Gene Symbol: Lrrtm2
Description: leucine rich repeat transmembrane neuronal 2
Alias: AI851755, BB129880, C630011A14Rik, mKIAA0416, leucine-rich repeat transmembrane neuronal protein 2, leucine-rich repeat transmembrane neuronal 2 protein
Lauren J, Airaksinen M, Saarma M, Timmusk T. A novel gene family encoding leucine-rich repeat transmembrane proteins differentially expressed in the nervous system. Genomics. 2003;81:411-21 pubmed
..The structure and expression profile of LRRTM mRNAs suggest that they may have a role in the development and maintenance of the vertebrate nervous system. ..
Haines B, Rigby P. Developmentally regulated expression of the LRRTM gene family during mid-gestation mouse embryogenesis. Gene Expr Patterns. 2007;7:23-9 pubmed
..b>LRRTM2 is expressed in a subset of progenitors in the neural tube...
Paatero A, Rosti K, Shkumatov A, Sèle C, Brunello C, Kysenius K, et al
. Crystal Structure of an Engineered LRRTM2 Synaptic Adhesion Molecule and a Model for Neurexin Binding. Biochemistry. 2016;55:914-26 pubmed publisher
..We report here the crystal structure of a thermostabilized mouse LRRTM2, with a Tm 30 Â°C higher than that of the wild-type protein...
Chamma I, Letellier M, Butler C, Tessier B, Lim K, Gauthereau I, et al
. Mapping the dynamics and nanoscale organization of synaptic adhesion proteins using monomeric streptavidin. Nat Commun. 2016;7:10773 pubmed publisher
..synaptic adhesion molecules neurexin-1Î², neuroligin-1 (Nlg1) and leucine-rich-repeat transmembrane protein 2 (LRRTM2) in a dual-colour configuration with GFP nanobody, and show that these proteins are diffusionally trapped at ..
Ko J, Soler Llavina G, Fuccillo M, Malenka R, Sudhof T. Neuroligins/LRRTMs prevent activity- and Ca2+/calmodulin-dependent synapse elimination in cultured neurons. J Cell Biol. 2011;194:323-34 pubmed publisher
..In this paper, we show that short hairpin ribonucleic acid-mediated knockdowns (KDs) of LRRTM1, LRRTM2, and/or NL-3, alone or together as double or triple KDs (TKDs) in cultured hippocampal neurons, did not decrease ..
Soler Llavina G, Arstikaitis P, Morishita W, Ahmad M, Sudhof T, Malenka R. Leucine-rich repeat transmembrane proteins are essential for maintenance of long-term potentiation. Neuron. 2013;79:439-46 pubmed publisher
..shRNA-mediated knockdown (KD) of LRRTM1 and LRRTM2 in vivo in CA1 pyramidal neurons of newborn mice blocked long-term potentiation (LTP) in acute hippocampal slices...
Hayer S, Bading H. Nuclear calcium signaling induces expression of the synaptic organizers Lrrtm1 and Lrrtm2. J Biol Chem. 2015;290:5523-32 pubmed publisher
..Here we identify two synaptic organizers, Lrrtm1 and Lrrtm2, as targets of nuclear calcium signaling...