Gene Symbol: Lrrtm1
Description: leucine rich repeat transmembrane neuronal 1
Alias: 4632401D06Rik, AW125451, leucine-rich repeat transmembrane neuronal protein 1
Lauren J, Airaksinen M, Saarma M, Timmusk T. A novel gene family encoding leucine-rich repeat transmembrane proteins differentially expressed in the nervous system. Genomics. 2003;81:411-21 pubmed
..The structure and expression profile of LRRTM mRNAs suggest that they may have a role in the development and maintenance of the vertebrate nervous system. ..
Linhoff M, Lauren J, Cassidy R, Dobie F, Takahashi H, Nygaard H, et al
. An unbiased expression screen for synaptogenic proteins identifies the LRRTM protein family as synaptic organizers. Neuron. 2009;61:734-49 pubmed publisher
..We identify LRRTM1 as a transmembrane protein that induces presynaptic differentiation in contacting axons...
Ko J, Soler Llavina G, Fuccillo M, Malenka R, Sudhof T. Neuroligins/LRRTMs prevent activity- and Ca2+/calmodulin-dependent synapse elimination in cultured neurons. J Cell Biol. 2011;194:323-34 pubmed publisher
..In this paper, we show that short hairpin ribonucleic acid-mediated knockdowns (KDs) of LRRTM1, LRRTM2, and/or NL-3, alone or together as double or triple KDs (TKDs) in cultured hippocampal neurons, did not ..
Takashima N, Odaka Y, Sakoori K, Akagi T, Hashikawa T, Morimura N, et al
. Impaired cognitive function and altered hippocampal synapse morphology in mice lacking Lrrtm1, a gene associated with schizophrenia. PLoS ONE. 2011;6:e22716 pubmed publisher
Recent genetic linkage analysis has shown that LRRTM1 (Leucine rich repeat transmembrane neuronal 1) is associated with schizophrenia. Here, we characterized Lrrtm1 knockout mice behaviorally and morphologically...
Hayer S, Bading H. Nuclear calcium signaling induces expression of the synaptic organizers Lrrtm1 and Lrrtm2. J Biol Chem. 2015;290:5523-32 pubmed publisher
..Here we identify two synaptic organizers, Lrrtm1 and Lrrtm2, as targets of nuclear calcium signaling...
Haines B, Rigby P. Developmentally regulated expression of the LRRTM gene family during mid-gestation mouse embryogenesis. Gene Expr Patterns. 2007;7:23-9 pubmed
..Each family member has a developmentally regulated pattern of expression distinct from all other members. LRRTM1 is expressed in the neural tube, otic vesicle, apical ectodermal ridge, forebrain and midbrain up to a sharp ..
Yoon H, Lee D, Kim M, Bok J. Identification of genes concordantly expressed with Atoh1 during inner ear development. Anat Cell Biol. 2011;44:69-78 pubmed publisher
..Here, by reanalyzing archived genetic profiling data, we identified a list of novel genes possibly involved in hair cell differentiation. ..
Voikar V, Kulesskaya N, Laakso T, Lauren J, Strittmatter S, Airaksinen M. LRRTM1-deficient mice show a rare phenotype of avoiding small enclosures--a tentative mouse model for claustrophobia-like behaviour. Behav Brain Res. 2013;238:69-78 pubmed publisher
..b>LRRTM1-knockout mice have subtle morphological deficits in excitatory hippocampal synapses and were suggested to have ..
Soler Llavina G, Arstikaitis P, Morishita W, Ahmad M, Sudhof T, Malenka R. Leucine-rich repeat transmembrane proteins are essential for maintenance of long-term potentiation. Neuron. 2013;79:439-46 pubmed publisher
..shRNA-mediated knockdown (KD) of LRRTM1 and LRRTM2 in vivo in CA1 pyramidal neurons of newborn mice blocked long-term potentiation (LTP) in acute ..