Lrp8

Summary

Gene Symbol: Lrp8
Description: low density lipoprotein receptor-related protein 8, apolipoprotein e receptor
Alias: 4932703M08Rik, AA921429, AI848122, ApoER2, Lr8b, low-density lipoprotein receptor-related protein 8, apolipoprotein E receptor 2, low density lipoprotein receptor relative, 8 ligand binding repeats, brain
Species: mouse
Products:     Lrp8

Top Publications

  1. Hack I, Hellwig S, Junghans D, Brunne B, Bock H, Zhao S, et al. Divergent roles of ApoER2 and Vldlr in the migration of cortical neurons. Development. 2007;134:3883-91 pubmed
    Reelin, its lipoprotein receptors [very low density lipoprotein receptor (Vldlr) and apolipoprotein E receptor 2 (ApoER2; also known as Lrp8)], and the cytoplasmic adaptor protein disabled 1 (Dab1) are important for the correct formation ..
  2. Bock H, Herz J. Reelin activates SRC family tyrosine kinases in neurons. Curr Biol. 2003;13:18-26 pubmed
    ..neurons requires binding to the very-low-density lipoprotein receptor (VLDLR) and the apolipoprotein E receptor-2 (apoER2)...
  3. Divekar S, Burrell T, Lee J, Weeber E, Rebeck G. Ligand-induced homotypic and heterotypic clustering of apolipoprotein E receptor 2. J Biol Chem. 2014;289:15894-903 pubmed publisher
    ApoE Receptor 2 (ApoER2) and the very low density lipoprotein receptor (VLDLR) are type I transmembrane proteins belonging to the LDLR family of receptors...
  4. Andersen O, Yeung C, Vorum H, Wellner M, Andreassen T, Erdmann B, et al. Essential role of the apolipoprotein E receptor-2 in sperm development. J Biol Chem. 2003;278:23989-95 pubmed
    The apolipoprotein (apo) E receptor-2 (apoER2) is a member of the low density lipoprotein receptor gene family and an important regulator of neuronal migration...
  5. Brandes C, Kahr L, Stockinger W, Hiesberger T, Schneider W, Nimpf J. Alternative splicing in the ligand binding domain of mouse ApoE receptor-2 produces receptor variants binding reelin but not alpha 2-macroglobulin. J Biol Chem. 2001;276:22160-9 pubmed
    LR7/8B and ApoER2 are recently discovered members of the low density lipoprotein (LDL) receptor family...
  6. Poirier S, Mayer G, Benjannet S, Bergeron E, Marcinkiewicz J, Nassoury N, et al. The proprotein convertase PCSK9 induces the degradation of low density lipoprotein receptor (LDLR) and its closest family members VLDLR and ApoER2. J Biol Chem. 2008;283:2363-72 pubmed
    ..These include the very low density lipoprotein receptor (VLDLR) and apolipoprotein E receptor 2 (ApoER2) implicated in neuronal development and lipid metabolism...
  7. Duit S, Mayer H, Blake S, Schneider W, Nimpf J. Differential functions of ApoER2 and very low density lipoprotein receptor in Reelin signaling depend on differential sorting of the receptors. J Biol Chem. 2010;285:4896-908 pubmed publisher
    b>ApoER2 and very low density lipoprotein (VLDL) receptor transmit the Reelin signal into target cells of the central nervous system...
  8. Shan L, Pang L, Zhang R, Murgolo N, Lan H, Hedrick J. PCSK9 binds to multiple receptors and can be functionally inhibited by an EGF-A peptide. Biochem Biophys Res Commun. 2008;375:69-73 pubmed publisher
    ..In addition to LDLR, we show that PCSK9 also binds directly to ApoER2 and mouse VLDLR...
  9. Hong C, Duit S, Jalonen P, Out R, Scheer L, Sorrentino V, et al. The E3 ubiquitin ligase IDOL induces the degradation of the low density lipoprotein receptor family members VLDLR and ApoER2. J Biol Chem. 2010;285:19720-6 pubmed publisher
    ..Here we demonstrate that Idol also targets two closely related LDLR family members, VLDLR and ApoE receptor 2 (ApoER2), proteins implicated in both neuronal development and lipid metabolism...
  10. Drakew A, Deller T, Heimrich B, Gebhardt C, Del Turco D, Tielsch A, et al. Dentate granule cells in reeler mutants and VLDLR and ApoER2 knockout mice. Exp Neurol. 2002;176:12-24 pubmed
    ..reelin and in mutants lacking the reelin receptors very low density lipoprotein receptor (VLDLR) and apolipoprotein E receptor 2 (ApoER2)...

Detail Information

Publications78

  1. Hack I, Hellwig S, Junghans D, Brunne B, Bock H, Zhao S, et al. Divergent roles of ApoER2 and Vldlr in the migration of cortical neurons. Development. 2007;134:3883-91 pubmed
    Reelin, its lipoprotein receptors [very low density lipoprotein receptor (Vldlr) and apolipoprotein E receptor 2 (ApoER2; also known as Lrp8)], and the cytoplasmic adaptor protein disabled 1 (Dab1) are important for the correct formation ..
  2. Bock H, Herz J. Reelin activates SRC family tyrosine kinases in neurons. Curr Biol. 2003;13:18-26 pubmed
    ..neurons requires binding to the very-low-density lipoprotein receptor (VLDLR) and the apolipoprotein E receptor-2 (apoER2)...
  3. Divekar S, Burrell T, Lee J, Weeber E, Rebeck G. Ligand-induced homotypic and heterotypic clustering of apolipoprotein E receptor 2. J Biol Chem. 2014;289:15894-903 pubmed publisher
    ApoE Receptor 2 (ApoER2) and the very low density lipoprotein receptor (VLDLR) are type I transmembrane proteins belonging to the LDLR family of receptors...
  4. Andersen O, Yeung C, Vorum H, Wellner M, Andreassen T, Erdmann B, et al. Essential role of the apolipoprotein E receptor-2 in sperm development. J Biol Chem. 2003;278:23989-95 pubmed
    The apolipoprotein (apo) E receptor-2 (apoER2) is a member of the low density lipoprotein receptor gene family and an important regulator of neuronal migration...
  5. Brandes C, Kahr L, Stockinger W, Hiesberger T, Schneider W, Nimpf J. Alternative splicing in the ligand binding domain of mouse ApoE receptor-2 produces receptor variants binding reelin but not alpha 2-macroglobulin. J Biol Chem. 2001;276:22160-9 pubmed
    LR7/8B and ApoER2 are recently discovered members of the low density lipoprotein (LDL) receptor family...
  6. Poirier S, Mayer G, Benjannet S, Bergeron E, Marcinkiewicz J, Nassoury N, et al. The proprotein convertase PCSK9 induces the degradation of low density lipoprotein receptor (LDLR) and its closest family members VLDLR and ApoER2. J Biol Chem. 2008;283:2363-72 pubmed
    ..These include the very low density lipoprotein receptor (VLDLR) and apolipoprotein E receptor 2 (ApoER2) implicated in neuronal development and lipid metabolism...
  7. Duit S, Mayer H, Blake S, Schneider W, Nimpf J. Differential functions of ApoER2 and very low density lipoprotein receptor in Reelin signaling depend on differential sorting of the receptors. J Biol Chem. 2010;285:4896-908 pubmed publisher
    b>ApoER2 and very low density lipoprotein (VLDL) receptor transmit the Reelin signal into target cells of the central nervous system...
  8. Shan L, Pang L, Zhang R, Murgolo N, Lan H, Hedrick J. PCSK9 binds to multiple receptors and can be functionally inhibited by an EGF-A peptide. Biochem Biophys Res Commun. 2008;375:69-73 pubmed publisher
    ..In addition to LDLR, we show that PCSK9 also binds directly to ApoER2 and mouse VLDLR...
  9. Hong C, Duit S, Jalonen P, Out R, Scheer L, Sorrentino V, et al. The E3 ubiquitin ligase IDOL induces the degradation of the low density lipoprotein receptor family members VLDLR and ApoER2. J Biol Chem. 2010;285:19720-6 pubmed publisher
    ..Here we demonstrate that Idol also targets two closely related LDLR family members, VLDLR and ApoE receptor 2 (ApoER2), proteins implicated in both neuronal development and lipid metabolism...
  10. Drakew A, Deller T, Heimrich B, Gebhardt C, Del Turco D, Tielsch A, et al. Dentate granule cells in reeler mutants and VLDLR and ApoER2 knockout mice. Exp Neurol. 2002;176:12-24 pubmed
    ..reelin and in mutants lacking the reelin receptors very low density lipoprotein receptor (VLDLR) and apolipoprotein E receptor 2 (ApoER2)...
  11. Uchida T, Baba A, Pérez Martínez F, Hibi T, Miyata T, Luque J, et al. Downregulation of functional Reelin receptors in projection neurons implies that primary Reelin action occurs at early/premigratory stages. J Neurosci. 2009;29:10653-62 pubmed publisher
    Reelin signaling is essential for correct development of the mammalian brain. Reelin binds to apolipoprotein E receptor 2 and very low-density lipoprotein receptor and induces phosphorylation of Dab1...
  12. Beffert U, Durudas A, Weeber E, Stolt P, Giehl K, Sweatt J, et al. Functional dissection of Reelin signaling by site-directed disruption of Disabled-1 adaptor binding to apolipoprotein E receptor 2: distinct roles in development and synaptic plasticity. J Neurosci. 2006;26:2041-52 pubmed
    ..Reelin signals by binding to two transmembrane receptors, apolipoprotein E receptor 2 (Apoer2) and very-low-density lipoprotein receptor...
  13. HOE H, Pocivavsek A, Chakraborty G, Fu Z, Vicini S, Ehlers M, et al. Apolipoprotein E receptor 2 interactions with the N-methyl-D-aspartate receptor. J Biol Chem. 2006;281:3425-31 pubmed
    ..present study, we confirmed through co-immunoprecipitation experiments an interaction between the apoE receptor, ApoEr2, and NMDAR1 through their extracellular domains...
  14. Beffert U, Weeber E, Durudas A, Qiu S, Masiulis I, Sweatt J, et al. Modulation of synaptic plasticity and memory by Reelin involves differential splicing of the lipoprotein receptor Apoer2. Neuron. 2005;47:567-79 pubmed
    b>Apolipoprotein E receptor 2 (Apoer2), a member of the LDL receptor gene family, and its ligand Reelin control neuronal migration during brain development...
  15. Leemhuis J, Bouché E, Frotscher M, Henle F, Hein L, Herz J, et al. Reelin signals through apolipoprotein E receptor 2 and Cdc42 to increase growth cone motility and filopodia formation. J Neurosci. 2010;30:14759-72 pubmed publisher
    ..the Rho GTPase Cdc42, known for its role in neuronal morphogenesis and directed migration, in an apolipoprotein E receptor 2-, Disabled-1-, and phosphatidylinositol 3-kinase-dependent manner...
  16. Magdaleno S, Keshvara L, Curran T. Rescue of ataxia and preplate splitting by ectopic expression of Reelin in reeler mice. Neuron. 2002;33:573-86 pubmed
    ..These results indicate that Reelin does not function simply as a positional signal. Rather, it appears to participate in multiple events critical for neuronal migration and cell positioning. ..
  17. Andrade N, Komnenovic V, Blake S, Jossin Y, Howell B, Goffinet A, et al. ApoER2/VLDL receptor and Dab1 in the rostral migratory stream function in postnatal neuronal migration independently of Reelin. Proc Natl Acad Sci U S A. 2007;104:8508-13 pubmed
    ..Here we show that ApoER2 and possibly very-low-density lipoprotein receptor (VLDLR) and their intracellular adapter protein Dab1 are ..
  18. Hashimoto Torii K, Torii M, Sarkisian M, Bartley C, Shen J, Radtke F, et al. Interaction between Reelin and Notch signaling regulates neuronal migration in the cerebral cortex. Neuron. 2008;60:273-84 pubmed publisher
    ..Finally, our in vitro biochemical studies show that Reelin signaling inhibits Notch ICD degradation via Dab1. Together, our results indicate that neuronal migration in the developing cerebral cortex requires a Reelin-Notch interaction. ..
  19. HOE H, Rebeck G. Regulation of ApoE receptor proteolysis by ligand binding. Brain Res Mol Brain Res. 2005;137:31-9 pubmed
    Two brain receptors for apolipoprotein E (apoE), the apoE receptor 2 (apoEr2) and the very low density lipoprotein receptor (VLDLr), are important in neuronal migration during development...
  20. D ARCANGELO G, Homayouni R, Keshvara L, Rice D, Sheldon M, Curran T. Reelin is a ligand for lipoprotein receptors. Neuron. 1999;24:471-9 pubmed
    ..directly to lipoprotein receptors, preferably the very low-density lipoprotein receptor (VLDLR) and apolipoprotein E receptor 2 (ApoER2). Binding requires calcium, and it is inhibited in the presence of apoE...
  21. Qiu Z, Hyman B, Rebeck G. Apolipoprotein E receptors mediate neurite outgrowth through activation of p44/42 mitogen-activated protein kinase in primary neurons. J Biol Chem. 2004;279:34948-56 pubmed
  22. Trotter J, Klein M, Jinwal U, Abisambra J, Dickey C, Tharkur J, et al. ApoER2 function in the establishment and maintenance of retinal synaptic connectivity. J Neurosci. 2011;31:14413-23 pubmed publisher
    ..Reelin and apolipoprotein E (apoE), ligands of apoE receptor 2 (ApoER2), are involved in retinal development and degeneration, respectively...
  23. Stockinger W, Brandes C, Fasching D, Hermann M, Gotthardt M, Herz J, et al. The reelin receptor ApoER2 recruits JNK-interacting proteins-1 and -2. J Biol Chem. 2000;275:25625-32 pubmed
    ..components of this signaling pathway characterized to date are cell surface receptors for reelin like apolipoprotein E receptor 2 (ApoER2), very low density lipoprotein receptor (VLDLR), and cadherin-related neuronal receptors, and ..
  24. Hiesberger T, Trommsdorff M, Howell B, Goffinet A, Mumby M, Cooper J, et al. Direct binding of Reelin to VLDL receptor and ApoE receptor 2 induces tyrosine phosphorylation of disabled-1 and modulates tau phosphorylation. Neuron. 1999;24:481-9 pubmed
    ..two neuronal cell surface proteins, the very low density lipoprotein receptor (VLDLR) and the apoE receptor 2 (ApoER2) as well as a cytosolic adaptor protein, Disabled-1 (Dab1)...
  25. Rossel M, Loulier K, Feuillet C, Alonso S, Carroll P. Reelin signaling is necessary for a specific step in the migration of hindbrain efferent neurons. Development. 2005;132:1175-85 pubmed
    ..However, examination of mice lacking both reelin receptors, ApoER2 and VLDLR, did not reveal the same phenotype, suggesting involvement of an additional reelin-binding receptor...
  26. Liu M, Wu G, Baysarowich J, Kavana M, Addona G, Bierilo K, et al. PCSK9 is not involved in the degradation of LDL receptors and BACE1 in the adult mouse brain. J Lipid Res. 2010;51:2611-8 pubmed publisher
    ..membrane-bound proteins in vitro, including the very low-density lipoprotein receptor (VLDLR), apolipoprotein E receptor 2 (ApoER2) and the beta-site amyloid precursor protein (APP)-cleaving enzyme 1 (BACE1), which are all ..
  27. Trommsdorff M, Gotthardt M, Hiesberger T, Shelton J, Stockinger W, Nimpf J, et al. Reeler/Disabled-like disruption of neuronal migration in knockout mice lacking the VLDL receptor and ApoE receptor 2. Cell. 1999;97:689-701 pubmed
    ..for two other proteins, cell surface receptors termed very low density lipoprotein receptor (VLDLR) and apolipoprotein E receptor 2 (ApoER2)...
  28. Perez Garcia C, Tissir F, Goffinet A, Meyer G. Reelin receptors in developing laminated brain structures of mouse and human. Eur J Neurosci. 2004;20:2827-32 pubmed
    ..cells for reelin express the cytoplasmic adapter protein Dab1, which binds to the reelin receptors VLDLR and ApoER2. In the present work, we have studied the localization of both receptors in developing mouse and human cortex, ..
  29. HOE H, Wessner D, Beffert U, Becker A, Matsuoka Y, Rebeck G. F-spondin interaction with the apolipoprotein E receptor ApoEr2 affects processing of amyloid precursor protein. Mol Cell Biol. 2005;25:9259-68 pubmed
    ..experiments, we demonstrated that F-spondin interacts with an apoE receptor (apoE receptor 2 [ApoEr2]) through the thrombospondin domain of F-spondin and the ligand binding domain of ApoEr2...
  30. HOE H, Minami S, Makarova A, Lee J, Hyman B, Matsuoka Y, et al. Fyn modulation of Dab1 effects on amyloid precursor protein and ApoE receptor 2 processing. J Biol Chem. 2008;283:6288-99 pubmed
    Dab1 is an intracellular adaptor protein that interacts with amyloid precursor protein (APP) and apoE receptor 2 (apoEr2), increases their levels on the cell surface, and increases their cleavage by alpha-secretases...
  31. Beffert U, Nematollah Farsian F, Masiulis I, Hammer R, Yoon S, Giehl K, et al. ApoE receptor 2 controls neuronal survival in the adult brain. Curr Biol. 2006;16:2446-52 pubmed
    ..We demonstrate that a differentially spliced isoform of an ApoE receptor, ApoE receptor 2 (Apoer2), is essential for protection against neuronal cell loss during normal aging...
  32. Blake S, Strasser V, Andrade N, Duit S, Hofbauer R, Schneider W, et al. Thrombospondin-1 binds to ApoER2 and VLDL receptor and functions in postnatal neuronal migration. EMBO J. 2008;27:3069-80 pubmed publisher
    b>Apolipoprotein E receptor 2 (ApoER2), very low-density lipoprotein receptor (VLDLR), and Dab1 are the main components of the Reelin signalling cascade. Reelin is the sole ligand defined so far in signalling through this pathway...
  33. Assadi A, Zhang G, Beffert U, McNeil R, Renfro A, Niu S, et al. Interaction of reelin signaling and Lis1 in brain development. Nat Genet. 2003;35:270-6 pubmed
    ..Reln encodes an extracellular protein that regulates layer formation by interacting with VLDLR and ApoER2 (Lrp8) receptors, thereby phosphorylating the Dab1 signaling molecule...
  34. Arnaud L, Ballif B, Forster E, Cooper J. Fyn tyrosine kinase is a critical regulator of disabled-1 during brain development. Curr Biol. 2003;13:9-17 pubmed
    ..The results were unexpected because Fyn deficiency does not cause the same developmental phenotype as Dab1 or Reelin deficiency. This suggests additional complexity in the Reelin signaling pathway. ..
  35. Weeber E, Beffert U, Jones C, Christian J, Forster E, Sweatt J, et al. Reelin and ApoE receptors cooperate to enhance hippocampal synaptic plasticity and learning. J Biol Chem. 2002;277:39944-52 pubmed
    Two apolipoprotein E (apoE) receptors, the very low density lipoprotein (VLDL) receptor and apoE receptor 2 (apoER2), are also receptors for Reelin, a signaling protein that regulates neuronal migration during brain development...
  36. Rogers J, Rusiana I, Trotter J, Zhao L, Donaldson E, Pak D, et al. Reelin supplementation enhances cognitive ability, synaptic plasticity, and dendritic spine density. Learn Mem. 2011;18:558-64 pubmed publisher
    ..The present study suggests that an acute elevation of in vivo Reelin can have long-term effects on synaptic function and cognitive ability in wild-type mice. ..
  37. Lee C, De Biasio A, Beglova N. Mode of interaction between beta2GPI and lipoprotein receptors suggests mutually exclusive binding of beta2GPI to the receptors and anionic phospholipids. Structure. 2010;18:366-76 pubmed publisher
    ..We compared four ligand-binding LA modules from LDLR and ApoER2 for their ability to bind domain V of beta2GPI (beta2GPI-DV)...
  38. Romay Penabad Z, Aguilar Valenzuela R, Urbanus R, Derksen R, Pennings M, Papalardo E, et al. Apolipoprotein E receptor 2 is involved in the thrombotic complications in a murine model of the antiphospholipid syndrome. Blood. 2011;117:1408-14 pubmed publisher
    ..We investigated the role of Apolipoprotein E receptor 2 (ApoER2') on the pathogenic effects of a patient-derived polyclonal aPL IgG preparation (IgG-APS), a ..
  39. Valentine W, Abel T, Hill K, Austin L, Burk R. Neurodegeneration in mice resulting from loss of functional selenoprotein P or its receptor apolipoprotein E receptor 2. J Neuropathol Exp Neurol. 2008;67:68-77 pubmed publisher
    ..of Sepp1, replacement of it by the shortened form Sepp1(Delta240-361), or deletion of its receptor apolipoprotein E receptor 2 develop severe neurologic dysfunction when fed low-selenium diet...
  40. Miyata T, Ono Y, Okamoto M, Masaoka M, Sakakibara A, Kawaguchi A, et al. Migration, early axonogenesis, and Reelin-dependent layer-forming behavior of early/posterior-born Purkinje cells in the developing mouse lateral cerebellum. Neural Dev. 2010;5:23 pubmed publisher
  41. Petit Turcotte C, Aumont N, Beffert U, Dea D, Herz J, Poirier J. The apoE receptor apoER2 is involved in the maintenance of efficient synaptic plasticity. Neurobiol Aging. 2005;26:195-206 pubmed
    b>ApoER2 is one of the major receptors for ApoE in the brain, and has been shown to be involved not only in lipoprotein endocytosis, as other members of the LDL receptor family of receptors, but also in various cellular functions such as ..
  42. Burk R, Hill K, Olson G, Weeber E, Motley A, Winfrey V, et al. Deletion of apolipoprotein E receptor-2 in mice lowers brain selenium and causes severe neurological dysfunction and death when a low-selenium diet is fed. J Neurosci. 2007;27:6207-11 pubmed
    ..The lipoprotein receptor apolipoprotein E receptor-2 (apoER2) binds Sepp1 and facilitates its uptake by Sertoli cells, thus providing selenium for spermatogenesis...
  43. Andersen O, Benhayon D, Curran T, Willnow T. Differential binding of ligands to the apolipoprotein E receptor 2. Biochemistry. 2003;42:9355-64 pubmed
    b>Apolipoprotein E receptor 2 (apoER2) is an important participant in the Reelin signaling pathway that directs cell positioning during embryogenesis...
  44. Lighthouse J, Zhang L, Hsieh J, Rosenquist T, Holdener B. MESD is essential for apical localization of megalin/LRP2 in the visceral endoderm. Dev Dyn. 2011;240:577-88 pubmed publisher
    ..Combined, our results provide evidence that MESD functions as a general LRP chaperone and suggest that the Mesd phenotype results from both signaling and endocytic defects resulting from misfolding of multiple LRP receptors...
  45. Baba K, Dekimoto H, Muraoka D, Agata K, Terashima T, Katsuyama Y. A mouse homologue of Strawberry Notch is transcriptionally regulated by Reelin signal. Biochem Biophys Res Commun. 2006;350:842-9 pubmed
    ..situ hybridization showed that mSno1 is expressed in the developing nervous system colocalizing with expression of ApoER2, a Reelin receptor. Treatment of P19 cells with Reelin protein enhanced mSno1 expression...
  46. Robertson J, Li W, Silverstein R, Topol E, Smith J. Deficiency of LRP8 in mice is associated with altered platelet function and prolonged time for in vivo thrombosis. Thromb Res. 2009;123:644-52 pubmed publisher
    Our group has previously reported genetic studies associating polymorphisms in the low density lipoprotein receptor related protein 8 (LRP8) gene with myocardial infarction...
  47. Bajari T, Strasser V, Nimpf J, Schneider W. A model for modulation of leptin activity by association with clusterin. FASEB J. 2003;17:1505-7 pubmed
    ..Thus, bioavailability of leptin at a given tissue site may be determined by the levels of clusterin and/or by the relative distribution of certain relatives of the LDL receptor vis-à-vis active leptin receptors. ..
  48. Herrick T, Cooper J. High affinity binding of Dab1 to Reelin receptors promotes normal positioning of upper layer cortical plate neurons. Brain Res Mol Brain Res. 2004;126:121-8 pubmed
    ..Dab1 and the Reelin receptors VLDLR and ApoER2 are expressed by neurons whose migrations are coordinated by Reelin...
  49. Gdalyahu A, Ghosh I, Levy T, Sapir T, Sapoznik S, Fishler Y, et al. DCX, a new mediator of the JNK pathway. EMBO J. 2004;23:823-32 pubmed
  50. Fuchigami T, Sato Y, Tomita Y, Takano T, Miyauchi S, Tsuchiya Y, et al. Dab1-mediated colocalization of multi-adaptor protein CIN85 with Reelin receptors, ApoER2 and VLDLR, in neurons. Genes Cells. 2013;18:410-24 pubmed publisher
    ..secreted from Cajal-Reztuis cells in marginal zone of cerebral cortex, and its receptors are Apolipoprotein E receptor 2 (ApoER2) or very low density lipoprotein receptor (VLDLR) expressed on migrating neurons...
  51. Burk R, Olson G, Hill K, Winfrey V, Motley A, Kurokawa S. Maternal-fetal transfer of selenium in the mouse. FASEB J. 2013;27:3249-56 pubmed publisher
    ..Mice with genetic alterations of Sepp1, the Sepp1 receptors apolipoprotein E receptor-2 (apoER2) and megalin, and Gpx3 were used to investigate maternal-fetal selenium transfer...
  52. Fraley E, Burkett Z, Day N, Schwartz B, Phelps P, White S. Mice with Dab1 or Vldlr insufficiency exhibit abnormal neonatal vocalization patterns. Sci Rep. 2016;6:25807 pubmed publisher
    ..including through the receptors, Very low-density lipoprotein receptor (Vldlr), Apolipoprotein receptor 2 (Apoer2), and intracellular signaling molecule Disabled-1 (Dab1)...
  53. Su J, Klemm M, Josephson A, Fox M. Contributions of VLDLR and LRP8 in the establishment of retinogeniculate projections. Neural Dev. 2013;8:11 pubmed publisher
    ..receptor (VLDLR) and low-density lipoprotein receptor-related protein 8 (LRP8), also known as apolipoprotein E receptor 2 (ApoER2). Here we examined the roles of these canonical reelin receptors in retinogeniculate targeting...
  54. Akopians A, Babayan A, Beffert U, Herz J, Basbaum A, Phelps P. Contribution of the Reelin signaling pathways to nociceptive processing. Eur J Neurosci. 2008;27:523-37 pubmed publisher
    ..Reelin, a secreted glycoprotein that binds to the very-low-density lipoprotein receptor (Vldlr) and apolipoprotein E receptor 2 (Apoer 2), and induces Src- and Fyn-mediated tyrosine phosphorylation of the intracellular adaptor ..
  55. May P, Bock H, Nimpf J, Herz J. Differential glycosylation regulates processing of lipoprotein receptors by gamma-secretase. J Biol Chem. 2003;278:37386-92 pubmed
    ..The apolipoprotein E (apoE) receptor-2 (apoER2), another member of the LDL receptor family with functions in cellular signal transmission, also undergoes ..
  56. Ramesh S, Morrell C, Tarango C, Thomas G, Yuhanna I, Girardi G, et al. Antiphospholipid antibodies promote leukocyte-endothelial cell adhesion and thrombosis in mice by antagonizing eNOS via ?2GPI and apoER2. J Clin Invest. 2011;121:120-31 pubmed publisher
    ..member antagonism with receptor-associated protein (RAP) prevented aPL inhibition of eNOS in cell culture, and ApoER2-/- mice were protected from aPL inhibition of eNOS in vivo...
  57. Dumanis S, Cha H, Song J, Trotter J, Spitzer M, Lee J, et al. ApoE receptor 2 regulates synapse and dendritic spine formation. PLoS ONE. 2011;6:e17203 pubmed publisher
    b>Apolipoprotein E receptor 2 (ApoEr2) is a postsynaptic protein involved in long-term potentiation (LTP), learning, and memory through unknown mechanisms...
  58. Choi H, Liu Y, Tennert C, Sugiura Y, Karakatsani A, Kroger S, et al. APP interacts with LRP4 and agrin to coordinate the development of the neuromuscular junction in mice. elife. 2013;2:e00220 pubmed publisher
    ..DOI:http://dx.doi.org/10.7554/eLife.00220.001. ..
  59. Palmesino E, Rousso D, Kao T, Klar A, Laufer E, Uemura O, et al. Foxp1 and lhx1 coordinate motor neuron migration with axon trajectory choice by gating Reelin signalling. PLoS Biol. 2010;8:e1000446 pubmed publisher
    ..Together, these observations point to identical transcription factors that control motor axon guidance and soma migration and reveal the molecular hierarchy of myotopic organisation. ..
  60. Larouche M, Beffert U, Herz J, Hawkes R. The Reelin receptors Apoer2 and Vldlr coordinate the patterning of Purkinje cell topography in the developing mouse cerebellum. PLoS ONE. 2008;3:e1653 pubmed publisher
    ..extracellular receptors on Purkinje cells-the Very low density lipoprotein receptor (Vldlr) and apolipoprotein E receptor 2 (Apoer2)...
  61. Brandes C, Novak S, Stockinger W, Herz J, Schneider W, Nimpf J. Avian and murine LR8B and human apolipoprotein E receptor 2: differentially spliced products from corresponding genes. Genomics. 1997;42:185-91 pubmed
    ..Novak, et al., 1996, J. Biol. Chem. 271: 11732-11736). The human receptor, termed "apolipoprotein E receptor 2," is a seven ligand-binding repeat receptor harboring a unique insertion in the cytoplasmic domain ..
  62. Leeb C, Eresheim C, Nimpf J. Clusterin is a ligand for apolipoprotein E receptor 2 (ApoER2) and very low density lipoprotein receptor (VLDLR) and signals via the Reelin-signaling pathway. J Biol Chem. 2014;289:4161-72 pubmed publisher
    ..Here we report, that clusterin binds to apolipoprotein E receptor 2 (ApoER2) and very low density lipoprotein receptor (VLDLR) and is internalized by cells expressing ..
  63. Zhang J, Zhang X, Zhang L, Zhou F, Van Dinther M, Ten Dijke P. LRP8 mediates Wnt/?-catenin signaling and controls osteoblast differentiation. J Bone Miner Res. 2012;27:2065-74 pubmed publisher
    ..Here, we identify low-density lipoprotein (LDL) receptor-related protein 8 (LRP8) as a positive regulator of Wnt/?-catenin signaling...
  64. Rollins B, Stier P, Ernst T, Wong G. The human homolog of the JE gene encodes a monocyte secretory protein. Mol Cell Biol. 1989;9:4687-95 pubmed
    ..Thus, human JE encodes yet another member of the large family of JE-related cytokinelike proteins, in this case a novel human monocyte and fibroblast secretory protein. ..
  65. Hibi T, Mizutani M, Baba A, Hattori M. Splicing variations in the ligand-binding domain of ApoER2 results in functional differences in the binding properties to Reelin. Neurosci Res. 2009;63:251-8 pubmed publisher
    Reelin plays critical roles in brain formation by binding to apolipoprotein E receptor 2 (ApoER2) and very low-density lipoprotein receptor...
  66. Luque J, Morante Oria J, Fairen A. Localization of ApoER2, VLDLR and Dab1 in radial glia: groundwork for a new model of reelin action during cortical development. Brain Res Dev Brain Res. 2003;140:195-203 pubmed
    ..Here we provide evidence that the reelin receptor machinery, including the lipoprotein receptors ApoER2 and VLDLR along with the cytoplasmic adaptor protein Dab1, is located in radial glia precursors whose processes ..
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    ..lipoprotein (LDL) receptor antagonist, receptor-associated protein (RAP), soluble recombinant apolipoprotein E receptor 2 (ApoER2), or the LDL-binding domain 1 or 2 of ApoER2...
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    ..several receptors, including two members of the low-density lipoprotein (LDL) receptor family, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR)...
  69. Hirota Y, Kubo K, Katayama K, Honda T, Fujino T, Yamamoto T, et al. Reelin receptors ApoER2 and VLDLR are expressed in distinct spatiotemporal patterns in developing mouse cerebral cortex. J Comp Neurol. 2015;523:463-78 pubmed publisher
    ..the marginal zone, playing essential roles in the formation of the layered neocortex via its receptors, apolipoprotein E receptor 2 (ApoER2) and very low density lipoprotein receptor (VLDLR)...
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    ..Genetic epistasis analysis showed that RelnCTRdel/Apoer2null double homozygotes have phenotypes akin to those of reeler mutants, while RelnCTRdel/..
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    b>Apolipoprotein E receptor 2 (Apoer2) is a multifunctional transport and signaling receptor that regulates the uptake of selenium into the mouse brain and testis through endocytosis of selenoprotein P (Sepp1)...
  72. Zhang G, Assadi A, McNeil R, Beffert U, Wynshaw Boris A, Herz J, et al. The Pafah1b complex interacts with the reelin receptor VLDLR. PLoS ONE. 2007;2:e252 pubmed
    ..through the activation of two receptors, the very low-density lipoprotein receptor (VLDLR) and the apolipoprotein E receptor 2 (ApoER2), and the phosphorylation of Disabled-1 (Dab1)...
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    ..The results extend our previous studies on cortical neurons in which Reelin in the marginal zone was found to stabilize the leading processes of migrating neurons and terminate the migration process. ..
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    b>Apoer2 is an essential receptor in the central nervous system that binds to the apolipoprotein ApoE. Various splice variants of Apoer2 are produced...
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    ..The binding of Reelin to its receptor, LRP8, triggers activation of this cohort of LRP8-Reelin-regulated neuronal (LRN) enhancers that serve as the ultimate ..