Gene Symbol: Lrrn1
Description: leucine rich repeat protein 1, neuronal
Alias: 2810047E21Rik, NLRR-1, leucine-rich repeat neuronal protein 1
Taguchi A, Wanaka A, Mori T, Matsumoto K, Imai Y, Tagaki T, et al
. Molecular cloning of novel leucine-rich repeat proteins and their expression in the developing mouse nervous system. Brain Res Mol Brain Res. 1996;35:31-40 pubmed
..These results suggest that there is at least one LRR protein family in the mouse and that these molecules may play significant but distinct roles in neural development and in the adult nervous system. ..
Abramova N, Charniga C, Goderie S, Temple S. Stage-specific changes in gene expression in acutely isolated mouse CNS progenitor cells. Dev Biol. 2005;283:269-81 pubmed
..These data indicate that progenitor cells change during development and that adult and embryonic neural progenitor cells are intrinsically different. ..
Haines B, Gupta R, Jones C, Summerbell D, Rigby P. The NLRR gene family and mouse development: Modified differential display PCR identifies NLRR-1 as a gene expressed in early somitic myoblasts. Dev Biol. 2005;281:145-59 pubmed
..The regulated embryonic expression and cellular location of these proteins suggest important roles during mouse development in the control of cell adhesion, movement or signalling. ..
Chambers D, Wilson L, Alfonsi F, Hunter E, Saxena U, Blanc E, et al
. Rhombomere-specific analysis reveals the repertoire of genetic cues expressed across the developing hindbrain. Neural Dev. 2009;4:6 pubmed publisher
..These findings give the first genome-wide insight into the complexity of gene expression during patterning of the developing hindbrain. ..
Aubert J, Stavridis M, Tweedie S, O Reilly M, Vierlinger K, Li M, et al
. Screening for mammalian neural genes via fluorescence-activated cell sorter purification of neural precursors from Sox1-gfp knock-in mice. Proc Natl Acad Sci U S A. 2003;100 Suppl 1:11836-41 pubmed
..Whole mount in situ hybridization against two genes of previously unknown embryonic expression, Lrrn1 and Musashi2, confirmed the selectivity of this screen for early neuroectodermal markers.
Gobert R, Joubert L, Curchod M, Salvat C, Foucault I, Jorand Lebrun C, et al
. Convergent functional genomics of oligodendrocyte differentiation identifies multiple autoinhibitory signaling circuits. Mol Cell Biol. 2009;29:1538-53 pubmed publisher
..Oligodendrocytic differentiation feedback loops may therefore yield pharmacological targets to treat disease related to dysfunctional myelin deposition. ..