Therefore, LTbeta-R signaling during gestation is not sufficient to establish normal cellular microarchitecture. We conclude that LT and TNF play critical roles in the genesis and cellular organization of lymph nodes. ..
  28. Neumann B, Luz A, Pfeffer K, Holzmann B. Defective Peyer's patch organogenesis in mice lacking the 55-kD receptor for tumor necrosis factor. J Exp Med. 1996;184:259-64 pubmed
  29. Wang Y, Koroleva E, Kruglov A, Kuprash D, Nedospasov S, Fu Y, et al. Lymphotoxin beta receptor signaling in intestinal epithelial cells orchestrates innate immune responses against mucosal bacterial infection. Immunity. 2010;32:403-13 pubmed publisher
    ..rodentium infection. We demonstrate that the LTbetaR signaling was required for the regulation of the early innate response against infection...
  30. Derudder E, Dejardin E, Pritchard L, Green D, Korner M, Baud V. RelB/p50 dimers are differentially regulated by tumor necrosis factor-alpha and lymphotoxin-beta receptor activation: critical roles for p100. J Biol Chem. 2003;278:23278-84 pubmed
    Tumor necrosis factor-alpha (TNF-alpha) and lymphotoxin-beta receptor (LTbetaR) signaling both play important roles in inflammatory and immune responses through activation of NF-kappaB...
  31. Matsumoto M, Mariathasan S, Nahm M, Baranyay F, Peschon J, Chaplin D. Role of lymphotoxin and the type I TNF receptor in the formation of germinal centers. Science. 1996;271:1289-91 pubmed
    ..Germinal center formation was restored in LT-alpha-deficient mice by transplantation of normal bone marrow, indicating that the LT-alpha-expressing cells required to establish this lymphoid structure are derived from bone marrow. ..
  32. Chin R, Lo J, Kim O, Blink S, Christiansen P, Peterson P, et al. Lymphotoxin pathway directs thymic Aire expression. Nat Immunol. 2003;4:1121-7 pubmed
    ..These findings define the essential cross-talk between thymocytes and thymic stroma that is required for central tolerance. ..
  33. Boehm T, Scheu S, Pfeffer K, Bleul C. Thymic medullary epithelial cell differentiation, thymocyte emigration, and the control of autoimmunity require lympho-epithelial cross talk via LTbetaR. J Exp Med. 2003;198:757-69 pubmed
    ..We show that thymocytes and medullary epithelial cells (MECs) communicate via the lymphotoxin beta receptor (LTbetaR) signaling axis...
  34. Kutsch S, Degrandi D, Pfeffer K. Immediate lymphotoxin beta receptor-mediated transcriptional response in host defense against L. monocytogenes. Immunobiology. 2008;213:353-66 pubmed publisher
    The lymphotoxin beta receptor (LTbetaR) mediates crucial signals in host defense against intracellular bacteria and viruses...
  35. Vondenhoff M, Greuter M, Goverse G, Elewaut D, Dewint P, Ware C, et al. LTbetaR signaling induces cytokine expression and up-regulates lymphangiogenic factors in lymph node anlagen. J Immunol. 2009;182:5439-45 pubmed publisher
    The formation of lymph nodes is a complex process crucially controlled through triggering of LTbetaR on mesenchymal cells by LTalpha(1)beta(2) expressing lymphoid tissue inducer (LTi) cells...
  36. Demoor T, Bracke K, Maes T, Vandooren B, Elewaut D, Pilette C, et al. Role of lymphotoxin-alpha in cigarette smoke-induced inflammation and lymphoid neogenesis. Eur Respir J. 2009;34:405-16 pubmed publisher
    ..In vitro lymphotoxin-beta receptor (LTbetaR) stimulation induced CXCL13 and CCL19 mRNA in WT lung fibroblasts...
  37. Van Den Broeck T, Van Ammel E, Delforche M, Taveirne S, Kerre T, Vandekerckhove B, et al. Differential Ly49e expression pathways in resting versus TCR-activated intraepithelial ?? T cells. J Immunol. 2013;190:1982-90 pubmed publisher
  38. Sorg U, Behnke K, Degrandi D, Reich M, Keitel V, Herebian D, et al. Cooperative role of lymphotoxin β receptor and tumor necrosis factor receptor p55 in murine liver regeneration. J Hepatol. 2016;64:1108-1117 pubmed publisher
    ..Differences in survival kinetics strongly suggest distinct functions for these two cytokine receptors in liver regeneration. Failure of TNFR and LTβR signalling renders liver regeneration impossible. ..
  39. Spahn T, Maaser C, Eckmann L, Heidemann J, Lugering A, Newberry R, et al. The lymphotoxin-beta receptor is critical for control of murine Citrobacter rodentium-induced colitis. Gastroenterology. 2004;127:1463-73 pubmed
    ..We studied the role of lymphotoxin alpha 1 beta 2 /lymphotoxin-beta receptor signaling in Citrobacter rodentium -induced colitis...
  40. Heikenwalder M, Zeller N, Seeger H, Prinz M, Klohn P, Schwarz P, et al. Chronic lymphocytic inflammation specifies the organ tropism of prions. Science. 2005;307:1107-10 pubmed
    ..By expanding the tissue distribution of prions, chronic inflammatory conditions may act as modifiers of natural and iatrogenic prion transmission. ..
  41. Fava R, Browning J, Gatumu M, Skarstein K, Bolstad A. LTBR-pathway in Sjogren's syndrome: CXCL13 levels and B-cell-enriched ectopic lymphoid aggregates in NOD mouse lacrimal glands are dependent on LTBR. Adv Exp Med Biol. 2011;691:383-90 pubmed publisher
  42. Lovas A, Radke D, Albrecht D, Yilmaz Z, Möller U, Habenicht A, et al. Differential RelA- and RelB-dependent gene transcription in LTbetaR-stimulated mouse embryonic fibroblasts. BMC Genomics. 2008;9:606 pubmed publisher
    Lymphotoxin signaling via the lymphotoxin-beta receptor (LTbetaR) has been implicated in biological processes ranging from development of secondary lymphoid organs, maintenance of spleen architecture, host defense against pathogens, ..
  43. Taylor R, Lugering A, Newell K, Williams I. Intestinal cryptopatch formation in mice requires lymphotoxin alpha and the lymphotoxin beta receptor. J Immunol. 2004;173:7183-9 pubmed
    Interactions between lymphotoxin (LT)alpha(1)beta(2) on inducer cells and the lymphotoxin beta receptor (LTbetaR) on stromal cells initiate development of lymph nodes and Peyer's patches...
  44. Krucken J, Braun J, Dkhil M, Grunwald A, Wunderlich F. Deletion of LTbetaR augments male susceptibility to Plasmodium chabaudi. Parasite Immunol. 2005;27:205-12 pubmed
    SUMMARY Disruption of the lymphotoxin beta receptor (LTbetaR) gene has been shown to result in enhanced resistance of female mice to blood-stage Plasmodium chabaudi malaria...
  45. Caulin C, Ware C, Magin T, Oshima R. Keratin-dependent, epithelial resistance to tumor necrosis factor-induced apoptosis. J Cell Biol. 2000;149:17-22 pubmed
  46. Grandoch M, Feldmann K, Göthert J, Dick L, Homann S, Klatt C, et al. Deficiency in lymphotoxin β receptor protects from atherosclerosis in apoE-deficient mice. Circ Res. 2015;116:e57-68 pubmed publisher
    Lymphotoxin β receptor (LTbR) regulates immune cell trafficking and communication in inflammatory diseases. However, the role of LTbR in atherosclerosis is still unclear...
  47. Chellan B, Koroleva E, Sontag T, Tumanov A, Fu Y, Getz G, et al. LIGHT/TNFSR14 can regulate hepatic lipase expression by hepatocytes independent of T cells and Kupffer cells. PLoS ONE. 2013;8:e54719 pubmed publisher
    ..LIGHT over expressed in T cells also down regulates hepatic lipase levels in mice through lymphotoxin beta receptor (LTβR) signaling...
  48. Sitnik K, Wendland K, Weishaupt H, Uronen Hansson H, White A, Anderson G, et al. Context-Dependent Development of Lymphoid Stroma from Adult CD34(+) Adventitial Progenitors. Cell Rep. 2016;14:2375-88 pubmed publisher
    ..These findings extend the current understanding of lymphoid mesenchymal cell heterogeneity and highlight a role of the CD34(+) adventitia as a potential ubiquitous source of lymphoid stromal precursors in postnatal tissues. ..
  49. Onder L, Danuser R, Scandella E, Firner S, Chai Q, Hehlgans T, et al. Endothelial cell-specific lymphotoxin-? receptor signaling is critical for lymph node and high endothelial venule formation. J Exp Med. 2013;210:465-73 pubmed publisher
    ..Thus, this study identifies ECs as an important LT?R-dependent lymphoid tissue organizer cell population and indicates that continuous triggering of the LT?R on LN ECs is critical for lymphocyte homeostasis. ..
  50. Ramírez Valle F, Gray E, Cyster J. Inflammation induces dermal Vγ4+ γδT17 memory-like cells that travel to distant skin and accelerate secondary IL-17-driven responses. Proc Natl Acad Sci U S A. 2015;112:8046-51 pubmed publisher
  51. Zhu M, Chin R, Tumanov A, Liu X, Fu Y. Lymphotoxin beta receptor is required for the migration and selection of autoreactive T cells in thymic medulla. J Immunol. 2007;179:8069-75 pubmed
    How organ-specific central tolerance is established and regulated has been an intriguing question. Lymphotoxin beta receptor (LTbetaR) deficiency is associated with autoimmune phenotypes characterized by humoral and cellular ..
  52. Franki A, Van Beneden K, Dewint P, Hammond K, Lambrecht S, Leclercq G, et al. A unique lymphotoxin {alpha}beta-dependent pathway regulates thymic emigration of V{alpha}14 invariant natural killer T cells. Proc Natl Acad Sci U S A. 2006;103:9160-5 pubmed
    ..Here we show that signaling of lymphotoxin (LT) alphabeta through the LTbeta receptor (LTbetaR) is indispensable for regulating peripheral but not thymic Valpha14i NKT cell numbers...
  53. McDonald K, Leach M, Brooke K, Wang C, Wheeler L, Hanly E, et al. Epithelial expression of the cytosolic retinoid chaperone cellular retinol binding protein II is essential for in vivo imprinting of local gut dendritic cells by lumenal retinoids. Am J Pathol. 2012;180:984-97 pubmed publisher
    ..These findings demonstrate in vivo roles for the expression of epithelial CRBPII and lumenal retinoids to imprint local gut DCs with an intestinal phenotype. ..
  54. Levisetti M, Suri A, Frederick K, Unanue E. Absence of lymph nodes in NOD mice treated with lymphotoxin-beta receptor immunoglobulin protects from diabetes. Diabetes. 2004;53:3115-9 pubmed
    Pregnant nonobese diabetic (NOD) mice were treated with lymphotoxin-beta receptor immunoglobulin fusion protein (LTbetaR-Ig) or control human immunoglobulin on days embryonic day 11 (E11) and E14, and offspring were followed for the ..
  55. Takaba H, Morishita Y, Tomofuji Y, Danks L, Nitta T, Komatsu N, et al. Fezf2 Orchestrates a Thymic Program of Self-Antigen Expression for Immune Tolerance. Cell. 2015;163:975-87 pubmed publisher
    ..Thus, two independent factors, Fezf2 and Aire, permit the expression of TRAs in the thymus to ensure immune tolerance. ..
  56. Cosway E, LUCAS B, James K, Parnell S, Carvalho Gaspar M, White A, et al. Redefining thymus medulla specialization for central tolerance. J Exp Med. 2017;214:3183-3195 pubmed publisher
    ..In all, our study demonstrates that thymus medulla specialization for thymic tolerance segregates from medulla organogenesis and instead involves LTβR-mediated regulation of the thymic DC pool. ..
  57. Fukuda K, Yoshida H, Sato T, Furumoto T, Mizutani Koseki Y, Suzuki Y, et al. Mesenchymal expression of Foxl1, a winged helix transcriptional factor, regulates generation and maintenance of gut-associated lymphoid organs. Dev Biol. 2003;255:278-89 pubmed
    ..Together, the data suggest that Foxl1 might be involved in cellular responses of gut-associated lymphoid tissues dependent upon the Lymphotoxins/Lymphotoxin beta-receptor axis. ..
  58. Hehlgans T, Muller P, Stopfer P, Männel D. Activation of the lymphotoxin-beta receptor induces NFkappaB-dependent interleukin-6 and MIP-2 secretion in mouse fibrosarcoma cells. Eur Cytokine Netw. 2003;14:103-7 pubmed
    Activation of the lymphotoxin beta-receptor (LTbetaR), a member of the tumor necrosis factor receptor family, plays a crucial role in lymphoid organogenesis and tumor development...
  59. Lin X, Ma X, Rodriguez M, Feng X, Zoecklein L, Fu Y, et al. Membrane lymphotoxin is required for resistance to Theiler's virus infection. Int Immunol. 2003;15:955-62 pubmed
    ..There was relatively little demyelination associated with inflammation in LT-alpha(-/-) and LT-beta-R(-/-) mice compared to susceptible SJL mice, suggesting the possibility that LT plays a role in mediating demyelination. ..
  60. Denicourt C, Kozak C, Rassart E. Gris1, a new common integration site in Graffi murine leukemia virus-induced leukemias: overexpression of a truncated cyclin D2 due to alternative splicing. J Virol. 2003;77:37-44 pubmed
    ..1-kb transcript from the cyclin D2 gene that encodes a truncated cyclin D2 of 17 kDa. The expression of this 1.1-kb transcript is specific to tumors in which Gris1 is rearranged but is also detected at low levels in normal tissue. ..
  61. Kosuge H, Suzuki J, Kakuta T, Haraguchi G, Koga N, Futamatsu H, et al. Attenuation of graft arterial disease by manipulation of the LIGHT pathway. Arterioscler Thromb Vasc Biol. 2004;24:1409-15 pubmed
    ..tumor necrosis factor (TNF) superfamily member LIGHT, which binds herpes virus entry mediator (HVEM) and lymphotoxin beta receptor (LTbetaR), plays important roles in regulating the immune response...
  62. Nayar S, Campos J, Chung M, Navarro Núñez L, Chachlani M, Steinthal N, et al. Bimodal Expansion of the Lymphatic Vessels Is Regulated by the Sequential Expression of IL-7 and Lymphotoxin α1β2 in Newly Formed Tertiary Lymphoid Structures. J Immunol. 2016;197:1957-67 pubmed publisher
  63. Blink S, Fu Y. IgE regulates T helper cell differentiation through FcgammaRIII mediated dendritic cell cytokine modulation. Cell Immunol. 2010;264:54-60 pubmed publisher
    ..We demonstrate a novel role for IgE in regulating differentiation of adaptive inflammatory responses through direct interaction with FcgammaRIII on dendritic cells. ..
  64. Nakamura T, Tashiro K, Nazarea M, Nakano T, Sasayama S, Honjo T. The murine lymphotoxin-beta receptor cDNA: isolation by the signal sequence trap and chromosomal mapping. Genomics. 1995;30:312-9 pubmed
    ..We performed chromosomal mapping of the murine LT beta-R gene by linkage analysis with recombinant inbred mouse strains and found that its locus is very close to the tumor necrosis factor receptor 1 gene on chromosome 6. ..
  65. Day T, Koch M, Nouailles G, Jacobsen M, Kosmiadi G, Miekley D, et al. Secondary lymphoid organs are dispensable for the development of T-cell-mediated immunity during tuberculosis. Eur J Immunol. 2010;40:1663-73 pubmed publisher
    ..Our data demonstrate that protective immune responses can be generated independently of SLO during MTB infection and implicate local pulmonary T-cell priming as a mechanism contributing to host defense. ..
  66. Randall L, Amante F, Zhou Y, Stanley A, Haque A, Rivera F, et al. Cutting edge: selective blockade of LIGHT-lymphotoxin beta receptor signaling protects mice from experimental cerebral malaria caused by Plasmodium berghei ANKA. J Immunol. 2008;181:7458-62 pubmed
    ..In this study we report a role for LIGHT-lymphotoxin beta Receptor (LTbetaR) signaling in the development of ECM and control of parasite growth...
  67. Martins V, Boehm T, Bleul C. Ltbetar signaling does not regulate Aire-dependent transcripts in medullary thymic epithelial cells. J Immunol. 2008;181:400-7 pubmed
    ..Aire has been proposed to be regulated by lymphotoxin beta receptor (Ltbetar) signaling and there is evidence that, additionally, Aire-independent transcripts may be ..
  68. Aebischer J, Cassina P, Otsmane B, Moumen A, Seilhean D, Meininger V, et al. IFN? triggers a LIGHT-dependent selective death of motoneurons contributing to the non-cell-autonomous effects of mutant SOD1. Cell Death Differ. 2011;18:754-68 pubmed publisher
    ..We propose that IFN? contributes to a cross-talk between motoneurons and astrocytes causing the selective loss of some motoneurons following activation of the LIGHT-induced death pathway. ..
  69. Tumanov A, Koroleva E, Christiansen P, Khan M, Ruddy M, Burnette B, et al. T cell-derived lymphotoxin regulates liver regeneration. Gastroenterology. 2009;136:694-704.e4 pubmed publisher
    ..We found that an agonistic antibody against the lymphotoxin beta receptor was able to facilitate liver regeneration by reducing liver injury, increasing interleukin-6 production, ..