Lrp8

Summary

Gene Symbol: Lrp8
Description: low density lipoprotein receptor-related protein 8, apolipoprotein e receptor
Alias: 4932703M08Rik, AA921429, AI848122, ApoER2, Lr8b, apolipoprotein E receptor 2, low density lipoprotein receptor relative, 8 ligand binding repeats, brain, low-density lipoprotein receptor-related protein 8
Species: mouse

Top Publications

  1. ncbi Reeler/Disabled-like disruption of neuronal migration in knockout mice lacking the VLDL receptor and ApoE receptor 2
    M Trommsdorff
    Department of Molecular Genetics, University of Texas Southwestern Medical Center, Dallas 75235 9046, USA
    Cell 97:689-701. 1999
  2. ncbi Reelin is a ligand for lipoprotein receptors
    G D'ARCANGELO
    Department of Developmental Neurobiology, St Jude Children s Research Hospital, Memphis, Tennessee 38105, USA
    Neuron 24:471-9. 1999
  3. pmc Nova2 regulates neuronal migration through an RNA switch in disabled-1 signaling
    Masato Yano
    Laboratory of Molecular Neuro Oncology and Howard Hughes Medical Institute, The Rockefeller University, 1230 York Avenue, New York, NY 10065, USA
    Neuron 66:848-58. 2010
  4. ncbi Divergent roles of ApoER2 and Vldlr in the migration of cortical neurons
    Iris Hack
    Institut fur Anatomie und Zellbiologie, Albert Ludwigs Universitat Freiburg, D 79104 Freiburg, Germany
    Development 134:3883-91. 2007
  5. ncbi Reelin signaling is necessary for a specific step in the migration of hindbrain efferent neurons
    Mireille Rossel
    EPHE Quantitative Cell Biology, INSERM EMI 343, IFR 122, University Montpellier 2, 34090 Montpellier, France
    Development 132:1175-85. 2005
  6. ncbi Reelin activates SRC family tyrosine kinases in neurons
    Hans H Bock
    Department of Molecular Genetics, University of Texas Southwestern Medical Center, 75390, Dallas, TX, USA
    Curr Biol 13:18-26. 2003
  7. ncbi Fyn tyrosine kinase is a critical regulator of disabled-1 during brain development
    Lionel Arnaud
    Fred Hutchinson Cancer Research Center, 1100 Fairview Avenue North, 98109, Seattle, WA, USA
    Curr Biol 13:9-17. 2003
  8. pmc Thrombospondin-1 binds to ApoER2 and VLDL receptor and functions in postnatal neuronal migration
    Sophia M Blake
    Department of Medical Biochemistry, Max F Perutz Laboratories, Medical University Vienna, Vienna, Austria
    EMBO J 27:3069-80. 2008
  9. doi PCSK9 binds to multiple receptors and can be functionally inhibited by an EGF-A peptide
    LiXin Shan
    Department of Cardiovascular and Metabolic Disease Research, Schering Plough Research Institute, 2015 Galloping Hill Road, K 15 1 1945, Kenilworth, NJ 07033, USA
    Biochem Biophys Res Commun 375:69-73. 2008
  10. ncbi Apolipoprotein E receptors are required for reelin-induced proteasomal degradation of the neuronal adaptor protein Disabled-1
    Hans H Bock
    Department of Medicine II, Albert Ludwigs Universitat, Albertstrasse 23, 79104 Freiburg, Germany
    J Biol Chem 279:33471-9. 2004

Scientific Experts

  • Gary Olson
  • Sabine Hellwig
  • Raymond Burk
  • Takaki Miyata
  • Petra May
  • Mireille Rossel
  • J M Luque
  • Hans H Bock
  • D S Rice
  • Kenneth N Fish
  • C G Perez-Garcia
  • Olav M Andersen
  • Joachim Herz
  • Uwe Beffert
  • HYANG SOOK HOE
  • Edwin J Weeber
  • Michael Frotscher
  • G William Rebeck
  • Johannes Nimpf
  • Irene Masiulis
  • Alasdair M Barr
  • Philip G de Groot
  • Rolf T Urbanus
  • Wolfgang J Schneider
  • Terumasa Hibi
  • Vera Strasser
  • Sophia M Blake
  • Nuno Andrade
  • Yves Jossin
  • Eckart Forster
  • W Stockinger
  • Robert E Hammer
  • Guangcheng Zhang
  • C Brandes
  • Xinping Chen
  • Hong Yang
  • Amir H Assadi
  • J David Sweatt
  • GABRIELLA D'ARCANGELO
  • Aycan Sentürk
  • Zurina Romay-Penabad
  • Justin H Trotter
  • Kieran L Quinn
  • Justin T Rogers
  • Elvira Khialeeva
  • Sangeetha Ramesh
  • Masato Yano
  • Jost Leemhuis
  • Marie T Krüger
  • Elena Palmesino
  • Elisabeth Bouché
  • Carlo C Quattrocchi
  • Jason O Robertson
  • Tara C White-Adams
  • Susan Magdaleno
  • Atsushi Baba
  • Takayuki Uchida
  • Mitsuharu Hattori
  • Shanting Zhao
  • Albrecht Tielsch
  • J Nimpf
  • Thomas Deller
  • Bianka Brunne
  • Carl Gebhardt
  • Alexander Drakew
  • Motonobu Nakamura
  • Gudrun Herrmann
  • Steve Poirier
  • Alin L Akopians
  • Kazue Hashimoto-Torii
  • Pascale Chavis
  • LiXin Shan
  • Iris Hack
  • Shingo Kurumada
  • M T T Pennings
  • Athina Markou
  • Yasuji Matsuoka
  • Kazunori Nakajima
  • Klaus M Giehl
  • Bradley T Hyman
  • Andre Goffinet
  • Andre Durudas
  • Robert S McNeil
  • Heiko Lickert
  • Gary D Clark
  • Anthony Wynshaw-Boris
  • Mélanie Sinagra
  • Anna Cariboni
  • Caroline Petit-Turcotte
  • Zhihua Qiu

Detail Information

Publications79

  1. ncbi Reeler/Disabled-like disruption of neuronal migration in knockout mice lacking the VLDL receptor and ApoE receptor 2
    M Trommsdorff
    Department of Molecular Genetics, University of Texas Southwestern Medical Center, Dallas 75235 9046, USA
    Cell 97:689-701. 1999
    ..for two other proteins, cell surface receptors termed very low density lipoprotein receptor (VLDLR) and apolipoprotein E receptor 2 (ApoER2)...
  2. ncbi Reelin is a ligand for lipoprotein receptors
    G D'ARCANGELO
    Department of Developmental Neurobiology, St Jude Children s Research Hospital, Memphis, Tennessee 38105, USA
    Neuron 24:471-9. 1999
    ..directly to lipoprotein receptors, preferably the very low-density lipoprotein receptor (VLDLR) and apolipoprotein E receptor 2 (ApoER2). Binding requires calcium, and it is inhibited in the presence of apoE...
  3. pmc Nova2 regulates neuronal migration through an RNA switch in disabled-1 signaling
    Masato Yano
    Laboratory of Molecular Neuro Oncology and Howard Hughes Medical Institute, The Rockefeller University, 1230 York Avenue, New York, NY 10065, USA
    Neuron 66:848-58. 2010
    ..Thus, Nova2 regulates an RNA switch controlling the ability of Dab1 to mediate neuronal responsiveness to reelin signaling and neuronal migration, suggesting new links between splicing regulation, brain disease, and development...
  4. ncbi Divergent roles of ApoER2 and Vldlr in the migration of cortical neurons
    Iris Hack
    Institut fur Anatomie und Zellbiologie, Albert Ludwigs Universitat Freiburg, D 79104 Freiburg, Germany
    Development 134:3883-91. 2007
    Reelin, its lipoprotein receptors [very low density lipoprotein receptor (Vldlr) and apolipoprotein E receptor 2 (ApoER2; also known as Lrp8)], and the cytoplasmic adaptor protein disabled 1 (Dab1) are important for the correct formation ..
  5. ncbi Reelin signaling is necessary for a specific step in the migration of hindbrain efferent neurons
    Mireille Rossel
    EPHE Quantitative Cell Biology, INSERM EMI 343, IFR 122, University Montpellier 2, 34090 Montpellier, France
    Development 132:1175-85. 2005
    ..However, examination of mice lacking both reelin receptors, ApoER2 and VLDLR, did not reveal the same phenotype, suggesting involvement of an additional reelin-binding receptor...
  6. ncbi Reelin activates SRC family tyrosine kinases in neurons
    Hans H Bock
    Department of Molecular Genetics, University of Texas Southwestern Medical Center, 75390, Dallas, TX, USA
    Curr Biol 13:18-26. 2003
    ..neurons requires binding to the very-low-density lipoprotein receptor (VLDLR) and the apolipoprotein E receptor-2 (apoER2)...
  7. ncbi Fyn tyrosine kinase is a critical regulator of disabled-1 during brain development
    Lionel Arnaud
    Fred Hutchinson Cancer Research Center, 1100 Fairview Avenue North, 98109, Seattle, WA, USA
    Curr Biol 13:9-17. 2003
    ..Mutations in Dab1, its phosphorylation sites, Reelin, or the Reelin receptors cause a common phenotype. However, the molecular mechanism whereby Reelin regulates Dab1 tyrosine phosphorylation is poorly understood...
  8. pmc Thrombospondin-1 binds to ApoER2 and VLDL receptor and functions in postnatal neuronal migration
    Sophia M Blake
    Department of Medical Biochemistry, Max F Perutz Laboratories, Medical University Vienna, Vienna, Austria
    EMBO J 27:3069-80. 2008
    b>Apolipoprotein E receptor 2 (ApoER2), very low-density lipoprotein receptor (VLDLR), and Dab1 are the main components of the Reelin signalling cascade. Reelin is the sole ligand defined so far in signalling through this pathway...
  9. doi PCSK9 binds to multiple receptors and can be functionally inhibited by an EGF-A peptide
    LiXin Shan
    Department of Cardiovascular and Metabolic Disease Research, Schering Plough Research Institute, 2015 Galloping Hill Road, K 15 1 1945, Kenilworth, NJ 07033, USA
    Biochem Biophys Res Commun 375:69-73. 2008
    ..In addition to LDLR, we show that PCSK9 also binds directly to ApoER2 and mouse VLDLR...
  10. ncbi Apolipoprotein E receptors are required for reelin-induced proteasomal degradation of the neuronal adaptor protein Disabled-1
    Hans H Bock
    Department of Medicine II, Albert Ludwigs Universitat, Albertstrasse 23, 79104 Freiburg, Germany
    J Biol Chem 279:33471-9. 2004
    ..Binding of Reelin to the neuronal apolipoprotein E receptors apoER2 and very low density lipoprotein receptor induces tyrosine phosphorylation of Dab1 and the subsequent activation ..
  11. ncbi The reelin receptor ApoER2 recruits JNK-interacting proteins-1 and -2
    W Stockinger
    The Institute of Medical Biochemistry, Department of Molecular Genetics, Biocenter and University of Vienna, Austria
    J Biol Chem 275:25625-32. 2000
    ..components of this signaling pathway characterized to date are cell surface receptors for reelin like apolipoprotein E receptor 2 (ApoER2), very low density lipoprotein receptor (VLDLR), and cadherin-related neuronal receptors, and ..
  12. pmc Interaction between Reelin and Notch signaling regulates neuronal migration in the cerebral cortex
    Kazue Hashimoto-Torii
    Department of Neurobiology, Yale Medical School, New Haven, CT 06510, USA
    Neuron 60:273-84. 2008
    ..Finally, our in vitro biochemical studies show that Reelin signaling inhibits Notch ICD degradation via Dab1. Together, our results indicate that neuronal migration in the developing cerebral cortex requires a Reelin-Notch interaction...
  13. ncbi Regulation of ApoE receptor proteolysis by ligand binding
    HYANG SOOK HOE
    Department of Neuroscience, Georgetown University, 3970 Reservoir Road NW, Washington, DC 20057 1464, USA
    Brain Res Mol Brain Res 137:31-9. 2005
    Two brain receptors for apolipoprotein E (apoE), the apoE receptor 2 (apoEr2) and the very low density lipoprotein receptor (VLDLr), are important in neuronal migration during development...
  14. pmc F-spondin interaction with the apolipoprotein E receptor ApoEr2 affects processing of amyloid precursor protein
    HYANG SOOK HOE
    Department of Neuroscience, Georgetown University Medical Center, 3970 Reservoir Road NW, Washington, DC 20057 1464, USA
    Mol Cell Biol 25:9259-68. 2005
    ..experiments, we demonstrated that F-spondin interacts with an apoE receptor (apoE receptor 2 [ApoEr2]) through the thrombospondin domain of F-spondin and the ligand binding domain of ApoEr2...
  15. ncbi Apolipoprotein E receptor 2 interactions with the N-methyl-D-aspartate receptor
    HYANG SOOK HOE
    Department of Neuroscience and Physiology, Georgetown University Medical Center, Washington, DC 20057 1464, USA
    J Biol Chem 281:3425-31. 2006
    ..present study, we confirmed through co-immunoprecipitation experiments an interaction between the apoE receptor, ApoEr2, and NMDAR1 through their extracellular domains...
  16. pmc ApoER2/VLDL receptor and Dab1 in the rostral migratory stream function in postnatal neuronal migration independently of Reelin
    Nuno Andrade
    Max F Perutz Laboratories, University Departments at the Vienna Biocenter, Department of Medical Biochemistry, Medical University of Vienna, A 1030 Vienna, Austria
    Proc Natl Acad Sci U S A 104:8508-13. 2007
    ..Here we show that ApoER2 and possibly very-low-density lipoprotein receptor (VLDLR) and their intracellular adapter protein Dab1 are ..
  17. ncbi Modulation of synaptic plasticity and memory by Reelin involves differential splicing of the lipoprotein receptor Apoer2
    Uwe Beffert
    Department of Molecular Genetics, University of Texas Southwestern Medical Center, Dallas, Texas 75390, USA
    Neuron 47:567-79. 2005
    b>Apolipoprotein E receptor 2 (Apoer2), a member of the LDL receptor gene family, and its ligand Reelin control neuronal migration during brain development...
  18. ncbi Apolipoprotein E receptors mediate neurite outgrowth through activation of p44/42 mitogen-activated protein kinase in primary neurons
    Zhihua Qiu
    Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA 02129, USA
    J Biol Chem 279:34948-56. 2004
    ....
  19. doi Downregulation of functional Reelin receptors in projection neurons implies that primary Reelin action occurs at early/premigratory stages
    Takayuki Uchida
    Department of Biomedical Science, Graduate School of Pharmaceutical Sciences, Nagoya City University, Mizuho ku, Nagoya, Aichi 467 8603, Japan
    J Neurosci 29:10653-62. 2009
    Reelin signaling is essential for correct development of the mammalian brain. Reelin binds to apolipoprotein E receptor 2 and very low-density lipoprotein receptor and induces phosphorylation of Dab1...
  20. ncbi Interaction of reelin signaling and Lis1 in brain development
    Amir H Assadi
    Cain Foundation Laboratories and Department of Pediatrics, Baylor College of Medicine, Houston, Texas 77030, USA
    Nat Genet 35:270-6. 2003
    ..Reln encodes an extracellular protein that regulates layer formation by interacting with VLDLR and ApoER2 (Lrp8) receptors, thereby phosphorylating the Dab1 signaling molecule...
  21. ncbi Alternative splicing in the ligand binding domain of mouse ApoE receptor-2 produces receptor variants binding reelin but not alpha 2-macroglobulin
    C Brandes
    Institute of Medical Biochemistry, Department of Molecular Genetics, Biocenter and University of Vienna, A 1030 Vienna, Austria
    J Biol Chem 276:22160-9. 2001
    LR7/8B and ApoER2 are recently discovered members of the low density lipoprotein (LDL) receptor family...
  22. ncbi Rescue of ataxia and preplate splitting by ectopic expression of Reelin in reeler mice
    Susan Magdaleno
    Department of Developmental Neurobiology, St Jude Children s Research Hospital, 332 North Lauderdale, Memphis, TN 38105, USA
    Neuron 33:573-86. 2002
    ..These results indicate that Reelin does not function simply as a positional signal. Rather, it appears to participate in multiple events critical for neuronal migration and cell positioning...
  23. ncbi Essential role of the apolipoprotein E receptor-2 in sperm development
    Olav M Andersen
    Max Delbrueck Center for Molecular Medicine and Medical Faculty of the Free University, D 13125 Berlin, Germany
    J Biol Chem 278:23989-95. 2003
    The apolipoprotein (apo) E receptor-2 (apoER2) is a member of the low density lipoprotein receptor gene family and an important regulator of neuronal migration...
  24. ncbi Functional dissection of Reelin signaling by site-directed disruption of Disabled-1 adaptor binding to apolipoprotein E receptor 2: distinct roles in development and synaptic plasticity
    Uwe Beffert
    Department of Molecular Genetics, University of Texas Southwestern Medical Center, Dallas, Texas 75390, USA
    J Neurosci 26:2041-52. 2006
    ..Reelin signals by binding to two transmembrane receptors, apolipoprotein E receptor 2 (Apoer2) and very-low-density lipoprotein receptor...
  25. ncbi Reelin and ApoE receptors cooperate to enhance hippocampal synaptic plasticity and learning
    Edwin J Weeber
    Division of Neuroscience, Baylor College of Medicine, Houston, Texas 77030, USA
    J Biol Chem 277:39944-52. 2002
    Two apolipoprotein E (apoE) receptors, the very low density lipoprotein (VLDL) receptor and apoE receptor 2 (apoER2), are also receptors for Reelin, a signaling protein that regulates neuronal migration during brain development...
  26. ncbi Reelin receptors in developing laminated brain structures of mouse and human
    C G Perez-Garcia
    Department of Anatomy, University La Laguna, 38071 La Laguna, Tenerife, Spain
    Eur J Neurosci 20:2827-32. 2004
    ..cells for reelin express the cytoplasmic adapter protein Dab1, which binds to the reelin receptors VLDLR and ApoER2. In the present work, we have studied the localization of both receptors in developing mouse and human cortex, ..
  27. ncbi ApoE receptor 2 controls neuronal survival in the adult brain
    Uwe Beffert
    Department of Molecular Genetics, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, Texas 75390, USA
    Curr Biol 16:2446-52. 2006
    ..We demonstrate that a differentially spliced isoform of an ApoE receptor, ApoE receptor 2 (Apoer2), is essential for protection against neuronal cell loss during normal aging...
  28. pmc Up-regulation of ATP binding cassette transporter A1 expression by very low density lipoprotein receptor and apolipoprotein E receptor 2
    Xinping Chen
    Department of Physiology, Meharry Medical College, Nashville, Tennessee 37208, USA
    J Biol Chem 287:3751-9. 2012
    Activation of very low density lipoprotein receptor (VLDLR) and apolipoprotein E receptor 2 (apoER2) results in either pro- or anti-atherogenic effects depending on the ligand...
  29. ncbi The proprotein convertase PCSK9 induces the degradation of low density lipoprotein receptor (LDLR) and its closest family members VLDLR and ApoER2
    Steve Poirier
    Laboratory of Biochemical Neuroendocrinology, Clinical Research Institute of Montreal, Montreal, Quebec H2W 1R7, Canada
    J Biol Chem 283:2363-72. 2008
    ..These include the very low density lipoprotein receptor (VLDLR) and apolipoprotein E receptor 2 (ApoER2) implicated in neuronal development and lipid metabolism...
  30. pmc Reelin supplementation enhances cognitive ability, synaptic plasticity, and dendritic spine density
    Justin T Rogers
    Department of Molecular Pharmacology and Physiology, University of South Florida, Tampa, Florida 33620, USA
    Learn Mem 18:558-64. 2011
    ..The present study suggests that an acute elevation of in vivo Reelin can have long-term effects on synaptic function and cognitive ability in wild-type mice...
  31. doi Human neutrophil peptides mediate endothelial-monocyte interaction, foam cell formation, and platelet activation
    Kieran L Quinn
    Keenan Research Centre in the Li Ka Shing Knowledge Institute of St Michael s Hospital, Toronto, Ontario, Canada
    Arterioscler Thromb Vasc Biol 31:2070-9. 2011
    ..Human neutrophil peptides (HNPs) released from activated neutrophils exert immune modulating properties. We hypothesized that HNPs play an important role in neutrophil-mediated inflammatory cardiovascular responses in atherosclerosis...
  32. doi Role for Reelin-induced cofilin phosphorylation in the assembly of sympathetic preganglionic neurons in the murine intermediolateral column
    Marie T Krüger
    Institut fur Anatomie und Zellbiologie, Albert Ludwigs Universitat Freiburg, Albertstr 17, Freiburg, Germany
    Eur J Neurosci 32:1611-7. 2010
    ..The results extend our previous studies on cortical neurons in which Reelin in the marginal zone was found to stabilize the leading processes of migrating neurons and terminate the migration process...
  33. pmc ApoER2 function in the establishment and maintenance of retinal synaptic connectivity
    Justin H Trotter
    Molecular Pharmacology and Physiology, USF Health Byrd Alzheimer s Institute, University of South Florida, Tampa, Florida 33613, USA
    J Neurosci 31:14413-23. 2011
    ..Reelin and apolipoprotein E (apoE), ligands of apoE receptor 2 (ApoER2), are involved in retinal development and degeneration, respectively...
  34. ncbi The localization of label-retaining cells in mouse nails
    Motonobu Nakamura
    J Invest Dermatol 128:728-30. 2008
  35. doi Contribution of the Reelin signaling pathways to nociceptive processing
    Alin L Akopians
    Department of Physiological Science, UCLA, Box 951606, Los Angeles, CA 90095 1606, USA
    Eur J Neurosci 27:523-37. 2008
    ..Reelin, a secreted glycoprotein that binds to the very-low-density lipoprotein receptor (Vldlr) and apolipoprotein E receptor 2 (Apoer 2), and induces Src- and Fyn-mediated tyrosine phosphorylation of the intracellular adaptor ..
  36. ncbi Fyn modulation of Dab1 effects on amyloid precursor protein and ApoE receptor 2 processing
    HYANG SOOK HOE
    Department of Neuroscience, Georgetown University Medical Center, 3970 Reservoir Road NW, Washington, DC 20057, USA
    J Biol Chem 283:6288-99. 2008
    Dab1 is an intracellular adaptor protein that interacts with amyloid precursor protein (APP) and apoE receptor 2 (apoEr2), increases their levels on the cell surface, and increases their cleavage by alpha-secretases...
  37. doi Megalin mediates selenoprotein P uptake by kidney proximal tubule epithelial cells
    Gary E Olson
    Department of Cell and Developmental Biology, Vanderbilt University School of Medicine, Nashville, Tennessee 37232, USA
    J Biol Chem 283:6854-60. 2008
    ..We recently demonstrated that apolipoprotein E receptor-2 (ApoER2) is required for Sepp1 uptake by the testis and that deletion of ApoER2 reduces testis and brain, but not kidney, ..
  38. pmc Deficiency of LRP8 in mice is associated with altered platelet function and prolonged time for in vivo thrombosis
    Jason O Robertson
    Department of Cell Biology, Cleveland Clinic, Cleveland, OH Cleveland Clinic Lerner College of Medicine, Cleveland Clinic, Cleveland, OH, USA
    Thromb Res 123:644-52. 2009
    Our group has previously reported genetic studies associating polymorphisms in the low density lipoprotein receptor related protein 8 (LRP8) gene with myocardial infarction...
  39. pmc Foxp1 and lhx1 coordinate motor neuron migration with axon trajectory choice by gating Reelin signalling
    Elena Palmesino
    Neural Circuit Development Laboratory, Institut de Recherches Cliniques de Montreal, Montreal, Canada
    PLoS Biol 8:e1000446. 2010
    ..Together, these observations point to identical transcription factors that control motor axon guidance and soma migration and reveal the molecular hierarchy of myotopic organisation...
  40. ncbi Abnormal positioning of granule cells alters afferent fiber distribution in the mouse fascia dentata: morphologic evidence from reeler, apolipoprotein E receptor 2-, and very low density lipoprotein receptor knockout mice
    Carl Gebhardt
    Department of Clinical Neuroanatomy, J W Goethe University, D 60590 Frankfurt Main, Germany
    J Comp Neurol 445:278-92. 2002
    ..and fiberarchitecture of three mouse mutants (very low density lipoprotein receptor knockout mouse, apolipoprotein E receptor 2 knockout mouse, and reeler mouse) that show different degrees of granule cell migration defects were ..
  41. pmc Apolipoprotein E receptor 2 is involved in the thrombotic complications in a murine model of the antiphospholipid syndrome
    Zurina Romay-Penabad
    Department of Internal Medicine, Division of Rheumatology, University of Texas Medical Branch, 301 University Blvd, Galveston, TX 77555 0883, USA
    Blood 117:1408-14. 2011
    ..We investigated the role of Apolipoprotein E receptor 2 (ApoER2') on the pathogenic effects of a patient-derived polyclonal aPL IgG preparation (IgG-APS), a ..
  42. pmc Antiphospholipid antibodies promote leukocyte-endothelial cell adhesion and thrombosis in mice by antagonizing eNOS via β2GPI and apoER2
    Sangeetha Ramesh
    Division of Pulmonary and Vascular Biology, Department of Pediatrics, University of Texas Southwestern Medical Center, Dallas, Texas, USA
    J Clin Invest 121:120-31. 2011
    ..member antagonism with receptor-associated protein (RAP) prevented aPL inhibition of eNOS in cell culture, and ApoER2-/- mice were protected from aPL inhibition of eNOS in vivo...
  43. pmc Disruption of reelin signaling alters mammary gland morphogenesis
    Elvira Khialeeva
    Department of Psychiatry and Biobehavioral Science, UCLA School of Medicine, Los Angeles, CA 90095, USA
    Development 138:767-76. 2011
    ....
  44. pmc Identification of coagulation factor XI as a ligand for platelet apolipoprotein E receptor 2 (ApoER2)
    Tara C White-Adams
    Division of Biomedical Engineering, Oregon Health and Science University School of Medicine, 3303 SW Bond Ave, Portland, OR 97239, USA
    Arterioscler Thromb Vasc Biol 29:1602-7. 2009
    ..The aim of this study was to investigate the mechanisms governing interactions between FXI and platelets...
  45. doi Splicing variations in the ligand-binding domain of ApoER2 results in functional differences in the binding properties to Reelin
    Terumasa Hibi
    Department of Biomedical Science, Graduate School of Pharmaceutical Sciences, Nagoya City University, 3 1 Tanabe dori, Mizuho ku, Nagoya, Aichi 467 8603, Japan
    Neurosci Res 63:251-8. 2009
    Reelin plays critical roles in brain formation by binding to apolipoprotein E receptor 2 (ApoER2) and very low-density lipoprotein receptor...
  46. pmc Reelin signals through apolipoprotein E receptor 2 and Cdc42 to increase growth cone motility and filopodia formation
    Jost Leemhuis
    Center for Neuroscience, Albert Ludwigs University, 79104 Freiburg, Germany
    J Neurosci 30:14759-72. 2010
    ..the Rho GTPase Cdc42, known for its role in neuronal morphogenesis and directed migration, in an apolipoprotein E receptor 2-, Disabled-1-, and phosphatidylinositol 3-kinase-dependent manner...
  47. doi Ephrin Bs are essential components of the Reelin pathway to regulate neuronal migration
    Aycan Sentürk
    Frankfurt Institute for Molecular Life Sciences and Institute of Cell Biology and Neuroscience, Goethe University Frankfurt, Max von Laue Str 9, D 60438, Frankfurt am Main, Germany
    Nature 472:356-60. 2011
    ..neurons by binding to two lipoprotein receptors, the very-low-density lipoprotein receptor (VLDLR) and apolipoprotein E receptor 2 (ApoER2, also known as LRP8)...
  48. pmc Migration, early axonogenesis, and Reelin-dependent layer-forming behavior of early/posterior-born Purkinje cells in the developing mouse lateral cerebellum
    Takaki Miyata
    Department of Anatomy and Cell Biology, Nagoya University Graduate School of Medicine, Nagoya, Aichi, Japan
    Neural Dev 5:23. 2010
    ..Furthermore, it is not known what nascent Purkinje cells look like in vivo. When and how Purkinje cells start axonogenesis must also be elucidated...
  49. ncbi Altered performance of reelin-receptor ApoER2 deficient mice on spatial tasks using the Barnes maze
    Alasdair M Barr
    Department of Psychiatry, University of British Columbia, Vancouver, BC, Canada
    Behav Neurosci 121:1101-5. 2007
    The apolipoprotein E receptor 2 (ApoER2), expressed predominantly in forebrain regions including the hippocampus, is 1 of 2 receptors for the extracellular matrix protein reelin, which is critical for cortical development...
  50. ncbi Deletion of apolipoprotein E receptor-2 in mice lowers brain selenium and causes severe neurological dysfunction and death when a low-selenium diet is fed
    Raymond F Burk
    Division of Gastroenterology, Hepatology, and Nutrition, Vanderbilt University School of Medicine, Nashville, Tennessee 37232, USA
    J Neurosci 27:6207-11. 2007
    ..The lipoprotein receptor apolipoprotein E receptor-2 (apoER2) binds Sepp1 and facilitates its uptake by Sertoli cells, thus providing selenium for spermatogenesis...
  51. ncbi Dissecting Wnt/beta-catenin signaling during gastrulation using RNA interference in mouse embryos
    Heiko Lickert
    Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto M5G 1X5, Canada
    Development 132:2599-609. 2005
    ..This functional genomic approach allows the rapid identification of functionally important components of embryonic development from large datasets of putative targets...
  52. ncbi Binding of low density lipoprotein to platelet apolipoprotein E receptor 2' results in phosphorylation of p38MAPK
    Suzanne J A Korporaal
    Laboratory for Thrombosis and Haemostasis, Department of Haematology, University Medical Center Utrecht and Institute of Biomembranes, University of Utrecht, Heidelberglaan 100, 3584 CX Utrecht, The Netherlands
    J Biol Chem 279:52526-34. 2004
    ..of co-localization of LDL and a splice variant of the LDL receptor family member apolipoprotein E receptor-2 (apoER2') at the platelet surface, suggesting that apoER2' may contribute to LDL-induced platelet signaling...
  53. ncbi High affinity binding of Dab1 to Reelin receptors promotes normal positioning of upper layer cortical plate neurons
    Tara M Herrick
    Division of Basic Sciences, Fred Hutchinson Cancer Research Center, 1100 Fairview Ave N, Seattle, WA 98109, USA
    Brain Res Mol Brain Res 126:121-8. 2004
    ..Dab1 and the Reelin receptors VLDLR and ApoER2 are expressed by neurons whose migrations are coordinated by Reelin...
  54. ncbi Differential binding of ligands to the apolipoprotein E receptor 2
    Olav M Andersen
    Max Delbrueck Center for Molecular Medicine, Robert Roessle Strasse 10, D 13125 Berlin, Germany
    Biochemistry 42:9355-64. 2003
    b>Apolipoprotein E receptor 2 (apoER2) is an important participant in the Reelin signaling pathway that directs cell positioning during embryogenesis...
  55. pmc The human homolog of the JE gene encodes a monocyte secretory protein
    B J Rollins
    Division of Medicine, Harvard Medical School, Boston, Massachusetts 02115
    Mol Cell Biol 9:4687-95. 1989
    ..Thus, human JE encodes yet another member of the large family of JE-related cytokinelike proteins, in this case a novel human monocyte and fibroblast secretory protein...
  56. ncbi Malformation of the radial glial scaffold in the dentate gyrus of reeler mice, scrambler mice, and ApoER2/VLDLR-deficient mice
    Karl Heinz Weiss
    Anatomisches Institut, Universitat Freiburg, D 79104 Freiburg, Germany
    J Comp Neurol 460:56-65. 2003
    ..of the Reelin signal into the cell, and in mutant mice lacking the Reelin receptors apolipoprotein receptor 2 (ApoER2) and/or the very low density lipoprotein receptor (VLDLR), known to transmit the Reelin signal via Dab1...
  57. ncbi Localization of ApoER2, VLDLR and Dab1 in radial glia: groundwork for a new model of reelin action during cortical development
    Juan M Luque
    Instituto de Neurociencias, Universidad Miguel Hernandez, CSIC, Campus de San Juan, E 03550, San Juan de Alicante, Spain
    Brain Res Dev Brain Res 140:195-203. 2003
    ..Here we provide evidence that the reelin receptor machinery, including the lipoprotein receptors ApoER2 and VLDLR along with the cytoplasmic adaptor protein Dab1, is located in radial glia precursors whose processes ..
  58. ncbi Dentate granule cells in reeler mutants and VLDLR and ApoER2 knockout mice
    Alexander Drakew
    Institute of Anatomy, University of Freiburg, Albertstrasse 17, Freiburg, D 79104, Germany
    Exp Neurol 176:12-24. 2002
    ..reelin and in mutants lacking the reelin receptors very low density lipoprotein receptor (VLDLR) and apolipoprotein E receptor 2 (ApoER2)...
  59. ncbi Mutant mice with scrambled brains: understanding the signaling pathways that control cell positioning in the CNS
    D S Rice
    Department of Developmental Neurobiology, St Jude Children s Research Hospital, Memphis, Tennessee 38105, USA
    Genes Dev 13:2758-73. 1999
  60. ncbi Reelin, very-low-density lipoprotein receptor, and apolipoprotein E receptor 2 control somatic NMDA receptor composition during hippocampal maturation in vitro
    Mélanie Sinagra
    Institut F Magendie des Neurosciences, 33077 Bordeaux Cedex, France
    J Neurosci 25:6127-36. 2005
    ..several receptors, including two members of the low-density lipoprotein (LDL) receptor family, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR)...
  61. pmc The reelin receptors VLDLR and ApoER2 regulate sensorimotor gating in mice
    Alasdair M Barr
    Department of Psychiatry, University of British Columbia, Vancouver, B C, Canada
    Neuropharmacology 52:1114-23. 2007
    ..the involvement of the two receptors for reelin, Very-Low-Density Lipoprotein Receptor (VLDLR) and Apolipoprotein E Receptor 2 (ApoER2), on pre-cognitive processes of relevance to deficits seen in schizophrenia...
  62. ncbi Apolipoprotein E receptor-2 (ApoER2) mediates selenium uptake from selenoprotein P by the mouse testis
    Gary E Olson
    Department of Cell and Developmental Biology, Department of Medicine, Vanderbilt University, Nashville, Tennessee 37232, USA
    J Biol Chem 282:12290-7. 2007
    ..of a testicular extract followed by mass spectrometry-based identification of bound proteins identified apolipoprotein E receptor 2 (ApoER2) as a candidate testis Sepp1 receptor...
  63. pmc The Pafah1b complex interacts with the reelin receptor VLDLR
    Guangcheng Zhang
    The Cain Foundation Laboratories, Texas Children s Hospital, Houston, Texas, United States of America
    PLoS ONE 2:e252. 2007
    ..through the activation of two receptors, the very low-density lipoprotein receptor (VLDLR) and the apolipoprotein E receptor 2 (ApoER2), and the phosphorylation of Disabled-1 (Dab1)...
  64. ncbi Stage-specific association of apolipoprotein A-I and E in developing mouse retina
    Shingo Kurumada
    Department of Biophysics, Graduate School of Science, Kyoto University, Kyoto 606 8502, Japan
    Invest Ophthalmol Vis Sci 48:1815-23. 2007
    ..To characterize the intercellular lipid transport systems in differentiating retina...
  65. ncbi The apoE receptor apoER2 is involved in the maintenance of efficient synaptic plasticity
    Caroline Petit-Turcotte
    Douglas Hospital Research Center, 6875 LaSalle Blvd, Verdun, Que, Canada H4H 1R3
    Neurobiol Aging 26:195-206. 2005
    b>ApoER2 is one of the major receptors for ApoE in the brain, and has been shown to be involved not only in lipoprotein endocytosis, as other members of the LDL receptor family of receptors, but also in various cellular functions such as ..
  66. ncbi Reelin provides an inhibitory signal in the migration of gonadotropin-releasing hormone neurons
    Anna Cariboni
    Department of Anatomy and Developmental Biology, University College London, London WC1E 6BT, UK
    Development 132:4709-18. 2005
    ..Only a small (approximately 5%) subpopulation of these neurons expresses one of the reelin receptors (ApoER2/Lrp8), and all GnRH neurons appear to lack the intracellular adaptor protein Dab1, suggesting that the function of ..
  67. ncbi Processing of Reelin by embryonic neurons is important for function in tissue but not in dissociated cultured neurons
    Yves Jossin
    Developmental Neurobiology Unit, Universite Catholique de Louvain, B1200 Brussels, Belgium
    J Neurosci 27:4243-52. 2007
    ....
  68. pmc The PX-domain protein SNX17 interacts with members of the LDL receptor family and modulates endocytosis of the LDL receptor
    Walter Stockinger
    The Institute of Medical Biochemistry, Department of Molecular Genetics, Biocenter and University of Vienna, A 1030 Vienna, Austria
    EMBO J 21:4259-67. 2002
    ..intracellular domain of some members of the low-density lipoprotein receptor (LDLR) family such as LDLR, VLDLR, ApoER2 and LDLR-related protein...
  69. pmc A secreted soluble form of ApoE receptor 2 acts as a dominant-negative receptor and inhibits Reelin signaling
    Stefanie Koch
    The Institute of Medical Biochemistry, Department of Molecular Genetics, Biocenter and University of Vienna, Vienna, Austria
    EMBO J 21:5996-6004. 2002
    ..Specialized neurons throughout the developing central nervous system secrete Reelin, which binds to ApoE receptor 2 (ApoER2) and very low density lipoprotein receptor (VLDLR), triggering a signal cascade that guides neurons to their ..
  70. ncbi Evolution of the apolipoprotein E receptor 2 gene by exon loss
    H J Kim
    Tohoku University Gene Research Center, Aoba, Sendai, 981 8555, Japan
    J Biochem 124:451-6. 1998
    The apolipoprotein E receptor 2 (apoER2) gene consists of a mosaic of exons, which may have been assembled by "exon shuffling...
  71. doi Olfactory bulb interneurons releasing NO exhibit the Reelin receptor ApoEr2 and part of those targeted by NO express Reelin
    Gudrun Herrmann
    Department of Anatomy, University of Bern, CH3012 Bern, Switzerland
    J Chem Neuroanat 36:160-9. 2008
    ..now studied the distribution of NO sensitive guanylyl cyclase (NOsGC), Reelin and its receptor Apolipoprotein E2 (ApoEr2) in the olfactory bulb by multiple fluorescence labelling and tested whether nNOS and ApoEr2 colocalize in this ..
  72. ncbi Differential glycosylation regulates processing of lipoprotein receptors by gamma-secretase
    Petra May
    Department of Molecular Genetics, University of Texas Southwestern Medical Center, Dallas, Texas 75390 9046, USA
    J Biol Chem 278:37386-92. 2003
    ..The apolipoprotein E (apoE) receptor-2 (apoER2), another member of the LDL receptor family with functions in cellular signal transmission, also undergoes ..
  73. ncbi Reelin promotes peripheral synapse elimination and maturation
    Carlo C Quattrocchi
    The Cain Foundation Laboratories, Houston, TX 77030, USA
    Science 301:649-53. 2003
    ..junction development requires a function of Reelin that is not mediated by Disabled1 or very-low-density lipoprotein receptors and apolipoprotein E receptor 2 receptors but by a distinct mechanism involving its protease activity.
  74. ncbi Platelet adhesion to dimeric beta-glycoprotein I under conditions of flow is mediated by at least two receptors: glycoprotein Ibalpha and apolipoprotein E receptor 2'
    M T T Pennings
    Laboratory of Clinical Chemistry and Haematology, University Medical Centre Utrecht, Utrecht, The Netherlands
    J Thromb Haemost 5:369-77. 2007
    ..Dimerized beta2GPI binds to apolipoprotein E receptor 2' (apoER2') on platelets and increases platelet adhesion to collagen under conditions of flow.
  75. ncbi Components of the reelin signaling pathway are expressed in the spinal cord
    Yee Ping Yip
    Department of Neurobiology, School of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania 15261, USA
    J Comp Neurol 470:210-9. 2004
    ..in the brain involves the binding of Reelin to very-low-density lipoprotein receptors (VLDLR) and apolipoprotein E receptor 2 (ApoER2)...
  76. pmc DCX, a new mediator of the JNK pathway
    Amos Gdalyahu
    Department of Molecular Genetics, The Weizmann Institute of Science, Rehovot, Israel
    EMBO J 23:823-32. 2004
    ....
  77. pmc Differential functions of the Apoer2 intracellular domain in selenium uptake and cell signaling
    Irene Masiulis
    Department of Molecular Genetics, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA
    Biol Chem 390:67-73. 2009
    b>Apolipoprotein E receptor 2 (Apoer2) is a multifunctional transport and signaling receptor that regulates the uptake of selenium into the mouse brain and testis through endocytosis of selenoprotein P (Sepp1)...
  78. pmc Functional consequences of hippocampal neuronal ectopia in the apolipoprotein E receptor-2 knockout mouse
    Kenneth N Fish
    Department of Psychiatry, Western Psychiatric Institute and Clinic, University of Pittsburgh School of Medicine, Biomedical Science Tower, Pittsburgh, PA 15213, USA
    Neurobiol Dis 32:391-401. 2008
    ..The ApoER2 knockout mouse has subtle cytoarchitectural disruptions, altered prepulse inhibition, and memory abnormalities...
  79. ncbi Avian and murine LR8B and human apolipoprotein E receptor 2: differentially spliced products from corresponding genes
    C Brandes
    Department of Molecular Genetics, Biocenter and University of Vienna, Austria
    Genomics 42:185-91. 1997
    ..Novak, et al., 1996, J. Biol. Chem. 271: 11732-11736). The human receptor, termed "apolipoprotein E receptor 2," is a seven ligand-binding repeat receptor harboring a unique insertion in the cytoplasmic domain of ..

Research Grants62

  1. SPERM FUNCTION IN FERTILIZATION EVENTS
    Gary Olson; Fiscal Year: 1993
    ....
  2. SPERM FUNCTION IN FERTILIZATION EVENTS
    Gary Olson; Fiscal Year: 1992
    ..Completion of these specific aims will provide new data on the mechanisms underlying the mosaic construction of the sperm plasma membrane and provide needed data on the molecular basis of specific fertilization events...
  3. SPERM FUNCTION IN FERTILIZATION EVENTS
    Gary Olson; Fiscal Year: 2001
    ....
  4. Role of Selenoprotein P in Male Fertility
    Gary Olson; Fiscal Year: 2007
    ..Aim 3: To identify and localize Se-P-binding proteins in the testis and epididymis. Aim 4: To determine the molecular basis for sperm defects in Se-P null mice. ..
  5. SPERM FUNCTION IN FERTILIZATION EVENTS
    Gary Olson; Fiscal Year: 2006
    ..3: To determine if eFGL binding to specific sperm ligands promotes sperm death and/or death cocoon polymerization.4: To define the function of eFGL by targeted disruption of the fgl2 gene in mice. ..
  6. Human Se Nutritional Requirement and Biomarkers in Health and Disease
    Raymond F Burk; Fiscal Year: 2010
    ..All these studies are aimed at facilitating efforts to determine the health effects of selenium deficiency and to guide supplementation of the element when that is needed. ..
  7. HUMAN SELENIUM NUTRITIONAL REQUIREMENT AND BIOMARKERS
    Raymond Burk; Fiscal Year: 2005
    ..They should also provide tools for investigators who need to evaluate subjects for selenium deficiency and for intake of pharmacologic amounts of selenium. ..
  8. NUTRITIONAL AND METABOLIC SIGNIFICANCE OF SELENIUM
    Raymond Burk; Fiscal Year: 2007
    ..Results of these studies will be interpreted to characterize the brain injury with the objective of selecting human neurological disorders to study for genetic abnormalities of Se-P and its receptor. ..
  9. Human Se Nutritional Requirement and Biomarkers in Health and Disease
    Raymond Burk; Fiscal Year: 2007
    ..All these studies are aimed at facilitating efforts to determine the health effects of selenium deficiency and to guide supplementation of the element when that is needed. ..
  10. Gpx3 Targeting and Extracellular Oxidative Stress
    Raymond F Burk; Fiscal Year: 2010
    ..We produced mice with Gpx3 deleted and will assess Gpx3 protection against oxidative stress in those mice to shed light on some diseases. ..
  11. NUTRITIONAL AND METABOLIC SIGNIFICANCE OF SELENIUM
    Raymond Burk; Fiscal Year: 2003
    ..These and other studies are proposed to evaluate the role of Se-P in protecting endothelial cells (and other cells) against oxidant substances in the extracellular space. ..
  12. NUTRITIONAL AND METABOLIC SIGNIFICANCE OF SELENIUM
    Raymond Burk; Fiscal Year: 1993
    ..Finally, human selenoprotein P will be purified and an assay for it will be devised. These studies will extend our understanding of the function of selenium and could lead to a better understanding of oxidant defenses...