Gene Symbol: Lrrtm3
Description: leucine rich repeat transmembrane neuronal 3
Alias: 9630044H04Rik, leucine-rich repeat transmembrane neuronal protein 3
Majercak J, Ray W, Espeseth A, Simon A, Shi X, Wolffe C, et al
. LRRTM3 promotes processing of amyloid-precursor protein by BACE1 and is a positional candidate gene for late-onset Alzheimer's disease. Proc Natl Acad Sci U S A. 2006;103:17967-72 pubmed
..we assessed 15,200 genes for their role in Abeta42 secretion and identified leucine-rich repeat transmembrane 3 (LRRTM3) as a neuronal gene that promotes APP processing by BACE1...
Lauren J, Airaksinen M, Saarma M, Timmusk T. A novel gene family encoding leucine-rich repeat transmembrane proteins differentially expressed in the nervous system. Genomics. 2003;81:411-21 pubmed
..The structure and expression profile of LRRTM mRNAs suggest that they may have a role in the development and maintenance of the vertebrate nervous system. ..
Haines B, Rigby P. Developmentally regulated expression of the LRRTM gene family during mid-gestation mouse embryogenesis. Gene Expr Patterns. 2007;7:23-9 pubmed
..LRRTM2 is expressed in a subset of progenitors in the neural tube. LRRTM3 is expressed in a half somite wide stripe in the presomitic mesoderm adjacent to the boundary with the most ..
Tomas Roca L, Perez Aytes A, Puelles L, Marin F. In silico identification of new candidate genes for hereditary congenital facial paresis. Int J Dev Neurosci. 2011;29:451-60 pubmed publisher
..as a large gene-desert region, flanked by two genes, Reep3, with specific expression in the FBM nucleus, and Lrrtm3, broadly expressed in the brainstem, including the same nucleus...
Lincoln S, Allen M, Cox C, Walker L, Malphrus K, Qiu Y, et al
. LRRTM3 interacts with APP and BACE1 and has variants associating with late-onset Alzheimer's disease (LOAD). PLoS ONE. 2013;8:e64164 pubmed publisher
Leucine rich repeat transmembrane protein 3 (LRRTM3) is member of a synaptic protein family...
Um J, Choi T, Kang H, Cho Y, Choii G, Uvarov P, et al
. LRRTM3 Regulates Excitatory Synapse Development through Alternative Splicing and Neurexin Binding. Cell Rep. 2016;14:808-822 pubmed publisher
..They have also been implicated in neuropsychiatric diseases. Here, we focus on LRRTM3, showing that two distinct LRRTM3 variants generated by alternative splicing regulate LRRTM3 interaction with PSD-..