Gene Symbol: Lss
Description: lanosterol synthase
Alias: 2810025N20Rik, D10Ertd116e, Osc, lanosterol synthase, 2,3-epoxysqualene--lanosterol cyclase, oxidosqualene--lanosterol cyclase
Species: mouse
Products:     Lss

Top Publications

  1. Dang H, Liu Y, Pang W, Li C, Wang N, Shyy J, et al. Suppression of 2,3-oxidosqualene cyclase by high fat diet contributes to liver X receptor-alpha-mediated improvement of hepatic lipid profile. J Biol Chem. 2009;284:6218-26 pubmed publisher
    ..Importantly, increased cholesterol level suppressed the expression of 2,3-oxidosqualene cyclase (OSC), which led to an increase in endogenous LXR ligand(s)...
  2. Nagashima S, Yagyu H, Tozawa R, Tazoe F, Takahashi M, Kitamine T, et al. Plasma cholesterol-lowering and transient liver dysfunction in mice lacking squalene synthase in the liver. J Lipid Res. 2015;56:998-1005 pubmed publisher
    ..In conclusion, liver-specific ablation of SS inhibits hepatic cholesterol biosynthesis and induces hypolipidemia without increasing significant mortality. ..
  3. Munkacsi A, Hammond N, Schneider R, Senanayake D, Higaki K, Lagutin K, et al. Normalization of Hepatic Homeostasis in the Npc1nmf164 Mouse Model of Niemann-Pick Type C Disease Treated with the Histone Deacetylase Inhibitor Vorinostat. J Biol Chem. 2017;292:4395-4410 pubmed publisher
    ..These results suggest that HDAC inhibitors have utility to treat visceral NP-C disease. However, it is clear that improved blood-brain barrier penetration will be required to alleviate the neurological symptoms of human NP-C disease. ..