Gene Symbol: Lsm11
Description: U7 snRNP-specific Sm-like protein LSM11
Alias: 2210404M20Rik, AV079530, U7 snRNA-associated Sm-like protein LSm11
Pillai R, Grimmler M, Meister G, Will C, Luhrmann R, Fischer U, et al
. Unique Sm core structure of U7 snRNPs: assembly by a specialized SMN complex and the role of a new component, Lsm11, in histone RNA processing. Genes Dev. 2003;17:2321-33 pubmed
..Here we characterize this factor, termed Lsm11, as a novel Sm-like protein with apparently two distinct functions...
Azzouz T, Gruber A, Schumperli D. U7 snRNP-specific Lsm11 protein: dual binding contacts with the 100 kDa zinc finger processing factor (ZFP100) and a ZFP100-independent function in histone RNA 3' end processing. Nucleic Acids Res. 2005;33:2106-17 pubmed
..The N-terminus of Lsm11, a U7-specific Sm-like protein, was shown to be crucial for histone RNA processing and to bind ZFP100...
Ruepp M, Vivarelli S, Pillai R, Kleinschmidt N, Azzouz T, Barabino S, et al
. The 68 kDa subunit of mammalian cleavage factor I interacts with the U7 small nuclear ribonucleoprotein and participates in 3'-end processing of animal histone mRNAs. Nucleic Acids Res. 2010;38:7637-50 pubmed publisher
..Its interaction with the U7 snRNP depends on the N-terminus of the U7 snRNP protein Lsm11, known to be important for histone RNA processing...
Azzouz T, Pillai R, Däpp C, Chari A, Meister G, Kambach C, et al
. Toward an assembly line for U7 snRNPs: interactions of U7-specific Lsm proteins with PRMT5 and SMN complexes. J Biol Chem. 2005;280:34435-40 pubmed
..Here, we provide evidence that Lsm10 and Lsm11, which replace the Sm proteins D1 and D2 in the histone RNA processing U7 snRNPs, associate with pICln in vitro ..
Yang X, Torres M, Marzluff W, Dominski Z. Three proteins of the U7-specific Sm ring function as the molecular ruler to determine the site of 3'-end processing in mammalian histone pre-mRNA. Mol Cell Biol. 2009;29:4045-56 pubmed publisher
..binding protein (SLBP), which interacts with the stem-loop structure upstream of the cleavage site, and both Lsm11 and SmB, which are components of the U7-specific Sm ring...